{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:31:38Z","timestamp":1793791898986,"version":"4.6.1"},"reference-count":0,"publisher":"China Medical University","issue":"4","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMedicine"],"abstract":"<jats:p>Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin\u2019s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).\nThe review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. Lifestyle factors, including diet, exercise, and sleep hygiene, enhance melatonin\u2019s effects, positioning it as a valuable component of multimodal treatment strategies. Within the PNI framework, melatonin facilitates communication between the nervous and immune systems, offering potential for targeted psychiatric interventions. This synthesis underscores melatonin\u2019s promise as a therapeutic and adjunctive strategy in personalized mental health care. Future research should prioritize rigorous clinical trials, biomarker-driven patient stratification, and integrative approaches combining melatonin with lifestyle interventions and digital health tools to optimize its therapeutic impact<\/jats:p>","DOI":"10.37796\/2211-8039.1682","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T01:59:37Z","timestamp":1764727177000},"source":"Crossref","is-referenced-by-count":2,"title":["The Integrative Role of Melatonin in Psychiatric Disorders: A Systematic Review of Evidence from Circadian Biology, Lifestyle Medicine, and Psychoneuroimmunology"],"prefix":"10.37796","volume":"15","author":[{"given":"Ho Bao Chau","family":"Le","sequence":"first","affiliation":[{"name":"(1)\tMedical Sciences (International Program), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kollawat","family":"Somsri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thansita","family":"Bhunyakarnjanarat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattiya","family":"Hirankarn","sequence":"additional","affiliation":[{"name":"Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asada","family":"Leelahavanichkul","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12796","published-online":{"date-parts":[[2025,11,30]]},"container-title":["BioMedicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:24:23Z","timestamp":1793791463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomedicinej.com\/biomedicine\/vol15\/iss4\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,11,30]]}},"URL":"https:\/\/doi.org\/10.37796\/2211-8039.1682","relation":{},"ISSN":["2211-8039"],"issn-type":[{"value":"2211-8039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]}}}