{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:31:36Z","timestamp":1793791896385,"version":"4.6.1"},"reference-count":0,"publisher":"China Medical University","issue":"1","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMedicine"],"abstract":"<jats:p>Background: The prevalence of obesity has increased significantly over the\nyears, and its health concerns cannot be underestimated. Obesity not only\ncauses potential mobility limitations in daily life but also increases the risk of\ndeveloping cardiovascular diseases, diabetes, cancer and other health\nconditions. While an imbalanced diet and lack of exercise are well-known\ncauses of obesity, genetic patterns also influence its development. Although the GNB3 gene is known to be involved in lipid metabolism and fat cell\ndifferentiation, studies have shown inconsistent associations between a\ncommon single nucleotide polymorphism of GNB3 (c.825C&gt;T, rs5443) and\nobesity across different populations. Therefore, this study aims to analyze the\nassociation between the GNB3 c.825C&gt;T polymorphism and obesity in the Taiwanese population using various grouping criteria. \nSubjects\/Methods: The study recruited 372 eligible subjects for GNB3 SNP\nrs5443 (c.825C&gt;T) testing at China Medical University Hospital in Taichung, Taiwan. Clinical parameters, including age, sex, weight, BMI and body fat\npercentage were assessed for all participants. The GNB3 rs5443 C\/T\ngenotypes were determined using two differentially labeled allele-specific probes and a specific paired PCR primer set.\nResults: Our results demonstrated that the distribution of GNB3 rs5443 genotypes (C\/C, C\/T, T\/T) was not significantly correlated with sex and age (p &gt; 0.05). However, the distribution of GNB3 genotypes (C\/C, T\/T) showed a\nstatistical significance between subjects with BMI &lt; 24 and BMI \uf0b3 27. Furthermore, our results revealed that the C\/T and T\/T genotypes had higher\nfrequency distributions compared to the C\/C genotype in females with body fat\npercentages below 30% (p = 0.022 and p = 0.004, respectively).\nConclusions: Taiwanese individuals carrying the C\/C homozygous genotype\nof the GNB3 gene may have a higher susceptibility to obesity, particularly\namong females. This finding could potentially be combined with polymorphisms\nof other obesity-related genes to develop a clinical screening tool for assessing\nobesity risk.<\/jats:p>","DOI":"10.37796\/2211-8039.1697","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:15:52Z","timestamp":1772093752000},"source":"Crossref","is-referenced-by-count":1,"title":["The association between the GNB3 rs5443 C\/C  genotype and obesity phenotypes in Taiwanese\tindividuals"],"prefix":"10.37796","volume":"16","author":[{"given":"Ling-Yi","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, China  \tMedical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Lun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Di","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, China \tMedical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, China 9 \tMedical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia-Jia","family":"Zheng","sequence":"additional","affiliation":[{"name":"1Department of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po- Ren","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12796","published-online":{"date-parts":[[2026,2,25]]},"container-title":["BioMedicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:24:08Z","timestamp":1793791448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomedicinej.com\/biomedicine\/vol16\/iss1\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,25]]}},"URL":"https:\/\/doi.org\/10.37796\/2211-8039.1697","relation":{},"ISSN":["2211-8039"],"issn-type":[{"value":"2211-8039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}