{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:39:00Z","timestamp":1792525140986,"version":"4.5.0"},"reference-count":9,"publisher":"MyJove Corporation","issue":"-1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/2203","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T15:04:06Z","timestamp":1282316646000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Spatial Distribution of &amp;gamma;H2AX following Ionizing Radiation"],"prefix":"10.3791","author":[{"given":"Raja S.","family":"Vasireddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jeen","family":"Mah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"Georgiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assam","family":"El-Osta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom C.","family":"Karagiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2010,8,7]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","type":"journal-article","article-title":"Megabase chromatin domains involved in DNA double-strand breaks in vivo","volume":"146","author":"Rogakou","year":"1999","unstructured":"Rogakou, E.P., Boon, C., Redon, C., & Bonner, W.M., Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146 (5), 905-916 (1999).","journal-title":"J Cell Biol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","type":"journal-article","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","unstructured":"Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., & Bonner, W.M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273 (10), 5858-5868 (1998).","journal-title":"J Biol Chem"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","type":"journal-article","volume":"8","author":"Bonner","year":"2008","unstructured":"Bonner, W.M. et al., GammaH2AX and cancer. Nat Rev Cancer 8 (12), 957-967 (2008).","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00412-009-0234-4","type":"journal-article","article-title":"H2AX: functional roles and potential applications","volume":"118","author":"Dickey","year":"2009","unstructured":"Dickey, J.S. et al., H2AX: functional roles and potential applications. Chromosoma 118 (6), 683-692 (2009).","journal-title":"Chromosoma"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.200612031","type":"journal-article","article-title":"Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals","volume":"178","author":"Kim","year":"2007","unstructured":"Kim, J.A., Kruhlak, M., Dotiwala, F., Nussenzweig, A., & Haber, J.E., Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol 178 (2), 209-218 (2007).","journal-title":"J Cell Biol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"e1057","DOI":"10.1371\/journal.pone.0001057","type":"journal-article","article-title":"gammaH2AX foci form preferentially in euchromatin after ionising-radiation","volume":"2","author":"Cowell","year":"2007","unstructured":"Cowell, I.G. et al., gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One 2 (10), e1057 (2007).","journal-title":"PLoS One"},{"issue":"17","key":"ref7","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1093\/nar\/gkn550","type":"journal-article","article-title":"Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin","volume":"36","author":"Kinner","year":"2008","unstructured":"Kinner, A., Wu, W., Staudt, C., & Iliakis, G., Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36 (17), 5678-5694 (2008).","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00018-009-0181-5","type":"journal-article","article-title":"gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci","volume":"67","author":"Vasireddy","year":"2010","unstructured":"Vasireddy, R.S., Karagiannis, T.C., & El-Osta, A., gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci. Cell Mol Life Sci 67 (2), 291-294 (2010).","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2008.05.017","type":"journal-article","article-title":"ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin","volume":"31","author":"Goodarzi","year":"2008","unstructured":"Goodarzi, A.A. et al., ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell 31 (2), 167-177 (2008).","journal-title":"Mol Cell"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/2203\/evaluation-spatial-distribution-h2ax-following-ionizing","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:48:26Z","timestamp":1792522106000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/2203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,7]]},"references-count":9,"journal-issue":{"issue":"-1","published-online":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.3791\/2203","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,7]]}}}