{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:38:24Z","timestamp":1792690704722,"version":"4.5.0"},"reference-count":16,"publisher":"MyJove Corporation","issue":"95","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/50472","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T18:59:25Z","timestamp":1422385165000},"source":"Crossref","is-referenced-by-count":5,"title":["Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis."],"prefix":"10.3791","author":[{"given":"Shun-Tai","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez-Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen J.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Lawton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1227\/00006123-199109000-00002","type":"journal-article","article-title":"Intracranial venous hypertension and the effects of venous outflow obstruction in a rat model of arteriovenous fistula","volume":"29","author":"Bederson","year":"1991","unstructured":"Bederson, J.B., Wiestler, O.D., Br\u00fcstle, O., Roth, P., Frick, R., & Ya\u015fargil, M.G. Intracranial venous hypertension and the effects of venous outflow obstruction in a rat model of arteriovenous fistula. Neurosurgery. 29, 341\u2013350, (1991).","journal-title":"Neurosurgery"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/jcbfm.2009.67","type":"journal-article","article-title":"Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9","volume":"29","author":"Gao","year":"2009","unstructured":"Gao, P., Zhu, Y., Ling, F., Shen, F., Lee, B., Gabriel, R.A., Hao, Q., Yang, G.Y., Su, H., & Young, W.L. Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J. Cereb. Blood Flow Metab. 29, 1482\u20131490, DOI 10.1038\/jcbfm.2009.67 (2009).","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-7091-0693-8_14","type":"journal-article","article-title":"arteriovenous malformation pathogenesis: a response-to-injury paradigm","volume":"111","author":"Kim","year":"2011","unstructured":"Kim, H., Su, H., Weinsheimer, S., Pawlikowska, L., & Young, W. L. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir. Suppl. 111, 83\u201392, DOI 10.1007\/978-3-7091-0693-8_14 (2011).","journal-title":"Acta Neurochir. Suppl"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1227\/01.NEU.0000313579.15666.8D","type":"journal-article","article-title":"Radiation arteriopathy in the transgenic arteriovenous fistula model","volume":"62","author":"Lawton","year":"2008","unstructured":"Lawton, M.T., Arnold, C.M., Kim, Y.J., Bogarin, E.A., Stewart, C.L., Wulfstat, A.A., Derugin, N., Deen, D., & Young, W.L. Radiation arteriopathy in the transgenic arteriovenous fistula model. Neurosurgery. 62, 1129\u20131138, DOI 10.1227\/01.neu.0000325875.82999.3c (2008).","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1227\/01.NEU.0000125004.89129.B9","type":"journal-article","article-title":"The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations","volume":"54","author":"Lawton","year":"2004","unstructured":"Lawton, M.T., Stewart, C.L., Wulfstat, A.A., Derugin, N., Hashimoto, T., & Young, W.L. The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations. Neurosurgery. 54, 1463\u20131471, (2004).","journal-title":"Neurosurgery"},{"key":"ref6","first-page":"1876","type":"journal-article","article-title":"Hemodynamic changes after occlusion of the posterior superior sagittal sinus: an experimental PET study in cats","volume":"24","author":"Schaller","year":"2003","unstructured":"Schaller, B., Graf, R., Sanada, Y., Tolnay, M., Rosner, G., Wienhard, K., & Heiss, W,D. Hemodynamic changes after occlusion of the posterior superior sagittal sinus: an experimental PET study in cats. AJNR Am J Neuroradiol. 24, 1876\u20131880 (2003).","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1227\/01.NEU.0000228962.68204.CF","type":"journal-article","article-title":"Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension","volume":"59","author":"Zhu","year":"2006","unstructured":"Zhu, Y., Lawton, M.T, Du, R., Shwe, Y., Chen, Y., Shen, F., Young, WL., & Yang, G.Y. Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension. Neurosurgery. 59, 687\u2013696; discussion 687\u2013696, DOI 10.1227\/01.NEU.0000228962.68204.CF (2006).","journal-title":"Neurosurgery"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3171\/jns.1995.83.3.0539","type":"journal-article","article-title":"Genesis of a dural arteriovenous malformation in a rat model","volume":"83","author":"Herman","year":"1995","unstructured":"Herman, J. M., Spetzler, R. F., Bederson, J. B., Kurbat, J. M., & Zabramski, J. M. Genesis of a dural arteriovenous malformation in a rat model. J. Neurosurg. 83, 539\u2013545, DOI 10.3171\/jns.1995.83.3.0539 (1995).","journal-title":"J. Neurosurg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3171\/jns.1994.80.5.0884","type":"journal-article","article-title":"Development of acquired arteriovenous fistulas in rats due to venous hypertension","volume":"80","author":"Terada","year":"1994","unstructured":"Terada, T., Higashida, R.T., Halbach, V.V., Dowd, C.F., Tsuura, M., Komai, N., Wilson, C.B., & Hieshima, G.B. Development of acquired arteriovenous fistulas in rats due to venous hypertension. J. Neurosurg. 80, 884\u2013889, DOI 10.3171\/jns.1994.80.5.0884 (1994).","journal-title":"J. Neurosurg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00701-004-0248-x","type":"journal-article","article-title":"Angiographic, hemodynamic and histological characterization of an arteriovenous fistula in rats","volume":"146","author":"Yassari","year":"2004","unstructured":"Yassari, R., Sayama, T., Jahromi, B.S., Aihara, Y., Stoodley, M., & Macdonald, R.L. Angiographic, hemodynamic and histological characterization of an arteriovenous fistula in rats. Acta Neurochir (Wien). 146, 495\u2013504 DOI 10.1007\/s00701-004-0248-x (2004).","journal-title":"Acta Neurochir (Wien)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.mehy.2005.05.042","type":"journal-article","article-title":"Transient global amnesia may be caused by cerebral vein thrombosis","volume":"65","author":"Solheim","year":"2005","unstructured":"Solheim, O., & Skeidsvoll, T. Transient global amnesia may be caused by cerebral vein thrombosis. Med. Hypotheses. 65, 1142\u20131149, DOI 10.1016\/j.mehy.2005.05.042 (2005).","journal-title":"Med. Hypotheses"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jvir.2009.03.044","type":"journal-article","article-title":"The mouse arteriovenous fistula model","volume":"20","author":"Yang","year":"2009","unstructured":"Yang, B., Shergill, U., Fu, A.A., Knudsen, B., & Misra, S. The mouse arteriovenous fistula model. J Vasc Interv Radiol. 20, 946\u2013950, DOI 10.1016\/j.jvir.2009.03.044 (2009).","journal-title":"J Vasc Interv Radiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1159\/000337762","type":"journal-article","article-title":"Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse","volume":"33","author":"Choi","year":"2012","unstructured":"Choi, E.J., Choi, E.J., Walker, E.J., Shen, F., Oh, S.P., Arthur, H.M., Young, W.L., & Su, H. Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse. Cerebrovascular diseases (Basel, Switzerland). 33, 540\u2013547, DOI 10.1159\/000337762 (2012).","journal-title":"Cerebrovascular diseases"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"H2250","DOI":"10.1152\/ajpheart.00083.2008","type":"journal-article","article-title":"Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation","volume":"295","author":"Hao","year":"2008","unstructured":"Hao, Q., Su, H., Marchuk, D.A., Rola, R., Wang, Y., Liu, W., Young, W.L., & Yang, G.Y. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am. J. Physiol. Heart Circ. Physiol. 295, H2250\u20132256, DOI 10.1152\/ajpheart.00083.2008 (2008).","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-211-09469-3_36","type":"journal-article","article-title":"Development of a cerebral microvascular dysplasia model in rodents","volume":"105","author":"Su","year":"2008","unstructured":"Su, H., Hao, Q., Shen, F., Zhu, Y., Lee, C.Z., Young, W.L., & Yang, G.Y. Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir. Suppl. 105, 185\u2013189 (2008).","journal-title":"Acta Neurochir. Suppl"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.111.647982","type":"journal-article","article-title":"Bevacizumab Attenuates VEGF-Induced Angiogenesis and Vascular Malformations in the Adult Mouse Brain","author":"Walker","year":"2012","unstructured":"Walker, E.J., Su, H., Shen, F., Degos, V., Jun, K., & Young, W.L. Bevacizumab Attenuates VEGF-Induced Angiogenesis and Vascular Malformations in the Adult Mouse Brain. Stroke; a journal of cerebral circulation.. DOI 10.1161\/STROKEAHA.111.647982 (2012).","journal-title":"Stroke; a journal of cerebral circulation"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/50472\/adult-mouse-venous-hypertension-model-common-carotid-artery-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:40:28Z","timestamp":1792687228000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/50472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,27]]},"references-count":16,"journal-issue":{"issue":"95","published-online":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3791\/50472","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,27]]}}}