{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:39:09Z","timestamp":1792694349989,"version":"4.5.0"},"reference-count":13,"publisher":"MyJove Corporation","issue":"87","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/51357","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T19:59:45Z","timestamp":1400702385000},"source":"Crossref","is-referenced-by-count":32,"title":["Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and &lt;em&gt;in vitro&lt;\/em&gt; Cardiac Hypertrophy"],"prefix":"10.3791","author":[{"given":"Daxiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"ref1","first-page":"288","type":"journal-article","article-title":"Methods in cardiomyocyte isolation, culture, and gene transfer","volume":"51","author":"Louch","year":"2011","unstructured":"Louch, W.E., Sheehan, K.A., & Wolska, B.M. Methods in cardiomyocyte isolation, culture, and gene transfer. J. Mol. Cell cardiol. 51: 288-298 (2011).","journal-title":"J. Mol. Cell"},{"key":"ref2","type":"book","volume-title":"Isolated heart preparations, problems, and pitfalls. In: Animal Models in Cardiovascular Research","author":"Gross","year":"2009","unstructured":"Gross, D.R. Isolated heart preparations, problems, and pitfalls. In: Animal Models in Cardiovascular Research. (third edition). Gross D.R., ed., Springer, 109-130 (2009)."},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-26574-0_28","type":"book","article-title":"Isolation and culture of adult ventricular cardiomyocytes","volume-title":"Practical Methods in Cardiovascular Research","author":"Schl\u00fcter","year":"2005","unstructured":"Schl\u00fcter, K.D., & Piper, H.M. Isolation and culture of adult ventricular cardiomyocytes. In: Practical Methods in Cardiovascular Research. Dhein S., Mohr F.W. and Delmar M., ed., Springer, 557-567 (2005)."},{"issue":"5","key":"ref4","first-page":"1","type":"journal-article","article-title":"Isolation and culture of adult cardiac myocytes for signaling studies","volume":"1","author":"O'Connell","year":"2003","unstructured":"O\u2019Connell, T.D., Ni, Y.G., Lin, K.M., Han, H.P., & Yan, Z. Isolation and culture of adult cardiac myocytes for signaling studies. AfCS research reports. 1 (5): 1-9 http:\/\/www.signaling-gateway.org\/reports\/v1\/CM0005\/CM0005.htm. (2003).","journal-title":"AfCS research reports"},{"key":"ref5","type":"book","article-title":"Isolation and culture of adult mouse cardiac myocytes","volume-title":"Methods in Molecular Biology","author":"O'Connell","year":"2007","unstructured":"O\u2019Connell, T.D., Rodrigo, M.C., & Simpon, P.C. Isolation and culture of adult mouse cardiac myocytes. In: Methods in Molecular Biology. 35, Vivanco F., ed., Humana Press, 271-296 (2007)."},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-6658-2_10","type":"book","article-title":"Cell culture models and methods","volume-title":"Cardiac Electrophysiology Methods and Models","author":"Nilolskaya","year":"2010","unstructured":"Nilolskaya, A., & Sharma, V. Cell culture models and methods. In: Cardiac Electrophysiology Methods and Models. Sigg D.C., Laizzo P.A., and Xiao Y.F., ed., Springer, 213-235 (2010)."},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-26574-0_10","type":"book","article-title":"The working heart","volume-title":"Practical Methods in Cardiovascular Research","author":"Merx","year":"2005","unstructured":"Merx, M.W., & Schrader, M. The working heart. In: Practical Methods in Cardiovascular Research. Dhein S., Mohr F.W., & Delmar M., ed., Springer-Verlag Berlin Heidelberg, Germany, 173-189 (2005)."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1152\/ajpheart.01144.2007","type":"journal-article","article-title":"Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression","volume":"294","author":"Kabaeva","year":"2008","unstructured":"Kabaeva, Z., Zhao, M., & Michele, D.E. Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression. Am. J. Physiol. Heart Circ. Physiol. 294: H1667-1674 (2008).","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1152\/ajpheart.00711.2011","type":"journal-article","article-title":"The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime","volume":"302","author":"Lou","year":"2012","unstructured":"Lou, Q., Li W., & Efimov, I.R. The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime. Am. J. Physiol. Heart Circ. Physiol. 302, H262-269 (2012).","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"issue":"20","key":"ref10","doi-asserted-by":"crossref","first-page":"16390","DOI":"10.1074\/jbc.M111.304451","type":"journal-article","article-title":"Reduction of Na\/K-ATPase potentiates Marinobufagenin-induced cardiac dysfunction and myocyte apoptosis","volume":"287","author":"Liu","year":"2012","unstructured":"Liu, C.X., et al. Reduction of Na\/K-ATPase potentiates Marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 287 (20): 16390-16398 (2012).","journal-title":"J. Biol. Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/ajpheart.00462.2012","type":"journal-article","article-title":"Different roles of the cardiac Na+\/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy","volume":"304","author":"Bai","year":"2013","unstructured":"Bai, Y., et al. Different roles of the cardiac Na+\/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 304: H427-H435 (2013).","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1152\/ajpcell.00158.2007","type":"journal-article","article-title":"Association of PI3K-AKT signaling pathway with digitalis-induced hypertrophy of cardiac myocytes","volume":"293","author":"Liu","year":"2007","unstructured":"Liu, L.J., Zhao, X. C., Pierre, S. V., & Askari, A. Association of PI3K-AKT signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am. J. Physiol. Cell Physiol. 293: 1489-1497 (2007).","journal-title":"Am. J. Physiol. Cell Physiol"},{"issue":"58","key":"ref13","doi-asserted-by":"crossref","DOI":"10.3791\/3302","type":"journal-article","article-title":"Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes","author":"Flynn","year":"2011","unstructured":"Flynn, J. M., Santana, L. F., & Melov, S. Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes. J. Vis. Exp. (58), e3302, doi:10.3791\/3302 (2011).","journal-title":"J. Vis. Exp"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/51357\/isolation-culture-adult-mouse-cardiomyocytes-for-cell-signaling-vitro","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:56:10Z","timestamp":1792691770000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/51357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":13,"journal-issue":{"issue":"87","published-online":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3791\/51357","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]}}}