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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 52, 239-248 (1988).","journal-title":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.vetimm.2004.09.008","type":"journal-article","article-title":"Bronchoalveolar immune defense in cattle exposed to primary and secondary challenge with bovine viral diarrhea virus","volume":"103","author":"Silflow","year":"2005","unstructured":"Silflow, R. M., Degel, P. M., & Harmsen, A. G. Bronchoalveolar immune defense in cattle exposed to primary and secondary challenge with bovine viral diarrhea virus. 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Population-based estimates of transbronchial lung biopsy utilization and complications. Respiratory medicine. 106, 1559-1565, doi:10.1016\/j.rmed.2012.08.008 (2012).","journal-title":"Respiratory medicine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2460\/javma.1999.215.05.679","type":"journal-article","article-title":"Percutaneous lung biopsy in cattle","volume":"215","author":"Braun","year":"1999","unstructured":"Braun, U., Estermann, U., Feige, K., Sydler, T., & Pospischil, A. Percutaneous lung biopsy in cattle. Journal of the American Veterinary Medical Association. 215, 679-681 (1999).","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"ref50","first-page":"254","type":"journal-article","article-title":"The development of a novel percutaneous lung biopsy procedure for use on feedlot steers","volume":"75","author":"Burgess","year":"2011","unstructured":"Burgess, B. A. et al. The development of a novel percutaneous lung biopsy procedure for use on feedlot steers. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 75, 254-260 (2011).","journal-title":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1439-0442.2004.00625.x","type":"journal-article","article-title":"A comparison of biopsy and post-mortem findings in the lungs of healthy cows","volume":"51","author":"Sydler","year":"2004","unstructured":"Sydler, T., Braun, U., Estermann, U., & Pospischil, A. A comparison of biopsy and post-mortem findings in the lungs of healthy cows. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. 51, 184-187, doi:10.1111\/j.1439-0442.2004.00625.x (2004).","journal-title":"Journal of veterinary medicine. A, Physiology, pathology clinical medicine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.rvsc.2007.02.001","type":"journal-article","article-title":"PCR examination of bronchoalveolar lavage samples is a useful tool in pre-clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte)","volume":"83","author":"Voigt","year":"2007","unstructured":"Voigt, K. et al. PCR examination of bronchoalveolar lavage samples is a useful tool in pre-clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte). Research in Veterinary Science. 83, 419-427 (2007).","journal-title":"Research in Veterinary Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/inpract.23.1.41","type":"journal-article","article-title":"Bronchoalveolar lavage in the investigation of bovine respiratory disease","volume":"1","author":"Caldow","year":"2001","unstructured":"Caldow, G. Bronchoalveolar lavage in the investigation of bovine respiratory disease. In Practice. 1, 41-43 (2001).","journal-title":"In Practice"},{"key":"ref54","first-page":"79","type":"journal-article","article-title":"Bronchoscopy and Segmental Bronchoalveolar Lung Lavage of Anesthetised Calf","volume":"43","author":"Heilmann","year":"1988","unstructured":"Heilmann, P., M\u00fcller, G., & Reinhold, P. [Bronchoscopy and Segmental Bronchoalveolar Lung Lavage of Anesthetised Calf]. Monatsh. Veterin\u00e4rmed. 43, 79-84 (1988).","journal-title":"Monatsh. Veterin\u00e4rmed"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/iai.55.6.1403-1411.1987","type":"journal-article","article-title":"Protective ability and specificity of convalescent serum from calves with Haemophilus somnus pneumonia","volume":"55","author":"Gogolewski","year":"1987","unstructured":"Gogolewski, R. P. et al. Protective ability and specificity of convalescent serum from calves with Haemophilus somnus pneumonia. Infection and immunity. 55, 1403-1411 (1987).","journal-title":"Infection and immunity"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/51557\/the-bovine-lung-biomedical-research-visually-guided-bronchoscopy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:28:28Z","timestamp":1792690108000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/51557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,3]]},"references-count":55,"journal-issue":{"issue":"89","published-online":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3791\/51557","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,3]]}}}