{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:41:38Z","timestamp":1792687298590,"version":"4.5.0"},"reference-count":33,"publisher":"MyJove Corporation","issue":"99","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/52454","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T20:00:07Z","timestamp":1431806407000},"source":"Crossref","is-referenced-by-count":17,"title":["A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.3791","author":[{"given":"Kasper J.","family":"Kyng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torjus","family":"Skajaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Kerrn-Jespersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer S.","family":"Andreassen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Bennedsgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine B.","family":"Henriksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2015,5,16]]},"reference":[{"key":"ref1","first-page":"330","type":"journal-article","article-title":"Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs","volume":"68","author":"Chakkarapani","year":"2010","unstructured":"Chakkarapani, E., et al. Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Annals of. 68, 330-341 (2010).","journal-title":"Annals of"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","type":"journal-article","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","unstructured":"Robertson, N. J., et al. Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain : a journal of neurology. 136, 90-105 (2013).","journal-title":"Brain : a journal of neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(14)60496-7","type":"journal-article","article-title":"Every Newborn: progress, priorities, and potential beyond survival","volume":"384","author":"Lawn","year":"2014","unstructured":"Lawn, J. E., et al. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 384, 189-205 (2014).","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","type":"journal-article","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","unstructured":"Lee, A. C., et al. Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatric research. 74, Suppl 1. 50-72 (2013).","journal-title":"Pediatric research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","type":"journal-article","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","unstructured":"Kurinczuk, J. J., White-Koning, M., Badawi, N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early human development. 86, 329-338 (2010).","journal-title":"Early human development"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","type":"journal-article","article-title":"Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants","volume":"25","author":"Shankaran","year":"1991","unstructured":"Shankaran, S., Woldt, E., Koepke, T., Bedard, M. P., Nandyal, R. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early human development. 25, 135-148 (1991).","journal-title":"Early human development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3476(89)80132-5","type":"journal-article","article-title":"School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term","volume":"114","author":"Robertson","year":"1989","unstructured":"Robertson, C. M., Finer, N. N., Grace, M. G. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. The Journal of pediatrics. 114, 753-760 (1989).","journal-title":"The Journal of pediatrics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.siny.2010.05.007","type":"journal-article","article-title":"Potential biomarkers for hypoxic-ischemic encephalopathy","volume":"15","author":"Bennet","year":"2010","unstructured":"Bennet, L., Booth, L., Gunn, A. J. Potential biomarkers for hypoxic-ischemic encephalopathy. Seminars in feta., & neonatal medicine. 15, 253-260 (2010).","journal-title":"Seminars in feta., & neonatal medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pediatrneurol.2008.10.025","type":"journal-article","article-title":"Animal models of perinatal hypoxic-ischemic brain damage","volume":"40","author":"Yager","year":"2009","unstructured":"Yager, J. Y., Ashwal, S. Animal models of perinatal hypoxic-ischemic brain damage. Pediatric neurology. 40, 156-167 (2009).","journal-title":"Pediatric neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-9629(86)90080-0","type":"journal-article","article-title":"Maturation of circulatory system in three mammalian models of human development","volume":"83","author":"Buckley","year":"1986","unstructured":"Buckley, N. M. Maturation of circulatory system in three mammalian models of human development. Comparative biochemistry and physiology. A, Comparative. 83, 1-7 (1986).","journal-title":"Comparative biochemistry and physiology. A, Comparative"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","type":"journal-article","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","unstructured":"Dobbing, J., Sands, J. Comparative aspects of the brain growth spurt. Early human development. 3, 79-83 (1979).","journal-title":"Early human development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/adc.48.10.757","type":"journal-article","article-title":"Quantitative growth and development of human brain","volume":"48","author":"Dobbing","year":"1973","unstructured":"Dobbing, J., Sands, J. Quantitative growth and development of human brain. Archives of disease in childhood. 48, 757-767 (1973).","journal-title":"Archives of disease in childhood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0006-8993(01)03011-6","type":"journal-article","article-title":"An improved survival model of hypoxia\/ischaemia in the piglet suitable for neuroprotection studies","volume":"919","author":"Foster","year":"2001","unstructured":"Foster, K. A., et al. An improved survival model of hypoxia\/ischaemia in the piglet suitable for neuroprotection studies. Brain research. 919, 122-131 (2001).","journal-title":"Brain research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1161\/01.STR.26.10.1908","type":"journal-article","article-title":"AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs","volume":"26","author":"LeBlanc","year":"1995","unstructured":"LeBlanc, M. H., Li, X. Q., Huang, M., Patel, D. M., Smith, E. E. AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs. Stroke; a journal of cerebral circulation. 26, 1908-1914 (1995).","journal-title":"Stroke; a journal of cerebral circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1515\/JPM.2009.081","type":"journal-article","article-title":"Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets","volume":"37","author":"Andresen","year":"2009","unstructured":"Andresen, J. H., et al. Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets. J Perinat Med. 37, 553-560 (2009).","journal-title":"J Perinat Med"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.3791\/3166","type":"journal-article","article-title":"A swine model of neonatal asphyxia","author":"Cheung","year":"2011","unstructured":"Cheung, P. Y., Gill, R. S., Bigam, D. L. A swine model of neonatal asphyxia. Journal of visualized experiments : JoVE. (2011).","journal-title":"Journal of visualized experiments : JoVE"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","type":"journal-article","article-title":"A piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","unstructured":"Thoresen, M., et al. A piglet survival model of posthypoxic encephalopathy. Pediatric research. 40, 738-748 (1996).","journal-title":"Pediatric research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1203\/PDR.0b013e31822941ee","type":"journal-article","article-title":"Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs","volume":"70","author":"Liu","year":"2011","unstructured":"Liu, X., Tooley, J., Loberg, E. M., Suleiman, M. S., Thoresen, M. Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs. Pediatric research. 70, 352-356 (2011).","journal-title":"Pediatric research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2006.04.119","type":"journal-article","article-title":"Hypoxic\/Ischemic models in newborn piglet: comparison of constant FiO2 versus variable FiO2 delivery","volume":"1100","author":"Bjorkman","year":"2006","unstructured":"Bjorkman, S. T., et al. Hypoxic\/Ischemic models in newborn piglet: comparison of constant FiO2 versus variable FiO2 delivery. Brain research. 1100, 110-117 (2006).","journal-title":"Brain research"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jpeds.2011.12.052","type":"journal-article","article-title":"Which neuroprotective agents are ready for bench to bedside translation in the newborn infant","volume":"160","author":"Robertson","year":"2012","unstructured":"Robertson, N. J., et al. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant. The Journal of pediatrics. 160, 544-552 (2012).","journal-title":"The Journal of pediatrics"},{"key":"ref21","first-page":"CD003311","type":"journal-article","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"1","author":"Jacobs","year":"2013","unstructured":"Jacobs, S. E., et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 1, CD003311 (2013).","journal-title":"Cochrane Database Syst Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000105523","type":"journal-article","article-title":"Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine","volume":"93","author":"Andresen","year":"2008","unstructured":"Andresen, J. H., et al. Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine. Neonatology. 93, 36-44 (2008).","journal-title":"Neonatology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1203\/PDR.0b013e318174efdd","type":"journal-article","article-title":"Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia","volume":"64","author":"Karlsson","year":"2008","unstructured":"Karlsson, M., et al. Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia. Pediatric research. 64, 74-78 (2008).","journal-title":"Pediatric research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0196-9781(01)00440-5","type":"journal-article","article-title":"Asphyxia-induced release of alpha-melanocyte-stimulating hormone in newborn pigs","volume":"22","author":"Kovacs","year":"2001","unstructured":"Kovacs, J., et al. Asphyxia-induced release of alpha-melanocyte-stimulating hormone in newborn pigs. Peptides. 22, 1049-1053 (2001).","journal-title":"Peptides"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1258\/la.2011.010176","type":"journal-article","article-title":"Asphyxial cardiac arrest, resuscitation and neurological outcome in a Landrace\/Large-White swine model","volume":"45","author":"Varvarousi","year":"2011","unstructured":"Varvarousi, G., et al. Asphyxial cardiac arrest, resuscitation and neurological outcome in a Landrace\/Large-White swine model. Laboratory animals. 45, 184-190 (2011).","journal-title":"Laboratory animals"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1471-4159.1993.tb03301.x","type":"journal-article","article-title":"Activity of tyrosine hydroxylase in the striatum of newborn piglets in response to hypocapnic hypoxia","volume":"60","author":"Tammela","year":"1993","unstructured":"Tammela, O., Pastuszko, A., Lajevardi, N. S., Delivoria-Papadopoulos, M., Wilson, D. F. Activity of tyrosine hydroxylase in the striatum of newborn piglets in response to hypocapnic hypoxia. Journal of neurochemistry. 60, 1399-1406 (1993).","journal-title":"Journal of neurochemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1139\/y99-141","type":"journal-article","article-title":"Age-dependent metabolic effects of repeated hypoxemia in piglets","volume":"78","author":"Cote","year":"2000","unstructured":"Cote, A., Barter, J., Meehan, B. Age-dependent metabolic effects of repeated hypoxemia in piglets. Canadian journal of physiology and pharmacology. 78, 321-328 (2000).","journal-title":"Canadian journal of physiology and pharmacology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1203\/PDR.0b013e318194faa6","type":"journal-article","article-title":"Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen","volume":"65","author":"Tichauer","year":"2009","unstructured":"Tichauer, K. M., et al. Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen. Pediatric research. 65, 301-306 (2009).","journal-title":"Pediatric research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0300-9572(96)01094-5","type":"journal-article","article-title":"Anesthetic regimen effects on a pediatric porcine model of asphyxial arrest","volume":"35","author":"Jasani","year":"1997","unstructured":"Jasani, M. S., Salzman, S. K., Tice, L. L., Ginn, A., Nadkarni, V. M. Anesthetic regimen effects on a pediatric porcine model of asphyxial arrest. Resuscitation. 35, 69-75 (1997).","journal-title":"Resuscitation"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00134-011-2442-7","type":"journal-article","article-title":"Xenon offers stable haemodynamics independent of induced hypothermia after hypoxia-ischaemia in newborn pigs","volume":"38","author":"Chakkarapani","year":"2012","unstructured":"Chakkarapani, E., Thoresen, M., Liu, X., Walloe, L., Dingley, J. Xenon offers stable haemodynamics independent of induced hypothermia after hypoxia-ischaemia in newborn pigs. Intensive care medicine. 38, 316-323 (2012).","journal-title":"Intensive care medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/02841850802334224","type":"journal-article","article-title":"A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging","volume":"49","author":"Munkeby","year":"2008","unstructured":"Munkeby, B. H., et al. A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging. Acta radiologica. 49, 1049-1057 (2008).","journal-title":"Acta radiologica"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/14767050802663186","type":"journal-article","article-title":"Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: long-term effects on brain and heart","volume":"22","author":"Andresen","year":"2009","unstructured":"Andresen, J. H., et al. Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: long-term effects on brain and heart. J Matern Fetal Neonatal Med. 22, 161-168 (2009).","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1203\/01.PDR.0000141988.89820.E3","type":"journal-article","article-title":"Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets","volume":"56","author":"Munkeby","year":"2004","unstructured":"Munkeby, B. H., et al. Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets. Pediatric research. 56, 783-790 (2004).","journal-title":"Pediatric research"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/52454\/a-piglet-model-of-neonatal-hypoxic-ischemic-encephalopathy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:13:22Z","timestamp":1792685602000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/52454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,16]]},"references-count":33,"journal-issue":{"issue":"99","published-online":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3791\/52454","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,16]]}}}