{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:43:26Z","timestamp":1792687406770,"version":"4.5.0"},"reference-count":31,"publisher":"MyJove Corporation","issue":"96","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/52538","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T19:00:06Z","timestamp":1424286006000},"source":"Crossref","is-referenced-by-count":8,"title":["Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice"],"prefix":"10.3791","author":[{"given":"Natarajan","family":"Bhaskaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Weinberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa","family":"Pandiyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1600-051X.2011.01752.x","type":"journal-article","article-title":"IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions","volume":"38","author":"Allam","year":"2011","unstructured":"Allam, J. P., et al. IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions. Journal of Clinical Periodontology. 38, (10), 879-886 (2011).","journal-title":"Journal of Clinical Periodontology"},{"issue":"6","key":"ref2","first-page":"463","type":"journal-article","article-title":"Periodontal disease: link to cardiovascular disease","volume":"21","author":"Loesche","year":"2000","unstructured":"Loesche, W. J. Periodontal disease: link to cardiovascular disease. Compendium Of Continuing Education In Dentistry. 21, (6), 463-466 (2000).","journal-title":"Compendium Of Continuing Education In Dentistry"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jvs.2011.10.008","type":"journal-article","article-title":"Association between periodontal disease and stroke","volume":"55","author":"Sfyroeras","year":"2012","unstructured":"Sfyroeras, G. S., Roussas, N., Saleptsis, V. G., Argyriou, C., Giannoukas, A. D. Association between periodontal disease and stroke. Journal Of Vascular Surgery. 55, (4), 1178-1184 (2012).","journal-title":"Journal Of Vascular Surgery"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/ar3893","type":"journal-article","article-title":"Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy","volume":"14","author":"Huppler","year":"2012","unstructured":"Huppler, A. R., Bishu, S., Gaffen, S. L. Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. Arthritis Research & Therapy. 14, (4), 217 (2012).","journal-title":"Arthritis Research & Therapy"},{"issue":"4","key":"ref5","first-page":"253","type":"journal-article","article-title":"Chronic hyperplastic candidosis\/candidiasis (candidal leukoplakia). Critical Reviews In","volume":"14","author":"Sitheeque","year":"2003","unstructured":"Sitheeque, M. A., Samaranayake, L. P. Chronic hyperplastic candidosis\/candidiasis (candidal leukoplakia). Critical Reviews In. Oral Biology And Medicine : An Official Publication Of The American Association Of Oral Biologists. 14, (4), 253-267 (2003).","journal-title":"Oral Biology And Medicine : An Official Publication Of The American Association Of Oral Biologists"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/jre.12022","type":"journal-article","article-title":"Association of subgingival colonization of Candida albicans and other yeasts with severity of chronic periodontitis","volume":"48","author":"Canabarro","year":"2013","unstructured":"Canabarro, A., et al. Association of subgingival colonization of Candida albicans and other yeasts with severity of chronic periodontitis. Journal Of Periodontal Research. 48, (4), 428-432 (2013).","journal-title":"Journal Of Periodontal Research"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/13693780802060899","type":"journal-article","article-title":"Yeast diversity in the oral microbiota of subjects with periodontitis: Candida albicans and Candida dubliniensis colonize the periodontal pockets","volume":"46","author":"Urzua","year":"2008","unstructured":"Urzua, B., et al. Yeast diversity in the oral microbiota of subjects with periodontitis: Candida albicans and Candida dubliniensis colonize the periodontal pockets. Medical Mycology. 46, (8), 783-793 (2008).","journal-title":"Medical Mycology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.4317\/medoral.15.e310","type":"journal-article","article-title":"Oral status and Candida colonization in patients with Sjogren's Syndrome","volume":"15","author":"Ergun","year":"2010","unstructured":"Ergun, S., et al. Oral status and Candida colonization in patients with Sjogren's Syndrome. Medicina Oral, Patologia Oral Y Cirugia Bucal. 15, (2), e310-e315 (2010).","journal-title":"Medicina Oral, Patologia Oral Y Cirugia Bucal"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0030-4220(89)90218-1","type":"journal-article","article-title":"Oral candidiasis in Sjogren's syndrome: prevalence, clinical correlations, and treatment","volume":"68","author":"Hernandez","year":"1989","unstructured":"Hernandez, Y. L., Daniels, T. E. Oral candidiasis in Sjogren's syndrome: prevalence, clinical correlations, and treatment. Oral Surgery, Oral Medicine, And Oral Pathology. 68, (3), 324-329 (1989).","journal-title":"Oral Surgery, Oral Medicine, And Oral Pathology"},{"issue":"3","key":"ref10","first-page":"283","type":"journal-article","article-title":"Candida spp. in oral cancer and oral precancerous lesions","volume":"36","author":"Gall","year":"2013","unstructured":"Gall, F., et al. Candida spp. in oral cancer and oral precancerous lesions. The New Microbiologica. 36, (3), 283-288 (2013).","journal-title":"The New Microbiologica"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/carcin\/13.5.783","type":"journal-article","article-title":"Candida albicans as a promoter of oral mucosal neoplasia","volume":"13","author":"Grady","year":"1992","unstructured":"Grady, J. F., Reade, P. C. Candida albicans as a promoter of oral mucosal neoplasia. Carcinogenesis. 13, (5), 783-786 (1992).","journal-title":"Carcinogenesis"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/13693780802165797","type":"journal-article","article-title":"A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia","volume":"47","author":"Dwivedi","year":"2009","unstructured":"Dwivedi, P. P., Mallya, S., Dongari-Bagtzoglou, A. A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia. Medical Mycology. 47, (2), 157-167 (2009).","journal-title":"Medical Mycology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/IAI.06146-11","type":"journal-article","article-title":"Interplay between Candida albicans and the mammalian innate host defense","volume":"80","author":"Cheng","year":"2012","unstructured":"Cheng, S. C., Joosten, L. A., Kullberg, B. J., Netea, M. G. Interplay between Candida albicans and the mammalian innate host defense. Infection and Immunity. 80, (4), 1304-1313 (2012).","journal-title":"Infection and Immunity"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/MOP.0b013e3282f1dde9","type":"journal-article","article-title":"Invasive Candida species disease in infants and children: occurrence, risk factors, management, and innate host defense mechanisms","volume":"19","author":"Marodi","year":"2007","unstructured":"Marodi, L., Johnston, R. B. Invasive Candida species disease in infants and children: occurrence, risk factors, management, and innate host defense mechanisms. Current Opinion In Pediatrics. 19, (6), 693-697 (2007).","journal-title":"Current Opinion In Pediatrics"},{"issue":"4","key":"ref15","first-page":"386","type":"journal-article","article-title":"Inflammation and gastrointestinal Candida colonization. Current Opinion In","volume":"14","author":"Kumamoto","year":"2011","unstructured":"Kumamoto, C. A. Inflammation and gastrointestinal Candida colonization. Current Opinion In. Microbiology. 14, (4), 386-391 (2011).","journal-title":"Microbiology"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"e42770","DOI":"10.1371\/journal.pone.0042770","type":"journal-article","article-title":"The relation between oral Candida load and bacterial microbiome profiles in Dutch older adults","volume":"7","author":"Kraneveld","year":"2012","unstructured":"Kraneveld, E. A., et al. The relation between oral Candida load and bacterial microbiome profiles in Dutch older adults. PloS One. 7, (8), e42770 (2012).","journal-title":"PloS One"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mi.2012.128","type":"journal-article","article-title":"Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections","volume":"6","author":"Hernandez-Santos","year":"2013","unstructured":"Hernandez-Santos, N., et al. Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunology. 6, (5), 900-910 (2013).","journal-title":"Mucosal Immunology"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1158\/1940-6207.CAPR-08-0211","type":"journal-article","article-title":"ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis","volume":"2","author":"Hasina","year":"2009","unstructured":"Hasina, R., et al. ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis. Cancer Prevention Research. 2, (4), 385-393 (2009).","journal-title":"Cancer Prevention Research"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.immuni.2011.03.002","type":"journal-article","article-title":"CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model","volume":"34","author":"Pandiyan","year":"2011","unstructured":"Pandiyan, P., et al. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 34, (3), 422-434 (2011).","journal-title":"Immunity"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.4049\/jimmunol.1201476","type":"journal-article","article-title":"The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes","volume":"189","author":"Pandiyan","year":"2012","unstructured":"Pandiyan, P., et al. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. J Immunol. 189, (9), 4237-4246 (2012).","journal-title":"J Immunol"},{"issue":"6","key":"ref21","type":"journal-article","article-title":"The control of CD4+CD25+Foxp3+ regulatory T cell survival","volume":"3","author":"Pandiyan","year":"2008","unstructured":"Pandiyan, P., Lenardo, M. J. The control of CD4+CD25+Foxp3+ regulatory T cell survival. Biology Direct. 3, (6), (2008).","journal-title":"Biology Direct"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ni1536","type":"journal-article","article-title":"CD4(+)CD25(+)Foxp3(+) regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4(+) T cells","volume":"8","author":"Pandiyan","year":"2007","unstructured":"Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., Lenardo, M. J. CD4(+)CD25(+)Foxp3(+) regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4(+) T cells. Nat Immunol. 8, (12), 1353-1362 (2007).","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/0471142735.im1906s105","type":"journal-article","article-title":"Animal models for candidiasis","volume":"105","author":"Conti","year":"2014","unstructured":"Conti, H. R., Huppler, A. R., Whibley, N., Gaffen, S. L., et al. Animal models for candidiasis. Current Protocols In Immunology. Coligan, J. E., et al. 105, 11-19 (2014).","journal-title":"Current Protocols In Immunology"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20081463","type":"journal-article","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis","volume":"206","author":"Conti","year":"2009","unstructured":"Conti, H. R., et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med. 206, (2), 299-311 (2009).","journal-title":"J Exp Med"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1128\/AAC.45.11.3195-3197.2001","type":"journal-article","article-title":"New model of oropharyngeal candidiasis in mice","volume":"45","author":"Kamai","year":"2001","unstructured":"Kamai, Y., et al. New model of oropharyngeal candidiasis in mice. Antimicrobial Agents And Chemotherapy. 45, (11), 3195-3197 (2001).","journal-title":"Antimicrobial Agents And Chemotherapy"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1480-9222-16-4","type":"journal-article","article-title":"Isolation of T cells from mouse oral tissues","volume":"16","author":"Pandiyan","year":"2014","unstructured":"Pandiyan, P., Bhaskaran, N., Zhang, Y., Weinberg, A. Isolation of T cells from mouse oral tissues. Biological Procedures Online. 16, (1), 4 (2014).","journal-title":"Biological Procedures Online"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4049\/jimmunol.1202924","type":"journal-article","article-title":"Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection","volume":"190","author":"Gladiator","year":"2013","unstructured":"Gladiator, A., Wangler, N., Trautwein-Weidner, K., LeibundGut-Landmann, S. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J Immunol. 190, (2), 521-525 (2013).","journal-title":"J Immunol"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/intimm\/dxu051","type":"journal-article","article-title":"Pleiotropic functions of TNF-alpha in the regulation of the intestinal epithelial response to inflammation","volume":"26","author":"Leppkes","year":"2014","unstructured":"Leppkes, M., Roulis, M., Neurath, M. F., Kollias, G., Becker, C. Pleiotropic functions of TNF-alpha in the regulation of the intestinal epithelial response to inflammation. International Immunology. 26, (9), 509-515 (2014).","journal-title":"International Immunology"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/IAI.01335-13","type":"journal-article","article-title":"The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections","volume":"82","author":"Bishu","year":"2014","unstructured":"Bishu, S., et al. The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Infection and Immunity. 82, (3), 1173-1180 (2014).","journal-title":"Infection and Immunity"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1002\/eji.201343828","type":"journal-article","article-title":"Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice","volume":"44","author":"Quintin","year":"2014","unstructured":"Quintin, J., et al. Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol. 44, (8), 2405-2414 (2014).","journal-title":"Eur J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1040841X.2014.913004","type":"journal-article","article-title":"Candida albicans and cancer: Can this yeast induce cancer development or progression","author":"Ramirez-Garcia","year":"2014","unstructured":"Ramirez-Garcia, A., et al. Candida albicans and cancer: Can this yeast induce cancer development or progression. Critical Reviews In Microbiology. 1-13 (2014).","journal-title":"Critical Reviews In Microbiology"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/52538\/th17-inflammation-model-oropharyngeal-candidiasis-immunodeficient","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:33:19Z","timestamp":1792686799000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/52538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,18]]},"references-count":31,"journal-issue":{"issue":"96","published-online":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3791\/52538","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,18]]}}}