{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:58:59Z","timestamp":1793764739223,"version":"4.6.1"},"reference-count":34,"publisher":"MyJove Corporation","issue":"94","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/52597","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T19:00:02Z","timestamp":1419620402000},"source":"Crossref","is-referenced-by-count":10,"title":["Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish"],"prefix":"10.3791","author":[{"given":"In\u00eas M.","family":"Tenente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Langenau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2014,12,26]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tig.2013.07.003","type":"journal-article","article-title":"The zebrafish as a model for complex tissue regeneration","volume":"29","author":"Gemberling","year":"2013","unstructured":"Gemberling, M., Bailey, T. J., Hyde, D. R., & Poss, K. D. The zebrafish as a model for complex tissue regeneration. Trends in genetics : TIG. 29 (11), 611\u201320, doi:10.1016\/j.tig.2013.07.003 (2013).","journal-title":"Trends in genetics TIG"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bcmd.2013.07.009","type":"journal-article","article-title":"Assaying hematopoiesis using zebrafish","volume":"51","author":"Boatman","year":"2013","unstructured":"Boatman, S., Barrett, F., Satishchandran, S., Jing, L., Shestopalov, I., & Zon, L. I. Assaying hematopoiesis using zebrafish. Blood cells, molecule., & diseases. 51 (4), 271\u20136, doi:10.1016\/j.bcmd.2013.07.009 (2013).","journal-title":"Blood cells, molecule., & diseases"},{"issue":"5608","key":"ref3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1126\/science.1080280","type":"journal-article","article-title":"Myc-induced T cell leukemia in transgenic zebrafish","volume":"299","author":"Langenau","year":"2003","unstructured":"Langenau, D. M., Traver, D., et al. Myc-induced T cell leukemia in transgenic zebrafish. Science. 299 (5608), 887\u201390, doi:10.1126\/science.1080280 (2003).","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1158\/0008-5472.CAN-04-0931","type":"journal-article","article-title":"Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish","author":"Yang","year":"2004","unstructured":"Yang, H. W., Kutok, J. L., et al. Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish. Cancer Research. 7256\u20137262 (2004).","journal-title":"Cancer Research"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cub.2005.01.031","type":"journal-article","article-title":"BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma","volume":"15","author":"Patton","year":"2005","unstructured":"Patton, E. E., Widlund, H. R., et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Current Biology. 15 (3), 249\u201354, doi:10.1016\/j.cub.2005.01.031 (2005).","journal-title":"Current Biology"},{"issue":"41","key":"ref6","doi-asserted-by":"crossref","first-page":"15166","DOI":"10.1073\/pnas.0603349103","type":"journal-article","article-title":"TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia","volume":"103","author":"Sabaawy","year":"2006","unstructured":"Sabaawy, H. E., Azuma, M., Embree, L. J., Tsai, H.-J., Starost, M. F., & Hickstein, D. D. TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 103 (41), 15166\u201371, doi:10.1073\/pnas.0603349103 (2006).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"ref7","first-page":"1382","type":"journal-article","volume":"21","author":"Langenau","year":"2007","unstructured":"Langenau, D. M., Keefe, M. D. M. D. M. D. M. D., et al. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Gene., & development. 21 (11), 1382\u201395, doi:10.1101\/gad.1545007 (2007).","journal-title":"Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Gene"},{"issue":"22","key":"ref8","doi-asserted-by":"crossref","first-page":"9410","DOI":"10.1073\/pnas.0611302104","type":"journal-article","article-title":"Heat shock-inducible Cre\/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish","volume":"104","author":"Le","year":"2007","unstructured":"Le, X., Langenau, D. M., Keefe, M. D., Kutok, J. L., Neuberg, D. S., & Zon, L. I. Heat shock-inducible Cre\/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104 (22), 9410\u20135, doi:10.1073\/pnas.0611302104 (2007).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1053\/j.gastro.2008.02.084","type":"journal-article","article-title":"Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas","volume":"134","author":"Park","year":"2008","unstructured":"Park, S. W., Davison, J. M., Rhee, J., Hruban, R. H., Maitra, A., & Leach, S. D. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology. 134 (7), 2080\u201390, doi:10.1053\/j.gastro.2008.02.084 (2008).","journal-title":"Gastroenterology"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2141.2008.07362.x","type":"journal-article","article-title":"MOZ\/TIF2-induced acute myeloid leukaemia in transgenic fish","volume":"143","author":"Zhuravleva","year":"2008","unstructured":"Zhuravleva, J., Paggetti, J., et al. MOZ\/TIF2-induced acute myeloid leukaemia in transgenic fish. British journal of haematology. 143 (3), 378\u201382, doi:10.1111\/j.1365-2141.2008.07362.x (2008).","journal-title":"British journal of haematology"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ccr.2012.03.043","type":"journal-article","article-title":"In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Suppl Data","volume":"21","author":"Ignatius","year":"2012","unstructured":"Ignatius, M. S., Chen, E. Y., et al. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Suppl Data. Cancer cell. 21 (5), 680\u201393, doi:10.1016\/j.ccr.2012.03.043 (2012).","journal-title":"Cancer cell"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ccr.2014.01.032","type":"journal-article","article-title":"Clonal Evolution Enhances Leukemia-Propagating Cell Frequency","volume":"25","author":"Blackburn","year":"2014","unstructured":"Blackburn, J. S., Liu, S., et al. Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt\/mTORC1 Pathway Activation. Cancer cell. 25 (3), 366\u201378, doi:10.1016\/j.ccr.2014.01.032 (2014).","journal-title":"Cancer cell"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1242\/dmm.015842","type":"journal-article","article-title":"Zebrafish as a model to assess cancer heterogeneity, progression and relapse","volume":"7","author":"Blackburn","year":"2014","unstructured":"Blackburn, J. S., & Langenau, D. M. Zebrafish as a model to assess cancer heterogeneity, progression and relapse. Disease model., & mechanisms. 7 (7), 755\u2013762, doi:10.1242\/dmm.015842 (2014).","journal-title":"Disease model"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"e21768","DOI":"10.1371\/journal.pone.0021768","type":"journal-article","article-title":"A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors","volume":"6","author":"Zhao","year":"2011","unstructured":"Zhao, C., Wang, X., et al. A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors. PloS one. 6 (7), e21768, doi:10.1371\/journal.pone.0021768 (2011).","journal-title":"PloS one"},{"issue":"14","key":"ref15","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1073\/pnas.1317731111","type":"journal-article","article-title":"Glycogen synthase kinase 3 inhibitors induce the canonical WNT\/\u03b2-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma","volume":"111","author":"Chen","year":"2014","unstructured":"Chen, E. Y., DeRan, M. T., et al. Glycogen synthase kinase 3 inhibitors induce the canonical WNT\/\u03b2-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111 (14), 5349\u201354, doi:10.1073\/pnas.1317731111 (2014).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"e61801","DOI":"10.1371\/journal.pone.0061801","type":"journal-article","article-title":"A novel zebrafish xenotransplantation model for study of glioma stem cell invasion","volume":"8","author":"Yang","year":"2013","unstructured":"Yang, X.-J., Cui, W., et al. A novel zebrafish xenotransplantation model for study of glioma stem cell invasion. PloS one 8 (4), e61801, doi:10.1371\/journal.pone.0061801 (2013).","journal-title":"PloS one"},{"issue":"8","key":"ref17","first-page":"1","type":"journal-article","article-title":"Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion","volume":"8","author":"Chapman","year":"2014","unstructured":"Chapman, A., Fernandez del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C., & Hurlstone, A. Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion. Cell Reports. (8), 1\u20138, doi:10.1016\/j.celrep.2014.06.045 (2014).","journal-title":"Cell Reports"},{"issue":"16","key":"ref18","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1182\/blood-2009-10-246488","type":"journal-article","article-title":"High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia","volume":"115","author":"Smith","year":"2010","unstructured":"Smith, A. C. H., Raimondi, A. R., et al. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 115 (16), 3296\u2013303, doi:10.1182\/blood-2009-10-246488 (2010).","journal-title":"Blood"},{"issue":"69","key":"ref19","first-page":"e50086","type":"journal-article","article-title":"Screening for melanoma modifiers using a zebrafish autochthonous tumor model","author":"Iyengar","year":"2012","unstructured":"Iyengar, S., Houvras, Y., & Ceol, C. J. Screening for melanoma modifiers using a zebrafish autochthonous tumor model. Journal of visualized experiments : JoVE. (69), e50086, doi:10.3791\/50086 (2012).","journal-title":"Journal of visualized experiments JoVE"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1158\/0008-5472.CAN-05-3800","type":"journal-article","article-title":"Transplantable tumor lines generated in clonal zebrafish","volume":"66","author":"Mizgireuv","year":"2006","unstructured":"Mizgireuv, I. ., & Revskoy, S. Y. Transplantable tumor lines generated in clonal zebrafish. Cancer research. 66 (6), 3120\u20133125, doi:10.1158\/0008-5472.CAN-05-3800 (2006).","journal-title":"Cancer research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/291293a0","type":"journal-article","article-title":"Production of clones of homozygous diploid zebra fish (Brachydanio rerio)","volume":"291","author":"Streisinger","year":"1981","unstructured":"Streisinger, G., Walker, C., Dower, N., Knauber, D., & Singer, F. Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature. 291, 293\u2013296 (1981).","journal-title":"Nature"},{"issue":"53","key":"ref22","first-page":"e2790","type":"journal-article","article-title":"Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish","author":"Blackburn","year":"2011","unstructured":"Blackburn, J. S., Liu, S., & Langenau, D. M. Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish. Journal of visualized experiments : JoVE. (53), e2790, doi:10.3791\/2790 (2011).","journal-title":"Journal of visualized experiments JoVE"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nmeth.3031","type":"journal-article","article-title":"Optimized cell transplantation using adult rag2 mutant zebrafish","volume":"11","author":"Tang","year":"2014","unstructured":"Tang, Q., Abdelfattah, N. S., et al. Optimized cell transplantation using adult rag2 mutant zebrafish. Nature methods. 11, 821\u2013824, doi:10.1038\/nmeth.3031 (2014).","journal-title":"Nature methods"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2013.10.015","type":"journal-article","article-title":"Humanized NOD-SCID IL2rg\u2013\/\u2013 mice as a preclinical model for cancer research and its potential use for individualized cancer therapies","volume":"344","author":"Zhou","year":"2014","unstructured":"Zhou, Q., Facciponte, J., Jin, M., Shen, Q., & Lin, Q. Humanized NOD-SCID IL2rg\u2013\/\u2013 mice as a preclinical model for cancer research and its potential use for individualized cancer therapies. Cancer letters. 344 (1), 13\u20139, doi:10.1016\/j.canlet.2013.10.015 (2014).","journal-title":"Cancer letters"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/dbio.1997.8779","type":"journal-article","article-title":"High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin","volume":"192","author":"Higashijima","year":"1997","unstructured":"Higashijima, S., Okamoto, H., Ueno, N., Hotta, Y., & Eguchi, G. High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Developmental biology. 192 (2), 289\u201399 (1997).","journal-title":"Developmental biology"},{"issue":"30","key":"ref26","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1038\/onc.2008.56","type":"journal-article","article-title":"Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish","volume":"27","author":"Langenau","year":"2008","unstructured":"Langenau, D. M., Keefe, M. D. D. D., et al. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 27 (30), 4242\u20138, doi:10.1038\/onc.2008.56 (2008).","journal-title":"Oncogene"},{"issue":"25","key":"ref27","first-page":"1","type":"journal-article","article-title":"Microinjection of zebrafish embryos to analyze gene function","author":"Rosen","year":"2009","unstructured":"Rosen, J. N., Sweeney, M. F., & Mably, J. D. Microinjection of zebrafish embryos to analyze gene function. Journal of visualized experiments : JoVE. (25), 1\u20135, doi:10.3791\/1115 (2009).","journal-title":"J Vis Exp"},{"key":"ref28","type":"book","volume-title":"The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio)","author":"Westerfield","year":"2000","unstructured":"Westerfield, M. The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio). University of Oregon Press: Eugene, (2000)."},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/mus.21972","type":"journal-article","article-title":"Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors)","volume":"43","author":"Alexander","year":"2011","unstructured":"Alexander, M. S., Kawahara, G., et al. Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscl., & nerve. 43 (5), 741\u201350, doi:10.1002\/mus.21972 (2011).","journal-title":"Muscl, & nerve"},{"issue":"86","key":"ref30","first-page":"1","type":"journal-article","article-title":"Isolation, culture, and transplantation of muscle satellite cells","author":"Motohashi","year":"2014","unstructured":"Motohashi, N., Asakura, Y., & Asakura, A. Isolation, culture, and transplantation of muscle satellite cells. Journal of visualized experiments : JoVE. (86), 1\u20137, doi:10.3791\/50846 (2014).","journal-title":"Journal of visualized experiments JoVE"},{"issue":"83","key":"ref31","first-page":"e50532","type":"journal-article","article-title":"Transplantation of induced pluripotent stem cell-derived mesoangioblast-like myogenic progenitors in mouse models of muscle regeneration","author":"Gerli","year":"2014","unstructured":"Gerli, M. F. M., Maffioletti, S. M., Millet, Q., & Tedesco, F. S. Transplantation of induced pluripotent stem cell-derived mesoangioblast-like myogenic progenitors in mouse models of muscle regeneration. Journal of visualized experiments : JoVE. (83), e50532, doi:10.3791\/50532 (2014).","journal-title":"J Vis Exp"},{"issue":"17","key":"ref32","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1111\/febs.12300","type":"journal-article","article-title":"A myogenic precursor cell that could contribute to regeneration in zebrafish and its similarity to the satellite cell","volume":"280","author":"Siegel","year":"2013","unstructured":"Siegel, A. L., Gurevich, D. B., & Currie, P. D. A myogenic precursor cell that could contribute to regeneration in zebrafish and its similarity to the satellite cell. The FEBS journal. 280 (17), 4074\u201388, doi:10.1111\/febs.12300 (2013).","journal-title":"The FEBS journal"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s004410050878","type":"journal-article","article-title":"Regeneration of skeletal muscle in two teleost fish: Sparus aurata and Brachydanio rerio","volume":"289","author":"Rowlerson","year":"1997","unstructured":"Rowlerson, a, Radaelli, G., Mascarello, F., & Veggetti, a Regeneration of skeletal muscle in two teleost fish: Sparus aurata and Brachydanio rerio. Cell and tissue research. 289 (2), 311\u201322 (1997).","journal-title":"Cell Tissue Res"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","type":"journal-article","article-title":"Transparent adult zebrafish as a tool for in vivo transplantation analysis","volume":"2","author":"White","year":"2008","unstructured":"White, R. M., Sessa, A., et al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell stem cell. 2 (2), 183\u20139, doi:10.1016\/j.stem.2007.11.002 (2008).","journal-title":"Cell stem cell"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jove.com\/video\/52597\/normal-malignant-muscle-cell-transplantation-into-immune-compromised","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:43:52Z","timestamp":1792687432000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/52597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,26]]},"references-count":34,"journal-issue":{"issue":"94","published-online":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3791\/52597","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,26]]}}}