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Neurotoxicol Teratol. 13 (1), 69-74 (1991).","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0091-3057(96)00248-1","type":"journal-article","article-title":"Temporal determinants of neonatal alcohol-induced cerebellar damage and motor performance deficits","volume":"55","author":"Goodlett","year":"1996","unstructured":"Goodlett, C. R., & Lundahl, K. R. Temporal determinants of neonatal alcohol-induced cerebellar damage and motor performance deficits. Pharmacol Biochem Behav. 55 (4), 531-540 (1996).","journal-title":"Pharmacol Biochem Behav"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuroscience.2016.03.033","type":"journal-article","article-title":"Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus","volume":"324","author":"Boschen","year":"2016","unstructured":"Boschen, K., Ruggiero, M., & Klintsova, A. 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Neurobiol Learn Mem. 64 (3), 265-275 (1995).","journal-title":"Neurobiol Learn Mem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2012.01.006","type":"journal-article","article-title":"Neonatal alcohol exposure and the hippocampus in developing male rats: effects on behaviorally induced CA1 c-Fos expression, CA1 pyramidal cell number, and contextual fear conditioning","volume":"206","author":"Murawski","year":"2012","unstructured":"Murawski, N. J., Klintsova, A. Y., & Stanton, M. E. Neonatal alcohol exposure and the hippocampus in developing male rats: effects on behaviorally induced CA1 c-Fos expression, CA1 pyramidal cell number, and contextual fear conditioning. Neuroscience. 206 89-99 (2012).","journal-title":"Neuroscience"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1037\/a0013271","type":"journal-article","article-title":"Voluntary exercise influences behavioral development in rats exposed to alcohol during the neonatal brain growth spurt","volume":"122","author":"Thomas","year":"2008","unstructured":"Thomas, J. D., Sather, T. M., & Whinery, L. A. Voluntary exercise influences behavioral development in rats exposed to alcohol during the neonatal brain growth spurt. Behav Neurosci. 122 (6), 1264-1273 (2008).","journal-title":"Behav Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2011.07.027","type":"journal-article","article-title":"Neonatal alcohol exposure disrupts hippocampal neurogenesis and contextual fear conditioning in adult rats","volume":"1412","author":"Hamilton","year":"2011","unstructured":"Hamilton, G. F. et al. 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