{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:44:54Z","timestamp":1792669494579,"version":"4.5.0"},"reference-count":59,"publisher":"MyJove Corporation","issue":"133","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/56810","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T20:00:09Z","timestamp":1522440009000},"source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats"],"prefix":"10.3791","author":[{"given":"John R.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Y.","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekhar","family":"Charavaryamath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique J.","family":"Griffon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/vr.116.3.66","type":"journal-article","article-title":"Epidemiological study of wastage among racehorses 1982 and 1983","volume":"116","author":"Rossdale","year":"1982","unstructured":"Rossdale, P. D., Hopes, R., Digby, N. J., & offord, K. Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec. 116 (3), 66-69 (1985).","journal-title":"Vet Rec"},{"key":"ref2","first-page":"112","type":"journal-article","article-title":"Strength of a new method of achilles tendon repair in the rat - biomed 2011","volume":"47","author":"Black","year":"2011","unstructured":"Black, D. A., Tucci, M., Puckett, A., Lawyer, T., & Benghuzzi, H. Strength of a new method of achilles tendon repair in the rat - biomed 2011. Biomed Sci Instrum. 47 112-117 (2011).","journal-title":"Biomed Sci Instrum"},{"issue":"20-22","key":"ref3","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1080\/09638280701785460","type":"journal-article","article-title":"Animal models of tendinopathy","volume":"30","author":"Lake","year":"2008","unstructured":"Lake, S. P., Ansorge, H. L., & Soslowsky, L. J. Animal models of tendinopathy. Disabil Rehabil. 30 (20-22), 1530-1541 (2008).","journal-title":"Disabil Rehabil"},{"issue":"2","key":"ref4","first-page":"199","type":"journal-article","article-title":"Ligament structure, physiology and function","volume":"4","author":"Frank","year":"2004","unstructured":"Frank, C. B. Ligament structure, physiology and function. J Musculoskelet Neuronal Interact. 4 (2), 199-201 (2004).","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.2042-3306.2011.00363.x","type":"journal-article","article-title":"Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon","volume":"44","author":"Godwin","year":"2012","unstructured":"Godwin, E. E., Young, N. J., Dudhia, J., Beamish, I. C., & Smith, R. K. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet J. 44 (1), 25-32 (2012).","journal-title":"Equine Vet J"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"e75697","DOI":"10.1371\/journal.pone.0075697","type":"journal-article","article-title":"Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy","volume":"8","author":"Smith","year":"2013","unstructured":"Smith, R. K. et al. Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy. PLoS One. 8 (9), e75697 (2013).","journal-title":"PLoS One"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jor.22057","type":"journal-article","article-title":"Effect of age and gender on cell proliferation and cell surface characterization of synovial fat pad derived mesenchymal stem cells","volume":"30","author":"Fossett","year":"2012","unstructured":"Fossett, E., Khan, W. S., Longo, U. G., & Smitham, P. J. Effect of age and gender on cell proliferation and cell surface characterization of synovial fat pad derived mesenchymal stem cells. J Orthop Res. 30 (7), 1013-1018 (2012).","journal-title":"J Orthop Res"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00277-012-1438-x","type":"journal-article","article-title":"Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells","volume":"91","author":"Zaim","year":"2012","unstructured":"Zaim, M., Karaman, S., Cetin, G., & Isik, S. Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells. Ann Hematol. 91 (8), 1175-1186 (2012).","journal-title":"Ann Hematol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.shpsc.2009.09.002","type":"journal-article","article-title":"What is stemness?","volume":"40","author":"Leychkis","year":"2009","unstructured":"Leychkis, Y., Munzer, S. R., & Richardson, J. L. What is stemness? Stud Hist Philos Biol Biomed Sci. 40 (4), 312-320 (2009).","journal-title":"Stud Hist Philos Biol Biomed Sci"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jbm.1270","type":"journal-article","article-title":"Evaluation of the biocompatibility of a chitosan scaffold in mice","volume":"59","author":"VandeVord","year":"2002","unstructured":"VandeVord, P. J. et al. Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res. 59 (3), 585-590 (2002).","journal-title":"J Biomed Mater Res"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/term.302","type":"journal-article","article-title":"A comparative study of seeding techniques and three-dimensional matrices for mesenchymal cell attachment","volume":"5","author":"Griffon","year":"2011","unstructured":"Griffon, D. J., Abulencia, J. P., Ragetly, G. R., Fredericks, L. P., & Chaieb, S. A comparative study of seeding techniques and three-dimensional matrices for mesenchymal cell attachment. J Tissue Eng Regen Med. 5 (3), 169-179 (2011).","journal-title":"J Tissue Eng Regen Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2460\/ajvr.72.1.42","type":"journal-article","article-title":"Hyaluronic acid and chondrogenesis of murine bone marrow mesenchymal stem cells in chitosan sponges","volume":"72","author":"Schwartz","year":"2011","unstructured":"Schwartz, Z., Griffon, D. J., Fredericks, L. P., Lee, H. B., & Weng, H. Y. Hyaluronic acid and chondrogenesis of murine bone marrow mesenchymal stem cells in chitosan sponges. Am J Vet Res. 72 (1), 42-50 (2011).","journal-title":"Am J Vet Res"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1016\/j.actbio.2010.05.016","type":"journal-article","article-title":"The effect of type II collagen coating of chitosan fibrous scaffolds on mesenchymal stem cell adhesion and chondrogenesis","volume":"6","author":"Ragetly","year":"2010","unstructured":"Ragetly, G., Griffon, D. J., & Chung, Y. S. The effect of type II collagen coating of chitosan fibrous scaffolds on mesenchymal stem cell adhesion and chondrogenesis. Acta Biomater. 6 (10), 3988-3997 (2010).","journal-title":"Acta Biomater"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s10856-010-4096-3","type":"journal-article","article-title":"Effect of collagen II coating on mesenchymal stem cell adhesion on chitosan and on reacetylated chitosan fibrous scaffolds","volume":"21","author":"Ragetly","year":"2010","unstructured":"Ragetly, G. R., Griffon, D. J., Lee, H. B., & Chung, Y. S. Effect of collagen II coating on mesenchymal stem cell adhesion on chitosan and on reacetylated chitosan fibrous scaffolds. J Mater Sci Mater Med. 21 (8), 2479-2490 (2010).","journal-title":"J Mater Sci Mater Med"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.actbio.2009.10.040","type":"journal-article","article-title":"Effect of chitosan scaffold microstructure on mesenchymal stem cell chondrogenesis","volume":"6","author":"Ragetly","year":"2010","unstructured":"Ragetly, G. R. et al. Effect of chitosan scaffold microstructure on mesenchymal stem cell chondrogenesis. Acta Biomater. 6 (4), 1430-1436 (2010).","journal-title":"Acta Biomater"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbm.a.32514","type":"journal-article","article-title":"Cartilage tissue engineering on fibrous chitosan scaffolds produced by a replica molding technique","volume":"93","author":"Ragetly","year":"2010","unstructured":"Ragetly, G. R., Slavik, G. J., Cunningham, B. T., Schaeffer, D. J., & Griffon, D. J. Cartilage tissue engineering on fibrous chitosan scaffolds produced by a replica molding technique. J Biomed Mater Res A. 93 (1), 46-55 (2010).","journal-title":"J Biomed Mater Res A"},{"issue":"38","key":"ref17","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1039\/b706726g","type":"journal-article","article-title":"A replica molding technique for producing fibrous chitosan scaffolds for cartilage engineering","volume":"17","author":"Slavik","year":"2007","unstructured":"Slavik, G. J., Ragetly, G., Ganesh, N., Griffon, D. J., & Cunningham, B. T. A replica molding technique for producing fibrous chitosan scaffolds for cartilage engineering. Journal of Materials Chemistry. 17 (38), 4095-4101 (2007).","journal-title":"Journal of Materials Chemistry"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.actbio.2005.12.007","type":"journal-article","article-title":"Chitosan scaffolds: interconnective pore size and cartilage engineering","volume":"2","author":"Griffon","year":"2006","unstructured":"Griffon, D. J., Sedighi, M. R., Schaeffer, D. V., Eurell, J. A., & Johnson, A. L. Chitosan scaffolds: interconnective pore size and cartilage engineering. Acta Biomater. 2 (3), 313-320 (2006).","journal-title":"Acta Biomater"},{"issue":"29","key":"ref19","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1016\/j.biomaterials.2011.05.092","type":"journal-article","article-title":"Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes","volume":"32","author":"Huang","year":"2011","unstructured":"Huang, G. S., Dai, L. G., Yen, B. L., & Hsu, S. H. Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes. Biomaterials. 32 (29), 6929-6945 (2011).","journal-title":"Biomaterials"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.biomaterials.2011.11.049","type":"journal-article","article-title":"The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities","volume":"33","author":"Cheng","year":"2012","unstructured":"Cheng, N. C., Wang, S., & Young, T. H. The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials. 33 (6), 1748-1758 (2012).","journal-title":"Biomaterials"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00480169.2012.683377","type":"journal-article","article-title":"The role of mesenchymal stem cells in veterinary therapeutics - a review","volume":"60","author":"Webster","year":"2012","unstructured":"Webster, R. A., Blaber, S. P., Herbert, B. R., Wilkins, M. R., & Vesey, G. The role of mesenchymal stem cells in veterinary therapeutics - a review. N Z Vet J. 60 (5), 265-272 (2012).","journal-title":"N Z Vet J"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00042752-200501000-00006","type":"journal-article","article-title":"Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration","volume":"15","author":"Khan","year":"2005","unstructured":"Khan, M. H., Li, Z., & Wang, J. H. Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration. Clin J Sport Med. 15 (1), 27-33 (2005).","journal-title":"Clin J Sport Med"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s007760100031","type":"journal-article","article-title":"The effects of prolonged peritendinous administration of PGE1 to the rat Achilles tendon: a possible animal model of chronic Achilles tendinopathy","volume":"6","author":"Sullo","year":"2001","unstructured":"Sullo, A., Maffulli, N., Capasso, G., & Testa, V. The effects of prolonged peritendinous administration of PGE1 to the rat Achilles tendon: a possible animal model of chronic Achilles tendinopathy. J Orthop Sci. 6 (4), 349-357 (2001).","journal-title":"J Orthop Sci"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2460\/ajvr.70.1.37","type":"journal-article","article-title":"Monitoring of the repair process of surgically created lesions in equine superficial digital flexor tendons by use of computerized ultrasonography","volume":"70","author":"van Schie","year":"2009","unstructured":"van Schie, H. T. et al. Monitoring of the repair process of surgically created lesions in equine superficial digital flexor tendons by use of computerized ultrasonography. Am J Vet Res. 70 (1), 37-48 (2009).","journal-title":"Am J Vet Res"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1740-8261.2009.01660.x","type":"journal-article","article-title":"Mr imaging features of surgically induced core lesions in the equine superficial digital flexor tendon","volume":"51","author":"Schramme","year":"2010","unstructured":"Schramme, M., Kerekes, Z., Hunter, S., & Labens, R. Mr imaging features of surgically induced core lesions in the equine superficial digital flexor tendon. Vet Radiol Ultrasound. 51 (3), 280-287 (2010).","journal-title":"Vet Radiol Ultrasound"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1302\/2046-3758.36.2000281","type":"journal-article","article-title":"The role of animal models in tendon research","volume":"3","author":"Hast","year":"2014","unstructured":"Hast, M. W., Zuskov, A., & Soslowsky, L. J. The role of animal models in tendon research. Bone Joint Res. 3 (6), 193-202 (2014).","journal-title":"Bone Joint Res"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/bjsm.2006.032342","type":"journal-article","article-title":"Animal models for the study of tendinopathy","volume":"41","author":"Warden","year":"2007","unstructured":"Warden, S. J. Animal models for the study of tendinopathy. Br J Sports Med. 41 (4), 232-240 (2007).","journal-title":"Br J Sports Med"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/107110079301400706","type":"journal-article","article-title":"Achilles tendon injuries: a comparison of surgical repair versus no repair in a rat model","volume":"14","author":"Murrell","year":"1993","unstructured":"Murrell, G. A. et al. Achilles tendon injuries: a comparison of surgical repair versus no repair in a rat model. Foot Ankle. 14 (7), 400-406 (1993).","journal-title":"Foot Ankle"},{"issue":"2","key":"ref29","first-page":"100","type":"journal-article","article-title":"Effect of glucosamine chondroitine sulphate on repaired tenotomized rat Achilles tendons","volume":"22","author":"Ozer","year":"2011","unstructured":"Ozer, H. et al. [Effect of glucosamine chondroitine sulphate on repaired tenotomized rat Achilles tendons]. Eklem Hastalik Cerrahisi. 22 (2), 100-106 (2011).","journal-title":"Eklem Hastalik Cerrahisi"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jor.1100160512","type":"journal-article","article-title":"Pyridinoline in relation to ultimate stress of the patellar tendon during healing: an animal study","volume":"16","author":"Chan","year":"1998","unstructured":"Chan, B. P., Fu, S. C., Qin, L., Rolf, C., & Chan, K. M. Pyridinoline in relation to ultimate stress of the patellar tendon during healing: an animal study. J Orthop Res. 16 (5), 597-603 (1998).","journal-title":"J Orthop Res"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jor.21559","type":"journal-article","article-title":"Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model","volume":"30","author":"Ni","year":"2012","unstructured":"Ni, M. et al. Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model. J Orthop Res. 30 (4), 613-619 (2012).","journal-title":"J Orthop Res"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/ten.tec.2012.0699","type":"journal-article","article-title":"Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering","volume":"19","author":"Orth","year":"2013","unstructured":"Orth, P., Zurakowski, D., Alini, M., Cucchiarini, M., & Madry, H. Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering. Tissue Eng Part C Methods. 19 (11), 885-891 (2013).","journal-title":"Tissue Eng Part C Methods"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jcp.21368","type":"journal-article","article-title":"Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing","volume":"215","author":"Kajikawa","year":"2008","unstructured":"Kajikawa, Y. et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 215 (3), 837-845 (2008).","journal-title":"J Cell Physiol"},{"issue":"21-22","key":"ref34","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1089\/ten.tea.2012.0453","type":"journal-article","article-title":"Human iPSC-derived neural crest stem cells promote tendon repair in a rat patellar tendon window defect model","volume":"19","author":"Xu","year":"2013","unstructured":"Xu, W. et al. Human iPSC-derived neural crest stem cells promote tendon repair in a rat patellar tendon window defect model. Tissue Eng Part A. 19 (21-22), 2439-2451 (2013).","journal-title":"Tissue Eng Part A"},{"key":"ref35","type":"journal-article","article-title":"Influence of hypoxia on the stemness of umbilical cord matrix-derived mesenchymal stem cells cultured on chitosan films","author":"Taguchi","year":"2017","unstructured":"Taguchi, T. et al. Influence of hypoxia on the stemness of umbilical cord matrix-derived mesenchymal stem cells cultured on chitosan films. J Biomed Mat Res B: Appl Biomat. n\/a-n\/a (2017).","journal-title":"J Biomed Mat Res B: Appl Biomat"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2987140","DOI":"10.1155\/2016\/2987140","type":"journal-article","article-title":"Effects of Hypoxia and Chitosan on Equine Umbilical Cord-Derived Mesenchymal Stem Cells","author":"Griffon","year":"2016","unstructured":"Griffon, D. J. et al. Effects of Hypoxia and Chitosan on Equine Umbilical Cord-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016 2987140 (2016).","journal-title":"Stem Cells Int"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1090-3801(02)00140-4","type":"journal-article","article-title":"Evaluation of a short duration behaviour-based post-operative pain scoring system in rats","volume":"7","author":"Roughan","year":"2003","unstructured":"Roughan, J. V., & Flecknell, P. A. Evaluation of a short duration behaviour-based post-operative pain scoring system in rats. Eur J Pain. 7 (5), 397-406 (2003).","journal-title":"Eur J Pain"},{"key":"ref38","first-page":"55","type":"journal-article","article-title":"The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","unstructured":"Sotocinal, S. G. et al. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain. 7 55 (2011).","journal-title":"Mol Pain"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11420-009-9152-5","type":"journal-article","article-title":"Histologic stages of healing correlate with restoration of tensile strength in a model of experimental tendon repair","volume":"6","author":"Rosenbaum","year":"2010","unstructured":"Rosenbaum, A. J. et al. Histologic stages of healing correlate with restoration of tensile strength in a model of experimental tendon repair. HSS J. 6 (2), 164-170 (2010).","journal-title":"HSS J"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/scd.2010.0589","type":"journal-article","article-title":"Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue","volume":"21","author":"Vidal","year":"2011","unstructured":"Vidal, M. A., Walker, N. J., Napoli, E., & Borjesson, D. L. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue. Stem cells and development. 21 (2), 273-283 (2011).","journal-title":"Stem cells and development"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jcpa.2012.05.010","type":"journal-article","article-title":"The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research","volume":"147","author":"Patterson-Kane","year":"2012","unstructured":"Patterson-Kane, J., Becker, D., & Rich, T. The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research. J Compar Pathol. 147 (2), 227-247 (2012).","journal-title":"J Compar Pathol"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","type":"journal-article","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells","volume":"8","author":"Dominici","year":"2006","unstructured":"Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The. Cytotherapy. 8 (4), 315-317 (2006).","journal-title":"Cytotherapy"},{"issue":"31","key":"ref43","doi-asserted-by":"crossref","first-page":"13724","DOI":"10.1073\/pnas.1008117107","type":"journal-article","article-title":"Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties","volume":"107","author":"Bartosh","year":"2010","unstructured":"Bartosh, T. J. et al. Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A. 107 (31), 13724-13729 (2010).","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biomaterials.2015.08.037","type":"journal-article","article-title":"In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)\/chitosan scaffold for hyaline-like cartilage regeneration","volume":"71","author":"Zhang","year":"2015","unstructured":"Zhang, K., Yan, S., Li, G., Cui, L., & Yin, J. In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)\/chitosan scaffold for hyaline-like cartilage regeneration. Biomaterials. 71 24-34 (2015).","journal-title":"Biomaterials"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00018-014-1738-5","type":"journal-article","article-title":"Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges","volume":"72","author":"Montanez-Sauri","year":"2015","unstructured":"Montanez-Sauri, S. I., Beebe, D. J., & Sung, K. E. Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges. Cellular and molecular life sciences : CMLS. 72 (2), 237-249 (2015).","journal-title":"Cellular and molecular life sciences : CMLS"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nprot.2010.14","type":"journal-article","article-title":"The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons","volume":"5","author":"Butler","year":"2010","unstructured":"Butler, D. L. et al. The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons. Nat Protoc. 5 (5), 849-863 (2010).","journal-title":"Nat Protoc"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/laban0309-87","type":"journal-article","article-title":"Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine","volume":"38","author":"Brennan","year":"2009","unstructured":"Brennan, M. P., Sinusas, A. J., Horvath, T. L., Collins, J. G., & Harding, M. J. Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine. Lab Anim (NY). 38 (3), 87-93 (2009).","journal-title":"Lab Anim (NY)"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0896-6273(00)80905-8","type":"journal-article","article-title":"Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia","volume":"25","author":"Ramon-Cueto","year":"2000","unstructured":"Ramon-Cueto, A., Cordero, M. I., Santos-Benito, F. F., & Avila, J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron. 25 (2), 425-435 (2000).","journal-title":"Neuron"},{"issue":"24","key":"ref49","first-page":"784","type":"journal-article","article-title":"Use of meloxicam as an analgesic in canine orthopaedic surgery","volume":"155","author":"Arculus","year":"2004","unstructured":"Arculus, S. L. Use of meloxicam as an analgesic in canine orthopaedic surgery. Vet Rec. 155 (24), 784 (2004).","journal-title":"Vet Rec"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-0270(00)00281-8","type":"journal-article","article-title":"Video analysis of standing--an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve","volume":"102","author":"Bervar","year":"2000","unstructured":"Bervar, M. Video analysis of standing--an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve. J Neurosci Methods. 102 (2), 109-116 (2000).","journal-title":"J Neurosci Methods"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jse.2008.10.008","type":"journal-article","article-title":"Alterations in function after rotator cuff tears in an animal model","volume":"18","author":"Perry","year":"2009","unstructured":"Perry, S. M., Getz, C. L., & Soslowsky, L. J. Alterations in function after rotator cuff tears in an animal model. J Shoulder Elbow Surg. 18 (2), 296-304 (2009).","journal-title":"J Shoulder Elbow Surg"},{"issue":"21","key":"ref52","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1016\/j.biomaterials.2011.03.026","type":"journal-article","article-title":"Healing parameters in a rabbit partial tendon defect following tenocyte\/biomaterial implantation","volume":"32","author":"Stoll","year":"2011","unstructured":"Stoll, C. et al. Healing parameters in a rabbit partial tendon defect following tenocyte\/biomaterial implantation. Biomaterials. 32 (21), 4806-4815 (2011).","journal-title":"Biomaterials"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/ten.tea.2008.0046","type":"journal-article","article-title":"Bone marrow stromal cells in a liquid fibrin matrix improve the healing process of patellar tendon window defects","volume":"15","author":"Hankemeier","year":"2009","unstructured":"Hankemeier, S. et al. Bone marrow stromal cells in a liquid fibrin matrix improve the healing process of patellar tendon window defects. Tissue Eng Part A. 15 (5), 1019-1030 (2009).","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"ref54","first-page":"1","type":"journal-article","article-title":"A clinical and experimental study of tendon injury, healing and treatment in the horse","author":"Silver","year":"1983","unstructured":"Silver, I. A. et al. A clinical and experimental study of tendon injury, healing and treatment in the horse. Equine Vet J Suppl. (1), 1-43 (1983).","journal-title":"Equine Vet J Suppl"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/ptj\/69.10.816","type":"journal-article","article-title":"Inflammation, cellularity, and fibrillogenesis in regenerating tendon: implications for tendon rehabilitation","volume":"69","author":"Enwemeka","year":"1989","unstructured":"Enwemeka, C. S. Inflammation, cellularity, and fibrillogenesis in regenerating tendon: implications for tendon rehabilitation. Phys Ther. 69 (10), 816-825 (1989).","journal-title":"Phys Ther"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0021-9290(80)90367-X","type":"journal-article","article-title":"Wound healing of tendon--I. Physical, mechanical and metabolic changes","volume":"13","author":"Goldin","year":"1980","unstructured":"Goldin, B., Block, W. D., & Pearson, J. R. Wound healing of tendon--I. Physical, mechanical and metabolic changes. J Biomech. 13 (3), 241-256 (1980).","journal-title":"J Biomech"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00402-009-0935-4","type":"journal-article","article-title":"The effect of platelet-rich plasma gel in the early phase of patellar tendon healing","volume":"129","author":"Lyras","year":"2009","unstructured":"Lyras, D. N. et al. The effect of platelet-rich plasma gel in the early phase of patellar tendon healing. Arch Orthop Trauma Surg. 129 (11), 1577-1582 (2009).","journal-title":"Arch Orthop Trauma Surg"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0363-5023(03)00366-6","type":"journal-article","article-title":"Flexor tendon healing in the rat: a histologic and gene expression study","volume":"28","author":"Oshiro","year":"2003","unstructured":"Oshiro, W., Lou, J., Xing, X., Tu, Y., & Manske, P. R. Flexor tendon healing in the rat: a histologic and gene expression study. J Hand Surg Am. 28 (5), 814-823 (2003).","journal-title":"J Hand Surg Am"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2460\/ajvr.72.5.699","type":"journal-article","article-title":"Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs","volume":"72","author":"Visser","year":"2011","unstructured":"Visser, L. C., Arnoczky, S. P., Caballero, O., & Gardner, K. L. Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs. Am J Vet Res. 72 (5), 699-705 (2011).","journal-title":"Am J Vet Res"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/video\/56810\/evaluation-stem-cell-therapies-bilateral-patellar-tendon-injury-model","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:32:12Z","timestamp":1792668732000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/56810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":59,"journal-issue":{"issue":"133","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.3791\/56810","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]}}}