{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:38:04Z","timestamp":1792669084517,"version":"4.5.0"},"reference-count":36,"publisher":"MyJove Corporation","issue":"138","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/57553","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T20:00:23Z","timestamp":1534363223000},"source":"Crossref","is-referenced-by-count":8,"title":["The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation"],"prefix":"10.3791","author":[{"given":"Payam","family":"Vali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Gugino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmon","family":"Koenigsknecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Helman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Chandrasekharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Rawat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasree","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.siny.2008.04.012","type":"journal-article","article-title":"Optimizing chest compressions during delivery-room resuscitation","volume":"13","author":"Wyckoff","year":"2008","unstructured":"Wyckoff, M. H., & Berg, R. A. Optimizing chest compressions during delivery-room resuscitation. Semin Fetal Neonatal Med. 13 (6), 410-415 (2008).","journal-title":"Semin Fetal Neonatal Med"},{"issue":"9730","key":"ref2","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0140-6736(10)60549-1","type":"journal-article","article-title":"Global, regional, and national causes of child mortality in 2008: a systematic analysis","volume":"375","author":"Black","year":"2010","unstructured":"Black, R. E. et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 375 (9730), 1969-1987 (2010).","journal-title":"Lancet"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1542\/pir.29.11.e59","type":"journal-article","article-title":"Transient tachypnea of the newborn","volume":"29","author":"Guglani","year":"2008","unstructured":"Guglani, L., Lakshminrusimha, S., & Ryan, R. M. Transient tachypnea of the newborn. Pediatr Rev. 29 (11), e59-65 (2008).","journal-title":"Pediatr Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1113\/jphysiol.1983.sp014929","type":"journal-article","article-title":"Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb","volume":"344","author":"Brown","year":"1983","unstructured":"Brown, M. J., Olver, R. E., Ramsden, C. A., Strang, L. B., & Walters, D. V. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol. 344 137-152 (1983).","journal-title":"J Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/jp.2016.43","type":"journal-article","article-title":"The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy","volume":"36 Suppl 2","author":"Lakshminrusimha","year":"2016","unstructured":"Lakshminrusimha, S., & Saugstad, O. D. The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy. J Perinatol. 36 Suppl 2 S3-S11 (2016).","journal-title":"J Perinatol"},{"issue":"18 suppl 2","key":"ref6","first-page":"S543","type":"journal-article","article-title":"Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"132","author":"Wyckoff","year":"2015","unstructured":"Wyckoff, M. H. et al. Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 132 (18 suppl 2), S543-S560 (2015).","journal-title":"Circulation"},{"issue":"Pt 8","key":"ref7","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1113\/jphysiol.2012.250084","type":"journal-article","article-title":"Delaying cord clamping until ventilation onset improves cardiovascular function at birth in preterm lambs","volume":"591","author":"Bhatt","year":"2013","unstructured":"Bhatt, S. et al. Delaying cord clamping until ventilation onset improves cardiovascular function at birth in preterm lambs. J Physiol. 591 (Pt 8), 2113-2126 (2013).","journal-title":"J Physiol"},{"issue":"1","key":"ref8","type":"journal-article","article-title":"Providing a Placental Transfusion in Newborns Who Need Resuscitation)","volume":"5","author":"Katheria","year":"2017","unstructured":"Katheria, A. C., Brown, M. K., Rich, W., & Arnell, K. Providing a Placental Transfusion in Newborns Who Need Resuscitation. Front Pediatr. 5 1 (2017).","journal-title":"Front Pediatr"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.siny.2013.08.001","type":"journal-article","article-title":"Drugs during delivery room resuscitation--what, when and why?","volume":"18","author":"Kapadia","year":"2013","unstructured":"Kapadia, V. S., & Wyckoff, M. H. Drugs during delivery room resuscitation--what, when and why? Semin Fetal Neonatal Med. 18 (6), 357-361 (2013).","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref10","type":"book","volume-title":"Researches on Pre-natal Life","author":"Barcroft","year":"1946","unstructured":"Barcroft, J. Researches on Pre-natal Life: Voume 1. 292 Blackwell Scientific Publications, (1946)."},{"key":"ref11","type":"book","volume-title":"Foetal and Neonatal Physiosolgy. A Comparative Study of the Changes at Birth","author":"Dawes","year":"1968","unstructured":"Dawes, G. S. Foetal and Neonatal Physiosolgy. A Comparative Study of the Changes at Birth. Yeark Book Medical Publishers, (1968)."},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1002\/9781444311822","type":"book","volume-title":"Congenital Diseases of the Heart: Clinical-Physiological Considerations","author":"Rudolph","year":"2009","unstructured":"Rudolph, A. in Congenital Diseases of the Heart: Clinical-Physiological Considerations. 1-24 Wiley-Blackwell, (2009)."},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1203\/PDR.0b013e31821d06a1","type":"journal-article","article-title":"An initial sustained inflation improves the respiratory and cardiovascular transition at birth in preterm lambs","volume":"70","author":"Sobotka","year":"2011","unstructured":"Sobotka, K. S. et al. An initial sustained inflation improves the respiratory and cardiovascular transition at birth in preterm lambs. Pediatr Res. 70 (1), 56-60 (2011).","journal-title":"Pediatr Res"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1152\/japplphysiol.00055.2005","type":"journal-article","article-title":"Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs","volume":"99","author":"Polglase","year":"2005","unstructured":"Polglase, G. R. et al. Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol (1985). 99 (4), 1453-1461 (2005).","journal-title":"J Appl Physiol (1985)"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1203\/PDR.0b013e3181bab0c7","type":"journal-article","article-title":"Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension","volume":"66","author":"Lakshminrusimha","year":"2009","unstructured":"Lakshminrusimha, S. et al. Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension. Pediatr Res. 66 (5), 539-544 (2009).","journal-title":"Pediatr Res"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1203\/PDR.0b013e3180db29fe","type":"journal-article","article-title":"Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50% and 100% oxygen","volume":"62","author":"Lakshminrusimha","year":"2007","unstructured":"Lakshminrusimha, S. et al. Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen. Pediatr Res. 62 (3), 313-318 (2007).","journal-title":"Pediatr Res"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/pr.2015.21","type":"journal-article","article-title":"Cardiovascular transition at birth: a physiological sequence","volume":"77","author":"Hooper","year":"2015","unstructured":"Hooper, S. B. et al. Cardiovascular transition at birth: a physiological sequence. Pediatr Res. 77 (5), 608-614 (2015).","journal-title":"Pediatr Res"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004402","type":"journal-article","article-title":"Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest","volume":"6","author":"Vali","year":"2017","unstructured":"Vali, P. et al. Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest. J Am Heart Assoc. 6 (2) (2017).","journal-title":"J Am Heart Assoc"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1097\/PCC.0000000000001248","type":"journal-article","article-title":"Continuous Chest Compressions During Sustained Inflations in a Perinatal Asphyxial Cardiac Arrest Lamb Model","author":"Vali","year":"2017","unstructured":"Vali, P. et al. Continuous Chest Compressions During Sustained Inflations in a Perinatal Asphyxial Cardiac Arrest Lamb Model. Pediatr Crit Care Med. (2017).","journal-title":"Pediatr Crit Care Med"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"e0176478","DOI":"10.1371\/journal.pone.0176478","type":"journal-article","article-title":"Hemodynamics and gas exchange during chest compressions in neonatal resuscitation","volume":"12","author":"Vali","year":"2017","unstructured":"Vali, P. et al. Hemodynamics and gas exchange during chest compressions in neonatal resuscitation. PLoS One. 12 (4), e0176478 (2017).","journal-title":"PLoS One"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/CCM.0000000000000967","type":"journal-article","article-title":"Determination of Lung Volume and Hemodynamic Changes During High-Frequency Ventilation Recruitment in Preterm Neonates With Respiratory Distress Syndrome","volume":"43","author":"Tana","year":"2015","unstructured":"Tana, M. et al. Determination of Lung Volume and Hemodynamic Changes During High-Frequency Ventilation Recruitment in Preterm Neonates With Respiratory Distress Syndrome. Crit Care Med. 43 (8), 1685-1691 (2015).","journal-title":"Crit Care Med"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1203\/00006450-198903000-00005","type":"journal-article","article-title":"Ligating the ductus arteriosus before birth causes persistent pulmonary hypertension in the newborn lamb","volume":"25","author":"Morin","year":"1989","unstructured":"Morin, F. C. Ligating the ductus arteriosus before birth causes persistent pulmonary hypertension in the newborn lamb. Pediatr Res. 25 (3), 245-250 (1989).","journal-title":"Pediatr Res"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1152\/jappl.1992.73.1.213","type":"journal-article","article-title":"Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension","volume":"73","author":"Morin","year":"1992","unstructured":"Morin, F. C., & Egan, E. A. Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension. J Appl Physiol (1985). 73 (1), 213-218 (1992).","journal-title":"J Appl Physiol (1985)"},{"issue":"3 Pt 2","key":"ref24","first-page":"H542","type":"journal-article","article-title":"Development of pulmonary vascular response to oxygen","volume":"254","author":"Morin","year":"1988","unstructured":"Morin, F. C., Egan, E. A., Ferguson, W., & Lundgren, C. E. Development of pulmonary vascular response to oxygen. Am J Physiol. 254 (3 Pt 2), H542-546 (1988).","journal-title":"Am J Physiol"},{"key":"ref25","type":"journal-article","article-title":"Neonatal resuscitation adhering to oxygen saturation guidelines in asphyxiated lambs with meconium aspiration","author":"Rawat","year":"2015","unstructured":"Rawat, M. et al. Neonatal resuscitation adhering to oxygen saturation guidelines in asphyxiated lambs with meconium aspiration. Pediatr Res. (2015).","journal-title":"Pediatr Res"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000443303","type":"journal-article","article-title":"Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs","volume":"109","author":"Chandrasekharan","year":"2016","unstructured":"Chandrasekharan, P. K. et al. Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs. Neonatology. 109 (4), 265-273 (2016).","journal-title":"Neonatology"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/pr.2014.186","type":"journal-article","article-title":"Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration","volume":"77","author":"Lakshminrusimha","year":"2015","unstructured":"Lakshminrusimha, S. et al. Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration. Pediatr Res. 77 (2), 347-355 (2015).","journal-title":"Pediatr Res"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm0495-342","type":"journal-article","article-title":"In utero surgery rescues neurological function at birth in sheep with spina bifida","volume":"1","author":"Meuli","year":"1995","unstructured":"Meuli, M. et al. In utero surgery rescues neurological function at birth in sheep with spina bifida. Nat Med. 1 (4), 342-347 (1995).","journal-title":"Nat Med"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/0022-3468(95)90335-6","type":"journal-article","article-title":"Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep","volume":"30","author":"Meuli","year":"1995","unstructured":"Meuli, M. et al. Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep. J Pediatr Surg. 30 (7), 1028-1032; discussion 1032-1023 (1995).","journal-title":"J Pediatr Surg"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0022-3468(85)80022-1","type":"journal-article","article-title":"Correction of congenital diaphragmatic hernia in utero. IV. An early gestational fetal lamb model for pulmonary vascular morphometric analysis","volume":"20","author":"Adzick","year":"1985","unstructured":"Adzick, N. S. et al. Correction of congenital diaphragmatic hernia in utero. IV. An early gestational fetal lamb model for pulmonary vascular morphometric analysis. J Pediatr Surg. 20 (6), 673-680 (1985).","journal-title":"J Pediatr Surg"},{"issue":"2","key":"ref31","first-page":"260","type":"journal-article","article-title":"Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth with survival at birth","volume":"88","author":"Harrison","year":"1980","unstructured":"Harrison, M. R., Bressack, M. A., Churg, A. M., & de Lorimier, A. A. Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth with survival at birth. Surgery. 88 (2), 260-268 (1980).","journal-title":"Surgery"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0003-4975(10)61404-X","type":"journal-article","article-title":"Intrauterine cardiothoracic surgery: the fetal lamb model","volume":"34","author":"Turley","year":"1982","unstructured":"Turley, K. et al. Intrauterine cardiothoracic surgery: the fetal lamb model. Ann Thorac Surg. 34 (4), 422-426 (1982).","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.CIR.92.3.606","type":"journal-article","article-title":"In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs","volume":"92","author":"Reddy","year":"1995","unstructured":"Reddy, V. M. et al. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation. 92 (3), 606-613 (1995).","journal-title":"Circulation"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"F42","DOI":"10.1136\/archdischild-2011-301334","type":"journal-article","article-title":"The 3:1 is superior to a 15:2 ratio in a newborn manikin model in terms of quality of chest compressions and number of ventilations","volume":"98","author":"Hemway","year":"2013","unstructured":"Hemway, R. J., Christman, C., & Perlman, J. The 3:1 is superior to a 15:2 ratio in a newborn manikin model in terms of quality of chest compressions and number of ventilations. Arch Dis Child Fetal Neonatal Ed. 98 (1), F42-45 (2013).","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"3","key":"ref35","type":"journal-article","article-title":"Optimal Chest Compression Rate and Compression to Ventilation Ratio in Delivery Room Resuscitation: Evidence from Newborn Piglets and Neonatal Manikins","volume":"5","author":"Solev\u00e5g","year":"2017","unstructured":"Solev\u00e5g, A. L., & Schm\u00f6lzer, G. M. Optimal Chest Compression Rate and Compression to Ventilation Ratio in Delivery Room Resuscitation: Evidence from Newborn Piglets and Neonatal Manikins. Frontiers in Pediatrics. 5 (3) (2017).","journal-title":"Frontiers in Pediatrics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.resuscitation.2015.08.001","type":"journal-article","article-title":"Chest compressions in newborn animal models: A review","volume":"96","author":"Solev\u00e5g","year":"2015","unstructured":"Solev\u00e5g, A. L. et al. Chest compressions in newborn animal models: A review. Resuscitation. 96 151-155 (2015).","journal-title":"Resuscitation"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/video\/57553\/the-perinatal-asphyxiated-lamb-model-a-model-for-newborn-resuscitation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:41:26Z","timestamp":1792665686000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/57553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,15]]},"references-count":36,"journal-issue":{"issue":"138","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.3791\/57553","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,15]]}}}