{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:40:51Z","timestamp":1792633251300,"version":"4.5.0"},"reference-count":18,"publisher":"MyJove Corporation","issue":"145","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/59089","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T20:01:49Z","timestamp":1552939309000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro"],"prefix":"10.3791","author":[{"given":"Aseel","family":"Marahleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kitaura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Shima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saika","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ren","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Ohori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Noguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Mizoguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"281287","DOI":"10.1155\/2015\/281287","type":"journal-article","article-title":"Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss","volume":"2015","author":"Crotti","year":"2015","unstructured":"Crotti, T. N., Dharmapatni, A. A., Alias, E., & Haynes, D. R. Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss. Journal of Immunology Research. 2015 281287 (2015).","journal-title":"Journal of Immunology Research"},{"issue":"5484","key":"ref2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","type":"journal-article","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","unstructured":"Teitelbaum, S. L. Bone resorption by osteoclasts. Science. 289 (5484), 1504-1508 (2000).","journal-title":"Science"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","type":"journal-article","article-title":"Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts","volume":"275","author":"Azuma","year":"2000","unstructured":"Azuma, Y., Kaji, K., Katogi, R., Takeshita, S., & Kudo, A. Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. Journal of Biological Chemistry. 275 (7), 4858-4864 (2000).","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","type":"journal-article","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","unstructured":"Kobayashi, K.et al. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction. Journal of Experimental Medicine. 191 (2), 275-286 (2000).","journal-title":"Journal of Experimental Medicine"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","type":"journal-article","article-title":"Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis","volume":"202","author":"Kim","year":"2005","unstructured":"Kim, N.et al. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. Journal of Experimental Medicine. 202 (5), 589-595 (2005).","journal-title":"Journal of Experimental Medicine"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1172\/JCI0215582","type":"journal-article","article-title":"Osteoclasts are essential for TNF-alpha-mediated joint destruction","volume":"110","author":"Redlich","year":"2002","unstructured":"Redlich, K.et al. Osteoclasts are essential for TNF-alpha-mediated joint destruction. Journal of Clinical Investestigation. 110 (10), 1419-1427 (2002).","journal-title":"Journal of Clinical Investestigation"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1172\/JCI119679","type":"journal-article","article-title":"Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor","volume":"100","author":"Abu-Amer","year":"1997","unstructured":"Abu-Amer, Y., Ross, F. P., Edwards, J., & Teitelbaum, S. L. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. Journal of Clinical Investestigation. 100 (6), 1557-1565 (1997).","journal-title":"Journal of Clinical Investestigation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.biopha.2018.03.080","type":"journal-article","article-title":"TNF-alpha contributes to postmenopausal osteoporosis by synergistically promoting RANKL-induced osteoclast formation","volume":"102","author":"Zha","year":"2018","unstructured":"Zha, L.et al. TNF-alpha contributes to postmenopausal osteoporosis by synergistically promoting RANKL-induced osteoclast formation. Biomedicine & Pharmacotherapy. 102 369-374 (2018).","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","type":"journal-article","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","unstructured":"Kitaura, H.et al. M-CSF mediates TNF-induced inflammatory osteolysis. Journal of Clinical Investigation. 115 (12), 3418-3427 (2005).","journal-title":"Journal of Clinical Investigation"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1574-695X.2011.00888.x","type":"journal-article","article-title":"Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo","volume":"64","author":"Kimura","year":"2012","unstructured":"Kimura, K., Kitaura, H., Fujii, T., Hakami, Z. W., & Takano-Yamamoto, T. Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo. FEMS Immunology and Medical Microbiology. 64 (2), 219-227 (2012).","journal-title":"FEMS Immunology and Medical Microbiology"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/odi.12117","type":"journal-article","article-title":"An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model","volume":"20","author":"Kimura","year":"2014","unstructured":"Kimura, K. et al. An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model. Oral Diseases. 20 (3), 319-324 (2014).","journal-title":"Oral Diseases"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2319\/080708-412.1","type":"journal-article","article-title":"An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice","volume":"79","author":"Kitaura","year":"2009","unstructured":"Kitaura, H. et al. An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice. Angle Orthodontist. 79 (5), 835-841 (2009).","journal-title":"Angle Orthodontist"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/154405910808700405","type":"journal-article","article-title":"An anti-c-Fms antibody inhibits orthodontic tooth movement","volume":"87","author":"Kitaura","year":"2008","unstructured":"Kitaura, H. et al. An anti-c-Fms antibody inhibits orthodontic tooth movement. Journal of Dental Research. 87 (4), 396-400 (2008).","journal-title":"Journal of Dental Research"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.4049\/jimmunol.1600306","type":"journal-article","article-title":"M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes","volume":"196","author":"Bettina","year":"2016","unstructured":"Bettina, A. et al. M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes. Journal of Immunology. 196 (12), 5047-5055 (2016).","journal-title":"Journal of Immunology"},{"issue":"18","key":"ref15","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","type":"journal-article","article-title":"RANK is essential for osteoclast and lymph node development","volume":"13","author":"Dougall","year":"1999","unstructured":"Dougall, W. C. et al. RANK is essential for osteoclast and lymph node development. Genes & Develpoment. 13 (18), 2412-2424 (1999).","journal-title":"Genes & Develpoment"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","type":"journal-article","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","unstructured":"Wiktor-Jedrzejczak, W.et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse. Proceedings of the National Academy of Sciences of the United States of America. 87 (12), 4828-4832 (1990).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1136\/ard.2006.054874","type":"journal-article","article-title":"Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis","volume":"65","author":"Yang","year":"2006","unstructured":"Yang, P. T. et al. Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis.Annals of the Rheumatic Diseases. 65 (12), 1671-1672 (2006).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"ref18","first-page":"894","type":"journal-article","article-title":"High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints","volume":"27","author":"Takei","year":"2000","unstructured":"Takei, I. et al. High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints. The Journal of Rheumatology. 27 (4), 894-899 (2000).","journal-title":"The Journal of Rheumatology"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/59089\/effect-anti-c-fms-antibody-on-osteoclast-formation-proliferation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:25:15Z","timestamp":1792632315000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/59089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":18,"journal-issue":{"issue":"145","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3791\/59089","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]}}}