{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:39:41Z","timestamp":1792633181886,"version":"4.5.0"},"reference-count":18,"publisher":"MyJove Corporation","issue":"146","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/59490","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T20:00:08Z","timestamp":1554321608000},"source":"Crossref","is-referenced-by-count":9,"title":["Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry"],"prefix":"10.3791","author":[{"given":"Katherine  E.","family":"Zink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna  E.","family":"Burdette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"e0154837","DOI":"10.1371\/journal.pone.0154837","type":"journal-article","article-title":"Whole Reproductive System Non-Negative Matrix Factorization Mass Spectrometry Imaging of an Early-Stage Ovarian Cancer Mouse Model","volume":"11","author":"Paine","year":"2016","unstructured":"Paine, M. R. et al. Whole Reproductive System Non-Negative Matrix Factorization Mass Spectrometry Imaging of an Early-Stage Ovarian Cancer Mouse Model. PLoS One. 11 (5), e0154837 (2016).","journal-title":"PLoS One"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.252","type":"journal-article","article-title":"Translating Metabolic Exchange with Imaging Mass Spectrometry","volume":"5","author":"Yang","year":"2009","unstructured":"Yang, Y.-L., Xu, Y., Straight, P., Dorrestein, P. C. Translating Metabolic Exchange with Imaging Mass Spectrometry. Nature Chemical Biology. 5 (12), 885-887 (2009).","journal-title":"Nature Chemical Biology"},{"issue":"22","key":"ref3","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1021\/ac202356g","type":"journal-article","article-title":"Imaging Mass Spectrometry of Three-Dimensional Cell Culture Systems","volume":"83","author":"Li","year":"2011","unstructured":"Li, H., Hummon, A. B. Imaging Mass Spectrometry of Three-Dimensional Cell Culture Systems. Analytical Chemistry. 83 (22), 8794-8801 (2011).","journal-title":"Analytical Chemistry"},{"issue":"22","key":"ref4","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1128\/JB.00823-12","type":"journal-article","article-title":"Primer on Agar-Based Microbial Imaging Mass Spectrometry","volume":"194","author":"Yang","year":"2012","unstructured":"Yang, J. Y. et al. Primer on Agar-Based Microbial Imaging Mass Spectrometry. Journal of Bacteriology. 194 (22), 6023-6028 (2012).","journal-title":"Journal of Bacteriology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1038\/ncomms12645","type":"journal-article","article-title":"Integrative Proteomic Profiling of Ovarian Cancer Cell Lines Reveals Precursor Cell Associated Proteins and Functional Status","volume":"7","author":"Coscia","year":"2016","unstructured":"Coscia, F. et al. Integrative Proteomic Profiling of Ovarian Cancer Cell Lines Reveals Precursor Cell Associated Proteins and Functional Status. Nature Communications. 7, 12645 (2016).","journal-title":"Nature Communications"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00962-1","type":"journal-article","article-title":"High Grade Serous Ovarian Carcinomas Originate in the Fallopian Tube","volume":"8","author":"Labidi-Galy","year":"2018","unstructured":"Labidi-Galy, S. I. et al. High Grade Serous Ovarian Carcinomas Originate in the Fallopian Tube. Nature Communications. 8 (1) (2018).","journal-title":"Nature Communications"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1158\/1541-7786.MCR-16-0097","type":"journal-article","article-title":"DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer","volume":"14","author":"Klinkebiel","year":"2016","unstructured":"Klinkebiel, D., Zhang, W., Akers, S. N., Odunsi, K., Karpf, A. R. DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer. Molecular Cancer Research. 14 (9), 787-794 (2016).","journal-title":"Molecular Cancer Research"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"dju410","DOI":"10.1093\/jnci\/dju410","type":"journal-article","article-title":"Ovarian Cancer Risk After Salpingectomy: A Nationwide Population-Based Study","volume":"107","author":"Falconer","year":"2015","unstructured":"Falconer, H., Yin, L., Gronberg, H., Altman, D. Ovarian Cancer Risk After Salpingectomy: A Nationwide Population-Based Study. JNCI Journal of the National Cancer Institute. 107 (2), dju410-dju410 (2015).","journal-title":"JNCI Journal of the National Cancer Institute"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.canlet.2017.01.011","type":"journal-article","article-title":"Activin A Stimulates Migration of the Fallopian Tube Epithelium, an Origin of High-Grade Serous Ovarian Cancer, through Non-Canonical Signaling","volume":"391","author":"Dean","year":"2017","unstructured":"Dean, M., Davis, D. A., Burdette, J. E. Activin A Stimulates Migration of the Fallopian Tube Epithelium, an Origin of High-Grade Serous Ovarian Cancer, through Non-Canonical Signaling. Cancer Letters. 391, 114-124 (2017).","journal-title":"Cancer Letters"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.5483\/BMBRep.2011.44.7.435","type":"journal-article","article-title":"Evaluating the Progenitor Cells of Ovarian Cancer: Analysis of Current Animal Models","volume":"44","author":"King","year":"2011","unstructured":"King, S. M., Burdette, J. E. Evaluating the Progenitor Cells of Ovarian Cancer: Analysis of Current Animal Models. BMB Reports. 44 (7), 435 (2011).","journal-title":"BMB Reports"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cels.2017.12.014","type":"journal-article","article-title":"Landscape of Metabolic Variation across Tumor Types","volume":"6","author":"Reznik","year":"2018","unstructured":"Reznik, E. et al. Landscape of Metabolic Variation across Tumor Types. Cell Systems. 6 (3), 301-313.e3 (2018).","journal-title":"Cell Systems"},{"issue":"19","key":"ref12","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1002\/cncr.29392","type":"journal-article","article-title":"Clinical Impact of Selective and Nonselective Beta-Blockers on Survival in Patients with Ovarian Cancer: Beta-Blockers and Ovarian Cancer Survival","volume":"121","author":"Watkins","year":"2015","unstructured":"Watkins, J. L. et al. Clinical Impact of Selective and Nonselective Beta-Blockers on Survival in Patients with Ovarian Cancer: Beta-Blockers and Ovarian Cancer Survival. Cancer. 121 (19), 3444-3451 (2015).","journal-title":"Cancer"},{"issue":"12","key":"ref13","first-page":"4514","type":"journal-article","article-title":"Stress-Related Mediators Stimulate Vascular Endothelial Growth Factor Secretion by Two Ovarian Cancer Cell Lines","volume":"9","author":"Lutgendorf","year":"2003","unstructured":"Lutgendorf, S. K. et al. Stress-Related Mediators Stimulate Vascular Endothelial Growth Factor Secretion by Two Ovarian Cancer Cell Lines. Clinical Cancer Research. 9 (12), 4514-4521 (2003).","journal-title":"Clinical Cancer Research"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1158\/1078-0432.CCR-05-1698","type":"journal-article","article-title":"Stress Hormone-Mediated Invasion of Ovarian Cancer Cells","volume":"12","author":"Sood","year":"2006","unstructured":"Sood, A. K. Stress Hormone-Mediated Invasion of Ovarian Cancer Cells. Clinical Cancer Research. 12 (2), 369-375 (2006).","journal-title":"Clinical Cancer Research"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s13361-015-1241-8","type":"journal-article","article-title":"Homogeneous Matrix Deposition on Dried Agar for MALDI Imaging Mass Spectrometry of Microbial Cultures","volume":"26","author":"Hoffmann","year":"2015","unstructured":"Hoffmann, T., Dorrestein, P. C. Homogeneous Matrix Deposition on Dried Agar for MALDI Imaging Mass Spectrometry of Microbial Cultures. Journal of The American Society for Mass Spectrometry. 26 (11), 1959-1962 (2015).","journal-title":"Journal of The American Society for Mass Spectrometry"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1021\/acscentsci.8b00405","type":"journal-article","article-title":"Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary That Drives Primary Metastasis of Ovarian Cancer","volume":"4","author":"Zink","year":"2018","unstructured":"Zink, K. E., Dean, M., Burdette, J. E., Sanchez, L. M. Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary That Drives Primary Metastasis of Ovarian Cancer. ACS Central Science. 4 (10), 1360-1370 (2018).","journal-title":"ACS Central Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ncomms2413","type":"journal-article","article-title":"Src Activation by \u03b2-Adrenoreceptors Is a Key Switch for Tumour Metastasis","volume":"4","author":"Armaiz-Pena","year":"2013","unstructured":"Armaiz-Pena, G. N. et al. Src Activation by \u03b2-Adrenoreceptors Is a Key Switch for Tumour Metastasis. Nature Communications. 4 1403 (2013).","journal-title":"Nature Communications"},{"issue":"26","key":"ref18","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1038\/onc.2014.270","type":"journal-article","article-title":"HTERT Mediates Norepinephrine-Induced Slug Expression and Ovarian Cancer Aggressiveness","volume":"34","author":"Choi","year":"2015","unstructured":"Choi, M. J. et al. HTERT Mediates Norepinephrine-Induced Slug Expression and Ovarian Cancer Aggressiveness. Oncogene. 34 (26), 3402 (2015).","journal-title":"Oncogene"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/59490\/capturing-small-molecule-communication-between-tissues-cells-using","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:20:59Z","timestamp":1792632059000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/59490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":18,"journal-issue":{"issue":"146","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3791\/59490","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]}}}