{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:49:41Z","timestamp":1792630181187,"version":"4.5.0"},"reference-count":29,"publisher":"MyJove Corporation","issue":"150","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/59521","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T20:01:03Z","timestamp":1565121663000},"source":"Crossref","is-referenced-by-count":11,"title":["Inducing Apical Periodontitis in Mice"],"prefix":"10.3791","author":[{"given":"Elisheva","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Reich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Abramovitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klutstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/iej.12196","type":"journal-article","article-title":"The role of IL-6 on apical periodontitis: a systematic review","volume":"47","author":"Azuma","year":"2014","unstructured":"Azuma, M. M., Samuel, R. O., Gomes-Filho, J. E., Dezan-Junior, E., Cintra, L. T. The role of IL-6 on apical periodontitis: a systematic review. International Endodontics Journal. 47 (7), 615-621 (2014).","journal-title":"International Endodontics Journal"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.joen.2013.10.036","type":"journal-article","article-title":"Overlapping protective and destructive regulatory pathways in apical periodontitis","volume":"40","author":"Marton","year":"2014","unstructured":"Marton, I. J., Kiss, C. Overlapping protective and destructive regulatory pathways in apical periodontitis. Journal of Endodontics. 40 (2), 155-163 (2014).","journal-title":"Journal of Endodontics"},{"issue":"4","key":"ref3","first-page":"e1","type":"journal-article","article-title":"Pathogenesis of apical periodontitis: a literature review","volume":"2","author":"Graunaite","year":"2012","unstructured":"Graunaite, I., Lodiene, G., Maciulskiene, V. Pathogenesis of apical periodontitis: a literature review. Journal of Oral and Maxillofacial Research. 2 (4), e1 (2012).","journal-title":"Journal of Oral and Maxillofacial Research"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joen.2016.07.009","type":"journal-article","article-title":"Factors Associated with Apical Periodontitis: A Multilevel Analysis","volume":"42","author":"Hussein","year":"2016","unstructured":"Hussein, F. E., Liew, A. K., Ramlee, R. A., Abdullah, D., Chong, B. S. Factors Associated with Apical Periodontitis: A Multilevel Analysis. Journal of Endodontics. 42 (10), 1441-1445 (2016).","journal-title":"Journal of Endodontics"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0714.1996.tb00272.x","type":"journal-article","article-title":"Analysis of immunoglobulin-synthesizing cells in human dental periapical lesions by in situ hybridization and immunohistochemistry","volume":"25","author":"Takahashi","year":"1996","unstructured":"Takahashi, K., MacDonald, D. G., Kinane, D. F. Analysis of immunoglobulin-synthesizing cells in human dental periapical lesions by in situ hybridization and immunohistochemistry. Journal of Oral Pathology Medicine. 25 (6), 331-335 (1996).","journal-title":"Journal of Oral Pathology Medicine"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.bbrc.2018.03.109","type":"journal-article","article-title":"Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K\/Akt\/mTOR pathway","volume":"498","author":"Lin","year":"2018","unstructured":"Lin, D. et al. Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K\/Akt\/mTOR pathway. Biochemical and Biophysical Research Community. 498 (4), 1028-1036 (2018).","journal-title":"Biochemical and Biophysical Research Community"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/0022034517741261","type":"journal-article","article-title":"5-Lipoxygenase Knockout Aggravated Apical Periodontitis in a Murine Model","volume":"97","author":"Wu","year":"2018","unstructured":"Wu, Y., Sun, H., Yang, B., Liu, X., Wang, J. 5-Lipoxygenase Knockout Aggravated Apical Periodontitis in a Murine Model. Journal of Dental Research. 97 (4), 442-450 (2018).","journal-title":"Journal of Dental Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e20170512","DOI":"10.1590\/1678-7757-2017-0512","type":"journal-article","article-title":"Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice","volume":"26","author":"Barreiros","year":"2018","unstructured":"Barreiros, D. et al. Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice. Journal of Applied Oral Science. 26 e20170512 (2018).","journal-title":"Journal of Applied Oral Science"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1590\/0103-6440201801731","type":"journal-article","article-title":"MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88","volume":"29","author":"Barreiros","year":"2018","unstructured":"Barreiros, D. et al. MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88. Brazillian Dentistry Journal. 29 (1), 43-47 (2018).","journal-title":"Brazillian Dentistry Journal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.3402\/jom.v8.32433","type":"journal-article","article-title":"VEGFR-2 reduces while combined VEGFR-2 and -3 signaling increases inflammation in apical periodontitis","volume":"8","author":"Virtej","year":"2016","unstructured":"Virtej, A., Papadakou, P., Sasaki, H., Bletsa, A., Berggreen, E. VEGFR-2 reduces while combined VEGFR-2 and -3 signaling increases inflammation in apical periodontitis. Journal of Oral Microbiology. 8 32433 (2016).","journal-title":"Journal of Oral Microbiology"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.joen.2016.05.009","type":"journal-article","article-title":"Cementocytes Express Receptor Activator of the Nuclear Factor Kappa-B Ligand in Response to Endodontic Infection in Mice","volume":"42","author":"De Rossi","year":"2016","unstructured":"De Rossi, A. et al. Cementocytes Express Receptor Activator of the Nuclear Factor Kappa-B Ligand in Response to Endodontic Infection in Mice. Journal of Endodontics. 42 (8), 1251-1257 (2016).","journal-title":"Journal of Endodontics"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/ar.23383","type":"journal-article","article-title":"Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice","volume":"299","author":"Rider","year":"2016","unstructured":"Rider, D. et al. Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice. Anatomy Records (Hoboken). 299 (9), 1281-1292 (2016).","journal-title":"Anatomy Records (Hoboken)"},{"issue":"1","key":"ref13","first-page":"e78","type":"journal-article","article-title":"Relationship between hypertension and periapical lesion: an in vitro and in vivo study","volume":"30","author":"Martins","year":"2016","unstructured":"Martins, C. M., Sasaki, H., Hirai, K., Andrada, A. C., Gomes-Filho, J. E. Relationship between hypertension and periapical lesion: an in vitro and in vivo study. Brazillian Oral Research. 30 (1), e78 (2016).","journal-title":"Brazillian Oral Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1560175","DOI":"10.1155\/2017\/1560175","type":"journal-article","article-title":"Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws","volume":"2017","author":"Rao","year":"2017","unstructured":"Rao, N. J., Wang, J. Y., Yu, R. Q., Leung, Y. Y., Zheng, L. W. Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws. Biomedical Research International. 2017 1560175 (2017).","journal-title":"Biomedical Research International"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.joen.2016.07.020","type":"journal-article","article-title":"Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction-induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice","volume":"42","author":"Song","year":"2016","unstructured":"Song, M. et al. Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction-induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice. Journal of Endodontics. 42 (11), 1641-1646 (2016).","journal-title":"Journal of Endodontics"},{"issue":"19-20","key":"ref16","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/ten.tea.2016.0086","type":"journal-article","article-title":"Hypoxic Preconditioning Enhances Dental Pulp Stem Cell Therapy for Infection-Caused Bone Destruction","volume":"22","author":"Wu","year":"2016","unstructured":"Wu, Y. et al. Hypoxic Preconditioning Enhances Dental Pulp Stem Cell Therapy for Infection-Caused Bone Destruction. Tissue Engineering Part A. 22 (19-20), 1191-1203 (2016).","journal-title":"Tissue Engineering Part A"},{"issue":"33","key":"ref17","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","type":"journal-article","article-title":"Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","unstructured":"Eichele, D. D., Kharbanda, K. K. Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis. World Journal of Gastroenterology. 23 (33), 6016-6029 (2017).","journal-title":"World Journal of Gastroenterology"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","type":"journal-article","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","unstructured":"Choudhary, N., Bhatt, L. K., Prabhavalkar, K. S. Experimental animal models for rheumatoid arthritis. Immunopharmacology and Immunotoxicology. 40 (3), 193-200 (2018).","journal-title":"Immunopharmacology and Immunotoxicology"},{"issue":"1-2","key":"ref19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/odi.12824","type":"journal-article","article-title":"Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice","volume":"24","author":"Shah","year":"2018","unstructured":"Shah, A. et al. Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice. Oral Disease. 24 (1-2), 57-62 (2018).","journal-title":"Oral Disease"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.joen.2014.01.003","type":"journal-article","article-title":"MMP9 deficiency increased the size of experimentally induced apical periodontitis","volume":"40","author":"Wan","year":"2014","unstructured":"Wan, C. et al. MMP9 deficiency increased the size of experimentally induced apical periodontitis. Journal of Endodontics. 40 (5), 658-664 (2014).","journal-title":"Journal of Endodontics"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/iej.12204","type":"journal-article","article-title":"MyD88 knockout mice develop initial enlarged periapical lesions with increased numbers of neutrophils","volume":"47","author":"Bezerra da Silva","year":"2014","unstructured":"Bezerra da Silva, R. A. et al. MyD88 knockout mice develop initial enlarged periapical lesions with increased numbers of neutrophils. International Endod Journal. 47 (7), 675-686 (2014).","journal-title":"International Endod Journal"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cden.2016.08.003","type":"journal-article","article-title":"Molecular Mechanisms of Apical Periodontitis: Emerging Role of Epigenetic Regulators","volume":"61","author":"Mehrazarin","year":"2017","unstructured":"Mehrazarin, S., Alshaikh, A., Kang, M. K. Molecular Mechanisms of Apical Periodontitis: Emerging Role of Epigenetic Regulators. Dental Clinics of North America . 61 (1), 17-35 (2017).","journal-title":"Dental Clinics of North America"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-9657.2000.016001001.x","type":"journal-article","article-title":"Macrophages in periapical lesions","volume":"16","author":"Metzger","year":"2000","unstructured":"Metzger, Z. Macrophages in periapical lesions. Endodontics Dentisrty and Traumatology. 16 (1), 1-8 (2000).","journal-title":"Endodontics Dentisrty and Traumatology"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1469-7580.2011.01367.x","type":"journal-article","article-title":"Tooth-bone morphogenesis during postnatal stages of mouse first molar development","volume":"218","author":"Lungova","year":"2011","unstructured":"Lungova, V. et al. Tooth-bone morphogenesis during postnatal stages of mouse first molar development. Journal of Anatomy. 218 (6), 699-716 (2011).","journal-title":"Journal of Anatomy"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tvjl.2007.10.011","type":"journal-article","article-title":"The effect of local anaesthesia on anaesthetic requirements for feline ovariectomy","volume":"178","author":"Zilberstein","year":"2008","unstructured":"Zilberstein, L. F., Moens, Y. P., Leterrier, E. The effect of local anaesthesia on anaesthetic requirements for feline ovariectomy. Veterinary Journal. 178 (2), 214-218 (2008).","journal-title":"Veterinary Journal"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2344\/0003-3006(2005)52[29:PAALAA]2.0.CO;2","type":"journal-article","article-title":"Preemptive analgesia and local anesthesia as a supplement to general anesthesia: a review","volume":"52","author":"Kaufman","year":"2005","unstructured":"Kaufman, E., Epstein, J. B., Gorsky, M., Jackson, D. L., Kadari, A. Preemptive analgesia and local anesthesia as a supplement to general anesthesia: a review. Anesthesia Progress . 52 (1), 29-38 (2005).","journal-title":"Anesthesia Progress"},{"issue":"119","key":"ref27","type":"journal-article","article-title":"Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice","author":"Song","year":"2017","unstructured":"Song, M. et al. Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice. Journal of Visual Experimentalization. 10.3791\/54973 (119) (2017).","journal-title":"Journal of Visual Experimentalization"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1038\/s41598-017-03628-6","type":"journal-article","article-title":"Development of a root canal treatment model in the rat","volume":"7","author":"Yoneda","year":"2017","unstructured":"Yoneda, N. et al. Development of a root canal treatment model in the rat. Scientific Reports. 7 (1), 3315 (2017).","journal-title":"Scientific Reports"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.joen.2009.06.006","type":"journal-article","article-title":"Regulatory T cells in mouse periapical lesions","volume":"35","author":"AlShwaimi","year":"2009","unstructured":"AlShwaimi, E. et al. Regulatory T cells in mouse periapical lesions. Journal of Endodontics. 35 (9), 1229-1233 (2009).","journal-title":"Journal of Endodontics"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/59521\/inducing-apical-periodontitis-in-mice","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:35:28Z","timestamp":1792629328000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/59521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,6]]},"references-count":29,"journal-issue":{"issue":"150","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3791\/59521","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,6]]}}}