{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:41:53Z","timestamp":1792629713340,"version":"4.5.0"},"reference-count":41,"publisher":"MyJove Corporation","issue":"153","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/60047","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T19:00:11Z","timestamp":1572980411000},"source":"Crossref","is-referenced-by-count":2,"title":["Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery"],"prefix":"10.3791","author":[{"given":"Chiara","family":"Pagliuca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Scaglione","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carraturo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mantova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Michela","family":"Marino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Virginia","family":"Pishbin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Pagliarulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Colicchio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Salvatore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/CMR.13.1.144","type":"journal-article","article-title":"Update on meningococcal disease with emphasis on pathogenesis and clinical management","volume":"13","author":"van Deuren","year":"2000","unstructured":"van Deuren, M., Brandtzaeg, P., van der Meer, J.W. Update on meningococcal disease with emphasis on pathogenesis and clinical management. Clinical Microbiology Reviews. 13, 144-166 (2000).","journal-title":"Clinical Microbiology Reviews"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1128\/AAC.01746-15","type":"journal-article","article-title":"Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In vitro Study of Mechanisms Associated with rpoB H553Y Mutation","volume":"59","author":"Colicchio","year":"2015","unstructured":"Colicchio, R. et al. Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In vitro Study of Mechanisms Associated with rpoB H553Y Mutation. Antimicrobial Agents and Chemotherapy. 59 (12), 7637-49 (2015).","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1128\/IAI.00501-13","type":"journal-article","article-title":"Serogroup-specific interaction of Neisseria meningitidis capsular polysaccharide with host cell microtubules and effects on tubulin polymerization","volume":"82","author":"Tal\u00e0","year":"2014","unstructured":"Tal\u00e0, A. et al. Serogroup-specific interaction of Neisseria meningitidis capsular polysaccharide with host cell microtubules and effects on tubulin polymerization. Infection and Immunity. 82, 265-274 (2014).","journal-title":"Infection and Immunity"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/j.1365-2958.2003.03947.x","type":"journal-article","article-title":"Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates","volume":"51","author":"Pagliarulo","year":"2004","unstructured":"Pagliarulo, C. et al. Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates. Molecular Microbiology. 51, 1757-1772 (2004).","journal-title":"Molecular Microbiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/00365540310016349","type":"journal-article","article-title":"Contacting the host: insights and implications of pathogenic Neisseria cell interactions","volume":"35","author":"Plant","year":"2003","unstructured":"Plant, L., Jonsson, A.B. Contacting the host: insights and implications of pathogenic Neisseria cell interactions. Scandinavian Journal of Infectious Diseases. 35, 608-613 (2003).","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1046\/j.1365-2958.1999.01411.x","type":"journal-article","article-title":"Iron acquisition systems in the pathogenic Neisseria","volume":"32","author":"Schryvers","year":"1999","unstructured":"Schryvers, A.B., Stojiljkovic, I. Iron acquisition systems in the pathogenic Neisseria. Molecular Microbiology. 32, 1117-1123 (1999).","journal-title":"Molecular Microbiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.1996.01551.x","type":"journal-article","article-title":"Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae","volume":"22","author":"Virji","year":"1996","unstructured":"Virji, M., Makepeace, K., Ferguson, D.J., Watt, S.M. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Molecular Microbiology. 22, 941-950 (1996).","journal-title":"Molecular Microbiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1128\/iai.64.8.2998-3006.1996","type":"journal-article","article-title":"Invasion of primary nasopharyngeal epithelial cells by Neisseria meningitidis is controlled by phase variation of multiple surface antigens","volume":"64","author":"de Vries","year":"1996","unstructured":"de Vries, F.P., van Der Ende, A., van Putten, J.P., Dankert, J. Invasion of primary nasopharyngeal epithelial cells by Neisseria meningitidis is controlled by phase variation of multiple surface antigens. Infection and Immunity. 64, 2998-3006 (1996).","journal-title":"Infection and Immunity"},{"key":"ref9","first-page":"2483","type":"journal-article","article-title":"Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of the meningococcal infection","volume":"132","author":"Tinsley","year":"1986","unstructured":"Tinsley, C.R., Heckels, J.E. Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of the meningococcal infection. Journal of General Microbiology. 132, 2483-90 (1986).","journal-title":"Journal of General Microbiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.vaccine.2005.01.053","type":"journal-article","article-title":"Experimental disease models for the assessment of meningococcal vaccines","volume":"23","author":"Gorringe","year":"2005","unstructured":"Gorringe, A.R. et al. Experimental disease models for the assessment of meningococcal vaccines. Vaccine. 23, 2214\u20132217 (2005).","journal-title":"Vaccine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/IAI.72.1.338-344.2004","type":"journal-article","article-title":"Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity","volume":"72","author":"Newcombe","year":"2004","unstructured":"Newcombe, J. et al. 2004. Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity. Infection and Immunity. 72, 338-344 (2004).","journal-title":"Infection and Immunity"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1574-695X.1999.tb01374.x","type":"journal-article","article-title":"A mouse model utilising human transferrin to study protection against Neisseria meningitidis serogroup B induced by outer membrane vesicle vaccination","volume":"26","author":"Oftung","year":"1999","unstructured":"Oftung, F., Lovik, M., Andersen, S.R., Froholm, L.O., Bjune, G. A mouse model utilising human transferrin to study protection against Neisseria meningitidis serogroup B induced by outer membrane vesicle vaccination. FEMS Immunology and Medical Microbiology. 26, 75-82 (1999).","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1139\/m84-162","type":"journal-article","article-title":"Experimental meningococcal infection in neonatal mice: differences in virulence between strains isolated from human cases and carriers","volume":"30","author":"Salit","year":"1984","unstructured":"Salit, I. E., Tomalty, L. Experimental meningococcal infection in neonatal mice: differences in virulence between strains isolated from human cases and carriers. Canadian Journal of Microbiology. 30, 1042-1045 (1984).","journal-title":"Canadian Journal of Microbiology"},{"key":"ref14","first-page":"119","type":"journal-article","article-title":"A neonatal mouse model of meningococcal disease","volume":"9","author":"Salit","year":"1986","unstructured":"Salit, I. E., Tomalty, L. A neonatal mouse model of meningococcal disease. Clinical and Investigative Medicine. 9, 119-123 (1986).","journal-title":"Clinical and Investigative Medicine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0882-4010(92)90004-8","type":"journal-article","article-title":"Intranasal infection of infant mice with Neisseria meningitidis","volume":"12","author":"Mackinnon","year":"1992","unstructured":"Mackinnon, F. G., A. R. Gorringe, S. G. Funnell, Robinson, A.Intranasal infection of infant mice with Neisseria meningitidis. Microbial Pathogenesis. 12, 415-420 (1992).","journal-title":"Microbial Pathogenesis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/mpat.1993.1085","type":"journal-article","article-title":"Demonstration of lipooligosaccharide immunotype and cap- sule as virulence factors for Neisseria meningitidis using an infant mouse intranasal infection model","volume":"15","author":"Mackinnon","year":"1993","unstructured":"Mackinnon, F.G. et al. Demonstration of lipooligosaccharide immunotype and cap- sule as virulence factors for Neisseria meningitidis using an infant mouse intranasal infection model. Microbial Pathogenesis. 15, 359\u2013366 (1993).","journal-title":"Microbial Pathogenesis"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1128\/IAI.71.4.1849-1855.2003","type":"journal-article","article-title":"Development and evaluation of an improved mouse model of meningococcal colonization","volume":"71","author":"Yi","year":"2003","unstructured":"Yi, K., Stephens, DS., Stojiljkovic, I. Development and evaluation of an improved mouse model of meningococcal colonization. Infection and Immunity. 71 (4), 1849-55 (2003).","journal-title":"Infection and Immunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/iai.24.2.545-551.1979","type":"journal-article","article-title":"Neisseria meningitidis infection in mice: influence of iron, variations in virulence among strains, and pathology","volume":"24","author":"Holbein","year":"1979","unstructured":"Holbein, B.E., Jericho, K.W.F., Likes, G.C. Neisseria meningitidis infection in mice: influence of iron, variations in virulence among strains, and pathology. Infection and Immunity. 24, 545-551 (1979).","journal-title":"Infection and Immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0882-4010(88)90070-8","type":"journal-article","article-title":"Experimental meningococcal meningitis in the infant rat","volume":"4","author":"Saukkonen","year":"1988","unstructured":"Saukkonen, K. Experimental meningococcal meningitis in the infant rat. Microbial Pathogenesis. 4, 203-211 (1988).","journal-title":"Microbial Pathogenesis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1086476","type":"journal-article","article-title":"CD46 in meningococcal disease","volume":"301","author":"Johansson","year":"2003","unstructured":"Johansson, L. et al. CD46 in meningococcal disease. Science. 301, 373-375 (2003).","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1128\/IAI.00781-07","type":"journal-article","article-title":"Transgenic mice expressing human transferrin as a model for meningococcal infection","volume":"75","author":"Zarantonelli","year":"2007","unstructured":"Zarantonelli, M.L. et al. Transgenic mice expressing human transferrin as a model for meningococcal infection. Infection and Immunity. 75, 5609-5614 (2007).","journal-title":"Infection and Immunity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/infdis\/jit301","type":"journal-article","article-title":"Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans","volume":"208","author":"Join-Lambert","year":"2013","unstructured":"Join-Lambert, O. et al. Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. Journal of Infection Disease. 208, 1590-1597 (2013).","journal-title":"Journal of Infection Disease"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1003139","DOI":"10.1371\/journal.ppat.1003139","type":"journal-article","article-title":"Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model","volume":"9","author":"Melican","year":"2013","unstructured":"Melican, K., Michea Veloso, P., Martin, T., Bruneval, P., Dum\u00e9nil, G. Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. PLoS Pathogen. 9, e1003139 (2013).","journal-title":"PLoS Pathogen"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1128\/IAI.01424-08","type":"journal-article","article-title":"The meningococcal ABC-Type L-glutamate transporter GltT is necessary for the development of experimental meningitis in mice","volume":"77","author":"Colicchio","year":"2009","unstructured":"Colicchio, R. et al. The meningococcal ABC-Type L-glutamate transporter GltT is necessary for the development of experimental meningitis in mice. Infection and Immunity. 77, 3578-3587 (2009).","journal-title":"Infection and Immunity"},{"key":"ref25","first-page":"00688","type":"journal-article","article-title":"Virulence traits of serogroup C meningococcus and isogenic cssA mutant, defective in surface-exposed sialic acid, in a murine model of meningitis","author":"Colicchio","year":"2019","unstructured":"Colicchio, R. et al. Virulence traits of serogroup C meningococcus and isogenic cssA mutant, defective in surface-exposed sialic acid, in a murine model of meningitis. Infection and Immunity. Pii, IAI.00688-18 (2019).","journal-title":"Infection and Immunity"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1186\/s12879-014-0726-6","type":"journal-article","article-title":"Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis","volume":"14","author":"Ricci","year":"2014","unstructured":"Ricci, S. et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infectious Diseases. 14, 726 (2014).","journal-title":"BMC Infectious Diseases"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/iai.57.8.2425-2429.1989","type":"journal-article","article-title":"Comparison of the abilities of different protein sources of iron to enhance Neisseria meningitidis infection in mice","volume":"57","author":"Schryvers","year":"1989","unstructured":"Schryvers, A.B., Gonzalez, G.C. Comparison of the abilities of different protein sources of iron to enhance Neisseria meningitidis infection in mice. Infection and Immunity. 57, 2425\u20132429 (1989).","journal-title":"Infection and Immunity"},{"key":"ref28","first-page":"448","type":"journal-article","article-title":"Chapter 105 - Cerebrospinal Fluid Sampling Small Animal","author":"Beverly","year":"2009","unstructured":"Beverly, K.S. Chapter 105 - Cerebrospinal Fluid Sampling Small Animal. Critical Care Medicine. Pages 448-452 (2009).","journal-title":"Critical Care Medicine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/IAI.00073-14","type":"journal-article","article-title":"Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis","volume":"82","author":"Liechti","year":"2014","unstructured":"Liechti, F.D., Grandgirard, D., Leppert, D., Leib, S.L. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and Immunity. 82, 1710-1718 (2014).","journal-title":"Infection and Immunity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.3389\/fmicb.2016.01750","type":"journal-article","article-title":"Novel Approach for Evaluation of Bacteroides fragilis Protective Role against Bartonella henselae Liver Damage in Immunocompromised Murine Model","volume":"7","author":"Pagliuca","year":"2016","unstructured":"Pagliuca, C. et al. Novel Approach for Evaluation of Bacteroides fragilis Protective Role against Bartonella henselae Liver Damage in Immunocompromised Murine Model. Frontiers in Microbiology. 7, 1750 (2016).","journal-title":"Frontiers in Microbiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2334-7-116","type":"journal-article","article-title":"Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospi- nal fluid","volume":"7","author":"Trampuz","year":"2007","unstructured":"Trampuz, A., Steinhuber, A., Wittwer, M., Leib, S.L. Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospi- nal fluid. BMC Infectious Diseases. 7, 116 (2007).","journal-title":"BMC Infectious Diseases"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1084\/jem.170.3.959","type":"journal-article","article-title":"Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes","volume":"170","author":"Tuomanen","year":"1989","unstructured":"Tuomanen, E.I., Saukkonen, K., Sande, S., Cioffe, C., Wright, S.D. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. Journal of Experimental Medicine. 170, 959-969 (1989).","journal-title":"Journal of Experimental Medicine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.129.6.1307","type":"journal-article","article-title":"Human immunity to the meningococcus. I. The role of humoral antibodies","volume":"129","author":"Goldschneider","year":"1969","unstructured":"Goldschneider, I., Gotschlich, E.C., Artenstein, M.S. Human immunity to the meningococcus. I. The role of humoral antibodies. Journal of Experimental Medicine. 129, 1307-1326 (1969).","journal-title":"Journal of Experimental Medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.129.6.1327","type":"journal-article","article-title":"Human immunity to the meningococcus. II. Development of natural immunity","volume":"129","author":"Goldschneider","year":"1969","unstructured":"Goldschneider, I., Gotschlich, E.C., Artenstein, M.S. Human immunity to the meningococcus. II. Development of natural immunity. Journal of Experimental Medicine. 129, 1327-1348 (1969).","journal-title":"Journal of Experimental Medicine"},{"key":"ref35","type":"book","article-title":"Laboratory methods for the diagnosis of meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae: WHO manual, 2nd Edition","volume-title":"World Health Organization","year":"2011","unstructured":"World Health Organization. Laboratory methods for the diagnosis of meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae: WHO manual, 2nd Edition. Geneva: WHO; (2011)."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2180-4-36","type":"journal-article","article-title":"Method for inducing experimental pneumococcal meningitis in outbred mice","volume":"4","author":"Chiavolini","year":"2004","unstructured":"Chiavolini, D. et al. Method for inducing experimental pneumococcal meningitis in outbred mice. BMC Microbiolology. 4, 36 (2004).","journal-title":"BMC Microbiolology"},{"issue":"1","key":"ref37","first-page":"e137","type":"journal-article","article-title":"Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model","author":"Zhang","year":"2018","unstructured":"Zhang, S. et al. Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model. Journal of Visualized Experiments. 1, 137 (2018).","journal-title":"Journal of Visualized Experiments"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"49653","DOI":"10.1371\/journal.pone.0049653","type":"journal-article","article-title":"Evidence of Bacteroides fragilis protection from Bartonella henselae-induced damage","volume":"7","author":"Pagliuca","year":"2012","unstructured":"Pagliuca, C. et al. Evidence of Bacteroides fragilis protection from Bartonella henselae-induced damage. PLoS One. 7, e49653 (2012).","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1365-2958.2004.04169.x","type":"journal-article","article-title":"Neisseria meningitidis accelerates ferritin degradation in host epithelial cells to yield an essential iron source","volume":"53","author":"Larson","year":"2004","unstructured":"Larson, J.A., Howie, H.L., So, M. Neisseria meningitidis accelerates ferritin degradation in host epithelial cells to yield an essential iron source. Molecular Microbiology. 53, 807-820 (2004).","journal-title":"Molecular Microbiology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/263230a0","type":"journal-article","article-title":"Phenotypic variability of inbred and outbred mice","volume":"263","author":"Festing","year":"1976","unstructured":"Festing, M.F.W. Phenotypic variability of inbred and outbred mice. Nature. 263, 230-232 (1976).","journal-title":"Nature"},{"key":"ref41","first-page":"237","type":"journal-article","article-title":"Warning: the use of heterogeneous mice may seriously damage your research","volume":"20","author":"Festing","year":"1999","unstructured":"Festing, M.F.W. Warning: the use of heterogeneous mice may seriously damage your research. Neurobiology of Aging. 20, 237-244 (1999).","journal-title":"Neurobiology of Aging"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/60047\/inducing-meningococcal-meningitis-serogroup-c-mice-via-intracisternal","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:30Z","timestamp":1792627230000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/60047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":41,"journal-issue":{"issue":"153","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3791\/60047","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]}}}