{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:38:36Z","timestamp":1792625916537,"version":"4.5.0"},"reference-count":76,"publisher":"MyJove Corporation","issue":"160","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/60300","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T20:00:23Z","timestamp":1592337623000},"source":"Crossref","is-referenced-by-count":13,"title":["Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease"],"prefix":"10.3791","author":[{"given":"Jonathan H.","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher  M.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hobbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"issue":"10103","key":"ref1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","type":"journal-article","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","unstructured":"Denton, C. P., Khanna, D. Systemic sclerosis. Lancet. 390 (10103), 1685-1699 (2017).","journal-title":"Lancet"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/1529-0131(200106)44:6<1359::AID-ART228>3.0.CO;2-S","type":"journal-article","article-title":"Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts","volume":"44","author":"Arnett","year":"2001","unstructured":"Arnett, F. C. et al. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis & Rheumatism. 44 (6), 1359-1362 (2001).","journal-title":"Arthritis & Rheumatism"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/BOR.0b013e32834ff2e8","type":"journal-article","article-title":"Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers","volume":"24","author":"Barnes","year":"2012","unstructured":"Barnes, J., Mayes, M. D. Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers. Current Opinion in Rheumatology. 24 (2), 165-170 (2012).","journal-title":"Current Opinion in Rheumatology"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00281-015-0507-3","type":"journal-article","article-title":"Environmental risk factors of systemic sclerosis","volume":"37","author":"Marie","year":"2015","unstructured":"Marie, I., Gehanno, J. F. Environmental risk factors of systemic sclerosis. Seminars in Immunopathology. 37 (5), 463-473 (2015).","journal-title":"Seminars in Immunopathology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1136\/ard.50.Suppl_4.846","type":"journal-article","article-title":"Epidemiology of scleroderma","volume":"50","author":"Silman","year":"1991","unstructured":"Silman, A. J. Epidemiology of scleroderma. Annals of the Rheumatic Diseases. 50 Suppl 4, 846-853 (1991).","journal-title":"Annals of the Rheumatic Diseases"},{"key":"ref6","first-page":"008","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: diagnosis and management","volume":"1","author":"Scholand","year":"2012","unstructured":"Scholand, M. B. et al. Interstitial lung disease in systemic sclerosis: diagnosis and management. Rheumatology. S1, 008 (2012).","journal-title":"Rheumatology"},{"issue":"127","key":"ref7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09059180.00005512","type":"journal-article","article-title":"Scleroderma lung disease","volume":"22","author":"Solomon","year":"2013","unstructured":"Solomon, J. J. et al. Scleroderma lung disease. European Respiratory Review. 22 (127), 6-19 (2013).","journal-title":"European Respiratory Review"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/ard.2006.062901","type":"journal-article","article-title":"Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database","volume":"66","author":"Walker","year":"2007","unstructured":"Walker, U. A. et al. Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Annals of the Rheumatic Diseases. 66 (6), 754-763 (2007).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3899\/jrheum.101243","type":"journal-article","article-title":"Pulmonary hypertension assessment and recognition of outcomes in scleroderma (PHAROS): baseline characteristics and description of study population","volume":"38","author":"Hinchcliff","year":"2011","unstructured":"Hinchcliff, M., Fischer, A., Schiopu, E., Steen, V. D., Investigators, P. Pulmonary hypertension assessment and recognition of outcomes in scleroderma (PHAROS): baseline characteristics and description of study population. The Journal of Rheumatology. 38 (10), 2172-2179 (2011).","journal-title":"The Journal of Rheumatology"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00296-016-3636-7","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: current and future treatment","volume":"37","author":"Giacomelli","year":"2017","unstructured":"Giacomelli, R. et al. Interstitial lung disease in systemic sclerosis: current and future treatment. Rheumatology International. 37 (6), 853-863 (2017).","journal-title":"Rheumatology International"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00296-017-3916-x","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: data from the spanish scleroderma study group","volume":"38","author":"Sanchez-Cano","year":"2018","unstructured":"Sanchez-Cano, D. et al. Interstitial lung disease in systemic sclerosis: data from the spanish scleroderma study group. Rheumatology International. 38 (3), 363-374 (2018).","journal-title":"Rheumatology International"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.rdc.2015.04.006","type":"journal-article","article-title":"Management of systemic-sclerosis-associated interstitial lung disease","volume":"41","author":"Silver","year":"2015","unstructured":"Silver, K. C., Silver, R. M. Management of systemic-sclerosis-associated interstitial lung disease. Rheumatic Diseases Clinics of North America. 41 (3), 439-457 (2015).","journal-title":"Rheumatic Diseases Clinics of North America"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3899\/jrheum.170307","type":"journal-article","article-title":"All-cause healthcare costs and mortality in patients with systemic sclerosis with lung involvement","volume":"45","author":"Fischer","year":"2018","unstructured":"Fischer, A., Kong, A. M., Swigris, J. J., Cole, A. L., Raimundo, K. All-cause healthcare costs and mortality in patients with systemic sclerosis with lung involvement. The Journal of Rheumatology. 45 (2), 235-241 (2018).","journal-title":"The Journal of Rheumatology"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","type":"journal-article","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","unstructured":"Tyndall, A. J. et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Annals of the Rheumatic Diseases. 69 (10), 1809-1815 (2010).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/art.38702","type":"journal-article","article-title":"Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct","volume":"66","author":"Herzog","year":"2014","unstructured":"Herzog, E. L. et al. Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? Arthritis & Rheumatology. 66 (8), 1967-1978 (2014).","journal-title":"Arthritis & Rheumatology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.semarthrit.2014.05.010","type":"journal-article","article-title":"Mortality and survival in systemic sclerosis: systematic review and meta-analysis","volume":"44","author":"Rubio-Rivas","year":"2014","unstructured":"Rubio-Rivas, M., Royo, C., Simeon, C. P., Corbella, X., Fonollosa, V. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Seminars in Arthritis and Rheumatism. 44 (2), 208-219 (2014).","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"ref17","type":"journal-article","article-title":"Serum KL-6 as a marker of disease progression in SSc-ILD","volume":"52","author":"Stock","year":"2018","unstructured":"Stock, C. et al. Serum KL-6 as a marker of disease progression in SSc-ILD. European Respiratory Journal. 52 (suppl 62) abstract PA3664 (2018).","journal-title":"European Respiratory Journal"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1378\/chest.13-2626","type":"journal-article","article-title":"Predictors of mortality and progression in scleroderma-associated interstitial lung disease: a systematic review","volume":"146","author":"Winstone","year":"2014","unstructured":"Winstone, T. A. et al. Predictors of mortality and progression in scleroderma-associated interstitial lung disease: a systematic review. Chest. 146 (2), 422-436 (2014).","journal-title":"Chest"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/rheumatology\/key151","type":"journal-article","article-title":"Ongoing clinical trials and treatment options for patients with systemic sclerosis-associated interstitial lung disease","volume":"58","author":"Khanna","year":"2019","unstructured":"Khanna, D. et al. Ongoing clinical trials and treatment options for patients with systemic sclerosis-associated interstitial lung disease. Rheumatology (Oxford). 58 (4), 567-579 (2019).","journal-title":"Rheumatology (Oxford)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/rheumatology\/ken313","type":"journal-article","article-title":"Pulmonary function tests","volume":"47","author":"Behr","year":"2008","unstructured":"Behr, J., Furst, D. E. Pulmonary function tests. Rheumatology (Oxford). 47 Suppl 5, v65-67 (2008).","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.semarthrit.2017.03.019","type":"journal-article","article-title":"Clinical algorithms for the diagnosis and prognosis of interstitial lung disease in systemic sclerosis","volume":"47","author":"Hax","year":"2017","unstructured":"Hax, V. et al. Clinical algorithms for the diagnosis and prognosis of interstitial lung disease in systemic sclerosis. Seminars in Arthritis and Rheumatism. 47 (2), 228-234 (2017).","journal-title":"Seminars in Arthritis and Rheumatism"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/BOR.0000000000000323","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: progress in screening and early diagnosis","volume":"28","author":"Molberg","year":"2016","unstructured":"Molberg, O., Hoffmann-Vold, A. M. Interstitial lung disease in systemic sclerosis: progress in screening and early diagnosis. Current Opinion in Rheumatology. 28 (6), 613-618 (2016).","journal-title":"Current Opinion in Rheumatology"},{"key":"ref23","type":"book","article-title":"Interstital lung disease","volume-title":"Goldman-Cecil Medicine","author":"Raghu","year":"2016","unstructured":"Raghu, G. Interstital lung disease. In: Goldman L, Schafer AI, editors. Goldman-Cecil Medicine. Philadelphia, USA: Elsevier Science. 575-588 (2016)."},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.3899\/jrheum.171362","type":"journal-article","article-title":"Performance of forced vital capacity and lung diffusion cutpoints for associated radiographic interstitial lung disease in systemic sclerosis","volume":"45","author":"Showalter","year":"2018","unstructured":"Showalter, K. et al. Performance of forced vital capacity and lung diffusion cutpoints for associated radiographic interstitial lung disease in systemic sclerosis. The Journal of Rheumatology. 45 (11), 1572-1576 (2018).","journal-title":"The Journal of Rheumatology"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1002\/art.39405","type":"journal-article","article-title":"Brief report: pulmonary function tests: high rate of false-negative results in the early detection and screening of scleroderma-related interstitial lung disease","volume":"67","author":"Suliman","year":"2015","unstructured":"Suliman, Y. A. et al. Brief report: pulmonary function tests: high rate of false-negative results in the early detection and screening of scleroderma-related interstitial lung disease. Arthritis & Rheumatology. 67 (12), 3256-3261 (2015).","journal-title":"Arthritis & Rheumatology"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/art.30438","type":"journal-article","article-title":"Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease","volume":"63","author":"Roth","year":"2011","unstructured":"Roth, M. D. et al. Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease. Arthritis & Rheumatology. 63 (9), 2797-2808 (2011).","journal-title":"Arthritis & Rheumatology"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3346\/jkms.2004.19.2.159","type":"journal-article","article-title":"Radiation exposure from chest CT: issues and strategies","volume":"19","author":"Kalra","year":"2004","unstructured":"Kalra, M. K., Maher, M. M., Rizzo, S., Kanarek, D., Shepard, J. A. Radiation exposure from chest CT: issues and strategies. Journal of Korean Medical Science. 19 (2), 159-166 (2004).","journal-title":"Journal of Korean Medical Science"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/COC.0000000000000244","type":"journal-article","article-title":"The birth of the illegitimate linear no-threshold model: an invalid paradigm for estimating risk following low-dose radiation exposure","volume":"41","author":"Siegel","year":"2018","unstructured":"Siegel, J. A., Pennington, C. W., Sacks, B., Welsh, J. S. The birth of the illegitimate linear no-threshold model: an invalid paradigm for estimating risk following low-dose radiation exposure. American Journal of Clinical Oncology. 41 (2), 173-177 (2018).","journal-title":"American Journal of Clinical Oncology"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1136\/annrheumdis-2014-205637","type":"journal-article","article-title":"Screening for interstitial lung disease in systemic sclerosis: performance of high-resolution CT with limited number of slices: a prospective study","volume":"73","author":"Frauenfelder","year":"2014","unstructured":"Frauenfelder, T. et al. Screening for interstitial lung disease in systemic sclerosis: performance of high-resolution CT with limited number of slices: a prospective study. Annals of the Rheumatic Diseases. 73 (12), 2069-2073 (2014).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2214\/AJR.07.2556","type":"journal-article","article-title":"Radiation dose reduction in chest CT: a review","volume":"190","author":"Kubo","year":"2008","unstructured":"Kubo, T. et al. Radiation dose reduction in chest CT: a review. American Journal of Roentgenology. 190 (2), 335-343 (2008).","journal-title":"American Journal of Roentgenology"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.21037\/jtd.2018.04.39","type":"journal-article","article-title":"The impact of slice-reduced computed tomography on histogram-based densitometry assessment of lung fibrosis in patients with systemic sclerosis","volume":"10","author":"Nguyen-Kim","year":"2018","unstructured":"Nguyen-Kim, T. D. L. et al. The impact of slice-reduced computed tomography on histogram-based densitometry assessment of lung fibrosis in patients with systemic sclerosis. Journal of Thoracic Disease. 10 (4), 2142-2152 (2018).","journal-title":"Journal of Thoracic Disease"},{"issue":"5","key":"ref32","first-page":"419","type":"journal-article","article-title":"Pulmonary magnetic resonance imaging is similar to chest tomography in detecting inflammation in patients with systemic sclerosis","volume":"57","author":"Muller","year":"2017","unstructured":"Muller, C. S., Warszawiak, D., Paiva, E. D. S., Escuissato, D. L. Pulmonary magnetic resonance imaging is similar to chest tomography in detecting inflammation in patients with systemic sclerosis. Revista Brasileira de Reumatologia English Edition. 57 (5), 419-424 (2017).","journal-title":"Revista Brasileira de Reumatologia English Edition"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s10067-016-3267-0","type":"journal-article","article-title":"Fast 1.5 T chest MRI for the assessment of interstitial lung disease extent secondary to systemic sclerosis","volume":"35","author":"Pinal-Fernandez","year":"2016","unstructured":"Pinal-Fernandez, I. et al. Fast 1.5 T chest MRI for the assessment of interstitial lung disease extent secondary to systemic sclerosis. Clinical Rheumatology. 35 (9), 2339-2345 (2016).","journal-title":"Clinical Rheumatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1465-9921-14-S1-S3","type":"journal-article","article-title":"Highlights of HRCT imaging in IPF","volume":"14","author":"Sverzellati","year":"2013","unstructured":"Sverzellati, N. Highlights of HRCT imaging in IPF. Respiratory Research. 14 Suppl 1, S3 (2013).","journal-title":"Respiratory Research"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","type":"journal-article","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper","volume":"6","author":"Lynch","year":"2018","unstructured":"Lynch, D. A. et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. The Lancet Respiratory Medicine. 6 (2), 138-153 (2018).","journal-title":"The Lancet Respiratory Medicine"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1164\/rccm.201807-1255ST","type":"journal-article","article-title":"Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","unstructured":"Raghu, G. et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline. American Journal of Respiratory and Critical Care Medicine. 198 (5), e44-e68 (2018).","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"ref37","volume-title":"Exam: CT thorax for interstitial lung disease","year":"2019","unstructured":"Exam: CT thorax for interstitial lung disease. <https:\/\/www.pulmonaryfibrosis.org\/docs\/default-source\/medical-community-documents\/ct-chest-for-ild-protocol.pdf?sfvrsn=0> (2019)."},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201108-1420PP","type":"journal-article","article-title":"Subclinical interstitial lung disease: why you should care","volume":"185","author":"Doyle","year":"2012","unstructured":"Doyle, T.J., Hunninghake, G.M., Rosas, I.O. Subclinical interstitial lung disease: why you should care. American Journal of Respiratory and Critical Care Medicine. 185 (11), 1147-1153 (2012).","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/prrv.2000.0059","type":"journal-article","article-title":"Atelectasis: mechanisms, diagnosis and management","volume":"1","author":"Peroni","year":"2000","unstructured":"Peroni, D. G., Boner, A. L. Atelectasis: mechanisms, diagnosis and management. Paediatric Respiratory Reviews. 1 (3), 274-278 (2000).","journal-title":"Paediatric Respiratory Reviews"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.rmedc.2009.09.016","type":"journal-article","article-title":"Pulmonary fibrosis in systemic sclerosis: diagnosis and management","volume":"3","author":"Branley","year":"2010","unstructured":"Branley, H. M. Pulmonary fibrosis in systemic sclerosis: diagnosis and management. Respiratory Medicine CME. 3, 10-14 (2010).","journal-title":"Respiratory Medicine CME"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2214\/ajr.160.2.8424326","type":"journal-article","article-title":"Ground-glass opacity of the lung parenchyma: a guide to analysis with high-resolution CT","volume":"160","author":"Engeler","year":"1993","unstructured":"Engeler, C. E., Tashjian, J. H., Trenkner, S. W., Walsh, J. W. Ground-glass opacity of the lung parenchyma: a guide to analysis with high-resolution CT. American Journal of Roentgenology. 160 (2), 249-251 (1993).","journal-title":"American Journal of Roentgenology"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1378\/chest.07-2444","type":"journal-article","article-title":"High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease","volume":"134","author":"Goldin","year":"2008","unstructured":"Goldin, J. G. et al. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest. 134 (2), 358-367 (2008).","journal-title":"Chest"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11926-010-0095-0","type":"journal-article","article-title":"Imaging lung disease in systemic sclerosis","volume":"12","author":"Strollo","year":"2010","unstructured":"Strollo, D., Goldin, J. Imaging lung disease in systemic sclerosis. Current Rheumatology Reports. 12 (2), 156-161 (2010).","journal-title":"Current Rheumatology Reports"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0971-3026.125570","type":"journal-article","article-title":"Significance of various pulmonary and extrapulmonary abnormalities on HRCT of the chest in scleroderma lung","volume":"23","author":"Pandey","year":"2013","unstructured":"Pandey, A. K. et al. Significance of various pulmonary and extrapulmonary abnormalities on HRCT of the chest in scleroderma lung. Indian Journal of Radiology and Imaging. 23 (4), 304-307 (2013).","journal-title":"Indian Journal of Radiology and Imaging"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2214\/AJR.17.18384","type":"journal-article","article-title":"CT Features of the usual interstitial pneumonia pattern: differentiating connective tissue disease-associated interstitial lung disease from idiopathic pulmonary fibrosis","volume":"210","author":"Chung","year":"2018","unstructured":"Chung, J. H. et al. CT Features of the usual interstitial pneumonia pattern: differentiating connective tissue disease-associated interstitial lung disease from idiopathic pulmonary fibrosis. American Journal of Roentgenology. 210 (2), 307-313 (2018).","journal-title":"American Journal of Roentgenology"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/RTI.0000000000000328","type":"journal-article","article-title":"Differentiating usual interstitial pneumonia from nonspecific interstitial pneumonia using high-resolution computed tomography: the \"Straight-edge Sign\"","volume":"33","author":"Zhan","year":"2018","unstructured":"Zhan, X. et al. Differentiating usual interstitial pneumonia from nonspecific interstitial pneumonia using high-resolution computed tomography: the \"Straight-edge Sign\". Journal of Thoracic Imaging. 33 (4), 266-270 (2018).","journal-title":"Journal of Thoracic Imaging"},{"issue":"3","key":"ref47","first-page":"193","type":"journal-article","article-title":"The extrapulmonary manifestations of systemic sclerosis on chest high resolution computed tomography","volume":"14","author":"Farrokh","year":"2015","unstructured":"Farrokh, D., Abbasi, B., Fallah-Rastegar, Y., Mirfeizi, Z. The extrapulmonary manifestations of systemic sclerosis on chest high resolution computed tomography. Tanaffos. 14 (3), 193-200 (2015).","journal-title":"Tanaffos"},{"issue":"9","key":"ref48","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11547-018-0894-3","type":"journal-article","article-title":"Relationship between interstitial lung disease and oesophageal dilatation on chest high-resolution computed tomography in patients with systemic sclerosis: a cross-sectional study","volume":"123","author":"Salaffi","year":"2018","unstructured":"Salaffi, F. et al. Relationship between interstitial lung disease and oesophageal dilatation on chest high-resolution computed tomography in patients with systemic sclerosis: a cross-sectional study. La Radiologia Medica. 123 (9), 655-663 (2018).","journal-title":"La Radiologia Medica"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/ard.2007.081612","type":"journal-article","article-title":"Oesophageal dilatation on high-resolution computed tomography scan of the lungs as a sign of scleroderma","volume":"67","author":"Vonk","year":"2008","unstructured":"Vonk, M. C. et al. Oesophageal dilatation on high-resolution computed tomography scan of the lungs as a sign of scleroderma. Annals of the Rheumatic Diseases. 67 (9), 1317-1321 (2008).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5114\/reum.2018.77977","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management","volume":"56","author":"Chowaniec","year":"2018","unstructured":"Chowaniec, M., Skoczynska, M., Sokolik, R., Wiland, P. Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management. Reumatologia. 56 (4), 249-254 (2018).","journal-title":"Reumatologia"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/RCT.0b013e3182aa7fc5","type":"journal-article","article-title":"Relationship of main pulmonary artery diameter to pulmonary arterial pressure in scleroderma patients with and without interstitial fibrosis","volume":"38","author":"McCall","year":"2014","unstructured":"McCall, R. K., Ravenel, J. G., Nietert, P. J., Granath, A., Silver, R. M. Relationship of main pulmonary artery diameter to pulmonary arterial pressure in scleroderma patients with and without interstitial fibrosis. Journal of Computer Assisted Tomography. 38 (2), 163-168 (2014).","journal-title":"Journal of Computer Assisted Tomography"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.carj.2010.02.006","type":"journal-article","article-title":"Predictors of pulmonary hypertension on high-resolution computed tomography of the chest in systemic sclerosis: a retrospective analysis","volume":"61","author":"Pandey","year":"2010","unstructured":"Pandey, A. K. et al. Predictors of pulmonary hypertension on high-resolution computed tomography of the chest in systemic sclerosis: a retrospective analysis. Canadian Association of Radiologists Journal. 61 (5), 291-296 (2010).","journal-title":"Canadian Association of Radiologists Journal"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1513\/AnnalsATS.201406-253PP","type":"journal-article","article-title":"Significance of main pulmonary artery dilation on imaging studies","volume":"11","author":"Raymond","year":"2014","unstructured":"Raymond, T. E., Khabbaza, J. E., Yadav, R., Tonelli, A. R. Significance of main pulmonary artery dilation on imaging studies. Annals of the American Thoracic Society. 11 (10), 1623-1632 (2014).","journal-title":"Annals of the American Thoracic Society"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.autrev.2012.06.003","type":"journal-article","article-title":"Lung cancer in scleroderma: results from an Italian rheumatologic center and review of the literature","volume":"12","author":"Colaci","year":"2013","unstructured":"Colaci, M. et al. Lung cancer in scleroderma: results from an Italian rheumatologic center and review of the literature. Autoimmunity Reviews. 12 (3), 374-379 (2013).","journal-title":"Autoimmunity Reviews"},{"issue":"4","key":"ref55","first-page":"75","type":"journal-article","article-title":"Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS)","volume":"35","author":"Distler","year":"2017","unstructured":"Distler, O. et al. Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS). Clinical and Experimental Rheumatology. 35 Suppl 106 (4), 75-81 (2017).","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1148\/radiol.2322031223","type":"journal-article","article-title":"CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia","volume":"232","author":"Desai","year":"2004","unstructured":"Desai, S. R. et al. CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. Radiology. 232 (2), 560-567 (2004).","journal-title":"Radiology"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.mayocp.2018.09.002","type":"journal-article","article-title":"Interstitial lung disease and other pulmonary manifestations in connective tissue diseases","volume":"94","author":"Mira-Avendano","year":"2019","unstructured":"Mira-Avendano, I. et al. Interstitial lung disease and other pulmonary manifestations in connective tissue diseases. Mayo Clinic Proceedings. 94 (2), 309-325 (2019).","journal-title":"Mayo Clinic Proceedings"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/RTI.0000000000000319","type":"journal-article","article-title":"The four corners sign: a specific imaging feature in differentiating systemic sclerosis-related interstitial lung disease from idiopathic pulmonary fibrosis","volume":"33","author":"Walkoff","year":"2018","unstructured":"Walkoff, L., White, D. B., Chung, J. H., Asante, D., Cox, C. W. The four corners sign: a specific imaging feature in differentiating systemic sclerosis-related interstitial lung disease from idiopathic pulmonary fibrosis. Journal of Thoracic Imaging. 33 (3), 197-203 (2018).","journal-title":"Journal of Thoracic Imaging"},{"issue":"6","key":"ref59","first-page":"16","type":"journal-article","article-title":"Systemic sclerosis with multiple pulmonary manifestations","volume":"10","author":"Kotnur","year":"2016","unstructured":"Kotnur, M. R., Suresh, P., Reddy, V. S., Sharma, T., Salim, N. A. Systemic sclerosis with multiple pulmonary manifestations. Journal of Clinical & Diagnostic Research. 10 (6), OD16-17 (2016).","journal-title":"Journal of Clinical & Diagnostic Research"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: a simple staging system","volume":"177","author":"Goh","year":"2008","unstructured":"Goh, N. S. et al. Interstitial lung disease in systemic sclerosis: a simple staging system. American Journal of Respiratory and Critical Care Medicine. 177 (11), 1248-1254 (2008).","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/resp.13175","type":"journal-article","article-title":"Radiographic fibrosis score predicts survival in systemic sclerosis-associated interstitial lung disease","volume":"23","author":"Takei","year":"2018","unstructured":"Takei, R. et al. Radiographic fibrosis score predicts survival in systemic sclerosis-associated interstitial lung disease. Respirology. 23 (4), 385-391 (2018).","journal-title":"Respirology"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/RTI.0000000000000279","type":"journal-article","article-title":"Lung density and pulmonary artery diameter are predictors of pulmonary hypertension in systemic sclerosis","volume":"32","author":"Bakker","year":"2017","unstructured":"Bakker, M. E. et al. Lung density and pulmonary artery diameter are predictors of pulmonary hypertension in systemic sclerosis. Journal of Thoracic Imaging. 32 (6), 391-397 (2017).","journal-title":"Journal of Thoracic Imaging"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13075-015-0872-2","type":"journal-article","article-title":"Predictors of lung function decline in scleroderma-related interstitial lung disease based on high-resolution computed tomography: implications for cohort enrichment in systemic sclerosis-associated interstitial lung disease trials","volume":"17","author":"Khanna","year":"2015","unstructured":"Khanna, D. et al. Predictors of lung function decline in scleroderma-related interstitial lung disease based on high-resolution computed tomography: implications for cohort enrichment in systemic sclerosis-associated interstitial lung disease trials. Arthritis Research & Therapy. 17, 372 (2015).","journal-title":"Arthritis Research & Therapy"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/rheumatology\/kew480","type":"journal-article","article-title":"Quantitative chest computed tomography is associated with two prediction models of mortality in interstitial lung disease related to systemic sclerosis","volume":"56","author":"Ariani","year":"2017","unstructured":"Ariani, A. et al. Quantitative chest computed tomography is associated with two prediction models of mortality in interstitial lung disease related to systemic sclerosis. Rheumatology (Oxford). 56 (6), 922-927 (2017).","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"ref65","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1378\/chest.09-0108","type":"journal-article","article-title":"Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study","volume":"136","author":"Goldin","year":"2009","unstructured":"Goldin, J. et al. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study. Chest. 136 (5), 1333-1340 (2009).","journal-title":"Chest"},{"issue":"9","key":"ref66","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S2213-2600(16)30152-7","type":"journal-article","article-title":"Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial","volume":"4","author":"Tashkin","year":"2016","unstructured":"Tashkin, D. P. et al. Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. The Lancet Respiratory Medicine. 4 (9), 708-719 (2016).","journal-title":"The Lancet Respiratory Medicine"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa1903076","type":"journal-article","article-title":"Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease","volume":"380","author":"Distler","year":"2019","unstructured":"Distler, O. et al. Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease. New England Journal of Medicine. 380, 2518-2528 (2019).","journal-title":"New England Journal of Medicine"},{"issue":"137","key":"ref68","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1183\/16000617.00002915","type":"journal-article","article-title":"Interstitial lung disease in systemic sclerosis: where do we stand","volume":"24","author":"Cappelli","year":"2015","unstructured":"Cappelli, S. et al. Interstitial lung disease in systemic sclerosis: where do we stand? European Respiratory Review. 24 (137), 411-419 (2015).","journal-title":"European Respiratory Review"},{"issue":"11","key":"ref69","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1513\/AnnalsATS.201802-079OC","type":"journal-article","article-title":"Longitudinal changes in quantitative interstitial lung disease on CT after immunosuppression in the Scleroderma Lung Study II","volume":"5","author":"Goldin","year":"2018","unstructured":"Goldin, J. G. et al. Longitudinal changes in quantitative interstitial lung disease on CT after immunosuppression in the Scleroderma Lung Study II. Annals of the American Thoracic Society. 5 (11), 1286-1295 (2018).","journal-title":"Annals of the American Thoracic Society"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"381","DOI":"10.21037\/qims.2016.08.08","type":"journal-article","article-title":"Correlation of delta high-resolution computed tomography (HRCT) score with delta clinical variables in early systemic sclerosis (SSc) patients","volume":"6","author":"Wangkaew","year":"2016","unstructured":"Wangkaew, S., Euathrongchit, J., Wattanawittawas, P., Kasitanon, N. Correlation of delta high-resolution computed tomography (HRCT) score with delta clinical variables in early systemic sclerosis (SSc) patients. Quantitative Imaging in Medicine and Surgery. 6 (4), 381-390 (2016).","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"issue":"7","key":"ref71","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1136\/annrheumdis-2015-208929","type":"journal-article","article-title":"Transitions to different patterns of interstitial lung disease in scleroderma with and without treatment","volume":"75","author":"Kim","year":"2016","unstructured":"Kim, H. J. et al. Transitions to different patterns of interstitial lung disease in scleroderma with and without treatment. Annals of the Rheumatic Diseases. 75 (7), 1367-1371 (2016).","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"18","key":"ref72","doi-asserted-by":"crossref","first-page":"0566","DOI":"10.1097\/MD.0000000000010566","type":"journal-article","article-title":"Ultrasound B-lines in the evaluation of interstitial lung disease in patients with systemic sclerosis: cut-off point definition for the presence of significant pulmonary fibrosis","volume":"97","author":"Tardella","year":"2018","unstructured":"Tardella, M. et al. Ultrasound B-lines in the evaluation of interstitial lung disease in patients with systemic sclerosis: cut-off point definition for the presence of significant pulmonary fibrosis. Medicine (Baltimore). 97 (18), e0566 (2018).","journal-title":"Medicine (Baltimore)"},{"key":"ref73","type":"journal-article","article-title":"Lung ultrasound as a screening method for interstitial lung disease in patients with systemic sclerosis","author":"Hassan","year":"2018","unstructured":"Hassan, R. I. et al. Lung ultrasound as a screening method for interstitial lung disease in patients with systemic sclerosis. Journal of Clinical Rheumatology. [Epub ahead of print] (2018).","journal-title":"Journal of Clinical Rheumatology"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13075-017-1409-7","type":"journal-article","article-title":"Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review","volume":"19","author":"Wang","year":"2017","unstructured":"Wang, Y., Gargani, L., Barskova, T., Furst, D. E., Cerinic, M. M. Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review. Arthritis Research & Therapy. 19 (1), 206 (2017).","journal-title":"Arthritis Research & Therapy"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/crj.12451","type":"journal-article","article-title":"Quantitative CT indexes are significantly associated with exercise oxygen desaturation in interstitial lung disease related to systemic sclerosis","volume":"11","author":"Ariani","year":"2017","unstructured":"Ariani, A. et al. Quantitative CT indexes are significantly associated with exercise oxygen desaturation in interstitial lung disease related to systemic sclerosis. The Clinical Respiratory Journal. 11 (6), 983-989 (2017).","journal-title":"The Clinical Respiratory Journal"},{"issue":"12","key":"ref76","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s00330-011-2223-2","type":"journal-article","article-title":"Quantitative texture-based assessment of one-year changes in fibrotic reticular patterns on HRCT in scleroderma lung disease treated with oral cyclophosphamide","volume":"21","author":"Kim","year":"2011","unstructured":"Kim, H. J. et al. Quantitative texture-based assessment of one-year changes in fibrotic reticular patterns on HRCT in scleroderma lung disease treated with oral cyclophosphamide. European Radiology. 21 (12), 2455-2465 (2011).","journal-title":"European Radiology"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/60300\/imaging-features-systemic-sclerosis-associated-interstitial-lung","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:54:48Z","timestamp":1792623288000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/60300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":76,"journal-issue":{"issue":"160","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.3791\/60300","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]}}}