{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:40:18Z","timestamp":1792622418511,"version":"4.5.0"},"reference-count":37,"publisher":"MyJove Corporation","issue":"168","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/61593","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T20:28:33Z","timestamp":1612902513000},"source":"Crossref","is-referenced-by-count":2,"title":["Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination"],"prefix":"10.3791","author":[{"given":"Hirotoshi","family":"Yasui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nishinaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Taki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isobe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"ref1","type":"journal-article","article-title":"Near Infrared Light Triggered Photo\/Immuno-Therapy Toward Cancers","volume":"8","author":"Xu","year":"2020","unstructured":"Xu, X., Lu, H., Lee, R. Near Infrared Light Triggered Photo\/Immuno-Therapy Toward Cancers. Frontiers in Bioengineering and Biotechnology. 8 (2020).","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/nm.2554","type":"journal-article","article-title":"Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules","volume":"17","author":"Mitsunaga","year":"2011","unstructured":"Mitsunaga, M. et al. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nature Medicine. 17, 1685-1691 (2011).","journal-title":"Nature Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1021\/acs.accounts.9b00273","type":"journal-article","article-title":"Near-Infrared Photoimmunotherapy of Cancer","volume":"52","author":"Kobayashi","year":"2019","unstructured":"Kobayashi, H., Choyke, P. L. Near-Infrared Photoimmunotherapy of Cancer. Accounts of Chemical Research. 52, 2332-2339 (2019).","journal-title":"Accounts of Chemical Research"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.1073\/pnas.83.22.8744","type":"journal-article","article-title":"Antibody-targeted photolysis: Selective photodestruction of human T-cell leukemia cells using monoclonal antibody-chlorin e6 conjugates","volume":"83","author":"Oseroff","year":"1986","unstructured":"Oseroff, A. R., Ohuoha, D., Hasan, T., Bommer, J. C., Yarmush, M. L. Antibody-targeted photolysis: Selective photodestruction of human T-cell leukemia cells using monoclonal antibody-chlorin e6 conjugates. Proceedings of the National Academy of Sciences of the United States of America. 83, 8744-8748 (1986).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.130.3.1473","type":"journal-article","article-title":"Photoimmunotherapy: treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates","volume":"130","author":"Mew","year":"1983","unstructured":"Mew, D., Wat, C. K., Towers, G. H., Levy, J. G. Photoimmunotherapy: treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates. Journal of Immunology. 130, 1473-7 (1983).","journal-title":"Journal of Immunology"},{"key":"ref6","first-page":"1505","type":"journal-article","article-title":"Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy","volume":"59","author":"Vrouenraets","year":"1999","unstructured":"Vrouenraets, M. B. et al. Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy. Cancer Research. 59, 1505-1513 (1999).","journal-title":"Cancer Research"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/bjc.1994.330","type":"journal-article","article-title":"Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model","volume":"70","author":"Goff","year":"1994","unstructured":"Goff, B. A. et al. Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model. British Journal of Cancer. 70, 474-480 (1994).","journal-title":"British Journal of Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1021\/acscentsci.8b00565","type":"journal-article","article-title":"Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy","volume":"4","author":"Sato","year":"2018","unstructured":"Sato, K. et al. Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy. ACS Central Science. 4, 1559-1569 (2018).","journal-title":"ACS Central Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7150\/thno.11559","type":"journal-article","article-title":"Near infrared photoimmunotherapy in the treatment of pleural disseminated NSCLC: Preclinical experience","volume":"5","author":"Sato","year":"2015","unstructured":"Sato, K., Nagaya, T., Choyke, P. L., Kobayashi, H. Near infrared photoimmunotherapy in the treatment of pleural disseminated NSCLC: Preclinical experience. Theranostics. 5, 698-709 (2015).","journal-title":"Theranostics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/cells9041019","type":"journal-article","article-title":"Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin","volume":"9","author":"Nishinaga","year":"2020","unstructured":"Nishinaga, Y. et al. Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin. Cells. 9, 1019 (2020).","journal-title":"Cells"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"19747","DOI":"10.18632\/oncotarget.3850","type":"journal-article","article-title":"Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model","volume":"6","author":"Sato","year":"2015","unstructured":"Sato, K. et al. Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model. Oncotarget. 6, 19747-19758 (2015).","journal-title":"Oncotarget"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.canlet.2015.05.018","type":"journal-article","article-title":"Near infrared photoimmunotherapy for lung metastases","volume":"365","author":"Sato","year":"2015","unstructured":"Sato, K., Nagaya, T., Mitsunaga, M., Choyke, P. L., Kobayashi, H. Near infrared photoimmunotherapy for lung metastases. Cancer Letters. 365, 112-121 (2015).","journal-title":"Cancer Letters"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"102632","DOI":"10.1016\/j.ebiom.2020.102632","type":"journal-article","article-title":"Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer","volume":"52","author":"Isobe","year":"2020","unstructured":"Isobe, Y. et al. Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer. EBioMedicine. 52, 102632 (2020).","journal-title":"EBioMedicine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1158\/1535-7163.MCT-16-0663","type":"journal-article","article-title":"Near infrared photoimmunotherapy in a transgenic mouse model of spontaneous epidermal growth factor receptor (EGFR)-expressing lung cancer","volume":"16","author":"Nakamura","year":"2017","unstructured":"Nakamura, Y. et al. Near infrared photoimmunotherapy in a transgenic mouse model of spontaneous epidermal growth factor receptor (EGFR)-expressing lung cancer. Molecular Cancer Therapeutics. 16, 408-414 (2017).","journal-title":"Molecular Cancer Therapeutics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.18632\/oncotarget.12410","type":"journal-article","article-title":"Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody","volume":"8","author":"Nagaya","year":"2017","unstructured":"Nagaya, T. et al. Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody. Oncotarget. 8, 8807-8817 (2017).","journal-title":"Oncotarget"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6843","type":"journal-article","article-title":"Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy","volume":"8","author":"Sato","year":"2016","unstructured":"Sato, K. et al. Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy. Science Translational Medicine. 8 (2016).","journal-title":"Science Translational Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"14324","DOI":"10.18632\/oncotarget.7365","type":"journal-article","article-title":"Comparative effectiveness of light emitting diodes (LEDs) and lasers in near infrared photoimmunotherapy","volume":"7","author":"Sato","year":"2016","unstructured":"Sato, K. et al. Comparative effectiveness of light emitting diodes (LEDs) and lasers in near infrared photoimmunotherapy. Oncotarget. 7, 14324-14335 (2016).","journal-title":"Oncotarget"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"113276","DOI":"10.1371\/journal.pone.0113276","type":"journal-article","article-title":"Photoimmunotherapy of Gastric Cancer Peritoneal Carcinomatosis in a Mouse Model","volume":"9","author":"Sato","year":"2014","unstructured":"Sato, K., Choyke, P. L., Kobayashi, H. Photoimmunotherapy of Gastric Cancer Peritoneal Carcinomatosis in a Mouse Model. PLoS One. 9, e113276 (2014).","journal-title":"PLoS One"},{"key":"ref19","first-page":"2880","type":"journal-article","article-title":"Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and nonpulmonary cancer cell lines in athymic nude mice","volume":"48","author":"McLemore","year":"1988","unstructured":"McLemore, T. L. et al. Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and nonpulmonary cancer cell lines in athymic nude mice. Cancer Research. 48, 2880-6 (1988).","journal-title":"Cancer Research"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00880061","type":"journal-article","article-title":"Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion","volume":"11","author":"Manzotti","year":"1993","unstructured":"Manzotti, C., Audisio, R. A., Pratesi, G. Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion. Clinical & Experimental Metastasis. 11, 5-14 (1993).","journal-title":"Clinical & Experimental Metastasis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jso.25150","type":"journal-article","article-title":"Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery","volume":"118","author":"Lwin","year":"2018","unstructured":"Lwin, T. M., Hoffman, R. M., Bouvet, M. Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery. Journal of Surgical Oncology. 118, 253-264 (2018).","journal-title":"Journal of Surgical Oncology"},{"key":"ref22","type":"book","volume-title":"From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype","author":"Sordat","year":"2017","unstructured":"Sordat, B. C. M. From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype. in 43\u201353 Humana Press, Cham. (2017)."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.molonc.2014.01.006","type":"journal-article","article-title":"Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor","volume":"8","author":"Sato","year":"2014","unstructured":"Sato, K. et al. Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor. Molecular Oncology. 8, 620-32 (2014).","journal-title":"Molecular Oncology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/1471-2407-14-389","type":"journal-article","article-title":"The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity","volume":"14","author":"Nakajima","year":"2014","unstructured":"Nakajima, T. et al. The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity. BMC Cancer. 14, 389 (2014).","journal-title":"BMC Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.molonc.2016.07.010","type":"journal-article","article-title":"Near infrared photoimmunotherapy of B-cell lymphoma","volume":"10","author":"Nagaya","year":"2016","unstructured":"Nagaya, T. et al. Near infrared photoimmunotherapy of B-cell lymphoma. Molecular Oncology. 10, 1404-1414 (2016).","journal-title":"Molecular Oncology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1158\/1535-7163.MCT-14-0658","type":"journal-article","article-title":"Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer","volume":"14","author":"Sato","year":"2015","unstructured":"Sato, K. et al. Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer. Molecular Cancer Therapeutics. 14, 141-150 (2015).","journal-title":"Molecular Cancer Therapeutics"},{"key":"ref27","type":"journal-article","article-title":"Implantation and monitoring by pet\/ct of an orthotopic model of human pleural mesothelioma in athymic mice","volume":"2019","author":"Colin","year":"2019","unstructured":"Colin, D. J., Bejuy, O., Germain, S., Triponez, F., Serre-Beinier, V. Implantation and monitoring by pet\/ct of an orthotopic model of human pleural mesothelioma in athymic mice. Journal of Visualized Experiments. 2019 (2019).","journal-title":"Journal of Visualized Experiments"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ejcts.2007.01.047","type":"journal-article","article-title":"Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment","volume":"31","author":"Opitz","year":"2007","unstructured":"Opitz, I. et al. Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment. European Journal of Cardio-Thoracic Surgery. 31, 772-778 (2007).","journal-title":"European Journal of Cardio-Thoracic Surgery"},{"key":"ref29","first-page":"1087","type":"journal-article","article-title":"New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: a review of the literature and future directions","volume":"4","author":"Bunn","year":"1998","unstructured":"Bunn, P. A., Kelly, K. New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: a review of the literature and future directions. Clinical Cancer Research. 4, 1087-100 (1998).","journal-title":"Clinical Cancer Research"},{"key":"ref30","first-page":"713","type":"journal-article","article-title":"Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review)","volume":"3","author":"Astoul","year":"1993","unstructured":"Astoul, P., Wang, X., Hoffman, R. Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review). International Journal of Oncology. 3, 713-8 (1993).","journal-title":"International Journal of Oncology"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235835","type":"journal-article","article-title":"Near-infrared photoimmunotherapy using a small protein mimetic for HER2-overexpressing breast cancer","volume":"20","author":"Yamaguchi","year":"2019","unstructured":"Yamaguchi, H., Pantarat, N., Suzuki, T., Evdokiou, A. Near-infrared photoimmunotherapy using a small protein mimetic for HER2-overexpressing breast cancer. International Journal of Molecular Sciences. 20 (2019).","journal-title":"International Journal of Molecular Sciences"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"862","DOI":"10.7150\/thno.12890","type":"journal-article","article-title":"Imaging and selective elimination of glioblastoma stem cells with theranostic Near-Infrared-Labeled CD133-Specific antibodies","volume":"6","author":"Jing","year":"2016","unstructured":"Jing, H. et al. Imaging and selective elimination of glioblastoma stem cells with theranostic Near-Infrared-Labeled CD133-Specific antibodies. Theranostics. 6, 862-874 (2016).","journal-title":"Theranostics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/ijc.31246","type":"journal-article","article-title":"Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment","volume":"142","author":"Burley","year":"2018","unstructured":"Burley, T. A. et al. Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment. International Journal of Cancer. 142, 2363-2374 (2018).","journal-title":"International Journal of Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10120-018-0871-5","type":"journal-article","article-title":"Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination","volume":"22","author":"Nagaya","year":"2019","unstructured":"Nagaya, T. et al. Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination. Gastric Cancer. 22, 463-472 (2019).","journal-title":"Gastric Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/cas.13621","type":"journal-article","article-title":"Endoscopic near infrared photoimmunotherapy using a fiber optic diffuser for peritoneal dissemination of gastric cancer","volume":"109","author":"Nagaya","year":"2018","unstructured":"Nagaya, T. et al. Endoscopic near infrared photoimmunotherapy using a fiber optic diffuser for peritoneal dissemination of gastric cancer. Cancer Science. 109, 1902-1908 (2018).","journal-title":"Cancer Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"79408","DOI":"10.18632\/oncotarget.12710","type":"journal-article","article-title":"Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer","volume":"7","author":"Harada","year":"2016","unstructured":"Harada, T. et al. Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer. Oncotarget. 7, 79408-79416 (2016).","journal-title":"Oncotarget"},{"key":"ref37","first-page":"1","type":"journal-article","article-title":"JNCI Journal of the National Cancer Institute Way to Better DNA","volume":"37","author":"Journals","year":"2008","unstructured":"Journals, O. JNCI Journal of the National Cancer Institute Way to Better DNA. Annals of Internal Medicine. 37, 1-9 (2008).","journal-title":"Annals of Internal Medicine"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/61593\/near-infrared-photoimmunotherapy-for-mouse-models-pleural","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:05:37Z","timestamp":1792620337000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/61593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":37,"journal-issue":{"issue":"168","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.3791\/61593","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}