{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:41:04Z","timestamp":1792618864597,"version":"4.5.0"},"reference-count":23,"publisher":"MyJove Corporation","issue":"172","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/62604","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T20:01:08Z","timestamp":1624996868000},"source":"Crossref","is-referenced-by-count":0,"title":["A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat"],"prefix":"10.3791","author":[{"given":"Yue-li","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-wen","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-fen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Yun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Sia","family":"Sng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jun","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.5435\/JAAOS-D-14-00250","type":"journal-article","article-title":"Update on the diagnosis and management of cervical spondylotic myelopathy","volume":"23","author":"Lebl","year":"2015","unstructured":"Lebl, D. R., Bono, C. M. Update on the diagnosis and management of cervical spondylotic myelopathy. The Journal of the American Academy of Orthopaedic Surgeons. 23 (11), 648-660 (2015).","journal-title":"The Journal of the American Academy of Orthopaedic Surgeons"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.spinee.2018.04.006","type":"journal-article","article-title":"Spine and lower extremity kinematics during gait in patients with cervical spondylotic myelopathy","volume":"18","author":"Haddas","year":"2018","unstructured":"Haddas, R. et al. Spine and lower extremity kinematics during gait in patients with cervical spondylotic myelopathy. The Spine Journal. 18 (9), 1645-1652 (2018).","journal-title":"The Spine Journal"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"22669","DOI":"10.1002\/jcla.22669","type":"journal-article","article-title":"Association of Vdr-Foki and Vdbp-Thr420 Lys polymorphisms with cervical spondylotic myelopathy: A case-control study in the population of China","volume":"33","author":"Song","year":"2019","unstructured":"Song, D. W., Wu, Y. D. Tian, D. D. Association of Vdr-Foki and Vdbp-Thr420 Lys polymorphisms with cervical spondylotic myelopathy: A case-control study in the population of China. Journal of Clinical Laboratory Analysis. 33 (2), e22669 (2019).","journal-title":"Journal of Clinical Laboratory Analysis"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/BRS.0b013e3181eaf33d","type":"journal-article","article-title":"Altered blood flow distribution in the rat spinal cord under chronic compression","volume":"36","author":"Kurokawa","year":"2011","unstructured":"Kurokawa, R., Murata, H., Ogino, M., Ueki, K., Kim, P. Altered blood flow distribution in the rat spinal cord under chronic compression. Spine. 36 (13), 1006-1009 (2011).","journal-title":"Spine"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1148\/radiol.13121885","type":"journal-article","article-title":"Is Diffusion anisotropy a biomarker for disease severity and surgical prognosis of cervical spondylotic myelopathy","volume":"270","author":"Wen","year":"2014","unstructured":"Wen, C. Y. et al. Is Diffusion anisotropy a biomarker for disease severity and surgical prognosis of cervical spondylotic myelopathy? Radiology. 270 (1), 197-204 (2014).","journal-title":"Radiology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mehy.2012.04.006","type":"journal-article","article-title":"Hif-1A\/Vegf signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy","volume":"79","author":"Long","year":"2012","unstructured":"Long, H. Q., Li, G. S., Hu, Y., Wen, C. Y. Xie, W. H. Hif-1\u0391\/Vegf signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy. Medical Hypotheses. 79 (1), 82-84 (2012).","journal-title":"Medical Hypotheses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/BRS.0b013e3182a7f2c3","type":"journal-article","article-title":"Pathophysiology and natural history of cervical spondylotic myelopathy","volume":"38","author":"Karadimas","year":"2013","unstructured":"Karadimas, S. K., Erwin, W. M., Ely, C. G., Dettori, J. R., Fehlings, M. G. Pathophysiology and natural history of cervical spondylotic myelopathy. Spine. 38, S21-S36 (2013).","journal-title":"Spine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/neuros\/nyw083","type":"journal-article","article-title":"State of the art in degenerative cervical myelopathy: an update on current clinical evidence","volume":"80","author":"Wilson","year":"2017","unstructured":"Wilson, J. R. et al. State of the art in degenerative cervical myelopathy: an update on current clinical evidence. Neurosurgery. 80, S33-S45 (2017).","journal-title":"Neurosurgery"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.spinee.2006.04.024","type":"journal-article","article-title":"Pathophysiology of cervical myelopathy","volume":"6","author":"Baptiste","year":"2006","unstructured":"Baptiste, D. C., Fehlings, M. G. Pathophysiology of cervical myelopathy. The spine Journal. 6, 190S-197S (2006).","journal-title":"The spine Journal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nbd.2017.05.009","type":"journal-article","article-title":"Generating level-dependent models of cervical and thoracic spinal cord injury: exploring the interplay of neuroanatomy, physiology, and function","volume":"105","author":"Wilcox","year":"2017","unstructured":"Wilcox, J. T. et al. Generating level-dependent models of cervical and thoracic spinal cord injury: exploring the interplay of neuroanatomy, physiology, and function. Neurobiology of Disease. 105, 194-212 (2017).","journal-title":"Neurobiology of Disease"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-2094-11-40","type":"journal-article","article-title":"Inflammatory cascades mediate synapse elimination in spinal cord compression","volume":"11","author":"Takano","year":"2014","unstructured":"Takano, M. et al. Inflammatory cascades mediate synapse elimination in spinal cord compression. Journal of Neuroinflammation. 11, 40 (2014).","journal-title":"Journal of Neuroinflammation"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.clinph.2010.12.051","type":"journal-article","article-title":"Somatosensory-evoked potentials as an indicator for the extent of ultrastructural damage of the spinal cord after chronic compressive injuries in a rat model","volume":"122","author":"Hu","year":"2011","unstructured":"Hu, Y. et al. Somatosensory-evoked potentials as an indicator for the extent of ultrastructural damage of the spinal cord after chronic compressive injuries in a rat model. Clinical Neurophysiology. 122 (7), 1440-1447 (2011).","journal-title":"Clinical Neurophysiology"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2176\/nmc.oa.2015-0022","type":"journal-article","article-title":"Inflammation level after decompression surgery for a rat model of chronic severe spinal cord compression and effects on ischemia-reperfusion injury","volume":"55","author":"Yang","year":"2015","unstructured":"Yang, T. et al. Inflammation level after decompression surgery for a rat model of chronic severe spinal cord compression and effects on ischemia-reperfusion injury. Neurologia Medico-Chirurgica. 55 (7), 578-586 (2015).","journal-title":"Neurologia Medico-Chirurgica"},{"issue":"18","key":"ref14","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/WNR.0000000000000907","type":"journal-article","article-title":"Experimental rat model for cervical compressive myelopathy","volume":"28","author":"Ijima","year":"2017","unstructured":"Ijima, Y. et al. Experimental rat model for cervical compressive myelopathy. Neuroreport. 28 (18), 1239-1245 (2017).","journal-title":"Neuroreport"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3171\/2013.9.SPINE121136","type":"journal-article","article-title":"Cilostazol, a selective type iii phosphodiesterase inhibitor: prevention of cervical myelopathy in a rat chronic compression model","volume":"20","author":"Yamamoto","year":"2014","unstructured":"Yamamoto, S., Kurokawa, R., Kim, P. Cilostazol, a selective type iii phosphodiesterase inhibitor: prevention of cervical myelopathy in a rat chronic compression model. Journal of Neurosurgery. Spine. 20 (1), 93-101 (2014).","journal-title":"Journal of Neurosurgery. Spine"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3171\/2012.5.SPINE1216","type":"journal-article","article-title":"Dietary therapy to promote neuroprotection in chronic spinal cord injury","volume":"17","author":"Holly","year":"2012","unstructured":"Holly, L. T. et al. Dietary therapy to promote neuroprotection in chronic spinal cord injury. Journal of Neurosurgery. Spine. 17 (2), 134-140 (2012).","journal-title":"Journal of Neurosurgery. Spine"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1177\/0284185116631185","type":"journal-article","article-title":"In vivo diffusion tensor imaging of chronic spinal cord compression: a rat model with special attention to the conus medullaris","volume":"57","author":"Zhao","year":"2016","unstructured":"Zhao, P .et al. In vivo diffusion tensor imaging of chronic spinal cord compression: a rat model with special attention to the conus medullaris. Acta Radiologica. 57 (12), 1531-1539 (2016).","journal-title":"Acta Radiologica"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/BRS.0b013e3181e878a1","type":"journal-article","article-title":"Limaprost alfadex, a prostaglandin E1 derivative, prevents deterioration of forced exercise capability in rats with chronic compression of the spinal cord","volume":"36","author":"Kurokawa","year":"2011","unstructured":"Kurokawa, R., Nagayama, E .,Murata, H., Kim, P. Limaprost alfadex, a prostaglandin E1 derivative, prevents deterioration of forced exercise capability in rats with chronic compression of the spinal cord. Spine. 36 (11), 865-869 (2011).","journal-title":"Spine"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1089\/neu.2010.1709","type":"journal-article","article-title":"Development and characterization of a novel rat model of cervical spondylotic myelopathy: the impact of chronic cord compression on clinical, neuroanatomical, and neurophysiological outcomes","volume":"29","author":"Lee","year":"2012","unstructured":"Lee J., Satkunendrarajah, K., Fehlings, M. G. Development and characterization of a novel rat model of cervical spondylotic myelopathy: the impact of chronic cord compression on clinical, neuroanatomical, and neurophysiological outcomes. Journal of Neurotrauma. 29 (5), 1012-1027 (2012).","journal-title":"Journal of Neurotrauma"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2018.06.005","type":"journal-article","article-title":"Reactivation of dormant relay pathways in injured spinal cord by Kcc2 manipulations","volume":"174","author":"Chen","year":"2018","unstructured":"Chen, B. et al. Reactivation of dormant relay pathways in injured spinal cord by Kcc2 manipulations. Cell. 174 (3), 521-535 (2018).","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/brain\/awr054","type":"journal-article","article-title":"Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy","volume":"134","author":"Yu","year":"2011","unstructured":"Yu, W. R., Liu, T., Kiehl, T. R., Fehlings, M. G. Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy. Brain. 134, 1277-1292 (2011).","journal-title":"Brain"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.nbd.2008.09.024","type":"journal-article","article-title":"Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy","volume":"33","author":"Yu","year":"2009","unstructured":"Yu, W. R. et al. Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiology of Disease. 33 (2), 149-163 (2009).","journal-title":"Neurobiology of Disease"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/BSD.0000000000000397","type":"journal-article","article-title":"Cervical spondylotic myelopathy","volume":"29","author":"Iyer","year":"2016","unstructured":"Iyer, A., Azad, T. D. Tharin, S. Cervical spondylotic myelopathy. Clinical Spine Surgery. 29 (10), 408-414 (2016).","journal-title":"Clinical Spine Surgery"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/62604\/a-neuronal-apoptosis-model-induced-by-spinal-cord-compression-in-rat","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:22:28Z","timestamp":1792617748000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/62604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":23,"journal-issue":{"issue":"172","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.3791\/62604","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]}}}