{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:40:43Z","timestamp":1792618843416,"version":"4.5.0"},"reference-count":27,"publisher":"MyJove Corporation","issue":"173","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/62738","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T20:19:46Z","timestamp":1625257186000},"source":"Crossref","is-referenced-by-count":17,"title":["A Preclinical Model of Exertional Heat Stroke in Mice"],"prefix":"10.3791","author":[{"given":"Michelle A.","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal M.","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Clanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Laitano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/j.2040-4603.2015.tb00612.x","type":"journal-article","article-title":"Heat stroke","volume":"5","author":"Leon","year":"2015","unstructured":"Leon, L. R., Bouchama, A. Heat stroke. Comprehensive Physiology. 5 (2), 611-647 (2015).","journal-title":"Comprehensive Physiology"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1152\/japplphysiol.00452.2019","type":"journal-article","article-title":"Controversies in exertional heat stroke diagnosis, prevention, and treatment","volume":"127","author":"Laitano","year":"2019","unstructured":"Laitano, O., Leon, L. R., Roberts, W. O., Sawka, M. N. Controversies in exertional heat stroke diagnosis, prevention, and treatment. Journal of Applied Physiology. 127 (5), 1338-1348 (2019).","journal-title":"Journal of Applied Physiology"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"0221329","DOI":"10.1371\/journal.pone.0221329","type":"journal-article","article-title":"Influence of prior illness on exertional heat stroke presentation and outcome","volume":"14","author":"King","year":"2019","unstructured":"King, M. A. et al. Influence of prior illness on exertional heat stroke presentation and outcome. PLOS One. 14 (8), e0221329 (2019).","journal-title":"PLOS One"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1249\/01.mss.0000174895.19639.ed","type":"journal-article","article-title":"Epidemiology of hospitalizations and deaths from heat illness in soldiers","volume":"37","author":"Carter","year":"2005","unstructured":"Carter, R. et al. Epidemiology of hospitalizations and deaths from heat illness in soldiers. Medicine and Science in Sports and Exercise. 37 (8), 1338-1344 (2005).","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1177\/0363546507305013","type":"journal-article","article-title":"Heat-related illness in athletes","volume":"35","author":"Howe","year":"2007","unstructured":"Howe, A. S., Boden, B. P. Heat-related illness in athletes. The American Journal of Sports Medicine. 35 (8), 1384-1395 (2007).","journal-title":"The American Journal of Sports Medicine"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.envres.2007.01.003","type":"journal-article","article-title":"Prior heat illness hospitalization and risk of early death","volume":"104","author":"Wallace","year":"2007","unstructured":"Wallace, R. F., Kriebel, D., Punnett, L., Wegman, D. H., Amoroso, P. J. Prior heat illness hospitalization and risk of early death. Environmental Research. 104 (2), 290-295 (2007).","journal-title":"Environmental Research"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"0211386","DOI":"10.1371\/journal.pone.0211386","type":"journal-article","article-title":"The association between heat stroke and subsequent cardiovascular diseases","volume":"14","author":"Wang","year":"2019","unstructured":"Wang, J. -C. et al. The association between heat stroke and subsequent cardiovascular diseases. PLOS One. 14 (2), e0211386 (2019).","journal-title":"PLOS One"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1152\/japplphysiol.01040.2005","type":"journal-article","article-title":"Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery","volume":"100","author":"Leon","year":"2006","unstructured":"Leon, L. R., Blaha, M. D., DuBose, D. A. Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery. Journal of Applied Physiology. 100 (4), 1400-1409 (2006).","journal-title":"Journal of Applied Physiology"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/ajpregu.00046.2004","type":"journal-article","article-title":"Heat stress induces a biphasic thermoregulatory response in mice","volume":"288","author":"Leon","year":"2005","unstructured":"Leon, L. R., DuBose, D. A., Mason, C. W. Heat stress induces a biphasic thermoregulatory response in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288 (1), R197-204 (2005).","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/ajpregu.00309.2009","type":"journal-article","article-title":"Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model","volume":"299","author":"Leon","year":"2010","unstructured":"Leon, L. R., Gordon, C. J., Helwig, B. G., Rufolo, D. M., Blaha, M. D. Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299 (1), R241-248 (2010).","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1152\/japplphysiol.00667.2016","type":"journal-article","article-title":"Unique cytokine and chemokine responses to exertional heat stroke in mice","volume":"122","author":"King","year":"2016","unstructured":"King, M. A., Leon, L. R., Morse, D. A., Clanton, T. L. Unique cytokine and chemokine responses to exertional heat stroke in mice. Journal of Applied Physiology. 122 (2), 296-306 (2016).","journal-title":"Journal of Applied Physiology"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3945\/jn.113.183186","type":"journal-article","article-title":"l-Arginine supplementation prevents increases in intestinal permeability and bacterial translocation in Male Swiss mice subjected to physical exercise under environmental heat stress","volume":"144","author":"Costa","year":"2014","unstructured":"Costa, K. A. et al. l-Arginine supplementation prevents increases in intestinal permeability and bacterial translocation in Male Swiss mice subjected to physical exercise under environmental heat stress. The Journal of Nutrition. 144 (2), 218-223 (2014).","journal-title":"The Journal of Nutrition"},{"issue":"1","key":"ref13","first-page":"66","type":"journal-article","article-title":"Effects of exercise in the heat on predisposition to heatstroke","volume":"11","author":"Hubbard","year":"1979","unstructured":"Hubbard, R. W. Effects of exercise in the heat on predisposition to heatstroke. Medicine and Science in Sports. 11 (1), 66-71 (1979).","journal-title":"Medicine and Science in Sports"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/jappl.1977.42.6.809","type":"journal-article","article-title":"Rat model of acute heatstroke mortality","volume":"42","author":"Hubbard","year":"1977","unstructured":"Hubbard, R. W. et al. Rat model of acute heatstroke mortality. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 42 (6), 809-816 (1977).","journal-title":"Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1152\/jappl.1979.46.2.334","type":"journal-article","article-title":"Diagnostic significance of selected serum enzymes in a rat heatstroke model","volume":"46","author":"Hubbard","year":"1979","unstructured":"Hubbard, R.W. et al. Diagnostic significance of selected serum enzymes in a rat heatstroke model. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 46 (2), 334-339 (1979).","journal-title":"Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1152\/jappl.1978.45.3.463","type":"journal-article","article-title":"Role of physical effort in the etiology of rat heatstroke injury and mortality","volume":"45","author":"Hubbard","year":"1978","unstructured":"Hubbard, R. W. et al. Role of physical effort in the etiology of rat heatstroke injury and mortality. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 45 (3), 463-468 (1978).","journal-title":"Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/japplphysiol.00220.2018","type":"journal-article","article-title":"Sex-dependent responses to exertional heat stroke in mice","volume":"125","author":"Garcia","year":"2018","unstructured":"Garcia, C. K. et al. Sex-dependent responses to exertional heat stroke in mice. Journal of Applied Physiology (Bethesda, Md.: 1985). 125 (3), 841-849 (2018).","journal-title":"Journal of Applied Physiology"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1249\/MSS.0000000000002329","type":"journal-article","article-title":"Effects of Ibuprofen during Exertional Heat Stroke in Mice","volume":"52","author":"Garcia","year":"2020","unstructured":"Garcia, C. K. et al. Effects of Ibuprofen during Exertional Heat Stroke in Mice. Medicine and Science in Sports and Exercise. 52 (9), 1870-1878 (2020).","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.01051.2014","type":"journal-article","article-title":"Biomarkers of multi-organ injury in a pre-clinical model of exertional heat stroke","volume":"118","author":"King","year":"2015","unstructured":"King, M. A., Leon, L. R., Mustico, D. L., Haines, J. M., Clanton, T. L. Biomarkers of multi-organ injury in a pre-clinical model of exertional heat stroke. Journal of Applied Physiology (Bethesda, Md.: 1985). 118 (10), jap.01051.2014 (2015).","journal-title":"Journal of Applied Physiology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1113\/JP280518","type":"journal-article","article-title":"Exertional heat stroke leads to concurrent long-term epigenetic memory, immunosuppression and altered heat shock response in female mice","volume":"599","author":"Murray","year":"2021","unstructured":"Murray, K. O. et al. Exertional heat stroke leads to concurrent long-term epigenetic memory, immunosuppression and altered heat shock response in female mice. The Journal of Physiology. 599 (1), 119-141 (2021).","journal-title":"The Journal of Physiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/ajpregu.00046.2004","type":"journal-article","article-title":"Heat stress induces a biphasic thermoregulatory response in mice","volume":"288","author":"Leon","year":"2005","unstructured":"Leon, L. R., DuBose, D. A., Mason, C. W. Heat stress induces a biphasic thermoregulatory response in mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288, R197-R204 (2005).","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1113\/JP279310","type":"journal-article","article-title":"Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice","volume":"598","author":"Laitano","year":"2020","unstructured":"Laitano, O. et al. Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice. The Journal of Physiology. 598 (5), 967-985 (2020).","journal-title":"The Journal of Physiology"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1113\/EP088501","type":"journal-article","article-title":"Acute phase response to exertional heat stroke in mice","volume":"106","author":"Iwaniec","year":"2020","unstructured":"Iwaniec, J. et al. Acute phase response to exertional heat stroke in mice. Experimental Physiology. 106 (1), 222-232 (2020).","journal-title":"Experimental Physiology"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00642","type":"journal-article","article-title":"Optimization of a rhabdomyolysis model in mice with exertional heat stroke mouse model of EHS-rhabdomyolysis","volume":"11","author":"He","year":"2020","unstructured":"He, S.-X. et al. Optimization of a rhabdomyolysis model in mice with exertional heat stroke mouse model of EHS-rhabdomyolysis. Frontiers in Physiology. 11 (2020).","journal-title":"Frontiers in Physiology"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.bja.2018.07.008","type":"journal-article","article-title":"Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1","volume":"121","author":"Lopez","year":"2018","unstructured":"Lopez, J. R., Kaura, V., Diggle, C. P., Hopkins, P. M., Allen, P. D. Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1. British Journal of Anaesthesia. 121 (4), 953-961 (2018).","journal-title":"British Journal of Anaesthesia"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40279-020-01318-4","type":"journal-article","article-title":"Overlapping mechanisms of exertional heat stroke and malignant hyperthermia: evidence vs. conjecture","volume":"50","author":"Laitano","year":"2020","unstructured":"Laitano, O., Murray, K. O., Leon, L. R. Overlapping mechanisms of exertional heat stroke and malignant hyperthermia: evidence vs. conjecture. Sports Medicine (Auckland, N.Z.). 50 (9), 1581-1592 (2020).","journal-title":"Sports Medicine"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1249\/JSR.0b013e31825615cc","type":"journal-article","article-title":"Exertional heat stroke: new concepts regarding cause and care","volume":"11","author":"Casa","year":"2012","unstructured":"Casa, D. J., Armstrong, L. E., Kenny, G. P., O'Connor, F. G., Huggins, R. A. Exertional heat stroke: new concepts regarding cause and care. Current Sports Medicine Reports. 11 (3), 115-123 (2012).","journal-title":"Current Sports Medicine Reports"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/62738\/a-preclinical-model-of-exertional-heat-stroke-in-mice","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:21:31Z","timestamp":1792617691000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/62738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":27,"journal-issue":{"issue":"173","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.3791\/62738","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}