{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:55:37Z","timestamp":1792616137648,"version":"4.5.0"},"reference-count":27,"publisher":"MyJove Corporation","issue":"180","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/63508","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T19:00:25Z","timestamp":1643742025000},"source":"Crossref","is-referenced-by-count":2,"title":["Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice"],"prefix":"10.3791","author":[{"given":"Ruoxi","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzheng","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairuo","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.echo.2013.12.001","type":"journal-article","article-title":"Right ventricular involvement in coronary artery disease: role of echocardiography for diagnosis and prognosis","volume":"27","author":"Rallidis","year":"2014","unstructured":"Rallidis, L. S., Makavos, G., Nihoyannopoulos, P. Right ventricular involvement in coronary artery disease: role of echocardiography for diagnosis and prognosis. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography. 27 (3), 223-229 (2014).","journal-title":"Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/cvr\/cvx146","type":"journal-article","article-title":"Fibroblasts and the extracellular matrix in right ventricular disease","volume":"113","author":"Frangogiannis","year":"2017","unstructured":"Frangogiannis, N. G. Fibroblasts and the extracellular matrix in right ventricular disease. Cardiovascular Research. 113 (12), 1453-1464 (2017).","journal-title":"Cardiovascular Research"},{"issue":"1","key":"ref3","first-page":"27","type":"journal-article","article-title":"Right ventricular myocardial infarction: From pathophysiology to prognosis","volume":"18","author":"Ondrus","year":"2013","unstructured":"Ondrus, T. et al. Right ventricular myocardial infarction: From pathophysiology to prognosis. Experimental & Clinical Cardiology. 18 (1), 27-30 (2013).","journal-title":"Experimental & Clinical Cardiology"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.healun.2016.04.006","type":"journal-article","article-title":"Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension","volume":"35","author":"Badagliacca","year":"2016","unstructured":"Badagliacca, R. et al. Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension. The Journal of Heart and Lung Transplantation. 35 (11), 1321-1329 (2016).","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"3","key":"ref5","first-page":"340","type":"journal-article","article-title":"Right ventricular response to intensive medical therapy in advanced decompensated heart failure","volume":"3","author":"Verhaert","year":"2010","unstructured":"Verhaert, D. et al. Right ventricular response to intensive medical therapy in advanced decompensated heart failure. Circulation: Heart Failure. 3 (3), 340-346 (2010).","journal-title":"Circulation: Heart Failure"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.18632\/aging.202385","type":"journal-article","article-title":"RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome","volume":"13","author":"Chen","year":"2021","unstructured":"Chen, K. et al. RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome. Aging (Albany NY). 13 (3), 4215-4241 (2021).","journal-title":"Aging (Albany NY)"},{"issue":"147","key":"ref7","first-page":"e59431","type":"journal-article","article-title":"Induction of right ventricular failure by pulmonary artery constriction and evaluation of right ventricular function in mice","author":"Wang","year":"2019","unstructured":"Wang, Q. et al. Induction of right ventricular failure by pulmonary artery constriction and evaluation of right ventricular function in mice. Journal of Visualized Experiments. 147, e59431 (2019).","journal-title":"Journal of Visualized Experiments"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ejhf.478","type":"journal-article","article-title":"Contemporary management of acute right ventricular failure: A statement from the heart failure association and the working group on pulmonary circulation and right ventricular function of the European society of cardiology","volume":"18","author":"Harjola","year":"2016","unstructured":"Harjola, V. P. et al. Contemporary management of acute right ventricular failure: A statement from the heart failure association and the working group on pulmonary circulation and right ventricular function of the European society of cardiology. European Journal of Heart Failure. 18 (3), 226-241 (2016).","journal-title":"European Journal of Heart Failure"},{"issue":"3","key":"ref9","first-page":"684","type":"journal-article","article-title":"Right coronary artery ligation in mice: a novel method to investigate right ventricular dysfunction and biventricular interaction","volume":"316","author":"Sicard","year":"2019","unstructured":"Sicard, P. et al. Right coronary artery ligation in mice: a novel method to investigate right ventricular dysfunction and biventricular interaction. American Journal of Physiology: Heart and Circulatory Physiology. 316 (3), H684-h692 (2019).","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0735-1097(02)02048-X","type":"journal-article","article-title":"Pathophysiology and management of right heart ischemia","volume":"40","author":"Goldstein","year":"2002","unstructured":"Goldstein, J. A. Pathophysiology and management of right heart ischemia. Journal of the American College of Cardiology. 40 (5), 841-853 (2002).","journal-title":"Journal of the American College of Cardiology"},{"key":"ref11","first-page":"1","type":"journal-article","article-title":"Frequency and prognostic impact of right ventricular involvement in acute myocardial infarction","volume":"0","author":"Stiermaier","year":"2020","unstructured":"Stiermaier, T. et al. Frequency and prognostic impact of right ventricular involvement in acute myocardial infarction. Heart. 0, 1-8 (2020).","journal-title":"Heart"},{"issue":"14","key":"ref12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM199304083281401","type":"journal-article","article-title":"Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction","volume":"328","author":"Zehender","year":"1993","unstructured":"Zehender, M. et al. Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. The New England Journal of Medicine. 328 (14), 981-988 (1993).","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.amjcard.2006.09.091","type":"journal-article","article-title":"Comparison of late survival in patients with cardiogenic shock due to right ventricular infarction versus left ventricular pump failure following primary percutaneous coronary intervention for ST-elevation acute myocardial infarction","volume":"99","author":"Brodie","year":"2007","unstructured":"Brodie, B. R. et al. Comparison of late survival in patients with cardiogenic shock due to right ventricular infarction versus left ventricular pump failure following primary percutaneous coronary intervention for ST-elevation acute myocardial infarction. The American Journal of Cardiology. 99 (4), 431-435 (2007).","journal-title":"The American Journal of Cardiology"},{"issue":"20","key":"ref14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/CIR.0000000000000560","type":"journal-article","article-title":"Evaluation and management of right-sided heart failure: A scientific statement from the american heart association","volume":"137","author":"Konstam","year":"2018","unstructured":"Konstam, M. A. et al. Evaluation and management of right-sided heart failure: A scientific statement from the american heart association. Circulation. 137 (20), e578-e622 (2018).","journal-title":"Circulation"},{"issue":"17","key":"ref15","doi-asserted-by":"crossref","first-page":"9830","DOI":"10.1073\/pnas.181329398","type":"journal-article","article-title":"Heart regeneration in adult MRL mice","volume":"98","author":"Leferovich","year":"2001","unstructured":"Leferovich, J. M. et al. Heart regeneration in adult MRL mice. Proceedings of the National Academy of Sciences of the United States of America. 98 (17), 9830-9835 (2001).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.75.5.996","type":"journal-article","article-title":"Hemodynamically important right ventricular infarction: Follow-up evaluation of right ventricular systolic function at rest and during exercise with radionuclide ventriculography and respiratory gas exchange","volume":"75","author":"Dell'Italia","year":"1987","unstructured":"Dell'Italia, L. J. et al. Hemodynamically important right ventricular infarction: Follow-up evaluation of right ventricular systolic function at rest and during exercise with radionuclide ventriculography and respiratory gas exchange. Circulation. 75 (5), 996-1003 (1987).","journal-title":"Circulation"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/CIRCULATIONAHA.113.001375","type":"journal-article","article-title":"Right versus left ventricular failure: differences, similarities, and interactions","volume":"129","author":"Friedberg","year":"2014","unstructured":"Friedberg, M. K., Redington, A. N. Right versus left ventricular failure: differences, similarities, and interactions. Circulation. 129 (9), 1033-1044 (2014).","journal-title":"Circulation"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/icvts\/ivt418","type":"journal-article","article-title":"A porcine model for acute ischaemic right ventricular dysfunction","volume":"18","author":"Haraldsen","year":"2014","unstructured":"Haraldsen, P., Lindstedt, S., Metzsch, C., Algotsson, L., Ingemansson, R. A porcine model for acute ischaemic right ventricular dysfunction. Interactive Cardiovascular and Thoracic Surgery. 18 (1), 43-48 (2014).","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MNH.0000000000000586","type":"journal-article","article-title":"Targeting angiotensinogen with RNA-based therapeutics","volume":"29","author":"Ren","year":"2020","unstructured":"Ren, L., Colafella, K. M. M., Bov\u00e9e, D. M., Uijl, E., Danser, A. H. J. Targeting angiotensinogen with RNA-based therapeutics. Current Opinion in Nephrology and Hypertension. 29 (2), 180-189 (2020).","journal-title":"Current Opinion in Nephrology and Hypertension"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-319-97421-7_3","type":"journal-article","article-title":"Animal models and cardiac extracellular matrix research","volume":"1098","author":"Hacker","year":"2018","unstructured":"Hacker, T. A. Animal models and cardiac extracellular matrix research. Advances in Experimental Medicine and Biology. 1098, 45-58 (2018).","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1017\/S1047951113000176","type":"journal-article","article-title":"Double right coronary artery and its clinical implications","volume":"24","author":"Chien","year":"2014","unstructured":"Chien, T. M. et al. Double right coronary artery and its clinical implications. Cardiology in the Young. 24 (1), 5-12 (2014).","journal-title":"Cardiology in the Young"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"13585","DOI":"10.18632\/aging.202879","type":"journal-article","article-title":"Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling","volume":"13","author":"Zhu","year":"2021","unstructured":"Zhu, Y. et al. Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling. Aging (Albany NY). 13 (10), 13585-13614 (2021).","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1038\/s41467-021-25653-w","type":"journal-article","article-title":"Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance","volume":"12","author":"Cui","year":"2021","unstructured":"Cui, M. et al. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nature Communications. 12 (1), 5270 (2021).","journal-title":"Nature Communications"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/CIRCULATIONAHA.109.887570","type":"journal-article","article-title":"Effects of right ventricular ejection fraction on outcomes in chronic systolic heart failure","volume":"121","author":"Meyer","year":"2010","unstructured":"Meyer, P. et al. Effects of right ventricular ejection fraction on outcomes in chronic systolic heart failure. Circulation. 121 (2), 252-258 (2010).","journal-title":"Circulation"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cmmi.1588","type":"journal-article","article-title":"Three-dimensional imaging of the mouse heart and vasculature using micro-CT and whole-body perfusion of iodine or phosphotungstic acid","volume":"9","author":"Dunmore-Buyze","year":"2014","unstructured":"Dunmore-Buyze, P. J. et al. Three-dimensional imaging of the mouse heart and vasculature using micro-CT and whole-body perfusion of iodine or phosphotungstic acid. Contrast Media & Molecular Imaging. 9 (5), 383-390 (2014).","journal-title":"Contrast Media & Molecular Imaging"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-7580.2007.00838.x","type":"journal-article","article-title":"The coronary arteries of the C57BL\/6 mouse strains: Implications for comparison with mutant models","volume":"212","author":"Fern\u00e1ndez","year":"2008","unstructured":"Fern\u00e1ndez, B. et al. The coronary arteries of the C57BL\/6 mouse strains: Implications for comparison with mutant models. Journal of Anatomy. 212 (1), 12-18 (2008).","journal-title":"Journal of Anatomy"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yjmcc.2015.07.020","type":"journal-article","article-title":"De-novo collateral formation following acute myocardial infarction: Dependence on CCR2+ bone marrow cells","volume":"87","author":"Zhang","year":"2015","unstructured":"Zhang, H., Faber, J. E. De-novo collateral formation following acute myocardial infarction: Dependence on CCR2+ bone marrow cells. Journal of Molecular and Cellular Cardiology. 87, 4-16 (2015).","journal-title":"Journal of Molecular and Cellular Cardiology"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/63508\/generation-characterization-right-ventricular-myocardial-infarction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:26:12Z","timestamp":1792614372000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/63508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":27,"journal-issue":{"issue":"180","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3791\/63508","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}