{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:39:34Z","timestamp":1792611574239,"version":"4.5.0"},"reference-count":26,"publisher":"MyJove Corporation","issue":"190","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/63663","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T19:00:41Z","timestamp":1671822041000},"source":"Crossref","is-referenced-by-count":0,"title":["Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence"],"prefix":"10.3791","author":[{"given":"Pawel","family":"Aftanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Maloku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Dannberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hamadanchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"G\u00fcnther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Christian","family":"Schulze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"M\u00f6bius-Winkler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref1","type":"book","volume-title":"The Developing Human: Clinically Oriented Embryology., 10th Edition","author":"Moore","year":"2015","unstructured":"Moore, K. L., Persaud, T. V. N., Torchia M. G. The Developing Human: Clinically Oriented Embryology., 10th Edition. Saunders. Philadelphia (2015)."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0025-6196(12)60336-X","type":"journal-article","article-title":"Incidence and size of patent foramen ovale during the first 10 decades of life: An autopsy study of 965 normal hearts","volume":"59","author":"Hagen","year":"1984","unstructured":"Hagen, P. T., Scholz, D. G., Edwards, W. D. Incidence and size of patent foramen ovale during the first 10 decades of life: An autopsy study of 965 normal hearts. Mayo Clinic Proceedings. 59 (1), 17-20 (1984).","journal-title":"Mayo Clinic Proceedings"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.4065\/74.9.862","type":"journal-article","article-title":"Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study","volume":"74","author":"Meissner","year":"1999","unstructured":"Meissner, I. et al. Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study. Mayo Clinic Proceedings. 74 (9), 862-869 (1999).","journal-title":"Mayo Clinic Proceedings"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/01.STR.0000085828.67563.42","type":"journal-article","article-title":"Race-ethnic differences in patent foramen ovale, atrial septal aneurysm, and right atrial anatomy among ischemic stroke patients","volume":"34","author":"Rodriguez","year":"2003","unstructured":"Rodriguez, C. J. et al. Race-ethnic differences in patent foramen ovale, atrial septal aneurysm, and right atrial anatomy among ischemic stroke patients. Stroke. 34 (9), 2097-2102 (2003).","journal-title":"Stroke"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.jacc.2005.08.038","type":"journal-article","article-title":"Patent foramen ovale: Current pathology, pathophysiology, and clinical status","volume":"46","author":"Hara","year":"2005","unstructured":"Hara, H. et al. Patent foramen ovale: Current pathology, pathophysiology, and clinical status. Journal of the American College of Cardiology. 46 (9), 1768-1776 (2005).","journal-title":"Journal of the American College of Cardiology"},{"issue":"21","key":"ref6","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1056\/NEJMcp1503946","type":"journal-article","article-title":"Cryptogenic stroke","volume":"374","author":"Saver","year":"2016","unstructured":"Saver, J. L. Cryptogenic stroke. New England Journal of Medicine. 374 (21), 2065-2074 (2016).","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"007146","DOI":"10.1161\/JAHA.117.007146","type":"journal-article","article-title":"Patent foramen ovale closure for stroke prevention and other disorders","volume":"7","author":"Collado","year":"2018","unstructured":"Collado, F. M. S., Poulin, M. F., Murphy, J. J., Jneid, H., Kavinsky, C. J. Patent foramen ovale closure for stroke prevention and other disorders. Journal of the American Heart Association. 7 (12), e007146 (2018).","journal-title":"Journal of the American Heart Association"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jtcvs.2007.10.090","type":"journal-article","article-title":"Life-threatening impending paradoxical embolus caught &#34;red-handed&#34;: Successful management by multidisciplinary team approach","volume":"136","author":"Choong","year":"2008","unstructured":"Choong, C. K. et al. Life-threatening impending paradoxical embolus caught \"red-handed\": Successful management by multidisciplinary team approach. Journal of Thoracic and Cardiovascular Surgery. 136 (2), 527-528.e8 (2008).","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/emj.2006.045104","type":"journal-article","article-title":"Paradoxical embolus illustrating speed of action of recombinant tissue plasminogen activator in massive pulmonary embolism","volume":"24","author":"Madani","year":"2007","unstructured":"Madani, H., Ransom, P. A. Paradoxical embolus illustrating speed of action of recombinant tissue plasminogen activator in massive pulmonary embolism. Emergency Medicine Journal. 24 (6), 441 (2007).","journal-title":"Emergency Medicine Journal"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jjcc.2020.09.005","type":"journal-article","article-title":"Transcatheter closure of patent foramen ovale: Current evidence and future perspectives","volume":"77","author":"Akagi","year":"2021","unstructured":"Akagi, T. Transcatheter closure of patent foramen ovale: Current evidence and future perspectives. Journal of Cardiology. 77 (1), 3-9 (2021).","journal-title":"Journal of Cardiology"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.echo.2019.03.021","type":"journal-article","article-title":"Identification of high-risk patent foramen ovale associated with cryptogenic stroke: Development of a scoring system","volume":"32","author":"Nakayama","year":"2019","unstructured":"Nakayama, R. et al. Identification of high-risk patent foramen ovale associated with cryptogenic stroke: Development of a scoring system. Journal of the American Society of Echocardiography. 32 (7), 811-816 (2019).","journal-title":"Journal of the American Society of Echocardiography"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1212\/WNL.0b013e3182a08d59","type":"journal-article","article-title":"An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke","volume":"81","author":"Kent","year":"2013","unstructured":"Kent, D. M. et al. An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology. 81 (7), 619-625 (2013).","journal-title":"Neurology"},{"key":"ref13","type":"journal-article","article-title":"Kryptogener Schlaganfall und offenes Foramen ovale, S2eLeitlinie, 2018","author":"Diener","year":"2021","unstructured":"Diener H. -C. et al. Kryptogener Schlaganfall und offenes Foramen ovale, S2eLeitlinie, 2018. In Deutsche Gesellschaft f\u00fcr Neurologie (Hrsg.), Leitlinien f\u00fcr Diagnostik und Therapie in der Neurologie. accessed on May 26, (2021).","journal-title":"Deutsche Gesellschaft f\u00fcr Neurologie (Hrsg.), Leitlinien f\u00fcr Diagnostik und Therapie in der Neurologie"},{"issue":"5","key":"ref14","first-page":"262","type":"journal-article","article-title":"Catheter closure of perforated secundum atrial septal defect under intracardiac echocardiographic guidance using a single amplatzer device: Feasibility of a new method","volume":"17","author":"Zanchetta","year":"2005","unstructured":"Zanchetta, M. et al. Catheter closure of perforated secundum atrial septal defect under intracardiac echocardiographic guidance using a single amplatzer device: Feasibility of a new method. Journal of Invasive Cardiology. 17 (5), 262-265 (2005).","journal-title":"Journal of Invasive Cardiology"},{"issue":"4","key":"ref15","first-page":"182","type":"journal-article","article-title":"The Occlutech Figulla PFO and ASD occluder: A new nitinol wire mesh device for closure of atrial septal defects","volume":"22","author":"Krizanic","year":"2010","unstructured":"Krizanic, F. et al. The Occlutech Figulla PFO and ASD occluder: A new nitinol wire mesh device for closure of atrial septal defects. Journal of Invasive Cardiology. 22 (4), 182-187 (2010).","journal-title":"Journal of Invasive Cardiology"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1707404","type":"journal-article","article-title":"Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke","volume":"377","author":"S\u00f8ndergaard","year":"2017","unstructured":"S\u00f8ndergaard, L. et al. Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. New England Journal of Medicine. 377 (11), 1033-1042 (2017).","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa1610057","type":"journal-article","article-title":"Long-term outcomes of patent foramen ovale closure or medical therapy after stroke","volume":"377","author":"Saver","year":"2017","unstructured":"Saver, J. L. et al. Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. New England Journal of Medicine. 377 (11), 1022-1032 (2017).","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1705915","type":"journal-article","article-title":"Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke","volume":"377","author":"Mas","year":"2017","unstructured":"Mas, J. -L. et al. Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke. New England Journal of Medicine. 377 (11), 1011-1021 (2017).","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1009639","type":"journal-article","article-title":"Closure or medical therapy for cryptogenic stroke with patent foramen ovale","volume":"366","author":"Furlan","year":"2012","unstructured":"Furlan, A. J. et al. Closure or medical therapy for cryptogenic stroke with patent foramen ovale. New England Journal of Medicine. 366 (11), 991-999 (2012).","journal-title":"New England Journal of Medicine"},{"issue":"20","key":"ref20","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2018.02.046","type":"journal-article","article-title":"Cryptogenic stroke and high-risk patent foramen ovale: The DEFENSE-PFO trial","volume":"71","author":"Lee","year":"2018","unstructured":"Lee, P. H. et al. Cryptogenic stroke and high-risk patent foramen ovale: The DEFENSE-PFO trial. Journal of the American College of Cardiology. 71 (20), 2335-2342 (2018).","journal-title":"Journal of the American College of Cardiology"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1056\/NEJMoa1301440","type":"journal-article","article-title":"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke","volume":"368","author":"Carroll","year":"2013","unstructured":"Carroll, J. D. et al. Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. New England Journal of Medicine. 368 (12), 1092-1100 (2013).","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/01.CIR.75.3.593","type":"journal-article","article-title":"Transcatheter umbrella closure of congenital heart defects","volume":"75","author":"Lock","year":"1987","unstructured":"Lock, J. E. et al. Transcatheter umbrella closure of congenital heart defects. Circulation. 75 (3), 593-599 (1987).","journal-title":"Circulation"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00059-021-05061-y","type":"journal-article","article-title":"Patent foramen ovale-When to close and how","volume":"46","author":"Maloku","year":"2021","unstructured":"Maloku, A. et al. Patent foramen ovale-When to close and how? Herz. 46 (5), 445-451 (2021).","journal-title":"Herz"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa1211716","type":"journal-article","article-title":"Percutaneous closure of patent foramen ovale in cryptogenic embolism","volume":"368","author":"Meier","year":"2013","unstructured":"Meier, B. et al. Percutaneous closure of patent foramen ovale in cryptogenic embolism. New England Journal of Medicine. 368 (12), 1083-1091 (2013).","journal-title":"New England Journal of Medicine"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jcin.2010.06.012","type":"journal-article","article-title":"Patent foramen ovale closure using a bioabsorbable closure device: Safety and efficacy at 6-month follow-up","volume":"3","author":"Vanden Branden","year":"2010","unstructured":"Van den Branden, B. J., Post, M. C., Plokker, H. W., ten Berg, J. M., Suttorp, M. J. Patent foramen ovale closure using a bioabsorbable closure device: Safety and efficacy at 6-month follow-up. JACC Cardiovascular Interventions. 3 (9), 968-973 (2010).","journal-title":"JACC Cardiovascular Interventions"},{"issue":"18","key":"ref26","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.4244\/EIJ-D-21-00740","type":"journal-article","article-title":"Transcatheter closure of atrial septal defect and patent foramen ovale with Carag bioresorbable septal occluder: First-in-man experience with 24-month follow-up","volume":"17","author":"Sievert","year":"2021","unstructured":"Sievert, K. et al. Transcatheter closure of atrial septal defect and patent foramen ovale with Carag bioresorbable septal occluder: First-in-man experience with 24-month follow-up. EuroIntervention. 17 (18), 1536-1537 (2021).","journal-title":"EuroIntervention"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/63663\/closure-of-a-patent-foramen-ovale-pfo-an-intervention-sequence","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:00:06Z","timestamp":1792609206000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/63663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":26,"journal-issue":{"issue":"190","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3791\/63663","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]}}}