{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:39:25Z","timestamp":1792611565005,"version":"4.5.0"},"reference-count":30,"publisher":"MyJove Corporation","issue":"191","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64544","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T19:00:22Z","timestamp":1673636422000},"source":"Crossref","is-referenced-by-count":2,"title":["Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model"],"prefix":"10.3791","author":[{"given":"Claire","family":"Wunker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Piorkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Keunen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Babichev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Regenold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dunne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Nomikos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Pichardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Foltz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Waspe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Gerstle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Drake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Gladdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-018-0051-2","type":"journal-article","article-title":"Rhabdomyosarcoma","volume":"5","author":"Skapek","year":"2019","unstructured":"Skapek, S. X. et al. Rhabdomyosarcoma. Nature Reviews Disease Primers. 5 (1), 1 (2019).","journal-title":"Nature Reviews Disease Primers"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/jayao.2020.0043","type":"journal-article","article-title":"Impact of rhabdomyosarcoma treatment modalities by age in a population-based setting","volume":"10","author":"Ferrari","year":"2021","unstructured":"Ferrari, A. et al. Impact of rhabdomyosarcoma treatment modalities by age in a population-based setting. Journal of Adolescent and Young Adult Oncology. 10 (3), 309-315 (2021).","journal-title":"Journal of Adolescent and Young Adult Oncology"},{"key":"ref3","volume-title":"Pediatric rhabdomyosarcoma surgery: Background, anatomy, pathophysiology","author":"Dasgupta","year":"2019","unstructured":"Dasgupta, R. Pediatric rhabdomyosarcoma surgery: Background, anatomy, pathophysiology. <https:\/\/emedicine.medscape.com\/article\/939156-overview#a2>. (2019)."},{"issue":"18","key":"ref4","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1002\/cncr.24465","type":"journal-article","article-title":"Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005","volume":"115","author":"Ognjanovic","year":"2009","unstructured":"Ognjanovic, S., Linabery, A. M., Charbonneau, B., Ross, J. A. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005. Cancer. 115 (18), 4218-4226 (2009).","journal-title":"Cancer"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b4606","type":"journal-article","article-title":"Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort","volume":"339","author":"Mulrooney","year":"2009","unstructured":"Mulrooney, D. A. et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ. 339, b4606 (2009).","journal-title":"BMJ"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrclinonc.2013.195","type":"journal-article","article-title":"Treatment-related cardiotoxicity in survivors of childhood cancer","volume":"10","author":"Lipshultz","year":"2013","unstructured":"Lipshultz, S. E., Cochran, T. R., Franco, V. I., Miller, T. L. Treatment-related cardiotoxicity in survivors of childhood cancer. Nature Reviews Clinical Oncology. 10 (12), 697-710 (2013).","journal-title":"Nature Reviews Clinical Oncology"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/pbc.25622","type":"journal-article","article-title":"Relapse after localized rhabdomyosarcoma: Evaluation of the efficacy of second-line chemotherapy","volume":"62","author":"Winter","year":"2015","unstructured":"Winter, S., Fasola, S., Brisse, H., Mosseri, V., Orbach, D. Relapse after localized rhabdomyosarcoma: Evaluation of the efficacy of second-line chemotherapy. Pediatric Blood & Cancer. 62 (11), 1935-1941 (2015).","journal-title":"Pediatric Blood & Cancer"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jvir.2011.10.018","type":"journal-article","article-title":"Phase I study of heat-deployed liposomal doxorubicin during radiofrequency ablation for hepatic malignancies","volume":"23","author":"Wood","year":"2012","unstructured":"Wood, B. J. et al. Phase I study of heat-deployed liposomal doxorubicin during radiofrequency ablation for hepatic malignancies. Journal of Vascular and Interventional Radiology. 23 (2), 248-255 (2012).","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics9020012","type":"journal-article","article-title":"Liposomal formulations in clinical use: an updated review","volume":"9","author":"Bulbake","year":"2017","unstructured":"Bulbake, U., Doppalapudi, S., Kommineni, N., Khan, W. Liposomal formulations in clinical use: an updated review. Pharmaceutics. 9 (2), 12 (2017).","journal-title":"Pharmaceutics"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/02656736.2014.936049","type":"journal-article","article-title":"Two phase I dose-escalation\/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer","volume":"30","author":"Zagar","year":"2014","unstructured":"Zagar, T. M. et al. Two phase I dose-escalation\/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. International Journal of Hyperthermia. 30 (5), 285-294 (2014).","journal-title":"International Journal of Hyperthermia"},{"key":"ref11","volume-title":"A phase I study of lyso-thermosensitive liposomal doxorubicin and MR-HIFU for pediatric refractory solid tumors","author":"Kim","year":"2019","unstructured":"Kim, A. A phase I study of lyso-thermosensitive liposomal doxorubicin and MR-HIFU for pediatric refractory solid tumors. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02536183. (2019)."},{"key":"ref12","article-title":"PanDox: targeted doxorubicin in pancreatic tumours (PanDox)","volume-title":"University of Oxford","year":"2021","unstructured":"University of Oxford. PanDox: targeted doxorubicin in pancreatic tumours (PanDox). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04852367. (2021)."},{"key":"ref13","volume-title":"Image-guided targeted doxorubicin delivery with hyperthermia to optimize loco-regional control in breast cancer (i-GO)","author":"Suelmann","year":"2018","unstructured":"Suelmann, B. B. M. Image-guided targeted doxorubicin delivery with hyperthermia to optimize loco-regional control in breast cancer (i-GO). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03749850. (2018)."},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1038\/s41598-021-84492-3","type":"journal-article","article-title":"Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer","volume":"11","author":"De Vita","year":"2021","unstructured":"De Vita, A. et al. Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer. Scientific Reports. 11 (1), 5107 (2021).","journal-title":"Scientific Reports"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0360-3016(84)90379-1","type":"journal-article","article-title":"Thermal dose determination in cancer therapy","volume":"10","author":"Sapareto","year":"1984","unstructured":"Sapareto, S. A., Dewey, W. C. Thermal dose determination in cancer therapy. International Journal of Radiation Oncology, Biology, Physics. 10 (6), 787-800 (1984).","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/02656736.2020.1779357","type":"journal-article","article-title":"Heating technology for malignant tumors: a review","volume":"37","author":"Kok","year":"2020","unstructured":"Kok, H. P. et al. Heating technology for malignant tumors: a review. International Journal of Hyperthermia. 37 (1), 711-741 (2020).","journal-title":"International Journal of Hyperthermia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.addr.2020.11.001","type":"journal-article","article-title":"Recent technological advancements in thermometry","volume":"163","author":"Kokuryo","year":"2020","unstructured":"Kokuryo, D., Kumamoto, E., Kuroda, K. Recent technological advancements in thermometry. Advanced Drug Delivery Reviews. 163, 19-39 (2020).","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"7","key":"ref18","first-page":"5737","type":"journal-article","article-title":"3-T magnetic resonance-guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors","volume":"30","author":"Bongiovanni","year":"2022","unstructured":"Bongiovanni, A. et al. 3-T magnetic resonance-guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors. Support Care Cancer. 30 (7), 5737-5745 (2022).","journal-title":"Support Care Cancer"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13014-016-0639-1","type":"journal-article","article-title":"Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives","volume":"11","author":"Seifert","year":"2016","unstructured":"Seifert, G. et al. Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives. Radiation Oncology. 11, 65 (2016).","journal-title":"Radiation Oncology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3109\/02656736.2015.1091093","type":"journal-article","article-title":"The future of biology in driving the field of hyperthermia","volume":"32","author":"Dewhirst","year":"2016","unstructured":"Dewhirst, M. W., Lee, C.-T., Ashcraft, K. A. The future of biology in driving the field of hyperthermia. International Journal of Hyperthermia. 32 (1), 4-13 (2016).","journal-title":"International Journal of Hyperthermia"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/02656730500271668","type":"journal-article","article-title":"Re-setting the biologic rationale for thermal therapy","volume":"21","author":"Dewhirst","year":"2005","unstructured":"Dewhirst, M. W., Vujaskovic, Z., Jones, E., Thrall, D. Re-setting the biologic rationale for thermal therapy. International Journal of Hyperthermia. 21 (8), 779-790 (2005).","journal-title":"International Journal of Hyperthermia"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1158\/2326-6066.CIR-13-0118","type":"journal-article","article-title":"Temperature matters! And why it should matter to tumor immunologists","volume":"1","author":"Repasky","year":"2013","unstructured":"Repasky, E. A., Evans, S. S., Dewhirst, M. W. Temperature matters! And why it should matter to tumor immunologists. Cancer Immunology Research. 1 (4), 210-216 (2013).","journal-title":"Cancer Immunology Research"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"E4802","DOI":"10.1073\/pnas.1700790114","type":"journal-article","article-title":"Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound","volume":"114","author":"Hijnen","year":"2017","unstructured":"Hijnen, N. et al. Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound. Proceedings of the National Academy of Sciences. 114 (24), E4802-E4811 (2017).","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1101\/pdb.top073585","type":"journal-article","article-title":"Human cancer growth and therapy in immunodeficient mouse models","volume":"2014","author":"Shultz","year":"2014","unstructured":"Shultz, L. D. et al. Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harbor Protocols. 2014 (7), 694-708 (2014).","journal-title":"Cold Spring Harbor Protocols"},{"issue":"21","key":"ref25","doi-asserted-by":"crossref","first-page":"11564","DOI":"10.3390\/ijms222111564","type":"journal-article","article-title":"Deciphering the genomic landscape and pharmacological profile of uncommon entities of adult rhabdomyosarcomas","volume":"22","author":"De Vita","year":"2021","unstructured":"De Vita, A. et al. Deciphering the genomic landscape and pharmacological profile of uncommon entities of adult rhabdomyosarcomas. International Journal of Molecular Sciences. 22 (21), 11564 (2021).","journal-title":"International Journal of Molecular Sciences"},{"issue":"20","key":"ref26","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1038\/s41388-017-0122-y","type":"journal-article","article-title":"Functional screening of FGFR4-driven tumorigenesis identifies PI3K\/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma","volume":"37","author":"McKinnon","year":"2018","unstructured":"McKinnon, T. et al. Functional screening of FGFR4-driven tumorigenesis identifies PI3K\/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma. Oncogene. 37 (20), 2630-2644 (2018).","journal-title":"Oncogene"},{"key":"ref27","doi-asserted-by":"crossref","DOI":"10.1186\/2050-5736-1-7","type":"journal-article","article-title":"MatMRI and MatHIFU: software toolboxes for real-time monitoring and control of MR-guided HIFU","volume":"1","author":"Zaporzan","year":"2013","unstructured":"Zaporzan, B. et al. MatMRI and MatHIFU: software toolboxes for real-time monitoring and control of MR-guided HIFU. Journal of Therapeutic Ultrasound. 1, 7 (2013).","journal-title":"Journal of Therapeutic Ultrasound"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jconrel.2019.06.012","type":"journal-article","article-title":"Heat-activated drug delivery increases tumor accumulation of synergistic chemotherapies","volume":"308","author":"Dunne","year":"2019","unstructured":"Dunne, M. et al. Heat-activated drug delivery increases tumor accumulation of synergistic chemotherapies. Journal of Controlled Release. 308, 197-208 (2019).","journal-title":"Journal of Controlled Release"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"14816","DOI":"10.1111\/dth.14816","type":"journal-article","article-title":"High-intensity focused ultrasound treatment as an alternative regimen for myxofibrosarcoma","volume":"34","author":"Zhao","year":"2021","unstructured":"Zhao, Y. X., Hu, X. Y., Zhong, X., Shen, H., Yuan, Y. High-intensity focused ultrasound treatment as an alternative regimen for myxofibrosarcoma. Dermatologic Therapy. 34 (2), e14816 (2021).","journal-title":"Dermatologic Therapy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"17588359221093973","DOI":"10.1177\/17588359221093973","type":"journal-article","article-title":"Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives","volume":"14","author":"Vanni","year":"2022","unstructured":"Vanni, S. et al. Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives. Therapeutic Advances in Medical Oncology. 14, 17588359221093973 (2022).","journal-title":"Therapeutic Advances in Medical Oncology"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64544\/magnetic-resonance-guided-high-intensity-focused-ultrasound-generated","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:57:23Z","timestamp":1792609043000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":30,"journal-issue":{"issue":"191","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3791\/64544","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]}}}