{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:39:55Z","timestamp":1792607995728,"version":"4.5.0"},"reference-count":24,"publisher":"MyJove Corporation","issue":"197","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64611","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T20:00:43Z","timestamp":1689364843000},"source":"Crossref","is-referenced-by-count":0,"title":["Generation of Hypoparathyroid Rats <em>via<\/em> Carbon-Nanoparticle-Assisted Parathyroidectomy"],"prefix":"10.3791","author":[{"given":"Yiming","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiye","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","type":"journal-article","article-title":"Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","unstructured":"Bilezikian, J. P. et al. Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. Journal of Bone and Mineral Research. 26 (10), 2317-2337 (2011).","journal-title":"Journal of Bone and Mineral Research"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1210\/clinem\/dgaa113","type":"journal-article","article-title":"Hypoparathyroidism","volume":"105","author":"Bilezikian","year":"2020","unstructured":"Bilezikian, J. P. Hypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 105 (6), 1722-1736 (2020).","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/jbmr.2273","type":"journal-article","article-title":"Postsurgical hypoparathyroidism-Risk of fractures, psychiatric diseases, cancer, cataract, and infections","volume":"29","author":"Underbjerg","year":"2014","unstructured":"Underbjerg, L., Sikjaer, T., Mosekilde, L., Rejnmark, L. Postsurgical hypoparathyroidism-Risk of fractures, psychiatric diseases, cancer, cataract, and infections. Journal of Bone and Mineral Research. 29 (11), 2504-2510 (2014).","journal-title":"Journal of Bone and Mineral Research"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/jbmr.2501","type":"journal-article","article-title":"The epidemiology of nonsurgical hypoparathyroidism in Denmark: A nationwide case finding study","volume":"30","author":"Underbjerg","year":"2015","unstructured":"Underbjerg, L., Sikjaer, T., Mosekilde, L., Rejnmark, L., The epidemiology of nonsurgical hypoparathyroidism in Denmark: A nationwide case finding study. Journal of Bone and Mineral Research. 30 (9), 1738-1744 (2015).","journal-title":"Journal of Bone and Mineral Research"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1210\/jc.2016-1477","type":"journal-article","article-title":"Epidemiology and health-related quality of life in hypoparathyroidism in Norway","volume":"101","author":"Astor","year":"2016","unstructured":"Astor, M. C. et al. Epidemiology and health-related quality of life in hypoparathyroidism in Norway. The Journal of Clinical Endocrinology and Metabolism. 101 (8), 3045-3053 (2016).","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1681\/ASN.2011101006","type":"journal-article","article-title":"Calcium deficiency reduces circulating levels of FGF23","volume":"23","author":"Rodriguez-Ortiz","year":"2012","unstructured":"Rodriguez-Ortiz, M. E. et al. Calcium deficiency reduces circulating levels of FGF23. Journal of the American Society of Nephrology. 23 (7), 1190-1197 (2012).","journal-title":"Journal of the American Society of Nephrology"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1113\/jphysiol.1954.sp005166","type":"journal-article","article-title":"A plasma calcium assay for parathyroid hormone, using parathyroidectomized rats","volume":"125","author":"Davies","year":"1954","unstructured":"Davies, B. M., Gordon, A. H., Mussett, M. V. A plasma calcium assay for parathyroid hormone, using parathyroidectomized rats. The Journal of Physiology. 125 (2), 383-395 (1954).","journal-title":"The Journal of Physiology"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1210\/jc.2015-3908","type":"journal-article","article-title":"Epidemiology and diagnosis of hypoparathyroidism","volume":"101","author":"Clarke","year":"2016","unstructured":"Clarke, B. L. et al. Epidemiology and diagnosis of hypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 101 (6), 2284-2299 (2016).","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/agm2.12165","type":"journal-article","article-title":"Expert consensus on diagnosis and treatment for elderly with thyroid diseases in China","volume":"4","author":"Liu","year":"2021","unstructured":"Liu, Y., Shan, Z. Expert consensus on diagnosis and treatment for elderly with thyroid diseases in China (2021). Aging Medicine. 4 (2), 70-92 (2021).","journal-title":"Aging Medicine"},{"issue":"2","key":"ref10","first-page":"130","type":"journal-article","article-title":"Annual incidence of thyroid disease in patients who first time visit department for thyroid diseases in Tuzla Canton","volume":"31","author":"Sulejmanovic","year":"2019","unstructured":"Sulejmanovic, M., Cickusic, A. J., Salkic, S., Bousbija, F. M. Annual incidence of thyroid disease in patients who first time visit department for thyroid diseases in Tuzla Canton. Materia Socio-Medica. 31 (2), 130-134 (2019).","journal-title":"Materia Socio-Medica"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"0133278","DOI":"10.1371\/journal.pone.0133278","type":"journal-article","article-title":"Relationship between fibroblast growth factor 23 and biochemical and bone histomorphometric alterations in a chronic kidney disease rat model undergoing parathyroidectomy","volume":"10","author":"Liao","year":"2015","unstructured":"Liao, H. W. et al. Relationship between fibroblast growth factor 23 and biochemical and bone histomorphometric alterations in a chronic kidney disease rat model undergoing parathyroidectomy. PloS One. 10 (7), e0133278 (2015).","journal-title":"PloS One"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1084\/jem.109.6.571","type":"journal-article","article-title":"Parathyroid transplants in rats: A comparison of their survival time with that of skin grafts","volume":"109","author":"Russell","year":"1959","unstructured":"Russell, P. S., Gittes, R. F. Parathyroid transplants in rats: A comparison of their survival time with that of skin grafts. The Journal of Experimental Medicine. 109 (6), 571-588 (1959).","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00774-004-0534-y","type":"journal-article","article-title":"Osteoclast development in immobilized bone is suppressed by parathyroidectomy in mice","volume":"23","author":"Sakai","year":"2005","unstructured":"Sakai, A. et al. Osteoclast development in immobilized bone is suppressed by parathyroidectomy in mice. Journal of Bone and Mineral Metabolism. 23 (1), 8-14 (2005).","journal-title":"Journal of Bone and Mineral Metabolism"},{"issue":"121","key":"ref14","first-page":"e55010","type":"journal-article","article-title":"Two techniques to create hypoparathyroid mice: parathyroidectomy using GFP glands and diphtheria-toxin-mediated parathyroid ablation","author":"Bi","year":"2017","unstructured":"Bi, R., Fan, Y., Luo, E., Yuan, Q., Mannstadt, M. Two techniques to create hypoparathyroid mice: parathyroidectomy using GFP glands and diphtheria-toxin-mediated parathyroid ablation. Journal of Visualized Experiments. (121), e55010 (2017).","journal-title":"Journal of Visualized Experiments"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jbmr.2769","type":"journal-article","article-title":"Diphtheria toxin- and GFP-based mouse models of acquired hypoparathyroidism and treatment with a long-acting parathyroid hormone analog","volume":"31","author":"Bi","year":"2016","unstructured":"Bi, R. et al. Diphtheria toxin- and GFP-based mouse models of acquired hypoparathyroidism and treatment with a long-acting parathyroid hormone analog. Journal of Bone and Mineral Research. 31 (5), 975-984 (2016).","journal-title":"Journal of Bone and Mineral Research"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/mco2.28","type":"journal-article","article-title":"Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo","volume":"1","author":"Huang","year":"2020","unstructured":"Huang, Y. et al. Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo. MedComm. 1 (2), 202-210 (2020).","journal-title":"MedComm"},{"key":"ref17","type":"journal-article","article-title":"Carbon nanoparticles for thyroidectomy and central lymph node dissection for thyroid cancer","author":"Zhang","year":"2022","unstructured":"Zhang, R. J., Chen, Y. L., Deng, X., Yang, H. Carbon nanoparticles for thyroidectomy and central lymph node dissection for thyroid cancer. The American Surgeon. (2022).","journal-title":"The American Surgeon"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1553350616668088","type":"journal-article","article-title":"A carbon nanoparticle lymphatic tracer protected parathyroid glands during radical thyroidectomy for papillary thyroid non-microcarcinoma","volume":"24","author":"Long","year":"2017","unstructured":"Long, M. et al. A carbon nanoparticle lymphatic tracer protected parathyroid glands during radical thyroidectomy for papillary thyroid non-microcarcinoma. Surgical Innovation. 24 (1), 29-34 (2017).","journal-title":"Surgical Innovation"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1089\/thy.2019.0067","type":"journal-article","article-title":"Efficacy and safety of long-term universal salt iodization on thyroid disorders: Epidemiological evidence from 31 provinces of mainland China","volume":"30","author":"Li","year":"2020","unstructured":"Li, Y. et al. Efficacy and safety of long-term universal salt iodization on thyroid disorders: Epidemiological evidence from 31 provinces of mainland China. Thyroid. 30 (4), 568-579 (2020).","journal-title":"Thyroid"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/jbmr.2004","type":"journal-article","article-title":"Prevalence and incidence of hypoparathyroidism in the United States using a large claims database","volume":"28","author":"Powers","year":"2013","unstructured":"Powers, J., Joy, K., Ruscio, A., Lagast, H. Prevalence and incidence of hypoparathyroidism in the United States using a large claims database. Journal of Bone and Mineral Research. 28 (12), 2570-2576 (2013).","journal-title":"Journal of Bone and Mineral Research"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.21037\/gs-21-809","type":"journal-article","article-title":"Promotion of allogeneic parathyroid cell transplantation in rats with hypoparathyroidism","volume":"10","author":"Zihao","year":"2021","unstructured":"Zihao, N. et al. Promotion of allogeneic parathyroid cell transplantation in rats with hypoparathyroidism. Gland Surgery. 10 (12), 3403-3414 (2021).","journal-title":"Gland Surgery"},{"key":"ref22","type":"journal-article","article-title":"Xenotransplantation of microencapsulated parathyroid cells as a potential treatment for autoimmune-related hypoparathyroidism","author":"Goncu","year":"2021","unstructured":"Goncu, B. et al. Xenotransplantation of microencapsulated parathyroid cells as a potential treatment for autoimmune-related hypoparathyroidism. Experimental and Clinical Transplantation. (2021).","journal-title":"Experimental and Clinical Transplantation"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"0163911","DOI":"10.1371\/journal.pone.0163911","type":"journal-article","article-title":"Standardization of a physiologic hypoparathyroidism animal model","volume":"11","author":"Jung","year":"2016","unstructured":"Jung, S. Y. et al. Standardization of a physiologic hypoparathyroidism animal model. PLoS One. 11 (10), e0163911 (2016).","journal-title":"PLoS One"},{"issue":"24","key":"ref24","first-page":"1918","type":"journal-article","article-title":"Application of lymphatic mapping to recognize and protect parathyroid in thyroid carcinoma surgery by using carbon nanoparticles","volume":"28","author":"Chen","year":"1924","unstructured":"Chen, W., Lv, Y., Xie, R., Xu, D., Yu, J., Application of lymphatic mapping to recognize and protect parathyroid in thyroid carcinoma surgery by using carbon nanoparticles. Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. 28 (24), 1918-1920, 1924 (2014).","journal-title":"Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64611\/generation-hypoparathyroid-rats-via-carbon-nanoparticle-assisted","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:57:56Z","timestamp":1792605476000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":24,"journal-issue":{"issue":"197","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3791\/64611","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]}}}