{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:39:41Z","timestamp":1792611581868,"version":"4.5.0"},"reference-count":20,"publisher":"MyJove Corporation","issue":"190","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64620","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T19:00:15Z","timestamp":1670612415000},"source":"Crossref","is-referenced-by-count":1,"title":["Culture and Imaging of <em>Ex Vivo<\/em> Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens"],"prefix":"10.3791","author":[{"given":"Jonathan","family":"Weitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Christian","family":"Montecillo Gulay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Hurtado de Mendoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Tiriac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Baumgartner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jula","family":"Veerapong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lowy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4251\/wjgo.v2.i1.44","type":"journal-article","article-title":"Pseudomyxoma peritonei","volume":"2","author":"Bevan","year":"2010","unstructured":"Bevan, K. E., Mohamed, F., Moran, B. J. Pseudomyxoma peritonei. World Journal of Gastrointestinal Oncology. 2 (1), 44-50 (2010).","journal-title":"World Journal of Gastrointestinal Oncology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1245\/s10434-018-7008-2","type":"journal-article","article-title":"Appendiceal cancer patient-specific tumor organoid model for predicting chemotherapy efficacy prior to initiation of treatment: A feasibility study","volume":"26","author":"Votanopoulos","year":"2019","unstructured":"Votanopoulos, K. I. et al. Appendiceal cancer patient-specific tumor organoid model for predicting chemotherapy efficacy prior to initiation of treatment: A feasibility study. Annals of Surgical Oncology. 26 (1), 139-147 (2019).","journal-title":"Annals of Surgical Oncology"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/jclinpath-2012-201147","type":"journal-article","article-title":"The practicalities of using tissue slices as preclinical organotypic breast cancer models","volume":"66","author":"Holliday","year":"2013","unstructured":"Holliday, D. L. et al. The practicalities of using tissue slices as preclinical organotypic breast cancer models. Journal of Clinical Pathology. 66 (3), 253-255 (2013).","journal-title":"Journal of Clinical Pathology"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/cam4.720","type":"journal-article","article-title":"Organotypic slice cultures of human gastric and esophagogastric junction cancer","volume":"5","author":"Koerfer","year":"2016","unstructured":"Koerfer, J. et al. Organotypic slice cultures of human gastric and esophagogastric junction cancer. Cancer Medicine. 5 (7), 1444-1453 (2016).","journal-title":"Cancer Medicine"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/s41598-019-38603-w","type":"journal-article","article-title":"Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma","volume":"9","author":"Misra","year":"2019","unstructured":"Misra, S. et al. Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma. Scientific Reports. 9 (1), 2133 (2019).","journal-title":"Scientific Reports"},{"issue":"14","key":"ref6","first-page":"2935","type":"journal-article","article-title":"A novel model of glioma cell invasion using organotypic brain slice culture","volume":"58","author":"Ohnishi","year":"1998","unstructured":"Ohnishi, T., Matsumura, H., Izumoto, S., Hiraga, S., Hayakawa, T. A novel model of glioma cell invasion using organotypic brain slice culture. Cancer Research. 58 (14), 2935-2940 (1998).","journal-title":"Cancer Research"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00000478-199301000-00003","type":"journal-article","article-title":"Association of mucinous tumors of the ovary and appendix. A clinicopathologic study of 25 cases","volume":"17","author":"Seidman","year":"1993","unstructured":"Seidman, J. D., Elsayed, A. M., Sobin, L. H., Tavassoli, F. A. Association of mucinous tumors of the ovary and appendix. A clinicopathologic study of 25 cases. The Amerian Journal of Surgical Pathology. 17 (1), 22-34 (1993).","journal-title":"The Amerian Journal of Surgical Pathology"},{"issue":"4-5","key":"ref8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1159\/000086551","type":"journal-article","article-title":"Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas","volume":"5","author":"Mizuta","year":"2005","unstructured":"Mizuta, Y. et al. Pseudomyxoma peritonei accompanied by intraductal papillary mucinous neoplasm of the pancreas. Pancreatology. 5 (4-5), 470-474 (2005).","journal-title":"Pancreatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5826214","DOI":"10.1155\/2020\/5826214","type":"journal-article","article-title":"Pseudomyxoma peritonei originating from transverse colon mucinous adenocarcinoma: A case report and literature review","volume":"2020","author":"Gong","year":"2020","unstructured":"Gong, Y., Wang, X., Zhu, Z. Pseudomyxoma peritonei originating from transverse colon mucinous adenocarcinoma: A case report and literature review. Gastroenterology Research and Practice. 2020, 5826214 (2020).","journal-title":"Gastroenterology Research and Practice"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"100793","DOI":"10.1016\/j.tranon.2020.100793","type":"journal-article","article-title":"Experimental treatment of mucinous peritoneal metastases using patient-derived xenograft models","volume":"13","author":"Fleten","year":"2020","unstructured":"Fleten, K. G. et al. Experimental treatment of mucinous peritoneal metastases using patient-derived xenograft models. Translational Oncology. 13 (8), 100793 (2020).","journal-title":"Translational Oncology"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/cam4.640","type":"journal-article","article-title":"Patient-derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment","volume":"5","author":"Kuracha","year":"2016","unstructured":"Kuracha, M. R., Thomas, P., Loggie, B. W., Govindarajan, V. Patient-derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment. Cancer Medicine. 5 (4), 711-719 (2016).","journal-title":"Cancer Medicine"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1333210","DOI":"10.1080\/2162402X.2017.1333210","type":"journal-article","article-title":"Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment","volume":"6","author":"Jiang","year":"2017","unstructured":"Jiang, X. et al. Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment. Oncoimmunology. 6 (7), e1333210 (2017).","journal-title":"Oncoimmunology"},{"issue":"14","key":"ref13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S1359-6446(05)03502-6","type":"journal-article","article-title":"Organotypic cultures as tools for functional screening in the CNS","volume":"10","author":"Sundstrom","year":"2005","unstructured":"Sundstrom, L., Morrison 3rd, B., Bradley, M., Pringle, A. Organotypic cultures as tools for functional screening in the CNS. Drug Discovery Today. 10 (14), 993-1000 (2005).","journal-title":"Drug Discovery Today"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12967-020-02677-2","type":"journal-article","article-title":"Patient-derived organoid (PDO) platforms to facilitate clinical decision making","volume":"19","author":"Liu","year":"2021","unstructured":"Liu, L., Yu, L., Li, Z., Li, W., Huang, W. Patient-derived organoid (PDO) platforms to facilitate clinical decision making. Journal of Translational Medicine. 19 (1), 40 (2021).","journal-title":"Journal of Translational Medicine"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-019-0346-0","type":"journal-article","article-title":"Organotypic brain slice cultures to model neurodegenerative proteinopathies","volume":"14","author":"Croft","year":"2019","unstructured":"Croft, C. L., Futch, H. S., Moore, B. D., Golde, T. E. Organotypic brain slice cultures to model neurodegenerative proteinopathies. Molecular Neurodegeneration. 14 (1), 45 (2019).","journal-title":"Molecular Neurodegeneration"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.21037\/jgo-2020-01","type":"journal-article","article-title":"New insights in the pathology of peritoneal surface malignancy","volume":"12","author":"Carr","year":"2021","unstructured":"Carr, N. J. New insights in the pathology of peritoneal surface malignancy. Journal of Gastrointestinal Oncology. 12 (Suppl 1), S216-S229 (2021).","journal-title":"Journal of Gastrointestinal Oncology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jamcollsurg.2012.04.023","type":"journal-article","article-title":"Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy","volume":"215","author":"Votanopoulos","year":"2012","unstructured":"Votanopoulos, K. I. et al. Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy. Journal of the American College of Surgeons. 215 (3), 412-417 (2012).","journal-title":"Journal of the American College of Surgeons"},{"issue":"21","key":"ref18","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1158\/1078-0432.CCR-22-0980","type":"journal-article","article-title":"An ex-vivo organotypic culture platform for functional interrogation of human appendiceal cancer reveals a prominent and heterogenous immunological landscape","volume":"28","author":"Weitz","year":"2022","unstructured":"Weitz, J. et al. An ex-vivo organotypic culture platform for functional interrogation of human appendiceal cancer reveals a prominent and heterogenous immunological landscape. Clinical Cancer Research. 28 (21), 4793-4806 (2022).","journal-title":"Clinical Cancer Research"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/cvr\/cvz341","type":"journal-article","article-title":"Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research","volume":"116","author":"Pitoulis","year":"2020","unstructured":"Pitoulis, F. G,. Watson, S. A., Perbellini, F., Terracciano, C. M. Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research. Cardiovascular Research. 116 (7), 1275-1287 (2020).","journal-title":"Cardiovascular Research"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4161\/org.5.2.9091","type":"journal-article","article-title":"Organotypic heart slices for cell transplantation and physiological studies","volume":"5","author":"Habeler","year":"2009","unstructured":"Habeler, W., Peschanski, M., Monville, C. Organotypic heart slices for cell transplantation and physiological studies. Organogenesis. 5 (2), 62-66 (2009).","journal-title":"Organogenesis"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64620\/culture-imaging-ex-vivo-organotypic-pseudomyxoma-peritonei-tumor","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:01:50Z","timestamp":1792609310000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":20,"journal-issue":{"issue":"190","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3791\/64620","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,9]]}}}