{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:41:56Z","timestamp":1792608116434,"version":"4.5.0"},"reference-count":22,"publisher":"MyJove Corporation","issue":"194","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64734","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T20:02:28Z","timestamp":1680897748000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring X Chromosomal Aberrations in Ovarian Cells by using Fluorescence <em>In Situ<\/em> Hybridization"],"prefix":"10.3791","author":[{"given":"Sapthami","family":"Nadesapillai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janielle","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didi","family":"Braat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","type":"journal-article","article-title":"Fertility and infertility: Definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","unstructured":"Vander Borght, M., Wyns, C. Fertility and infertility: Definition and epidemiology. Clinical Biochemistry. 62, 2-10 (2018).","journal-title":"Clinical Biochemistry"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/biolre\/ioz084","type":"journal-article","article-title":"Genetics of human female infertility","volume":"101","author":"Yatsenko","year":"2019","unstructured":"Yatsenko, S. A., Rajkovic, A. Genetics of human female infertility\u2020. Biology of Reproduction. 101 (3), 549-566 (2019).","journal-title":"Biology of Reproduction"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s42269-021-00523-z","type":"journal-article","article-title":"Chromosomal abnormalities predisposing to infertility, testing, and management: a narrative review","volume":"45","author":"Yahaya","year":"2021","unstructured":"Yahaya, T. O. et al. Chromosomal abnormalities predisposing to infertility, testing, and management: a narrative review. Bulletin of the National Research Centre. 45 (1), 65 (2021).","journal-title":"Bulletin of the National Research Centre"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/sj.ejhg.5200805","type":"journal-article","article-title":"Guidelines for the appropriate use of genetic tests in infertile couples","volume":"10","author":"Foresta","year":"2002","unstructured":"Foresta, C., Ferlin, A., Gianaroli, L., Dallapiccola, B. Guidelines for the appropriate use of genetic tests in infertile couples. European Journal of Human Genetics. 10 (5), 303-312 (2002).","journal-title":"European Journal of Human Genetics"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"002675","DOI":"10.1101\/cshperspect.a002675","type":"journal-article","article-title":"Function of the sex chromosomes in mammalian fertility","volume":"3","author":"Heard","year":"2011","unstructured":"Heard, E., Turner, J. Function of the sex chromosomes in mammalian fertility. Cold Spring Harbor Perspectives in Biology. 3 (10), a002675 (2011).","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.fertnstert.2003.12.011","type":"journal-article","article-title":"Number of ovarian follicles in human fetuses with the 45,X karyotype","volume":"81","author":"Reynaud","year":"2004","unstructured":"Reynaud, K. et al. Number of ovarian follicles in human fetuses with the 45,X karyotype. Fertility and Sterility. 81 (4), 1112-1119 (2004).","journal-title":"Fertility and Sterility"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ejhg.2009.109","type":"journal-article","article-title":"Triple X syndrome: a review of the literature","volume":"18","author":"Otter","year":"2010","unstructured":"Otter, M., Schrander-Stumpel, C. T., Curfs, L. M. Triple X syndrome: a review of the literature. European Journal of Human Genetics. 18 (3), 265-271 (2010).","journal-title":"European Journal of Human Genetics"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/molehr\/gag031","type":"journal-article","article-title":"Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads","volume":"9","author":"Modi","year":"2003","unstructured":"Modi, D. N., Sane, S., Bhartiya, D. Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads. Molecular Human Reproduction. 9 (4), 219-225 (2003).","journal-title":"Molecular Human Reproduction"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","type":"journal-article","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","unstructured":"Hassold, T., Hunt, P. To err (meiotically) is human: the genesis of human aneuploidy. Nature Reviews Genetics. 2 (4), 280-291 (2001).","journal-title":"Nature Reviews Genetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mne.2018.10.006","type":"journal-article","article-title":"Fluorescence in situ hybridization (FISH): History, limitations and what to expect from micro-scale FISH","volume":"1","author":"Huber","year":"2018","unstructured":"Huber, D., von Voithenberg, L. V., Kaigala, G. V. Fluorescence in situ hybridization (FISH): History, limitations and what to expect from micro-scale FISH? Micro and Nano Engineering. 1, 15-24 (2018).","journal-title":"Micro and Nano Engineering"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2050-7771-2-3","type":"journal-article","article-title":"Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine","volume":"2","author":"Hu","year":"2014","unstructured":"Hu, L. et al. Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine. Biomarker Research. 2 (1), 3 (2014).","journal-title":"Biomarker Research"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1756287210373758","type":"journal-article","article-title":"The use of fluorescent in situ hybridization in male infertility","volume":"2","author":"Hwang","year":"2010","unstructured":"Hwang, K., Weedin, J. W., Lamb, D. J. The use of fluorescent in situ hybridization in male infertility. Therapeutic Advances in Urology. 2 (4), 157-169 (2010).","journal-title":"Therapeutic Advances in Urology"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.fertnstert.2014.09.013","type":"journal-article","article-title":"Fluorescent in situ hybridization of human sperm: diagnostics, indications, and therapeutic implications","volume":"102","author":"Ramasamy","year":"2014","unstructured":"Ramasamy, R., Besada, S., Lamb, D. J. Fluorescent in situ hybridization of human sperm: diagnostics, indications, and therapeutic implications. Fertility and Sterility. 102 (6), 1534-1539 (2014).","journal-title":"Fertility and Sterility"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/and.12362","type":"journal-article","article-title":"Sperm aneuploidy in infertile male patients: a systematic review of the literature","volume":"47","author":"Chatziparasidou","year":"2015","unstructured":"Chatziparasidou, A., Christoforidis, N., Samolada, G., Nijs, M. Sperm aneuploidy in infertile male patients: a systematic review of the literature. Andrologia. 47 (8), 847-860 (2015).","journal-title":"Andrologia"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"030855","DOI":"10.1136\/bmjopen-2019-030855","type":"journal-article","article-title":"TurnerFertility trial: PROTOCOL for an observational cohort study to describe the efficacy of ovarian tissue cryopreservation for fertility preservation in females with Turner syndrome","volume":"9","author":"Schleedoorn","year":"2019","unstructured":"Schleedoorn, M. et al. TurnerFertility trial: PROTOCOL for an observational cohort study to describe the efficacy of ovarian tissue cryopreservation for fertility preservation in females with Turner syndrome. BMJ Open. 9 (12), e030855 (2019).","journal-title":"BMJ Open"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/humrep\/dez135","type":"journal-article","article-title":"Ovarian follicles of young patients with Turner's syndrome contain normal oocytes but monosomic 45,X granulosa cells","volume":"34","author":"Peek","year":"2019","unstructured":"Peek, R. et al. Ovarian follicles of young patients with Turner's syndrome contain normal oocytes but monosomic 45,X granulosa cells. Human Reproduction. 34 (9), 1686-1696 (2019).","journal-title":"Human Reproduction"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.fertnstert.2020.11.006","type":"journal-article","article-title":"Why are some patients with 45,X Turner syndrome fertile? A young girl with classical 45,X Turner syndrome and a cryptic mosaicism in the ovary","volume":"115","author":"Nadesapillai","year":"2021","unstructured":"Nadesapillai, S. et al. Why are some patients with 45,X Turner syndrome fertile? A young girl with classical 45,X Turner syndrome and a cryptic mosaicism in the ovary. Fertility and Sterility. 115 (5), 1280-1287 (2021).","journal-title":"Fertility and Sterility"},{"issue":"16","key":"ref18","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1182\/blood-2010-01-265751","type":"journal-article","article-title":"Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe","volume":"116","author":"Dolmans","year":"2010","unstructured":"Dolmans, M. M. et al. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood. 116 (16), 2908-2914 (2010).","journal-title":"Blood"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/humrep\/deq131","type":"journal-article","article-title":"Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites","volume":"25","author":"Dath","year":"2010","unstructured":"Dath, C. et al. Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites. Human Reproduction. 25 (7), 1734-1743 (2010).","journal-title":"Human Reproduction"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.rbmo.2021.06.019","type":"journal-article","article-title":"Ovarian tissue damage after grafting: systematic review of strategies to improve follicle outcomes","volume":"43","author":"Cacciottola","year":"2021","unstructured":"Cacciottola, L., Donnez, J., Dolmans, M. M. Ovarian tissue damage after grafting: systematic review of strategies to improve follicle outcomes. Reproductive BioMedicine Online. 43 (3), 351-369 (2021).","journal-title":"Reproductive BioMedicine Online"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/biohorizons\/hzq009","type":"journal-article","article-title":"Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance","volume":"3","author":"Bishop","year":"2010","unstructured":"Bishop, R. Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance. Bioscience Horizons. 3 (1), 85-95 (2010).","journal-title":"Bioscience Horizons"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrg2505","type":"journal-article","article-title":"The consequences of asynapsis for mammalian meiosis","volume":"10","author":"Burgoyne","year":"2009","unstructured":"Burgoyne, P. S., Mahadevaiah, S. K., Turner, J. M. The consequences of asynapsis for mammalian meiosis. Nature Reviews Genetics. 10 (3), 207-216 (2009).","journal-title":"Nature Reviews Genetics"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64734\/exploring-x-chromosomal-aberrations-ovarian-cells-using-fluorescence","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:35:51Z","timestamp":1792607751000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,7]]},"references-count":22,"journal-issue":{"issue":"194","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3791\/64734","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,7]]}}}