{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:40:06Z","timestamp":1792604406168,"version":"4.5.0"},"reference-count":35,"publisher":"MyJove Corporation","issue":"206","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64850","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T20:00:53Z","timestamp":1713556853000},"source":"Crossref","is-referenced-by-count":0,"title":["<em>Ex Vivo<\/em> Porcine Experimental Model for Studying and Teaching Lung Mechanics"],"prefix":"10.3791","author":[{"given":"Milena Gomes","family":"Parzianello Eg\u00fasquiza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Aya","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ot\u00e1vio","family":"Costa Auler Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"issue":"2","key":"ref1","first-page":"54","type":"journal-article","article-title":"Mechanical Ventilation: Principles, graphic analysis and ventilation modalities","volume":"33","author":"Roberto","year":"2007","unstructured":"Roberto, C., Carvalho, R., Toufen Jr, C., Franca S. A. Mechanical Ventilation: Principles, graphic analysis and ventilation modalities. Jornal Brasileiro de Pneumologia. 33 (2), 54-55 (2007).","journal-title":"Jornal Brasileiro de Pneumologia"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5935\/0103-507X.20140017","type":"journal-article","article-title":"Brazilian recommendations for mechanical ventilation 2013. Part I","volume":"26","author":"Barbas","year":"2014","unstructured":"Barbas, C. S. V. et al. Brazilian recommendations for mechanical ventilation 2013. Part I. Revista Brasileira de Terapia Intensiva. 26 (2), 89-121 (2014).","journal-title":"Revista Brasileira de Terapia Intensiva"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.14423\/SMJ.0000000000000905","type":"journal-article","article-title":"Invasive mechanical ventilation","volume":"111","author":"Walter","year":"2018","unstructured":"Walter, J. M., Corbridge, T. C., Singer, B. D. Invasive mechanical ventilation. Southern Medical Journal. 111 (12), 746 -753 (2018).","journal-title":"Southern Medical Journal"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1590\/S0103-507X2007000200004","type":"journal-article","article-title":"Concepts and monitoring of pulmonary mechanics in patients under ventilatory support in the intensive care unit","volume":"19","author":"Faustino","year":"2007","unstructured":"Faustino, E. A. Concepts and monitoring of pulmonary mechanics in patients under ventilatory support in the intensive care unit. Revista Brasileira de Terapia Intensiva. 19 (2), 161-169 (2007).","journal-title":"Revista Brasileira de Terapia Intensiva"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1590\/s1806-37562017000000185","type":"journal-article","article-title":"Patient-ventilator asynchrony","volume":"44","author":"Holanda","year":"2018","unstructured":"Holanda, M. A., Vasconcelos, R. S., Ferreira, J. C., Pinheiro, B. V. Patient-ventilator asynchrony. Jornal Brasileiro de Pneumologia. 44 (2), 321-333 (2018).","journal-title":"Jornal Brasileiro de Pneumologia"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1055\/s-0042-1748917","type":"journal-article","article-title":"Monitoring lung injury severity and ventilation intensity during mechanical ventilation","volume":"43","author":"Rezoagli","year":"2022","unstructured":"Rezoagli, E., Laffey, J. G., Bellani, G. Monitoring lung injury severity and ventilation intensity during mechanical ventilation. Seminars in Respiratory and Critical Care Medicine. 43 (3), 346-368 (2022).","journal-title":"Seminars in Respiratory and Critical Care Medicine"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.6061\/clinics\/2017(02)01","type":"journal-article","article-title":"Evaluation of self-perception of mechanical ventilation knowledge among Brazilian final-year medical students, residents, and emergency physicians","volume":"72","author":"Tallo","year":"2017","unstructured":"Tallo, F. S. Evaluation of self-perception of mechanical ventilation knowledge among Brazilian final-year medical students, residents, and emergency physicians. Clinics. 72 (2), 65-70 (2017).","journal-title":"Clinics"},{"issue":"1","key":"ref8","first-page":"34","type":"journal-article","article-title":"Impact of simulation-based mastery learning on resident skill managing mechanical ventilators","volume":"2","author":"Schroedl","year":"2021","unstructured":"Schroedl, C. J. et al. Impact of simulation-based mastery learning on resident skill managing mechanical ventilators. American Thoracic Society Scholar. 2 (1), 34-48 (2021).","journal-title":"American Thoracic Society Scholar"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5811\/westjem.2016.2.29517","type":"journal-article","article-title":"Academic emergency medicine physicians' knowledge of mechanical ventilation","volume":"17","author":"Wilcox","year":"2016","unstructured":"Wilcox, S. R. et al. Academic emergency medicine physicians' knowledge of mechanical ventilation. The Western Journal of Emergency Medicine. 17 (3), 271-279 (2016).","journal-title":"The Western Journal of Emergency Medicine"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1164\/rccm.200206-624OC","type":"journal-article","article-title":"Effectiveness of medical resident education in mechanical ventilation","volume":"167","author":"Cox","year":"2003","unstructured":"Cox, C. E. et al. Effectiveness of medical resident education in mechanical ventilation. American Journal of Respiratory and Critical Care Medicine. 167 (1), 32-38 (2003).","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3138\/jvme.36.4.436","type":"journal-article","article-title":"Use of the virtual ventilator, a screen-based computer simulation, to teach the principles of mechanical ventilation","volume":"36","author":"Keegan","year":"2009","unstructured":"Keegan, R., Henderson, T., Brown, G. Use of the virtual ventilator, a screen-based computer simulation, to teach the principles of mechanical ventilation. Journal of Veterinary Medical Education. 36 (4), 436-443 (2009).","journal-title":"Journal of Veterinary Medical Education"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/SIH.0000000000000249","type":"journal-article","article-title":"Simulation training for residents focused on mechanical ventilation: A randomized trial using mannequin-based versus computer-based simulation","volume":"12","author":"Spadaro","year":"2017","unstructured":"Spadaro, S. et al. Simulation training for residents focused on mechanical ventilation: A randomized trial using mannequin-based versus computer-based simulation. Simulation in Healthcare. 12 (6), 349-355 (2017).","journal-title":"Simulation in Healthcare"},{"issue":"21","key":"ref13","first-page":"1","type":"journal-article","article-title":"A novel mechanical lung model of pulmonary diseases to assist with teaching and training","volume":"6","author":"Chase","year":"2006","unstructured":"Chase, J. G., Yuta, T., Mulligan, K. J., Shaw, G. M., Horn, B. A novel mechanical lung model of pulmonary diseases to assist with teaching and training. BMC Pulmonary Medicine. 6 (21), 1-11 (2006).","journal-title":"BMC Pulmonary Medicine"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1152\/advan.00001.2007","type":"journal-article","article-title":"A two-component simulation model to teach respiratory mechanics","volume":"31","author":"Kuebler","year":"2007","unstructured":"Kuebler, W. M., Mertens, M., Pries, A. R. A two-component simulation model to teach respiratory mechanics. Advances in Physiology Education. 31 (2), 218-222 (2007).","journal-title":"Advances in Physiology Education"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1157\/13112966","type":"journal-article","article-title":"Design of a lung simulator for learning lung mechanics in mechanical ventilation","volume":"43","author":"Heili-Frades","year":"2007","unstructured":"Heili-Frades, S., Peces-Barba, G., Rodr\u00edguez-Nieto, M. J. Design of a lung simulator for learning lung mechanics in mechanical ventilation. Archivos de Bronconeumolog\u00eda. 43 (12), 674-679 (2007).","journal-title":"Archivos de Bronconeumolog\u00eda"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmpb.2018.03.008","type":"journal-article","article-title":"An object-oriented computational model to study cardiopulmonary hemodynamic interactions in humans","volume":"159","author":"Ngo","year":"2018","unstructured":"Ngo, C., Dahlmanns, S., Vollmer, T., Misgeld, B., Leonhardt, S. An object-oriented computational model to study cardiopulmonary hemodynamic interactions in humans. Computer Methods and Programs in Biomedicine. 159, 167-183 (2018).","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"172","key":"ref17","first-page":"1","type":"journal-article","article-title":"Interactive simulator for e-Learning environments: a teaching software for health care professionals","volume":"13","author":"Lazzari","year":"2014","unstructured":"Lazzari, C. D., Genuini, I., Pisanelli, D. M., D'Ambrosi, A., Fedele, F. Interactive simulator for e-Learning environments: a teaching software for health care professionals. Biomedical Engineering Online. 13 (172), 1-18 (2014).","journal-title":"Biomedical Engineering Online"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep43121","type":"journal-article","article-title":"Development of an ex vivo human-porcine respiratory model for preclinical studies","volume":"7","author":"Perinel","year":"2017","unstructured":"Perinel, S. et al. Development of an ex vivo human-porcine respiratory model for preclinical studies. Scientific Reports. 7, 1-6 (2017).","journal-title":"Scientific Reports"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.healun.2017.09.007","type":"journal-article","article-title":"Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion","volume":"37","author":"Aboelnazar","year":"2018","unstructured":"Aboelnazar, N. S. et al. Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion. The Journal of Heart and Lung Transplantation. 37 (4), 520-530 (2018).","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2020.578762","type":"journal-article","article-title":"Introducing a custom-designed volume-pressure machine for novel measurements of whole lung organ viscoelasticity and direct comparisons between positive- and negative-pressure ventilation","volume":"8","author":"Sattari","year":"2020","unstructured":"Sattari, S. et al. Introducing a custom-designed volume-pressure machine for novel measurements of whole lung organ viscoelasticity and direct comparisons between positive- and negative-pressure ventilation. Frontiers in Bioengineering and Biotechnology. 8, 1-12 (2020).","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1164\/rccm.202111-2480OC","type":"journal-article","article-title":"Positive- and negative-pressure ventilation characterized by local and global pulmonary mechanics","volume":"207","author":"Sattari","year":"2023","unstructured":"Sattari, S. et al. Positive- and negative-pressure ventilation characterized by local and global pulmonary mechanics. American Journal of Respiratory and Critical Care Medicine. 207 (5), 577-586 (2023).","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"17949","DOI":"10.1038\/s41598-019-54479-2","type":"journal-article","article-title":"Development of an ex vivo preclinical respiratory model of idiopathic pulmonary fibrosis for aerosol regional studies","volume":"9","author":"Montigaud","year":"2019","unstructured":"Montigaud, Y. et al. Development of an ex vivo preclinical respiratory model of idiopathic pulmonary fibrosis for aerosol regional studies. Scientific Reports. 9 (1), 17949 (2019).","journal-title":"Scientific Reports"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"17930","DOI":"10.1038\/s41598-019-54480-9","type":"journal-article","article-title":"Aerosol delivery during invasive mechanical ventilation: development of a preclinical ex vivo respiratory model for aerosol regional deposition","volume":"9","author":"Montigaud","year":"2019","unstructured":"Montigaud, Y. et al. Aerosol delivery during invasive mechanical ventilation: development of a preclinical ex vivo respiratory model for aerosol regional deposition. Scientific Reports. 9 (1), 17930 (2019).","journal-title":"Scientific Reports"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1038\/s41598-019-42103-2","type":"journal-article","article-title":"Development of an ex vivo respiratory pediatric model of bronchopulmonary dysplasia for aerosol deposition studies","volume":"9","author":"Montigaud","year":"2019","unstructured":"Montigaud, Y. et al. Development of an ex vivo respiratory pediatric model of bronchopulmonary dysplasia for aerosol deposition studies. Scientific Reports. 9 (1), 5720 (2019).","journal-title":"Scientific Reports"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.transproceed.2020.05.007","type":"journal-article","article-title":"A low-cost perfusate alternative for ex vivo. lung perfusion","volume":"52","author":"Buchko","year":"2020","unstructured":"Buchko, M. T. et al. A low-cost perfusate alternative for ex vivo lung perfusion. transplantation proceedings. Transplant Proc. 52 (10), 2941-2946 (2020).","journal-title":"transplantation proceedings"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13019-020-01158-3","type":"journal-article","article-title":"Development of an effective method utilizing fibrin glue to repair pleural defects in an ex-vivo pig model","volume":"15","author":"Kondo","year":"2020","unstructured":"Kondo, N. Development of an effective method utilizing fibrin glue to repair pleural defects in an ex-vivo pig model. Journal of Cardiothoracic Surgery. 15 (1), 110 (2020).","journal-title":"Journal of Cardiothoracic Surgery"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.actbio.2021.06.048","type":"journal-article","article-title":"Development of alginate and gelatin-based pleural and tracheal sealants","volume":"131","author":"Gasek","year":"2021","unstructured":"Gasek, N. et al. Development of alginate and gelatin-based pleural and tracheal sealants. Acta Biomaterialia. 131, 222-235 (2021).","journal-title":"Acta Biomaterialia"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00540-021-03012-9","type":"journal-article","article-title":"Effects of individualized positive end-expiratory pressure combined with recruitment maneuver on intraoperative ventilation during abdominal surgery: a systematic review and network meta-analysis of randomized controlled trials","volume":"36","author":"Li","year":"2022","unstructured":"Li, X. et al. Effects of individualized positive end-expiratory pressure combined with recruitment maneuver on intraoperative ventilation during abdominal surgery: a systematic review and network meta-analysis of randomized controlled trials. Journal of Anesthesia. 36 (2), 303-315 (2022).","journal-title":"Journal of Anesthesia"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jtcvs.2020.10.142","type":"journal-article","article-title":"Recruitment maneuvers to reduce pulmonary atelectasis after cardiac surgery: A meta-analysis of randomized trials","volume":"164","author":"Hu","year":"2020","unstructured":"Hu, M. C., Yang, Y. L., Chen, T. T., Lee, C. I., Tam, K. W. T. Recruitment maneuvers to reduce pulmonary atelectasis after cardiac surgery: A meta-analysis of randomized trials. The Journal of Thoracic and Cardiovascular Surgery. 164 (1), 171-181 (2020).","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s11748-021-01673-7","type":"journal-article","article-title":"Recruitment maneuvers in patients undergoing thoracic surgery: a meta-analysis","volume":"69","author":"Hu","year":"2021","unstructured":"Hu, M. C. et al. Recruitment maneuvers in patients undergoing thoracic surgery: a meta-analysis. General Thoracic and Cardiovascular Surgery. 69 (12), 1553-1559 (2021).","journal-title":"General Thoracic and Cardiovascular Surgery"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/ALN.0000000000003943","type":"journal-article","article-title":"Perioperative pulmonary atelectasis: Part I. Biology and mechanisms","volume":"136","author":"Zeng","year":"2022","unstructured":"Zeng, C., Lagier, D., Lee, J. W., Melo, M. F. V. Perioperative pulmonary atelectasis: Part I. Biology and mechanisms. Anesthesiology. 136 (1), 181-205 (2022).","journal-title":"Anesthesiology"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.21037\/jtd-22-226","type":"journal-article","article-title":"Lung recruitment after cardiac arrest during procurement of atelectatic donor lungs is a protective measure in lung transplantation","volume":"14","author":"Niman","year":"2022","unstructured":"Niman, E. et al. Lung recruitment after cardiac arrest during procurement of atelectatic donor lungs is a protective measure in lung transplantation. Journal of Thoracic Disease. 14 (8), 2802-2811 (2022).","journal-title":"Journal of Thoracic Disease"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.rvsc.2022.06.016","type":"journal-article","article-title":"Comparison of the efficacy of two alveolar recruitment maneuvers in improving the lung mechanics and the degree of atelectasis in anesthetized healthy sheep","volume":"150","author":"Calvo","year":"2022","unstructured":"Calvo, R. N. et al. Comparison of the efficacy of two alveolar recruitment maneuvers in improving the lung mechanics and the degree of atelectasis in anesthetized healthy sheep. Research in Veterinary Science. 150 (5), 164-169 (2022).","journal-title":"Research in Veterinary Science"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s00134-019-05821-9","type":"journal-article","article-title":"Effect of lung recruitment maneuver on oxygenation, physiological parameters and mortality in acute respiratory distress syndrome patients: a systematic review and meta-analysis","volume":"45","author":"Pensier","year":"2019","unstructured":"Pensier, J. et al. Effect of lung recruitment maneuver on oxygenation, physiological parameters and mortality in acute respiratory distress syndrome patients: a systematic review and meta-analysis. Intensive Care Medicine. 45 (12), 1691-1702 (2019).","journal-title":"Intensive Care Medicine"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12931-022-01999-7","type":"journal-article","article-title":"Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation","volume":"23","author":"Mariano","year":"2022","unstructured":"Mariano, C. A., Sattari, S., Quiros, K. A. M., Nelson T. M., Eskandari, M. Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation. Respiratory Research. 23 (1), 92 (2022).","journal-title":"Respiratory Research"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64850\/ex-vivo-porcine-experimental-model-for-studying-teaching-lung","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:03:42Z","timestamp":1792602222000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":35,"journal-issue":{"issue":"206","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3791\/64850","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,19]]}}}