{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:38:28Z","timestamp":1792611508819,"version":"4.5.0"},"reference-count":15,"publisher":"MyJove Corporation","issue":"192","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64886","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T19:00:07Z","timestamp":1677265207000},"source":"Crossref","is-referenced-by-count":6,"title":["Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice"],"prefix":"10.3791","author":[{"given":"Kyra","family":"Harvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Madsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Patterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Vitanza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B.","family":"Storm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Resnick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref1","first-page":"1","type":"journal-article","article-title":"Declines in cancer death rates among children and adolescents in the United States, 1999-2014","volume":"257","author":"Curtin","year":"2016","unstructured":"Curtin, S. C., Minino, A. M., Anderson, R. N. Declines in cancer death rates among children and adolescents in the United States, 1999-2014. NCHS Data Brief. 257, 1-8 (2016).","journal-title":"NCHS Data Brief"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00428-018-2484-0","type":"journal-article","article-title":"Adoptive cellular therapies: the current landscape","volume":"474","author":"Rohaan","year":"2019","unstructured":"Rohaan, M. W., Wilgenhof, S., Haanen, J. B. A. G. Adoptive cellular therapies: the current landscape. Virchows Archiv. 474 (4), 449-461 (2019).","journal-title":"Virchows Archiv"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1158\/2159-8290.CD-12-0548","type":"journal-article","article-title":"The basic principles of chimeric antigen receptor design","volume":"3","author":"Sadelain","year":"2013","unstructured":"Sadelain, M., Brentjens, R., Riviere, I. The basic principles of chimeric antigen receptor design. Cancer Discovery. 3 (4), 388-398 (2013).","journal-title":"Cancer Discovery"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMoa1709866","type":"journal-article","article-title":"Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia","volume":"378","author":"Maude","year":"2018","unstructured":"Maude, S. L. et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. The New England Journal of Medicine. 378 (5), 439-448 (2018).","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.ymthe.2020.09.015","type":"journal-article","article-title":"CAR T cell therapy for solid tumors: Bright future or dark reality","volume":"28","author":"Wagner","year":"2020","unstructured":"Wagner, J., Wickman, E., DeRenzo, C., Gottschalk, S. CAR T cell therapy for solid tumors: Bright future or dark reality? Molecular Therapy. 28 (11), 2320-2339 (2020).","journal-title":"Molecular Therapy"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/s41591-021-01404-8","type":"journal-article","article-title":"Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis","volume":"27","author":"Vitanza","year":"2021","unstructured":"Vitanza, N. A. et al. Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis. Nature Medicine. 27 (9), 1544-1552 (2021).","journal-title":"Nature Medicine"},{"issue":"7903","key":"ref7","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41586-022-04489-4","type":"journal-article","article-title":"GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas","volume":"603","author":"Majzner","year":"2022","unstructured":"Majzner, R. G. et al. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature. 603 (7903), 934-941 (2022).","journal-title":"Nature"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1158\/2159-8290.CD-22-0750","type":"journal-article","article-title":"Intraventricular B7-H3 CAR T cells for diffuse intrinsic pontine glioma: preliminary first-in-human bioactivity and safety","volume":"13","author":"Vitanza","year":"2023","unstructured":"Vitanza, N. A. et al. Intraventricular B7-H3 CAR T cells for diffuse intrinsic pontine glioma: preliminary first-in-human bioactivity and safety. Cancer Discovery. 13 (1), 114-131 (2023).","journal-title":"Cancer Discovery"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41591-020-0821-8","type":"journal-article","article-title":"Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid\/rhabdoid tumors","volume":"26","author":"Theruvath","year":"2020","unstructured":"Theruvath, J. et al. Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid\/rhabdoid tumors. Nature Medicine. 26 (5), 712-719 (2020).","journal-title":"Nature Medicine"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41591-020-0827-2","type":"journal-article","article-title":"Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma","volume":"26","author":"Donovan","year":"2020","unstructured":"Donovan, L. K. et al. Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nature Medicine. 26 (5), 720-731 (2020).","journal-title":"Nature Medicine"},{"issue":"26","key":"ref11","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1056\/NEJMoa1610497","type":"journal-article","article-title":"Regression of glioblastoma after chimeric antigen receptor T-Cell therapy","volume":"375","author":"Brown","year":"2016","unstructured":"Brown, C. E. et al. Regression of glioblastoma after chimeric antigen receptor T-Cell therapy. The New England Journal of Medicine. 375 (26), 2561-2569 (2016).","journal-title":"The New England Journal of Medicine"},{"issue":"1-2","key":"ref12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.1440-1681.2003.03789.x","type":"journal-article","article-title":"Intracerebral microdialysis: 30 years as a tool for the neuroscientist","volume":"30","author":"Bourne","year":"2003","unstructured":"Bourne, J. A. Intracerebral microdialysis: 30 years as a tool for the neuroscientist. Clinical and Experimental Pharmacology and Physiology. 30 (1-2), 16-24 (2003).","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"0244378","DOI":"10.1371\/journal.pone.0244378","type":"journal-article","article-title":"Automatically detecting bregma and lambda points in rodent skull anatomy images","volume":"15","author":"Zhou","year":"2020","unstructured":"Zhou, P. et al. Automatically detecting bregma and lambda points in rodent skull anatomy images. PLoS One. 15 (12), e0244378 (2020).","journal-title":"PLoS One"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"004450","DOI":"10.1136\/jitc-2021-004450","type":"journal-article","article-title":"Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors","volume":"10","author":"Foster","year":"2022","unstructured":"Foster, J. B. et al. Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. Journal for Immunotherapy of Cancer. 10 (9), e004450 (2022).","journal-title":"Journal for Immunotherapy of Cancer"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/imr.12773","type":"journal-article","article-title":"T cells for brain tumors: Lessons learned and road ahead","volume":"290","author":"Akhavan","year":"2019","unstructured":"Akhavan, D. et al. CAR T cells for brain tumors: Lessons learned and road ahead. Immunological Reviews. 290 (1), 60-84 (2019).","journal-title":"Immunological Reviews"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/64886\/intracranial-cannula-implantation-for-serial-locoregional-chimeric","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:45:44Z","timestamp":1792608344000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":15,"journal-issue":{"issue":"192","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3791\/64886","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]}}}