{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:39:14Z","timestamp":1792611554323,"version":"4.5.0"},"reference-count":32,"publisher":"MyJove Corporation","issue":"192","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/64932","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T09:43:29Z","timestamp":1678873409000},"source":"Crossref","is-referenced-by-count":1,"title":["An Innovative Toolkit to Investigate the Complex Mechanisms of Cardiac Arrhythmias"],"prefix":"10.3791","author":[{"given":"Sebastian","family":"Clauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3389\/fphys.2018.01380","type":"journal-article","article-title":"Calcium in the pathophysiology of atrial fibrillation and heart failure","volume":"9","author":"Denham","year":"2018","unstructured":"Denham, N. C. et al. Calcium in the pathophysiology of atrial fibrillation and heart failure. Frontiers in Physiology. 9, 1380 (2018).","journal-title":"Frontiers in Physiology"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/CIRCRESAHA.111.253955","type":"journal-article","article-title":"Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation","volume":"109","author":"Grandi","year":"2011","unstructured":"Grandi, E. et al. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research. 109 (9), 1055-1066 (2011).","journal-title":"Circulation Research"},{"issue":"165","key":"ref3","first-page":"e61964","type":"journal-article","article-title":"Isolation of high quality murine atrial and ventricular myocytes for simultaneous measurements of Ca2+ transients and L-Type calcium current","author":"Tomsits","year":"2020","unstructured":"Tomsits, P., Schuttler, D., Kaab, S., Clauss, S., Voigt, N. Isolation of high quality murine atrial and ventricular myocytes for simultaneous measurements of Ca2+ transients and L-Type calcium current. Journal of Visualized Experiments. (165), 10.3791\/61964 (2020).","journal-title":"Journal of Visualized Experiments"},{"issue":"73","key":"ref4","first-page":"e50145","type":"journal-article","article-title":"Isolation and Kv channel recordings in murine atrial and ventricular cardiomyocytes","author":"Kohncke","year":"2013","unstructured":"Kohncke, C. et al. Isolation and Kv channel recordings in murine atrial and ventricular cardiomyocytes. Journal of Visualized Experiments. (73), e50145 (2013).","journal-title":"Journal of Visualized Experiments"},{"issue":"166","key":"ref5","first-page":"e61890","type":"journal-article","article-title":"Single-Cell optical action potential measurement in human induced pluripotent stem cell-derived cardiomyocytes","author":"Seibertz","year":"2020","unstructured":"Seibertz, F., Reynolds, M., Voigt, N. Single-Cell optical action potential measurement in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Visualized Experiments. (166), 10.3791\/61890 (2020).","journal-title":"Journal of Visualized Experiments"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s44161-022-00094-w","type":"journal-article","article-title":"Neutrophils incite and macrophages avert electrical storm after myocardial infarction","volume":"1","author":"Grune","year":"2022","unstructured":"Grune, J. et al. Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nature Cardiovascular Research. 1 (7), 649-664 (2022).","journal-title":"Nature Cardiovascular Research"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","type":"journal-article","article-title":"Macrophages facilitate electrical conduction in the heart","volume":"169","author":"Hulsmans","year":"2017","unstructured":"Hulsmans, M. et al. Macrophages facilitate electrical conduction in the heart. Cell. 169 (3), 510-522 e520 (2017).","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"900094","DOI":"10.3389\/fphys.2022.900094","type":"journal-article","article-title":"Cardiac macrophages and their effects on arrhythmogenesis","volume":"13","author":"Xia","year":"2022","unstructured":"Xia, R. et al. Cardiac macrophages and their effects on arrhythmogenesis. Frontiers in Physiology. 13, 900094 (2022).","journal-title":"Frontiers in Physiology"},{"issue":"171","key":"ref9","first-page":"e62236","type":"journal-article","article-title":"Isolation and culture of resident cardiac macrophages from the murine sinoatrial and atrioventricular node","author":"Xia","year":"2021","unstructured":"Xia, R. et al. Isolation and culture of resident cardiac macrophages from the murine sinoatrial and atrioventricular node. Journal of Visualized Experiments. (171), 10.3791\/62236 (2021).","journal-title":"Journal of Visualized Experiments"},{"issue":"166","key":"ref10","first-page":"e62058","type":"journal-article","article-title":"Whole-Mount immunofluorescence staining, confocal imaging and 3D reconstruction of the sinoatrial and atrioventricular node in the mouse","author":"Xia","year":"2020","unstructured":"Xia, R. et al. Whole-Mount immunofluorescence staining, confocal imaging and 3D reconstruction of the sinoatrial and atrioventricular node in the mouse. Journal of Visualized Experiments. (166), 10.3791\/62058 (2020).","journal-title":"Journal of Visualized Experiments"},{"issue":"173","key":"ref11","first-page":"e62735","type":"journal-article","article-title":"Microelectrode array recording of sinoatrial node firing rate to identify intrinsic cardiac pacemaking defects in mice","author":"Kumar","year":"2021","unstructured":"Kumar, P., Si, M., Paulhus, K., Glasscock, E. Microelectrode array recording of sinoatrial node firing rate to identify intrinsic cardiac pacemaking defects in mice. Journal of Visualized Experiments. (173), 10.3791\/62735 (2021).","journal-title":"Journal of Visualized Experiments"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.hrthm.2010.05.020","type":"journal-article","article-title":"Cardiac neural remodeling and its role in arrhythmogenesis","volume":"7","author":"Chen","year":"2010","unstructured":"Chen, P. S., Choi, E. K., Zhou, S., Lin, S. F., Chen, L. S. Cardiac neural remodeling and its role in arrhythmogenesis. Heart Rhythm. 7 (10), 1512-1513 (2010).","journal-title":"Heart Rhythm"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1161\/CIRCRESAHA.116.304679","type":"journal-article","article-title":"Cardiac innervation and sudden cardiac death","volume":"116","author":"Fukuda","year":"2015","unstructured":"Fukuda, K., Kanazawa, H., Aizawa, Y., Ardell, J. L., Shivkumar, K. Cardiac innervation and sudden cardiac death. Circulation Research. 116 (12), 2005-2019 (2015).","journal-title":"Circulation Research"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"001359","DOI":"10.1161\/CIRCEP.115.001359","type":"journal-article","article-title":"Molecular mechanisms of sympathetic remodeling and arrhythmias","volume":"9","author":"Gardner","year":"2016","unstructured":"Gardner, R. T., Ripplinger, C. M., Myles, R. C., Habecker, B. A. Molecular mechanisms of sympathetic remodeling and arrhythmias. Circulation. Arrhythmia and Electrophysiology. 9 (2), e001359 (2016).","journal-title":"Circulation. Arrhythmia and Electrophysiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fcvm.2019.00027","type":"journal-article","article-title":"Cardiac sympathetic denervation in channelopathies","volume":"6","author":"Dusi","year":"2019","unstructured":"Dusi, V., De Ferrari, G. M., Pugliese, L., Schwartz, P. J. Cardiac sympathetic denervation in channelopathies. Frontiers in Cardiovascular Medicine. 6, 27 (2019).","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jacep.2021.09.002","type":"journal-article","article-title":"Left cardiac sympathetic denervation for long QT syndrome: 50 years' experience provides guidance for management","volume":"8","author":"Dusi","year":"2022","unstructured":"Dusi, V. et al. Left cardiac sympathetic denervation for long QT syndrome: 50 years' experience provides guidance for management. JACC Clinical Electrophysiology. 8 (3), 281-294 (2022).","journal-title":"JACC Clinical Electrophysiology"},{"issue":"25","key":"ref17","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1161\/CIRCULATIONAHA.115.015731","type":"journal-article","article-title":"Clinical management of catecholaminergic polymorphic ventricular tachycardia: The role of left cardiac sympathetic denervation","volume":"131","author":"De Ferrari","year":"2015","unstructured":"De Ferrari, G. M. et al. Clinical management of catecholaminergic polymorphic ventricular tachycardia: The role of left cardiac sympathetic denervation. Circulation. 131 (25), 2185-2193 (2015).","journal-title":"Circulation"},{"issue":"22","key":"ref18","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/eurheartj\/ehac134","type":"journal-article","article-title":"Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias","volume":"43","author":"Schwartz","year":"2022","unstructured":"Schwartz, P. J., Ackerman, M. J. Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias. European Heart Journal. 43 (22), 2096-2102 (2022).","journal-title":"European Heart Journal"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/clc.23190","type":"journal-article","article-title":"The cardiac autonomic nervous system: A target for modulation of atrial fibrillation","volume":"42","author":"Qin","year":"2019","unstructured":"Qin, M., Zeng, C., Liu, X. The cardiac autonomic nervous system: A target for modulation of atrial fibrillation. Clinical Cardiology. 42 (6), 644-652 (2019).","journal-title":"Clinical Cardiology"},{"issue":"166","key":"ref20","first-page":"e62026","type":"journal-article","article-title":"dissection, and analysis of the murine stellate ganglion","author":"Scherschel","year":"2020","unstructured":"Scherschel, K. et al. Location, dissection, and analysis of the murine stellate ganglion. Journal of Visualized Experiments. (166), 10.3791\/62026 (2020).","journal-title":"Journal of Visualized Experiments"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41569-019-0179-0","type":"journal-article","article-title":"Animal models of arrhythmia: classic electrophysiology to genetically modified large animals","volume":"16","author":"Clauss","year":"2019","unstructured":"Clauss, S. et al. Animal models of arrhythmia: classic electrophysiology to genetically modified large animals. Nat Reviews. Cardiology. 16 (8), 457-475 (2019).","journal-title":"Nat Reviews. Cardiology"},{"issue":"181","key":"ref22","first-page":"e63405","type":"journal-article","article-title":"Removal of an internal translational start site from mRNA while retaining expression of the full-length protein","author":"Shimura","year":"2022","unstructured":"Shimura, D., Hunter, J., Katsumata, M., Shaw, R. M. Removal of an internal translational start site from mRNA while retaining expression of the full-length protein. Journal of Visualized Experiments. (181), 10.3791\/63405 (2022).","journal-title":"Journal of Visualized Experiments"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cvex.2021.08.013","type":"journal-article","article-title":"Sedation and anesthesia in rodents","volume":"25","author":"Bennett","year":"2022","unstructured":"Bennett, K., Lewis, K. Sedation and anesthesia in rodents. The Veterinary Clinics of North America. Exotic Animal Practice. 25 (1), 211-255 (2022).","journal-title":"The Veterinary Clinics of North America. Exotic Animal Practice"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41684-020-00684-w","type":"journal-article","article-title":"Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice","volume":"50","author":"Poon","year":"2021","unstructured":"Poon, Y. Y. et al. Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice. Lab Animal (NY). 50 (1), 26-31 (2021).","journal-title":"Lab Animal (NY)"},{"issue":"57","key":"ref25","first-page":"e3260","type":"journal-article","article-title":"Implantation of radiotelemetry transmitters yielding data on ECG, heart rate, core body temperature and activity in free-moving laboratory mice","author":"Cesarovic","year":"2011","unstructured":"Cesarovic, N., Jirkof, P., Rettich, A., Arras, M. Implantation of radiotelemetry transmitters yielding data on ECG, heart rate, core body temperature and activity in free-moving laboratory mice. Journal of Visualized Experiments. (57), 10.3791\/3260 (2011).","journal-title":"Journal of Visualized Experiments"},{"issue":"39","key":"ref26","first-page":"10","type":"journal-article","article-title":"Ambulatory ECG recording in mice","author":"McCauley","year":"2010","unstructured":"McCauley, M. D., Wehrens, X. H. Ambulatory ECG recording in mice. Journal of Visualized Experiments. (39), 10.3791\/1739 (2010).","journal-title":"Journal of Visualized Experiments"},{"issue":"168","key":"ref27","first-page":"e62101","type":"journal-article","article-title":"Implantation of combined telemetric ECG and blood pressure transmitters to determine spontaneous baroreflex sensitivity in conscious mice","author":"Rotzer","year":"2021","unstructured":"Rotzer, R. D. et al. Implantation of combined telemetric ECG and blood pressure transmitters to determine spontaneous baroreflex sensitivity in conscious mice. Journal of Visualized Experiments. (168), 10.3791\/62101 (2021).","journal-title":"Journal of Visualized Experiments"},{"issue":"171","key":"ref28","first-page":"e62386","type":"journal-article","article-title":"Analyzing long-term electrocardiography recordings to detect arrhythmias in mice","author":"Tomsits","year":"2021","unstructured":"Tomsits, P. et al. Analyzing long-term electrocardiography recordings to detect arrhythmias in mice. Journal of Visualized Experiments. (171), 10.3791\/62386 (2021).","journal-title":"Journal of Visualized Experiments"},{"issue":"186","key":"ref29","first-page":"e64038","type":"journal-article","article-title":"Preclinical evaluation of coronary artery stents","author":"Hytonen","year":"2022","unstructured":"Hytonen, J. P., Yla-Herttuala, S. Preclinical evaluation of coronary artery stents. Journal of Visualized Experiments. (186), 10.3791\/64038 (2022).","journal-title":"Journal of Visualized Experiments"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.17691\/stm2021.13.1.06","type":"journal-article","article-title":"Comparative analysis of the hemostasiological profile in sheep and patients with cardiovascular pathology as the basis for predicting thrombotic risks during preclinical tests of vascular prostheses","volume":"13","author":"Gruzdeva","year":"2021","unstructured":"Gruzdeva, O. V. et al. Comparative analysis of the hemostasiological profile in sheep and patients with cardiovascular pathology as the basis for predicting thrombotic risks during preclinical tests of vascular prostheses. Sovremennye Tekhnologii v Meditsine. 13 (1), 52-56 (2021).","journal-title":"Sovremennye Tekhnologii v Meditsine"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/03913988211025537","type":"journal-article","article-title":"The sheep as a pre-clinical model for testing intra-aortic percutaneous mechanical circulatory support devices","volume":"44","author":"Weisskopf","year":"2021","unstructured":"Weisskopf, M., Kron, M., Giering, T., Walker, T., Cesarovic, N. The sheep as a pre-clinical model for testing intra-aortic percutaneous mechanical circulatory support devices. The International Journal of Artificial Organs. 44 (10), 703-710 (2021).","journal-title":"The International Journal of Artificial Organs"},{"issue":"167","key":"ref32","first-page":"e62063","type":"journal-article","article-title":"Development and evaluation of 3D-printed cardiovascular phantoms for interventional planning and training","author":"Grab","year":"2021","unstructured":"Grab, M. et al. Development and evaluation of 3D-printed cardiovascular phantoms for interventional planning and training. Journal of Visualized Experiments. (167), 10.3791\/62063 (2021).","journal-title":"Journal of Visualized Experiments"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:50:03Z","timestamp":1792608603000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/64932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":32,"journal-issue":{"issue":"192","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3791\/64932","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}