{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:42:51Z","timestamp":1792604571250,"version":"4.5.0"},"reference-count":15,"publisher":"MyJove Corporation","issue":"204","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/65935","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T19:00:55Z","timestamp":1708110055000},"source":"Crossref","is-referenced-by-count":5,"title":["The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice"],"prefix":"10.3791","author":[{"given":"Asad A.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Blackmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(00)01019-3","type":"journal-article","article-title":"Functional inactivation of dorsal hippocampus impairs active place avoidance in rats","volume":"285","author":"Cimadevilla","year":"2000","unstructured":"Cimadevilla, J. M., Fenton, A. A., Bures, J. Functional inactivation of dorsal hippocampus impairs active place avoidance in rats. Neurosci Lett. 285 (1), 53-56 (2000).","journal-title":"Neurosci Lett"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fnbeh.2017.00197","type":"journal-article","article-title":"Protocol for short- and longer-term spatial learning and memory in mice","volume":"11","author":"Willis","year":"2017","unstructured":"Willis, E. F., Bartlett, P. F., Vukovic, J. Protocol for short- and longer-term spatial learning and memory in mice. Front Behav Neurosci. 11,197 (2017).","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"101500","DOI":"10.1016\/j.xpro.2022.101500","type":"journal-article","article-title":"Protocol for three alternative paradigms to test spatial learning and memory in mice","volume":"3","author":"Blackmore","year":"2022","unstructured":"Blackmore, D. G., Brici, D., Walker, T. L. Protocol for three alternative paradigms to test spatial learning and memory in mice. STAR Protoc. 3 (3), 101500 (2022).","journal-title":"STAR Protoc"},{"issue":"5790","key":"ref4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.1128657","type":"journal-article","article-title":"Storage of spatial information by the maintenance mechanism of LTP","volume":"313","author":"Pastalkova","year":"2006","unstructured":"Pastalkova, E. et al. Storage of spatial information by the maintenance mechanism of LTP. Science. 313 (5790), 1141-1144 (2006).","journal-title":"Science"},{"issue":"Suppl 1","key":"ref5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.33549\/physiolres.932635","type":"journal-article","article-title":"Place avoidance tasks as tools in the behavioral neuroscience of learning and memory","volume":"62","author":"Stuchlik","year":"2013","unstructured":"Stuchlik, A. et al. Place avoidance tasks as tools in the behavioral neuroscience of learning and memory. Physiol Res. 62 (Suppl 1), S1-S19 (2013).","journal-title":"Physiol Res"},{"issue":"15","key":"ref6","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1523\/JNEUROSCI.3064-12.2013","type":"journal-article","article-title":"Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering","volume":"33","author":"Vukovic","year":"2013","unstructured":"Vukovic, J. et al. Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. J Neurosci. 33 (15), 6603-6613 (2013).","journal-title":"J Neurosci"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"103275","DOI":"10.1016\/j.isci.2021.103275","type":"journal-article","article-title":"An exercise &#34;sweet spot&#34; reverses cognitive deficits of aging by growth-hormone-induced neurogenesis","volume":"24","author":"Blackmore","year":"2021","unstructured":"Blackmore, D. G. et al. An exercise \"sweet spot\" reverses cognitive deficits of aging by growth-hormone-induced neurogenesis. iScience. 24 (11), 103275 (2021).","journal-title":"iScience"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"19269","DOI":"10.1038\/s41598-020-76176-1","type":"journal-article","article-title":"Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis","volume":"10","author":"Codd","year":"2020","unstructured":"Codd, L. N., Blackmore, D. G., Vukovic, J., Bartlett, P. F. Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis. Sci Rep. 10 (1), 19269 (2020).","journal-title":"Sci Rep"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbr.2008.10.015","type":"journal-article","article-title":"Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks","volume":"198","author":"Harrison","year":"2009","unstructured":"Harrison, F. E., Hosseini, A. H., McDonald, M. P. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav Brain Res. 198 (1), 247-251 (2009).","journal-title":"Behav Brain Res"},{"issue":"38","key":"ref10","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1731-05.2005","type":"journal-article","article-title":"Exercise enhances learning and hippocampal neurogenesis in aged mice","volume":"25","author":"van Praag","year":"2005","unstructured":"van Praag, H., Shubert, T., Zhao, C., Gage, F. H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 25 (38), 8680-8685 (2005).","journal-title":"J Neurosci"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"103450","DOI":"10.1016\/j.isci.2021.103450","type":"journal-article","article-title":"Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice","volume":"24","author":"Zhou","year":"2021","unstructured":"Zhou, X. A. et al. Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice. iScience. 24 (12), 103450 (2021).","journal-title":"iScience"},{"issue":"278","key":"ref12","doi-asserted-by":"crossref","first-page":"278ra33","DOI":"10.1126\/scitranslmed.aaa2512","type":"journal-article","article-title":"Scanning ultrasound removes amyloid-\u03b2 and restores memory in an Alzheimer's disease mouse model","volume":"7","author":"Leinenga","year":"2015","unstructured":"Leinenga, G., Gotz, J. Scanning ultrasound removes amyloid-\u03b2 and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 7 (278), 278ra33 (2015).","journal-title":"Sci Transl Med"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","type":"journal-article","article-title":"Repopulating microglia promote brain repair in an IL-6-dependent manner","volume":"180","author":"Willis","year":"2020","unstructured":"Willis, E. F. et al. Repopulating microglia promote brain repair in an IL-6-dependent manner. Cell. 180 (5), 833-846 e816 (2020).","journal-title":"Cell"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/hipo.22666","type":"journal-article","article-title":"Active place avoidance is no more stressful than unreinforced exploration of a familiar environment","volume":"26","author":"Lesburgueres","year":"2016","unstructured":"Lesburgueres, E., Sparks, F. T., O'Reilly, K. C., Fenton, A. A. Active place avoidance is no more stressful than unreinforced exploration of a familiar environment. Hippocampus. 26 (12), 1481-1485 (2016).","journal-title":"Hippocampus"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuron.2008.03.001","type":"journal-article","article-title":"Behavioral phenotyping strategies for mutant mice","volume":"57","author":"Crawley","year":"2008","unstructured":"Crawley, J. N. Behavioral phenotyping strategies for mutant mice. Neuron. 57 (6), 809-818, (2008).","journal-title":"Neuron"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/65935\/the-active-place-avoidance-apa-test-an-effective-versatile-repeatable","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:14:18Z","timestamp":1792602858000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/65935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":15,"journal-issue":{"issue":"204","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3791\/65935","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]}}}