{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:39:45Z","timestamp":1792604385427,"version":"4.5.0"},"reference-count":32,"publisher":"MyJove Corporation","issue":"206","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/65969","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T20:00:51Z","timestamp":1713556851000},"source":"Crossref","is-referenced-by-count":1,"title":["The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3791","author":[{"given":"Chuyao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"755875","DOI":"10.3389\/fncel.2021.755875","type":"journal-article","article-title":"The causes and long-term consequences of viral encephalitis","volume":"15","author":"Bohmwald","year":"2021","unstructured":"Bohmwald, K. et al. The causes and long-term consequences of viral encephalitis. Front Cellular Neurosci. 15, 755875 (2021).","journal-title":"Front Cellular Neurosci"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","type":"journal-article","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium","volume":"57","author":"Venkatesan","year":"2013","unstructured":"Venkatesan, A. et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 57 (8), 1114-1128 (2013).","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"0209993","DOI":"10.1371\/journal.pone.0209993","type":"journal-article","article-title":"Molecular characterization of viruses associated with encephalitis in S\u00e3o Paulo, Brazil","volume":"14","author":"Ferreira","year":"2019","unstructured":"Ferreira, J. E. et al. Molecular characterization of viruses associated with encephalitis in S\u00e3o Paulo, Brazil. PLoS One. 14 (1), e0209993 (2019).","journal-title":"PLoS One"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ana.25131","type":"journal-article","article-title":"Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis","volume":"83","author":"Dubey","year":"2018","unstructured":"Dubey, D. et al. Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis. Ann Neurol. 83 (1), 166-177 (2018).","journal-title":"Ann Neurol"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1212\/WNL.0000000000000086","type":"journal-article","article-title":"Burden of encephalitis-associated hospitalizations in the United States","volume":"82","author":"Vora","year":"2014","unstructured":"Vora, N. M. et al. Burden of encephalitis-associated hospitalizations in the United States, 1998-2010. Neurology. 82 (5), 443-451 (2014).","journal-title":"Neurology"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"e104169","DOI":"10.1371\/journal.pone.0104169","type":"journal-article","article-title":"Encephalitis hospitalization rates and inpatient mortality in the United States","volume":"9","author":"George","year":"2014","unstructured":"George, B. P., Schneider, E. B., Venkatesan, A. Encephalitis hospitalization rates and inpatient mortality in the United States, 2000-2010. PLoS One. 9 (9), e104169 (2014).","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1104858","DOI":"10.3389\/fcimb.2023.1104858","type":"journal-article","article-title":"Metagenomic next-generation sequencing and proteomics analysis in pediatric viral encephalitis and meningitis","volume":"13","author":"Wang","year":"2023","unstructured":"Wang, Y. L. et al. Metagenomic next-generation sequencing and proteomics analysis in pediatric viral encephalitis and meningitis. Front Cell Infect Microbiol. 13, 1104858 (2023).","journal-title":"Front Cell Infect Microbiol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMra1708714","type":"journal-article","article-title":"Acute viral encephalitis","volume":"379","author":"Tyler","year":"2018","unstructured":"Tyler, K. L. Acute viral encephalitis. N Engl J Med. 379 (6), 557-566 (2018).","journal-title":"N Engl J Med"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/WCO.0000000000001155","type":"journal-article","article-title":"Diagnosing viral encephalitis and emerging concepts","volume":"36","author":"Yong","year":"2023","unstructured":"Yong, H. Y. F., Pastula, D. M., Kapadia, R. K. Diagnosing viral encephalitis and emerging concepts. Curr Opin Neurol. 36 (3), 175-184 (2023).","journal-title":"Curr Opin Neurol"},{"key":"ref10","first-page":"933","type":"journal-article","article-title":"Experts consensus on clinical application of Angong Niuhuang Pill","volume":"42","year":"2022","unstructured":"Association, China Medical Education. Experts consensus on clinical application of Angong Niuhuang Pill. Chi J Integr. 42, 933-946 (2022).","journal-title":"Chi J Integr"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s40279-016-0552-7","type":"journal-article","article-title":"Effects of psychological and psychosocial interventions on sport performance: A meta-analysis","volume":"47","author":"Brown","year":"2017","unstructured":"Brown, D. J., Fletcher, D. Effects of psychological and psychosocial interventions on sport performance: A meta-analysis. Sports Med. 47 (1), 77-99 (2017).","journal-title":"Sports Med"},{"key":"ref12","first-page":"1827","type":"journal-article","article-title":"Clinical study on Angong Niuhuang Pills combined with human immunoglobulin in treatment of children with severe viral encephalitis","volume":"37","author":"Wang","year":"2022","unstructured":"Wang, Y. C., Pan, X. J., Ma, L. Clinical study on Angong Niuhuang Pills combined with human immunoglobulin in treatment of children with severe viral encephalitis. Drugs & Clinic. 37, 1827-1831 (2022).","journal-title":"Drugs & Clinic"},{"key":"ref13","first-page":"909","type":"journal-article","article-title":"Clinical study on Angong Niuhuang Pills combined with acyclovir in treatment of viral encephalitis in children","volume":"35","author":"Zhao","year":"2020","unstructured":"Zhao, C. H., Fu, Y. X., Zhao, S. Q. Clinical study on Angong Niuhuang Pills combined with acyclovir in treatment of viral encephalitis in children. Drugs & Clinic. 35, 909-913 (2020).","journal-title":"Drugs & Clinic"},{"key":"ref14","first-page":"1337","type":"journal-article","article-title":"Clinical study on Angong Niuhuang Pills combined with ganciclovir in treatment of severe viral encephalitis","volume":"35","author":"Li","year":"2020","unstructured":"Li, W. J. Clinical study on Angong Niuhuang Pills combined with ganciclovir in treatment of severe viral encephalitis. Drugs & Clinic. 35, 1337-1340 (2020).","journal-title":"Drugs & Clinic"},{"key":"ref15","first-page":"110","type":"journal-article","article-title":"Clinical observation on efficacy of combined treatment with Angong Niuhuang Pills in the treatment of pediatric viral encephalitis","volume":"16","author":"Pang","year":"2019","unstructured":"Pang, S. K. Clinical observation on efficacy of combined treatment with Angong Niuhuang Pills in the treatment of pediatric viral encephalitis. Chinese Journal of Rational Drug Use. 16, 110-112 (2019).","journal-title":"Chinese Journal of Rational Drug Use"},{"key":"ref16","first-page":"755","type":"journal-article","article-title":"Clinical study on Angong Niuhuang Pills combined with ganglioside in treatment of viral encephalitis in children","volume":"34","author":"Fu","year":"2019","unstructured":"Fu, Y. Clinical study on Angong Niuhuang Pills combined with ganglioside in treatment of viral encephalitis in children. Drugs & Clinic. 34, 755-760 (2019).","journal-title":"Drugs & Clinic"},{"issue":"29","key":"ref17","first-page":"5995","type":"journal-article","article-title":"Clinical treatment and observation of 34 cases of children with Japanese encephalitis","volume":"2","author":"Huang","year":"2015","unstructured":"Huang, Q. D. Clinical treatment and observation of 34 cases of children with Japanese encephalitis. Electron J Clinic Med Literature. 2 (29), 5995-5996 (2015).","journal-title":"Electron J Clinic Med Literature"},{"issue":"4","key":"ref18","first-page":"326","type":"journal-article","article-title":"Effect of Angong Niuhuang pill on the treatment of viral encephalitis in children","volume":"6","author":"Zhang","year":"2014","unstructured":"Zhang, H. J., Dong, X. L. Effect of Angong Niuhuang pill on the treatment of viral encephalitis in children. Zhongguo Zhong xi yi jie he er ke xue\u200b. 6 (4), 326-328 (2014).","journal-title":"Zhongguo Zhong xi yi jie he er ke xue"},{"issue":"30","key":"ref19","first-page":"177","type":"journal-article","article-title":"Angong Niuhuang pill in treatment of children with viral encephalitis through retention enema","volume":"11","author":"Lin","year":"2013","unstructured":"Lin, S. L., Lin, D. H. Angong Niuhuang pill in treatment of children with viral encephalitis through retention enema. Guide China Med. 11 (30), 177-178 (2013).","journal-title":"Guide China Med"},{"key":"ref20","first-page":"13","type":"journal-article","article-title":"Comparative study on treatment of Japanese encephalitis with integrated Chinese and Western medicine","volume":"33","author":"Zhou","year":"2011","unstructured":"Zhou, H. L., Yan, Y., Hua, D. L. Comparative study on treatment of Japanese encephalitis with integrated Chinese and Western medicine. Hubei Journal of Traditional Chinese Medicine. 33, 13-14 (2011).","journal-title":"Hubei Journal of Traditional Chinese Medicine"},{"key":"ref21","first-page":"109","type":"journal-article","article-title":"Observation on the effect of combined treatment of Chinese and Western medicine on children with viral encephalitis","volume":"8","author":"Liang","year":"2010","unstructured":"Liang, H. R. Observation on the effect of combined treatment of Chinese and Western medicine on children with viral encephalitis. Guide of China Medicine. 8, 109-110 (2010).","journal-title":"Guide of China Medicine"},{"issue":"7","key":"ref22","first-page":"22","type":"journal-article","article-title":"Study on treatment of viral encephalitis of children by Angong Niuhuang Pill combined naloxone","volume":"2","author":"Tang","year":"2008","unstructured":"Tang, J. Q., Sun, J. M., Zhang, F. R. et al. Study on treatment of viral encephalitis of children by Angong Niuhuang Pill combined naloxone. China Clinic Pract Med. 2 (7), 22-24 (2008).","journal-title":"China Clinic Pract Med"},{"issue":"6","key":"ref23","first-page":"33","type":"journal-article","article-title":"Clinical observation of adjuvant therapy with Angong Niuhuang pill in the treatment of viral encephalitis","volume":"28","author":"Yu","year":"2006","unstructured":"Yu, P. L., Yan, S. Q. Clinical observation of adjuvant therapy with Angong Niuhuang pill in the treatment of viral encephalitis. Hubei Zhongyi zazhi. 28 (6), 33 (2006).","journal-title":"Hubei Zhongyi zazhi"},{"issue":"11","key":"ref24","first-page":"43","type":"journal-article","article-title":"Clinical observation of adjuvant therapy with Angong Niuhuang Pill in the treatment of 42 children with severe viral encephalitis","author":"Wang","year":"1997","unstructured":"Wang, Q. Clinical observation of adjuvant therapy with Angong Niuhuang Pill in the treatment of 42 children with severe viral encephalitis. Zhongguo Zhongxiyi jiehe jijiu zazhi. (11), 43 (1997).","journal-title":"Zhongguo Zhongxiyi jiehe jijiu zazhi"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15181","DOI":"10.1097\/MD.0000000000015181","type":"journal-article","article-title":"Evaluation of the adjunctive effect of Xing Nao Jing Injection for viral encephalitis: A systematic review and meta-analysis of randomized controlled trials","volume":"98","author":"Cao","year":"2019","unstructured":"Cao, H. J. et al. Evaluation of the adjunctive effect of Xing Nao Jing Injection for viral encephalitis: A systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore). 98, e15181 (2019).","journal-title":"Medicine (Baltimore)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1128\/AAC.02427-14","type":"journal-article","article-title":"Downregulation of cellular c-Jun N-terminal protein kinase and NF-\u03baB activation by berberine may result in inhibition of herpes simplex virus replication","volume":"58","author":"Song","year":"2014","unstructured":"Song, S. et al. Downregulation of cellular c-Jun N-terminal protein kinase and NF-\u03baB activation by berberine may result in inhibition of herpes simplex virus replication. Antimicrob Agents Chemother. 58, 5068-5078 (2014).","journal-title":"Antimicrob Agents Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"907047","DOI":"10.3389\/fimmu.2022.907047","type":"journal-article","article-title":"Baicalin induces a potent innate immune response to inhibit respiratory syncytial virus replication via regulating viral non-structural 1 and matrix RNA","volume":"13","author":"Qin","year":"2022","unstructured":"Qin, S., Huang, X., Qu, S. Baicalin induces a potent innate immune response to inhibit respiratory syncytial virus replication via regulating viral non-structural 1 and matrix RNA. Front Immunol. 13, 907047 (2022).","journal-title":"Front Immunol"},{"key":"ref28","type":"journal-article","article-title":"Borneol-modified Schisandrin B Micelles cross the blood-brain barrier to treat Alzheimer's disease in aged mice","author":"Li","year":"2024","unstructured":"Li, F. R. et al. Borneol-modified Schisandrin B Micelles cross the blood-brain barrier to treat Alzheimer's disease in aged mice. ACS Chem Neurosci. doi:10.1021\/acschemneuro.3c00625 (2024).","journal-title":"ACS Chem Neurosci"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.7555\/JBR.31.20160138","type":"journal-article","article-title":"Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines","volume":"31","author":"Chang","year":"2017","unstructured":"Chang, L. et al. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines. J Biomed Res. 31 (4), 306-314 (2017).","journal-title":"J Biomed Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"116647","DOI":"10.1016\/j.lfs.2019.116647","type":"journal-article","article-title":"Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin","volume":"232","author":"Wang","year":"2019","unstructured":"Wang, L. et al. Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin. Life Sci. 232, 116647 (2019).","journal-title":"Life Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"115475","DOI":"10.1016\/j.jep.2022.115475","type":"journal-article","article-title":"Proteomics on the role of muscone in the "consciousness-restoring resuscitation" effect of musk on ischemic stroke","volume":"296","author":"Han","year":"2022","unstructured":"Han, B. et al. Proteomics on the role of muscone in the \"consciousness-restoring resuscitation\" effect of musk on ischemic stroke. J Ethnopharmacol. 296, 115475 (2022).","journal-title":"J Ethnopharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"17562848231219234","DOI":"10.1177\/17562848231219234","type":"journal-article","article-title":"Association between hiatal hernia and Barrett's esophagus: an updated meta-analysis with trial sequential analysis","volume":"17","author":"Ma","year":"2024","unstructured":"Ma, S. et al. Association between hiatal hernia and Barrett's esophagus: an updated meta-analysis with trial sequential analysis. Therap Adv Gastroenterol. 17, 17562848231219234 (2024).","journal-title":"Therap Adv Gastroenterol"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/65969\/the-adjuvant-efficacy-angong-niuhuang-pill-treatment-viral","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:03:36Z","timestamp":1792602216000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/65969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":32,"journal-issue":{"issue":"206","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3791\/65969","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,19]]}}}