{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:46:59Z","timestamp":1792601219466,"version":"4.5.0"},"reference-count":16,"publisher":"MyJove Corporation","issue":"207","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/66635","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T20:00:10Z","timestamp":1716062410000},"source":"Crossref","is-referenced-by-count":0,"title":["A Rat Model of Middle Cerebral Artery Occlusion\/Reperfusion without Damaging the Anatomical Structure of Cerebral Vessels"],"prefix":"10.3791","author":[{"given":"Zhang","family":"Jiren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Yufei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huiwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shilei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Dongman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Mingming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Pinyuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"issue":"1","key":"ref1","first-page":"33","type":"journal-article","article-title":"China stroke surveillance report 2021","volume":"10","author":"Tu","year":"2023","unstructured":"Tu, W. J. et al. China stroke surveillance report 2021. Mil Med Res. 10 (1), 33 (2023).","journal-title":"Mil Med Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnmol.2020.00028","type":"journal-article","article-title":"Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury","volume":"13","author":"Wu","year":"2020","unstructured":"Wu, L. et al. Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front in Mol Neurosci. 13, 28 (2020).","journal-title":"Front in Mol Neurosci"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1212\/WNL.42.2.289","type":"journal-article","article-title":"Type and extent of hemispheric brain infarctions and clinical outcome in early and delayed middle cerebral artery recanalization","volume":"42","author":"Ringelstein","year":"1992","unstructured":"Ringelstein, E. B. et al. Type and extent of hemispheric brain infarctions and clinical outcome in early and delayed middle cerebral artery recanalization. Neurology. 42 (2), 289-298 (1992).","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3995\/jstroke.8.1","type":"journal-article","article-title":"Experimental studies of ischemic brain edema: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area","volume":"8","author":"Koizumi","year":"1986","unstructured":"Koizumi, J., Yoshida, Y., Nakazawa, T., Ooneda, G. E. Experimental studies of ischemic brain edema: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jap J Stroke. 8, 1-8 (1986).","journal-title":"Jap J Stroke"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","type":"journal-article","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","unstructured":"Longa, E. Z., Weinstein, P. R., Carlson, S., Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20 (1), 84-91 (1989).","journal-title":"Stroke"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s12975-011-0102-4","type":"journal-article","article-title":"A critical re-examination of the intraluminal filament MCAO model: Impact of external carotid artery transection","volume":"2","author":"Trueman","year":"2011","unstructured":"Trueman, R. C. et al. A critical re-examination of the intraluminal filament MCAO model: Impact of external carotid artery transection. Transl Stroke Res. 2 (4), 651-661 (2011).","journal-title":"Transl Stroke Res"},{"issue":"51","key":"ref7","first-page":"e2879","type":"journal-article","article-title":"Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser Doppler flowmetry guidance in mice","author":"Ansari","year":"2011","unstructured":"Ansari, S., Azari, H., McConnell, D. J., Afzal, A., Mocco, J. Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser Doppler flowmetry guidance in mice. J Vis Exp. 8 (51), e2879 (2011).","journal-title":"J Vis Exp"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s10020-022-00573-7","type":"journal-article","article-title":"Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-\u03baB signaling pathway","volume":"28","author":"Yu","year":"2022","unstructured":"Yu, Z. et al. Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-\u03baB signaling pathway. Mol Med. 28 (1), 142 (2022).","journal-title":"Mol Med"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","type":"journal-article","article-title":"Neurological Deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats","volume":"26","author":"Garcia","year":"1995","unstructured":"Garcia, J. H., Wagner, S., Liu, K. F., Hu, X. J. Neurological Deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Stroke. 26 (4), 627-634 (1995).","journal-title":"Stroke"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/jcbfm.2014.112","type":"journal-article","article-title":"3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow","volume":"34","author":"Bracko","year":"2014","unstructured":"Bracko, O. et al. 3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow. J Cereb Blood Flow Metab. 34 (9), 1522-1530 (2014).","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e60049","DOI":"10.1371\/journal.pone.0060049","type":"journal-article","article-title":"Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stroke model","volume":"8","author":"Goldmacher","year":"2013","unstructured":"Goldmacher, G. V. et al. Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stroke model. PLoS One. 8 (3), e60049 (2013).","journal-title":"PLoS One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2010.06.045","type":"journal-article","article-title":"The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease","volume":"481","author":"Lee","year":"2010","unstructured":"Lee, H. J. et al. The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease. Neurosci Lett. 481 (1), 30-35 (2010).","journal-title":"Neurosci Lett"},{"issue":"3","key":"ref13","first-page":"523","type":"journal-article","article-title":"Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia","volume":"38","author":"Connolly","year":"1996","unstructured":"Connolly, E. S., Winfree, C. J., Solomon, R. A. Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery. 38 (3), 523-531 (1996).","journal-title":"Neurosurgery"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/jcbfm.1993.87","type":"journal-article","article-title":"Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy","volume":"13","author":"Barone","year":"1993","unstructured":"Barone, F. C., Knudsen, D. J., Nelson, A. H., Feuerstein, G. Z., Willette, R. N. Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J Cereb Blood Flow Metab. 13 (4), 683-692 (1993).","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1161\/01.STR.0000083625.54851.9A","type":"journal-article","article-title":"External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats","volume":"34","author":"Dittmar","year":"2003","unstructured":"Dittmar, M., Spruss, T., Schuierer, G., Horn, M. External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats. Stroke. 34 (9), 2252-2257 (2003).","journal-title":"Stroke"},{"issue":"9","key":"ref16","first-page":"2252","type":"journal-article","article-title":"External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats","volume":"34","author":"Virtanen","year":"2004","unstructured":"Virtanen, T., Jolkkonen, J., Sivenius, J. External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats. Stroke. 34 (9), 2252-2257 (2004).","journal-title":"Stroke"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/66635\/a-rat-model-middle-cerebral-artery-occlusionreperfusion-without","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:25:46Z","timestamp":1792599946000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/66635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":16,"journal-issue":{"issue":"207","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3791\/66635","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]}}}