{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:44:49Z","timestamp":1792593889370,"version":"4.5.0"},"reference-count":14,"publisher":"MyJove Corporation","issue":"223","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/67240","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T23:00:17Z","timestamp":1758668417000},"source":"Crossref","is-referenced-by-count":1,"title":["Elucidating Tissue- and Plasma-Specific Proteomic Alterations in Health and Disease"],"prefix":"10.3791","author":[{"given":"Lily S.","family":"Neff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"DeMar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas C.","family":"Gary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mital Y.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burook","family":"Misganaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Hammamieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"issue":"7502","key":"ref1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature13319","type":"journal-article","article-title":"Mass-spectrometry-based draft of the human proteome","volume":"509","author":"Wilhelm","year":"2014","unstructured":"Wilhelm, M. et al. Mass-spectrometry-based draft of the human proteome. Nature. 509 (7502), 582-587 (2014).","journal-title":"Nature"},{"issue":"16","key":"ref2","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1002\/pmic.200500135","type":"journal-article","article-title":"Bridging proteomics and systems biology: what are the roads to be traveled","volume":"5","author":"Souchelnytskyi","year":"2005","unstructured":"Souchelnytskyi, S. Bridging proteomics and systems biology: what are the roads to be traveled? Proteomics. 5 (16), 4123-4137 (2005).","journal-title":"Proteomics"},{"issue":"6928","key":"ref3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature01511","type":"journal-article","article-title":"Mass spectrometry-based proteomics","volume":"422","author":"Aebersold","year":"2003","unstructured":"Aebersold, R., Mann, M. Mass spectrometry-based proteomics. Nature. 422 (6928), 198-207 (2003).","journal-title":"Nature"},{"issue":"7620","key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","type":"journal-article","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","unstructured":"Aebersold, R., Mann, M. Mass-spectrometric exploration of proteome structure and function. Nature. 537 (7620), 347-355 (2016).","journal-title":"Nature"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41392-022-01288-1","type":"journal-article","article-title":"Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes","volume":"8","author":"Casado","year":"2023","unstructured":"Casado, P. et al. Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Signal Transduct Target Ther. 8 (1), 80 (2023).","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41467-023-36549-2","type":"journal-article","article-title":"Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance","volume":"14","author":"Fazakerley","year":"2023","unstructured":"Fazakerley, D. et al. Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nat Commun. 14 (1), 923 (2023).","journal-title":"Nat Commun"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"111177","DOI":"10.1016\/j.celrep.2022.111177","type":"journal-article","article-title":"Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance","volume":"40","author":"Emdal","year":"2022","unstructured":"Emdal, K. B. et al. Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance. Cell Rep. 40 (6), 111177 (2022).","journal-title":"Cell Rep"},{"issue":"24","key":"ref8","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1002\/elps.201200196","type":"journal-article","article-title":"Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury","volume":"33","author":"Boutt\u00e9","year":"2012","unstructured":"Boutt\u00e9, A. M. et al. Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury. Electrophoresis. 33 (24), 3693-3704 (2012).","journal-title":"Electrophoresis"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/02699052.2016.1231344","type":"journal-article","article-title":"Head injury serum markers for assessing response to trauma: Design of the HeadSMART study","volume":"31","author":"Peters","year":"2017","unstructured":"Peters, M. E. et al. Head injury serum markers for assessing response to trauma: Design of the HeadSMART study. Brain Inj. 31 (3), 370-378 (2017).","journal-title":"Brain Inj"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1089\/neu.2018.6114","type":"journal-article","article-title":"Proteomic analysis and biochemical correlates of mitochondrial dysfunction after low-intensity primary blast exposure","volume":"36","author":"Song","year":"2019","unstructured":"Song, H. et al. Proteomic analysis and biochemical correlates of mitochondrial dysfunction after low-intensity primary blast exposure. J Neurotrauma. 36 (10), 1591-1605 (2019).","journal-title":"J Neurotrauma"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8398072","DOI":"10.1155\/2017\/8398072","type":"journal-article","article-title":"The effects of blast exposure on protein deimination in the brain","volume":"2017","author":"Attilio","year":"2017","unstructured":"Attilio, P. J. et al. The effects of blast exposure on protein deimination in the brain. Oxid Med Cell Longev. 2017, 8398072 (2017).","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.medj.2021.05.005","type":"journal-article","article-title":"Acetylated tau: A missing link between head injury and dementia","volume":"2","author":"Zhao","year":"2021","unstructured":"Zhao, Z., Zlokovic, B. V. Acetylated tau: A missing link between head injury and dementia. Med. 2 (6), 637-639 (2021).","journal-title":"Med"},{"issue":"168","key":"ref13","first-page":"e61941","type":"journal-article","article-title":"Microdissection of mouse brain into functionally and anatomically different regions","author":"Meyerhoff","year":"2021","unstructured":"Meyerhoff, J. et al. Microdissection of mouse brain into functionally and anatomically different regions. J Vis Exp. 168, e61941 (2021).","journal-title":"J Vis Exp"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/nbt1005","type":"journal-article","article-title":"Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics","volume":"22","author":"Blagoev","year":"2004","unstructured":"Blagoev, B., Ong, S. E., Kratchmarova, I., Mann, M. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol. 22 (9), 1139-1145 (2004).","journal-title":"Nat Biotechnol"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/app.jove.com\/t\/67240\/elucidating-tissue-plasma-specific-proteomic-alterations-health","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:29:34Z","timestamp":1792592974000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/67240\/elucidating-tissue-plasma-specific-proteomic-alterations-health"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":14,"journal-issue":{"issue":"223","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3791\/67240","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}