{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:38:14Z","timestamp":1792600694959,"version":"4.5.0"},"reference-count":23,"publisher":"MyJove Corporation","issue":"216","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/67529","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T19:00:55Z","timestamp":1740769255000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy"],"prefix":"10.3791","author":[{"given":"Olivia L.","family":"Bossardet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara C.","family":"Cousins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel S.","family":"Buys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren K.","family":"Wareham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1007\/s10067-022-06354-1","type":"journal-article","article-title":"Nailfold capillaroscopy: tips and challenges","volume":"41","author":"El Miedany","year":"2022","unstructured":"El Miedany, Y., Ismail, S., Wadie, M., Hassan, M. Nailfold capillaroscopy: tips and challenges. Clin Rheumatol. 41 (12), 3629-3640 (2022).","journal-title":"Clin Rheumatol"},{"issue":"1","key":"ref2","first-page":"974530","type":"journal-article","article-title":"Nailfold capillaroscopy in rheumatic diseases: Which parameters should be evaluated","volume":"2015","author":"Etehad Tavakol","year":"2015","unstructured":"Etehad Tavakol, M., Fatemi, A., Karbalaie, A., Emrani, Z., Erlandsson, B. -E. Nailfold capillaroscopy in rheumatic diseases: Which parameters should be evaluated? BioMed Res Int. 2015 (1), 974530 (2015).","journal-title":"BioMed Res Int"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41584-021-00685-0","type":"journal-article","article-title":"Detection of microvascular changes in systemic sclerosis and other rheumatic diseases","volume":"17","author":"Cutolo","year":"2021","unstructured":"Cutolo, M., Smith, V. Detection of microvascular changes in systemic sclerosis and other rheumatic diseases. Nat Rev Rheumatol. 17 (11), 665-677 (2021).","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MBP.0000000000000624","type":"journal-article","article-title":"Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review","volume":"28","author":"Lim","year":"2023","unstructured":"Lim, M. W. S. et al. Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review. Blood Press Monit. 28 (1), 24-32 (2023).","journal-title":"Blood Press Monit"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamaophthalmol.2019.0434","type":"journal-article","article-title":"Nailfold capillaroscopy of resting peripheral blood flow in exfoliation glaucoma and primary open-angle glaucoma","volume":"137","author":"Philip","year":"2019","unstructured":"Philip, S., Najafi, A., Tantraworasin, A., Pasquale, L. R., Ritch, R. Nailfold capillaroscopy of resting peripheral blood flow in exfoliation glaucoma and primary open-angle glaucoma. JAMA Ophthalmol. 137 (6), 618-625 (2019).","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ogla.2022.10.004","type":"journal-article","article-title":"Peripheral microvascular abnormalities associated with open-angle glaucoma","volume":"6","author":"Taniguchi","year":"2023","unstructured":"Taniguchi, E. V. et al. Peripheral microvascular abnormalities associated with open-angle glaucoma. Ophthalmol Glaucoma. 6 (3), 291-299 (2023).","journal-title":"Ophthalmol Glaucoma"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mvr.2017.03.001","type":"journal-article","article-title":"Nailfold capillaroscopy in diabetes mellitus","volume":"112","author":"Maldonado","year":"2017","unstructured":"Maldonado, G., Guerrero, R., Paredes, C., R\u00edos, C. Nailfold capillaroscopy in diabetes mellitus. Microvasc Res. 112, 41-46 (2017).","journal-title":"Microvasc Res"},{"key":"ref8","first-page":"944804","type":"journal-article","article-title":"Digital capillaroscopy as important tool for early diagnostics of arterial hypertension Proc","author":"Gurfinkel","year":"2015","unstructured":"Gurfinkel, Y. I., Sasonko, M., Priezzhev, A. Digital capillaroscopy as important tool for early diagnostics of arterial hypertension Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics. 944804 (2015).","journal-title":"SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"586852","DOI":"10.3389\/fphys.2020.586852","type":"journal-article","article-title":"Remodeling of the microvasculature: May the blood flow be with you","volume":"11","author":"Santamar\u00eda","year":"2020","unstructured":"Santamar\u00eda, R., Gonz\u00e1lez-\u00c1lvarez, M., Delgado, R., Esteban, S., Arroyo, A. G. Remodeling of the microvasculature: May the blood flow be with you. Front Physiol. 11, 586852 (2020).","journal-title":"Front Physiol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1152\/physiol.00012.2014","type":"journal-article","article-title":"Making microvascular networks work: angiogenesis, remodeling, and pruning","volume":"29","author":"Pries","year":"2014","unstructured":"Pries, A. R., Secomb, T. W. Making microvascular networks work: angiogenesis, remodeling, and pruning. Physiology. 29 (6), 446-455 (2014).","journal-title":"Physiology"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/rheumatology\/ket153","type":"journal-article","article-title":"State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology","volume":"52","author":"Cutolo","year":"2013","unstructured":"Cutolo, M., Smith, V. State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology? Rheumatology. 52 (11), 1933-1940 (2013).","journal-title":"Rheumatology"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"R1267","DOI":"10.1152\/ajpregu.00560.2001","type":"journal-article","article-title":"The use of microcomputed tomography to study microvasculature in small rodents","volume":"282","author":"Bentley","year":"2002","unstructured":"Bentley, M. D., Ortiz, M. C., Ritman, E. L., Romero, J. C. The use of microcomputed tomography to study microvasculature in small rodents. Am J Physiol Regul Integr Comp Physiol. 282 (5), R1267-R1279 (2002).","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2040-2384-2-7","type":"journal-article","article-title":"Micro computed tomography for vascular exploration","volume":"2","author":"Zagorchev","year":"2010","unstructured":"Zagorchev, L. et al. Micro computed tomography for vascular exploration. J Angiogenes Res. 2, 7 (2010).","journal-title":"J Angiogenes Res"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41598-022-26871-y","type":"journal-article","article-title":"Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people","volume":"13","author":"Untracht","year":"2023","unstructured":"Untracht, G. R. et al. Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people. Sci Rep. 13 (1), 1122 (2023).","journal-title":"Sci Rep"},{"issue":"6-7","key":"ref15","doi-asserted-by":"crossref","first-page":"e12776","DOI":"10.1111\/micc.12776","type":"journal-article","article-title":"Photoacoustic imaging for microcirculation","volume":"29","author":"Mirg","year":"2022","unstructured":"Mirg, S., Turner, K. L., Chen, H., Drew, P. J., Kothapalli, S. -R. Photoacoustic imaging for microcirculation. Microcirculation. 29 (6-7), e12776 (2022).","journal-title":"Microcirculation"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"e011058","DOI":"10.1161\/JAHA.118.011058","type":"journal-article","article-title":"Dynamic changes in microvascular flow conductivity and perfusion after myocardial infarction shown by image-based modeling","volume":"8","author":"Gkontra","year":"2019","unstructured":"Gkontra, P. et al. Dynamic changes in microvascular flow conductivity and perfusion after myocardial infarction shown by image-based modeling. J Am Heart Assoc. 8 (7), e011058 (2019).","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/HYPERTENSIONAHA.121.17962","type":"journal-article","article-title":"Microcirculation and macrocirculation in hypertension: A dangerous cross-link","volume":"79","author":"Laurent","year":"2022","unstructured":"Laurent, S., Agabiti-Rosei, C., Bruno, R. M., Rizzoni, D. Microcirculation and macrocirculation in hypertension: A dangerous cross-link? Hypertension. 79 (3), 479-490 (2022).","journal-title":"Hypertension"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","type":"journal-article","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease","volume":"18","author":"Kisler","year":"2017","unstructured":"Kisler, K., Nelson, A. R., Montagne, A., Zlokovic, B. V. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 18 (7), 419-434 (2017).","journal-title":"Nat Rev Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fcell.2020.00452","type":"journal-article","article-title":"The neurovascular unit in glaucomatous neurodegeneration","volume":"8","author":"Wareham","year":"2020","unstructured":"Wareham, L. K., Calkins, D. J. The neurovascular unit in glaucomatous neurodegeneration. Front Cell Dev Biol. 8, 452 (2020).","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/life12050703","type":"journal-article","article-title":"Animal models of systemic sclerosis: using nailfold capillaroscopy as a potential tool to evaluate microcirculation and microangiopathy: a narrative review","volume":"12","author":"Mandujano","year":"2022","unstructured":"Mandujano, A., Golubov, M. Animal models of systemic sclerosis: using nailfold capillaroscopy as a potential tool to evaluate microcirculation and microangiopathy: a narrative review. Life. 12 (5), 703 (2022).","journal-title":"Life"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40543-024-00449-x","type":"journal-article","article-title":"Nail fold capillaroscopy as a potential tool to evaluate breast tumor","volume":"15","author":"Kim","year":"2024","unstructured":"Kim, M. Nail fold capillaroscopy as a potential tool to evaluate breast tumor. J Anal Sci Technol. 15 (1), 35 (2024).","journal-title":"J Anal Sci Technol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1364\/BOE.382376","type":"journal-article","article-title":"Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy","volume":"11","author":"McKay","year":"2020","unstructured":"McKay, G. N. et al. Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy. Biomed Opt Express. 11 (4), 2268-2276 (2020).","journal-title":"Biomed Opt Express"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ultrasmedbio.2018.01.018","type":"journal-article","article-title":"In vivo imaging of microvasculature during anesthesia with high-resolution photoacoustic microscopy","volume":"44","author":"Zhang","year":"2018","unstructured":"Zhang, X., Qian, X., Tao, C., Liu, X. In vivo imaging of microvasculature during anesthesia with high-resolution photoacoustic microscopy. Ultrasound Med Biol. 44 (5), 1110-1118 (2018).","journal-title":"Ultrasound Med Biol"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/app.jove.com\/t\/67529\/non-invasive-visualization-nailbed-microvascular-morphology-mice","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:39:37Z","timestamp":1792597177000},"score":1,"resource":{"primary":{"URL":"https:\/\/app.jove.com\/t\/67529\/non-invasive-visualization-nailbed-microvascular-morphology-mice"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":23,"journal-issue":{"issue":"216","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3791\/67529","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}