{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:56:24Z","timestamp":1792598184281,"version":"4.5.0"},"reference-count":23,"publisher":"MyJove Corporation","issue":"218","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/67941","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T19:03:44Z","timestamp":1745003024000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model"],"prefix":"10.3791","author":[{"given":"Jinyan","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maorun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"issue":"1","key":"ref1","first-page":"12","type":"journal-article","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","unstructured":"Siegel, R. L., Giaquinto, A. N., Jemal, A. Cancer statistics, 2024. CA Cancer J Clin. 74 (1), 12-49 (2024).","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41416-019-0548-9","type":"journal-article","article-title":"Signet ring cell colorectal cancer: Genomic insights into a rare subpopulation of colorectal adenocarcinoma","volume":"121","author":"Korphaisarn","year":"2019","unstructured":"Korphaisarn, K. et al. Signet ring cell colorectal cancer: Genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer. 121 (6), 505-510 (2019).","journal-title":"Br J Cancer"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/cncr.31994","type":"journal-article","article-title":"Clinical and molecular characterization of early-onset colorectal cancer","volume":"125","author":"Willauer","year":"2019","unstructured":"Willauer, A. N. et al. Clinical and molecular characterization of early-onset colorectal cancer. Cancer. 125 (12), 2002-2010 (2019).","journal-title":"Cancer"},{"issue":"4","key":"ref4","first-page":"361","type":"journal-article","article-title":"A case of primary colonic signet ring cell carcinoma in a young man which preoperatively mimicked Phlebosclerotic colitis","volume":"73","author":"Watanabe","year":"2019","unstructured":"Watanabe, A. et al. A case of primary colonic signet ring cell carcinoma in a young man which preoperatively mimicked Phlebosclerotic colitis. Acta Med Okayama. 73 (4), 361-365 (2019).","journal-title":"Acta Med Okayama"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"152566","DOI":"10.1016\/j.prp.2019.152566","type":"journal-article","article-title":"Genomic alterations in signet ring and mucinous patterned colorectal carcinoma","volume":"215","author":"Kim","year":"2019","unstructured":"Kim, H., Kim, B. H., Lee, D., Shin, E. Genomic alterations in signet ring and mucinous patterned colorectal carcinoma. Pathol Res Pract. 215 (10), 152566 (2019).","journal-title":"Pathol Res Pract"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/SLA.0000000000003649","type":"journal-article","article-title":"Neoadjuvant radiotherapy versus surgery alone for stage II\/III mid-low rectal cancer with or without high-risk factors: A prospective multicenter stratified randomized trial","volume":"272","author":"Deng","year":"2020","unstructured":"Deng, X. et al. Neoadjuvant radiotherapy versus surgery alone for stage II\/III mid-low rectal cancer with or without high-risk factors: A prospective multicenter stratified randomized trial. Ann Surg. 272 (6), 1060-1069 (2020).","journal-title":"Ann Surg"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1038\/s41598-023-35649-9","type":"journal-article","article-title":"Machine learning for predicting survival of colorectal cancer patients","volume":"13","author":"Buk Cardoso","year":"2023","unstructured":"Buk Cardoso, L. et al. Machine learning for predicting survival of colorectal cancer patients. Sci Rep. 13 (1), 8874 (2023).","journal-title":"Sci Rep"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"e2300060","DOI":"10.1002\/bimj.202300060","type":"journal-article","article-title":"A review on statistical and machine learning competing risks methods","volume":"66","author":"Monterrubio-G\u00f3mez","year":"2024","unstructured":"Monterrubio-G\u00f3mez, K., Constantine-Cooke, N., Vallejos, C. A. A review on statistical and machine learning competing risks methods. Biom J. 66 (2), e2300060 (2024).","journal-title":"Biom J"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3393\/ac.2019.06.12","type":"journal-article","article-title":"Clinical implications of lymph node metastasis in colorectal cancer: Current status and future perspectives","volume":"35","author":"Kim","year":"2019","unstructured":"Kim, H. J., Choi, G. S. Clinical implications of lymph node metastasis in colorectal cancer: Current status and future perspectives. Ann Coloproctol. 35 (3), 109-117 (2019).","journal-title":"Ann Coloproctol"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.21037\/atm-20-7590","type":"journal-article","article-title":"Log odds of positive lymph nodes is an excellent prognostic factor for patients with rectal cancer after neoadjuvant chemoradiotherapy","volume":"9","author":"Xu","year":"2021","unstructured":"Xu, T. et al. Log odds of positive lymph nodes is an excellent prognostic factor for patients with rectal cancer after neoadjuvant chemoradiotherapy. Ann Transl Med. 9 (8), 637 (2021).","journal-title":"Ann Transl Med"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.21037\/jgo-21-185","type":"journal-article","article-title":"Prognostic performance of different lymph node classification systems in young gastric cancer","volume":"12","author":"Chen","year":"2021","unstructured":"Chen, Y. R. et al. Prognostic performance of different lymph node classification systems in young gastric cancer. J Gastrointest Oncol. 12 (4), 285-1300 (2021).","journal-title":"J Gastrointest Oncol"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1002\/cncr.10550","type":"journal-article","article-title":"How many nodes must be examined to accurately stage gastric carcinomas? Results from a population based study","volume":"94","author":"Bouvier","year":"2002","unstructured":"Bouvier, A. M. et al. How many nodes must be examined to accurately stage gastric carcinomas? Results from a population based study. Cancer. 94 (11), 2862-2866 (2002).","journal-title":"Cancer"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/cncr.22229","type":"journal-article","article-title":"Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer","volume":"107","author":"Coburn","year":"2006","unstructured":"Coburn, N. G., Swallow, C. J., Kiss, A., Law, C. Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer. Cancer. 107 (9), 2143-2151 (2006).","journal-title":"Cancer"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3748\/wjg.v20.i8.1951","type":"journal-article","article-title":"Colorectal cancer and lymph nodes: the obsession with the number 12","volume":"20","author":"Li Destri","year":"2014","unstructured":"Li Destri, G., Di Carlo, I., Scilletta, R., Scilletta, B., Puleo, S. Colorectal cancer and lymph nodes: the obsession with the number 12. World J Gastroenterol. 20 (8), 1951-1960 (2014).","journal-title":"World J Gastroenterol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.surg.2017.10.021","type":"journal-article","article-title":"Outcomes of persistent lymph node involvement after neoadjuvant therapy for stage III rectal cancer","volume":"163","author":"Dinaux","year":"2018","unstructured":"Dinaux, A. M. et al. Outcomes of persistent lymph node involvement after neoadjuvant therapy for stage III rectal cancer. Surgery. 163 (4), 784-788 (2018).","journal-title":"Surgery"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s11605-018-3942-3","type":"journal-article","article-title":"Prognostic implication of negative lymph node count in ypN+ rectal cancer after neoadjuvant chemoradiotherapy and construction of a prediction nomogram","volume":"23","author":"Sun","year":"2019","unstructured":"Sun, Y., Zhang, Y., Huang, Z., Chi, P. Prognostic implication of negative lymph node count in ypN+ rectal cancer after neoadjuvant chemoradiotherapy and construction of a prediction nomogram. J Gastrointest Surg. 23 (5), 1006-1014 (2019).","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"778","DOI":"10.21147\/j.issn.1000-9604.2020.06.11","type":"journal-article","article-title":"Development and validation of prognostic nomogram based on log odds of positive lymph nodes for patients with gastric signet ring cell carcinoma","volume":"32","author":"Xu","year":"2020","unstructured":"Xu, Z., Jing, J., Ma, G. Development and validation of prognostic nomogram based on log odds of positive lymph nodes for patients with gastric signet ring cell carcinoma. Chin J Cancer Res. 32 (6), 778-793 (2020).","journal-title":"Chin J Cancer Res"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13304-018-0519-3","type":"journal-article","article-title":"The impact of log odds of positive lymph nodes (LODDS) in colon and rectal cancer patient stratification: a single-center analysis of 323 patients","volume":"70","author":"Scarinci","year":"2018","unstructured":"Scarinci, A. et al. The impact of log odds of positive lymph nodes (LODDS) in colon and rectal cancer patient stratification: a single-center analysis of 323 patients. Updates Surg. 70 (1), 23-31 (2018).","journal-title":"Updates Surg"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00432-016-2224-2","type":"journal-article","article-title":"Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort","volume":"142","author":"Nitsche","year":"2016","unstructured":"Nitsche, U. et al. Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort. J Cancer Res Clin Oncol. 142 (11), 2357-2366 (2016).","journal-title":"J Cancer Res Clin Oncol"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s10350-004-0932-1","type":"journal-article","article-title":"A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum","volume":"48","author":"Kang","year":"2005","unstructured":"Kang, H., O'Connell, J. B., Maggard, M. A., Sack, J., Ko, C. Y. A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum. 48 (6), 1161-1168 (2005).","journal-title":"Dis Colon Rectum"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/modpathol.2008.170","type":"journal-article","article-title":"Clinical significance of signet ring cells in colorectal mucinous adenocarcinoma","volume":"21","author":"Sung","year":"2008","unstructured":"Sung, C. O. et al. Clinical significance of signet ring cells in colorectal mucinous adenocarcinoma. Mod Pathol. 21 (12), 1533-1541 (2008).","journal-title":"Mod Pathol"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/bjc.2017.168","type":"journal-article","article-title":"Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies","volume":"117","author":"Alvi","year":"2017","unstructured":"Alvi, M. A. et al. Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies. Br J Cancer. 117 (2), 203-209 (2017).","journal-title":"Br J Cancer"},{"issue":"10090","key":"ref23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(16)32585-5","type":"journal-article","article-title":"Evidence for overuse of medical services around the world","volume":"390","author":"Brownlee","year":"2017","unstructured":"Brownlee, S. et al. Evidence for overuse of medical services around the world. Lancet. 390 (10090), 156-168 (2017).","journal-title":"Lancet"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/67941\/comparison-predictive-performance-three-lymph-node-staging-systems","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:28:55Z","timestamp":1792596535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/67941\/comparison-predictive-performance-three-lymph-node-staging-systems"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":23,"journal-issue":{"issue":"218","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3791\/67941","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}