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J Vis Exp. 100, e53010 (2015).","journal-title":"J Vis Exp"},{"issue":"9","key":"ref59","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.cub.2024.03.023","type":"journal-article","article-title":"Information flow between motor cortex and striatum reverses during skill learning","volume":"34","author":"Lemke","year":"2024","unstructured":"Lemke, S. M. et al. Information flow between motor cortex and striatum reverses during skill learning. Curr Biol. 34 (9), 1831-1843.e7 (2024).","journal-title":"Curr Biol"},{"issue":"1-2","key":"ref60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0031-9384(00)00392-9","type":"journal-article","article-title":"A behavioral characterization of the effects of food deprivation on food and nonfood object interaction: an investigation of the information-gathering functions of exploratory behavior","volume":"72","author":"Pierre","year":"2001","unstructured":"Pierre, P. J. et al. 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