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S., Nainangu, P., Chen, B. \u03b2-Elemene: mechanistic studies on cancer cell interaction and its chemosensitization effect. Front Pharmacol. 8, 105 (2017).","journal-title":"Front Pharmacol"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"BSR20171701","DOI":"10.1042\/BSR20171701","type":"journal-article","article-title":"Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing Wnt\/\u03b2-catenin signaling pathway","volume":"38","author":"Li","year":"2018","unstructured":"Li, J., Li, Y., Meng, F., Fu, L., Kong, C. Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing Wnt\/\u03b2-catenin signaling pathway. Biosci Rep. 38 (4), BSR20171701 (2018).","journal-title":"Biosci Rep"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"101913","DOI":"10.1016\/j.mcp.2023.101913","type":"journal-article","article-title":"Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt\/\u03b2-catenin pathway","volume":"69","author":"Tan","year":"2023","unstructured":"Tan, Z. et al. Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt\/\u03b2-catenin pathway. Mol Cell Probes. 69, 101913 (2023).","journal-title":"Mol Cell Probes"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1116445","DOI":"10.3389\/fgene.2023.1116445","type":"journal-article","article-title":"A review on the role of LINC00511 in cancer","volume":"14","author":"Ghafouri-Fard","year":"2023","unstructured":"Ghafouri-Fard, S., Safarzadeh, A., Hussen, B. M., Taheri, M., Ayatollahi, S. A. A review on the role of LINC00511 in cancer. Front Genet. 14, 1116445 (2023).","journal-title":"Front Genet"},{"issue":"50","key":"ref52","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1073\/pnas.1314239110","type":"journal-article","article-title":"Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974","volume":"110","author":"Liu","year":"2013","unstructured":"Liu, J. et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 110 (50), 20224-20229 (2013).","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"9495","DOI":"10.2147\/CMAR.S259586","type":"journal-article","article-title":"Serum lncRNAs (CCAT2, LINC01133, LINC00511) with squamous cell carcinoma antigen panel as novel non-invasive biomarkers for detection of cervical squamous carcinoma","volume":"12","author":"Wang","year":"2020","unstructured":"Wang, W. J. et al. Serum lncRNAs (CCAT2, LINC01133, LINC00511) with squamous cell carcinoma antigen panel as novel non-invasive biomarkers for detection of cervical squamous carcinoma. Cancer Manag Res. 12, 9495-9502 (2020).","journal-title":"Cancer Manag Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"820173","DOI":"10.3389\/fonc.2022.820173","type":"journal-article","article-title":"Targeting nutrient dependency in cancer treatment","volume":"12","author":"Fan","year":"2022","unstructured":"Fan, K., Liu, Z., Gao, M., Tu, K., Xu, Q., Zhang, Y. Targeting nutrient dependency in cancer treatment. Front Oncol. 12, 820173 (2022).","journal-title":"Front Oncol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"9603271221089000","DOI":"10.1177\/09603271221089000","type":"journal-article","article-title":"Knockdown of LINC00511 decreased cisplatin resistance in non-small cell lung cancer by elevating miR-625 level to suppress the expression of leucine rich repeat containing eight volume-regulated anion channel subunit E","volume":"41","author":"Liu","year":"2022","unstructured":"Liu, B. et al. Knockdown of LINC00511 decreased cisplatin resistance in non-small cell lung cancer by elevating miR-625 level to suppress the expression of leucine rich repeat containing eight volume-regulated anion channel subunit E. 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