{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:43:54Z","timestamp":1792593834467,"version":"4.5.0"},"reference-count":34,"publisher":"MyJove Corporation","issue":"224","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/69009","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:01:39Z","timestamp":1760137299000},"source":"Crossref","is-referenced-by-count":1,"title":["Experimental Study on Muscone Reducing NF-κB Pathway Activity by Targeting IL-1R1 to Attenuate Oxidative Stress Injury in Schwann Cells"],"prefix":"10.3791","author":[{"given":"Xiaoyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeran","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fphar.2020.00348","type":"journal-article","article-title":"Muscone ameliorates ovariectomy-induced bone loss and receptor activator of nuclear factor-\u03bab ligand-induced osteoclastogenesis by suppressing TNF receptor-associated factor 6-mediated signaling pathways","volume":"11","author":"Zhai","year":"2020","unstructured":"Zhai, X. et al. Muscone ameliorates ovariectomy-induced bone loss and receptor activator of nuclear factor-\u03bab ligand-induced osteoclastogenesis by suppressing TNF receptor-associated factor 6-mediated signaling pathways. Front. Pharmacol. 11, 348 (2020).","journal-title":"Front. Pharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"114799","DOI":"10.1016\/j.jep.2021.114799","type":"journal-article","article-title":"Chemical compositions and pharmacological activities of natural musk (Moschus) and artificial musk: A review","volume":"284","author":"Lv","year":"2022","unstructured":"Lv, S. et al. Chemical compositions and pharmacological activities of natural musk (Moschus) and artificial musk: A review. J Ethnopharmacol. 284, 114799 (2022).","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"e25267","DOI":"10.1016\/j.heliyon.2024.e25267","type":"journal-article","article-title":"Xingnaojing injection alleviates cerebral ischemia\/reperfusion injury through regulating endoplasmic reticulum stress in vivo and in vitro","volume":"10","author":"Dong","year":"2024","unstructured":"Dong, X. et al. Xingnaojing injection alleviates cerebral ischemia\/reperfusion injury through regulating endoplasmic reticulum stress in vivo and in vitro. Heliyon. 10 (3), e25267 (2024).","journal-title":"Heliyon"},{"issue":"23","key":"ref4","doi-asserted-by":"crossref","first-page":"714","DOI":"10.21037\/atm.2019.12.22","type":"journal-article","article-title":"The atheroprotective roles of heart-protecting musk pills against atherosclerosis development in apolipoprotein E-deficient mice","volume":"7","author":"Lu","year":"2019","unstructured":"Lu, L. et al. The atheroprotective roles of heart-protecting musk pills against atherosclerosis development in apolipoprotein E-deficient mice. Ann Transl Med. 7 (23), 714 (2019).","journal-title":"Ann Transl Med"},{"issue":"5","key":"ref5","first-page":"1569","type":"journal-article","article-title":"Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model","volume":"40","author":"Zhuang","year":"2012","unstructured":"Zhuang, Q. et al. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol. 40 (5), 1569-1574 (2012).","journal-title":"Int J Oncol"},{"issue":"22","key":"ref6","first-page":"4953","type":"journal-article","article-title":"Babaodan capsules for viral hepatitis: Systematic review of clinical efficacy and safety and Meta-analysis of randomized clinical trials","volume":"44","author":"Yang","year":"2019","unstructured":"Yang, H. X. et al. Babaodan capsules for viral hepatitis: Systematic review of clinical efficacy and safety and Meta-analysis of randomized clinical trials. Zhongguo Zhong Yao Za Zhi. 44 (22), 4953-4961 (2019).","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1142\/S0192415X20500068","type":"journal-article","article-title":"Chinese medicine She-Xiang-Xin-Tong-Ning, Containing Moschus, Corydalis and Ginseng, protects from myocardial ischemia injury via angiogenesis","volume":"48","author":"Li","year":"2020","unstructured":"Li, J. et al. Chinese medicine She-Xiang-Xin-Tong-Ning, Containing Moschus, Corydalis and Ginseng, protects from myocardial ischemia injury via angiogenesis. Am J Chin Med. 48 (1), 107-126 (2020).","journal-title":"Am J Chin Med"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3390\/antiox11081455","type":"journal-article","article-title":"Muscone and (+)-borneol cooperatively strengthen CREB induction of claudin 5 in IL-1\u03b2-induced endothelium injury","volume":"11","author":"Li","year":"2022","unstructured":"Li, Y. C. et al. Muscone and (+)-borneol cooperatively strengthen CREB induction of claudin 5 in IL-1\u03b2-induced endothelium injury. Antioxidants (Basel). 11 (8), 1455 (2022).","journal-title":"Antioxidants (Basel)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"106355","DOI":"10.1016\/j.intimp.2020.106355","type":"journal-article","article-title":"Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4\/JAK2-STAT3 pathway and NLRP3 inflammasome","volume":"82","author":"Yu","year":"2020","unstructured":"Yu, S. et al. Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4\/JAK2-STAT3 pathway and NLRP3 inflammasome. Int Immunopharmacol. 82, 106355 (2020).","journal-title":"Int Immunopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.12659\/MSM.912051","type":"journal-article","article-title":"Hypoxia-inducible factor 1 alpha (HIF-1alpha)\/vascular endothelial growth factor (VEGF) pathway participates in angiogenesis of myocardial infarction in muscone-treated mice: Preliminary study","volume":"24","author":"Du","year":"2018","unstructured":"Du, Y. et al. Hypoxia-inducible factor 1 alpha (HIF-1alpha)\/vascular endothelial growth factor (VEGF) pathway participates in angiogenesis of myocardial infarction in muscone-treated mice: Preliminary study. Med Sci Monit. 24, 8870-8877 (2018).","journal-title":"Med Sci Monit"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1111\/jphp.13157","type":"journal-article","article-title":"Muscone ameliorates diabetic peripheral neuropathy through activating AKT\/mTOR signalling pathway","volume":"71","author":"Dong","year":"2019","unstructured":"Dong, J., Li, H., Bai, Y., Wu, C. Muscone ameliorates diabetic peripheral neuropathy through activating AKT\/mTOR signalling pathway. J Pharm Pharmacol. 71 (11), 1706-1713 (2019).","journal-title":"J Pharm Pharmacol"},{"key":"ref12","first-page":"54","type":"journal-article","article-title":"Acupoint application for facial neuritis: 32 cases","volume":"2","author":"Zhao","year":"1996","unstructured":"Zhao, M. Acupoint application for facial neuritis: 32 cases. Sichuan Tradit Chinese Med. 2, 54 (1996).","journal-title":"Sichuan Tradit Chinese Med"},{"key":"ref13","first-page":"617","type":"journal-article","article-title":"Clinical observation and analysis of 96 cases of facial neuritis treated by integrated Chinese and Western medicine","volume":"4","author":"Wang","year":"1997","unstructured":"Wang, L. Chen, X. Clinical observation and analysis of 96 cases of facial neuritis treated by integrated Chinese and Western medicine. J Mod Integr Chinese West Med. 4, 617-618 (1997).","journal-title":"J Mod Integr Chinese West Med"},{"key":"ref14","first-page":"134","type":"journal-article","article-title":"Observation of curative effect of acupuncture with musk combined with physical factors on facial neuritis","volume":"45","author":"Meng","year":"2013","unstructured":"Meng, S., Hu, C., Zhang, H., Shang, C. Observation of curative effect of acupuncture with musk combined with physical factors on facial neuritis. New Chinese Med. 45, 134-136 (2013).","journal-title":"New Chinese Med"},{"key":"ref15","first-page":"1197","type":"journal-article","article-title":"Effect of artificial musk acupoint application combined with acupuncture on peripheral facial paralysis","volume":"60","author":"Chen","year":"2017","unstructured":"Chen, N. Qin, Y. Effect of artificial musk acupoint application combined with acupuncture on peripheral facial paralysis. People's Mil Med. 60, 1197-1198 (2017).","journal-title":"People's Mil Med"},{"key":"ref16","first-page":"59","type":"journal-article","article-title":"Literature analysis of acupoint application of Chinese medicine in treatment of peripheral facial palsy","volume":"23","author":"Qi","year":"2014","unstructured":"Qi, Q., Ni, S., Li, C., Wang, X. Literature analysis of acupoint application of Chinese medicine in treatment of peripheral facial palsy. J Extern Treat Chinese Med. 23, 59-60 (2014).","journal-title":"J Extern Treat Chinese Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"711421","DOI":"10.3389\/fcvm.2022.711421","type":"journal-article","article-title":"Molecular and cellular response of the myocardium (H9C2 cells) towards hypoxia and HIF-1alpha inhibition","volume":"9","author":"Osuru","year":"2022","unstructured":"Osuru, H. P., Lavallee, M., Thiele, R. H. Molecular and cellular response of the myocardium (H9C2 cells) towards hypoxia and HIF-1alpha inhibition. Front Cardiovasc Med. 9, 711421 (2022).","journal-title":"Front Cardiovasc Med"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/jcmm.17403","type":"journal-article","article-title":"Insulin-like growth factor 1 ameliorates pre-eclampsia by inhibiting zinc finger E-box binding homeobox 1 by up-regulation of microRNA-183","volume":"27","author":"Lai","year":"2023","unstructured":"Lai, W. Yu, L. Insulin-like growth factor 1 ameliorates pre-eclampsia by inhibiting zinc finger E-box binding homeobox 1 by up-regulation of microRNA-183. J Cell Mol Med. 27 (9), 1179-1191 (2023).","journal-title":"J Cell Mol Med"},{"issue":"22","key":"ref19","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4103\/1673-5374.145374","type":"journal-article","article-title":"Dorsal root ganglion-derived Schwann cells combined with poly(lactic-co-glycolic acid)\/chitosan conduits for the repair of sciatic nerve defects in rats","volume":"9","author":"Zhao","year":"2014","unstructured":"Zhao, L., Qu, W., Wu, Y., Ma, H., Jiang, H. Dorsal root ganglion-derived Schwann cells combined with poly(lactic-co-glycolic acid)\/chitosan conduits for the repair of sciatic nerve defects in rats. Neural Regen Res. 9 (22), 1961-1967 (2014).","journal-title":"Neural Regen Res"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/cas.13191","type":"journal-article","article-title":"Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion","volume":"108","author":"Tong","year":"2017","unstructured":"Tong, Y. et al. Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion. Cancer Sci. 108 (4), 753-762 (2017).","journal-title":"Cancer Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3605977","DOI":"10.1155\/2022\/3605977","type":"journal-article","article-title":"Modulating oxidative stress in B cells promotes immunotherapy in food allergy","volume":"2022","author":"Zeng","year":"2022","unstructured":"Zeng, H. T. et al. Modulating oxidative stress in B cells promotes immunotherapy in food allergy. Oxid Med Cell Longev. 2022, 3605977 (2022).","journal-title":"Oxid Med Cell Longev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"514658","DOI":"10.3389\/fpsyt.2020.514658","type":"journal-article","article-title":"Circulating brain-derived neurotrophic factor, antioxidant enzymes activities, and mitochondrial DNA in bipolar disorder: An exploratory report","volume":"11","author":"Wang","year":"2020","unstructured":"Wang, D. et al. Circulating brain-derived neurotrophic factor, antioxidant enzymes activities, and mitochondrial DNA in bipolar disorder: An exploratory report. Front Psychiatry. 11, 514658 (2020).","journal-title":"Front Psychiatry"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00031.2018","type":"journal-article","article-title":"Myelin in the central nervous system: Structure, function, and pathology","volume":"99","author":"Stadelmann","year":"2019","unstructured":"Stadelmann, C., Timmler, S., Barrantes-Freer, A., Simons, M. Myelin in the central nervous system: Structure, function, and pathology. Physiol Rev. 99 (3), 1381-1431 (2019).","journal-title":"Physiol Rev"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"ac457c","DOI":"10.1088\/1758-5090\/ac457c","type":"journal-article","article-title":"An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion","volume":"14","author":"Intisar","year":"2022","unstructured":"Intisar, A. et al. An electroceutical approach enhances myelination via upregulation of lipid biosynthesis in the dorsal root ganglion. Biofabrication. 14 (1), ac457c (2022).","journal-title":"Biofabrication"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fneur.2019.00087","type":"journal-article","article-title":"Peripheral demyelinating diseases: From biology to translational medicine","volume":"10","author":"Kamil","year":"2019","unstructured":"Kamil, K., Yazid, M. D., Idrus, R. B. H., Das, S., Kumar, J. Peripheral demyelinating diseases: From biology to translational medicine. Front Neurol. 10, 87 (2019).","journal-title":"Front Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1496101","DOI":"10.1155\/2021\/1496101","type":"journal-article","article-title":"Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote the proliferation of Schwann cells by regulating the PI3K\/AKT signaling pathway via transferring miR-21","volume":"2021","author":"Ma","year":"2021","unstructured":"Ma, Y. et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote the proliferation of Schwann cells by regulating the PI3K\/AKT signaling pathway via transferring miR-21. Stem Cells Int. 2021, 1496101 (2021).","journal-title":"Stem Cells Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"100434","DOI":"10.1016\/j.mtbio.2022.100434","type":"journal-article","article-title":"Aptamer engineering exosomes loaded on biomimetic periosteum to promote angiogenesis and bone regeneration by targeting injured nerves via JNK3 MAPK pathway","volume":"16","author":"Su","year":"2022","unstructured":"Su, Y. et al. Aptamer engineering exosomes loaded on biomimetic periosteum to promote angiogenesis and bone regeneration by targeting injured nerves via JNK3 MAPK pathway. Mater Today Bio. 16, 100434 (2022).","journal-title":"Mater Today Bio"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1158\/2326-6066.CIR-19-0552","type":"journal-article","article-title":"IL1alpha antagonizes IL1beta and promotes adaptive immune rejection of malignant tumors","volume":"8","author":"Tian","year":"2020","unstructured":"Tian, T. et al. IL1alpha antagonizes IL1beta and promotes adaptive immune rejection of malignant tumors. Cancer Immunol Res. 8 (5), 660-671 (2020).","journal-title":"Cancer Immunol Res"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/S0021-9258(18)61450-4","type":"journal-article","article-title":"The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor","volume":"262","author":"Mosley","year":"1987","unstructured":"Mosley, B. et al. The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem. 262 (7), 2941-2944 (1987).","journal-title":"J Biol Chem"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/pro.2441","type":"journal-article","article-title":"Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses","volume":"23","author":"Krumm","year":"2014","unstructured":"Krumm, B., Xiang, Y., Deng, J. Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses. Protein Sci. 23 (5), 526-538 (2014).","journal-title":"Protein Sci"},{"issue":"20","key":"ref31","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMoa1706314","type":"journal-article","article-title":"Canakinumab for the treatment of autoinflammatory recurrent fever syndromes","volume":"378","author":"De Benedetti","year":"2018","unstructured":"De Benedetti, F. et al. Canakinumab for the treatment of autoinflammatory recurrent fever syndromes. N Engl J Med. 378 (20), 1908-1919 (2018).","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbi.2019.03.016","type":"journal-article","article-title":"Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling","volume":"80","author":"Liskiewicz","year":"2019","unstructured":"Liskiewicz, A. et al. Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling. Brain Behav Immun. 80, 247-254 (2019).","journal-title":"Brain Behav Immun"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/cns.13282","type":"journal-article","article-title":"Activated Schwann cells and increased inflammatory cytokines IL-1beta, IL-6, and TNF-alpha in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease","volume":"26","author":"Zhang","year":"2020","unstructured":"Zhang, H. et al. Activated Schwann cells and increased inflammatory cytokines IL-1beta, IL-6, and TNF-alpha in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease. CNS Neurosci Ther. 26 (5), 518-526 (2020).","journal-title":"CNS Neurosci Ther"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.7150\/thno.42440","type":"journal-article","article-title":"Tumor-neuroglia interaction promotes pancreatic cancer metastasis","volume":"10","author":"Su","year":"2020","unstructured":"Su, D. et al. Tumor-neuroglia interaction promotes pancreatic cancer metastasis. Theranostics. 10 (11), 5029-5047 (2020).","journal-title":"Theranostics"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/app.jove.com\/t\/69009\/experimental-study-on-muscone-reducing-nf-b-pathway-activity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:23:27Z","timestamp":1792592607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/69009\/experimental-study-on-muscone-reducing-nf-b-pathway-activity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":34,"journal-issue":{"issue":"224","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3791\/69009","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}