{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:49:31Z","timestamp":1792590571064,"version":"4.5.0"},"reference-count":18,"publisher":"MyJove Corporation","issue":"228","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/69120","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:02:13Z","timestamp":1770163333000},"source":"Crossref","is-referenced-by-count":0,"title":["&lt;em&gt;In Vitro&lt;\/em&gt; Resident Memory CD8 T Cell Differentiation Using Epithelial Organoid-T Cell Co-culture System"],"prefix":"10.3791","author":[{"given":"Ying","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian C.","family":"Ramprashad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K.","family":"Beura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coviro.2016.11.011","type":"journal-article","article-title":"Tissue resident memory T cells and viral immunity","volume":"22","author":"Rosato","year":"2017","unstructured":"Rosato, P. C., Beura, L. K., Masopust, D. Tissue resident memory T cells and viral immunity. Curr Opin Virol. 22, 44-50 (2017).","journal-title":"Curr Opin Virol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm.3883","type":"journal-article","article-title":"The emerging role of resident memory T cells in protective immunity and inflammatory disease","volume":"21","author":"Park","year":"2015","unstructured":"Park, C. O., Kupper, T. S. The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med. 21, 688-697 (2015).","journal-title":"Nat Med"},{"issue":"6205","key":"ref3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1254536","type":"journal-article","article-title":"Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","unstructured":"Schenkel, J. M. et al. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science. 346 (6205), 98-101 (2014).","journal-title":"Science"},{"issue":"6205","key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.1254803","type":"journal-article","article-title":"Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert","volume":"346","author":"Ariotti","year":"2014","unstructured":"Ariotti, S. et al. Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert. Science. 346 (6205), 101-105 (2014).","journal-title":"Science"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-immunol-101320-020220","type":"journal-article","article-title":"The Multifaceted Role of Tissue-Resident Memory T Cells","volume":"42","author":"Christo","year":"2024","unstructured":"Christo, S. N., Park, S. L., Mueller, S. N., Mackay, L. K. The Multifaceted Role of Tissue-Resident Memory T Cells. Annu Rev Immunol. 42 (1), 317-345 (2024).","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.immuni.2024.06.017","type":"journal-article","article-title":"Resident memory T cells and cancer","volume":"57","author":"Gavil","year":"2024","unstructured":"Gavil, N. V., Cheng, K., Masopust, D. Resident memory T cells and cancer. Immunity. 57 (8), 1734-1751 (2024).","journal-title":"Immunity"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41590-021-01004-1","type":"journal-article","article-title":"Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity","volume":"22","author":"Christo","year":"2021","unstructured":"Christo, S. N. et al. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nat Immunol. 22 (9), 1140-1151 (2021).","journal-title":"Nat Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","type":"journal-article","article-title":"Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Pan","year":"2017","unstructured":"Pan, Y. et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 543, 252-256 (2017).","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2021.10.005","type":"journal-article","article-title":"Cellular interactions in resident memory T cell establishment and function","volume":"74","author":"Hasan","year":"2022","unstructured":"Hasan, M. H., Beura, L. K. Cellular interactions in resident memory T cell establishment and function. Curr Opin Immunol. 74, 68-75 (2022).","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"114621","DOI":"10.1016\/j.celrep.2024.114621","type":"journal-article","article-title":"Epithelial organoid supports resident memory CD8 T cell differentiation","volume":"43","author":"Ulibarri","year":"2024","unstructured":"Ulibarri, M. R. et al. Epithelial organoid supports resident memory CD8 T cell differentiation. Cell Rep. 43 (8), 114621 (2024).","journal-title":"Cell Rep"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.immuni.2023.06.005","type":"journal-article","article-title":"Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts","volume":"56","author":"Evrard","year":"2023","unstructured":"Evrard, M. et al. Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts. Immunity. 56 (7), 1664-1680.e9 (2023).","journal-title":"Immunity"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.4049\/jimmunol.1801613","type":"journal-article","article-title":"ARTC2.2\/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets","volume":"202","author":"Borges da Silva","year":"2019","unstructured":"Borges da Silva, H., Wang, H., Qian, L. J., Hogquist, K. A., Jameson, S. C. ARTC2.2\/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets. J Immunol. 202 (7), 2153-2163 (2019).","journal-title":"J Immunol"},{"issue":"45","key":"ref13","doi-asserted-by":"crossref","first-page":"eaay5552","DOI":"10.1126\/sciimmunol.aay5552","type":"journal-article","article-title":"Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity","volume":"5","author":"K\u00fcnzli","year":"2020","unstructured":"K\u00fcnzli, M. et al. Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity. Sci Immunol. 5 (45), eaay5552 (2020).","journal-title":"Sci Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1038\/s41467-025-58450-w","type":"journal-article","article-title":"Generation of induced alveolar assembloids with functional alveolar-like macrophages","volume":"16","author":"Kang","year":"2025","unstructured":"Kang, J. S. et al. Generation of induced alveolar assembloids with functional alveolar-like macrophages. Nat Commun. 16, 3346 (2025).","journal-title":"Nat Commun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1038\/s41467-023-38780-3","type":"journal-article","article-title":"Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche","volume":"14","author":"Lin","year":"2023","unstructured":"Lin, M. et al. Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche. Nat Commun. 14, 3025 (2023).","journal-title":"Nat Commun"},{"issue":"6444","key":"ref16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.aaw7894","type":"journal-article","article-title":"Organoids-on-a-chip","volume":"364","author":"Park","year":"2019","unstructured":"Park, S. E., Georgescu, A., Huh, D. Organoids-on-a-chip. Science. 364 (6444), 960-965 (2019).","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","type":"journal-article","article-title":"A microfluidic platform integrating functional vascularized organoids-on-chip","volume":"15","author":"Quintard","year":"2024","unstructured":"Quintard, C. et al. A microfluidic platform integrating functional vascularized organoids-on-chip. Nat Commun. 15, 1452 (2024).","journal-title":"Nat Commun"},{"issue":"640","key":"ref18","doi-asserted-by":"crossref","first-page":"eabl6058","DOI":"10.1126\/scitranslmed.abl6058","type":"journal-article","article-title":"Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS","volume":"14","author":"Vincenti","year":"2022","unstructured":"Vincenti, I. et al. Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS. Sci Transl Med. 14 (640), eabl6058 (2022).","journal-title":"Sci Transl Med"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/app.jove.com\/t\/69120\/in-vitro-resident-memory-cd8-t-cell-differentiation-using-epithelial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:28:08Z","timestamp":1792589288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/69120\/in-vitro-resident-memory-cd8-t-cell-differentiation-using-epithelial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":18,"journal-issue":{"issue":"228","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3791\/69120","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}