{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:45:53Z","timestamp":1792590353799,"version":"4.5.0"},"reference-count":26,"publisher":"MyJove Corporation","issue":"229","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/69620","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:03:27Z","timestamp":1773270207000},"source":"Crossref","is-referenced-by-count":0,"title":["&lt;em&gt;In Vivo&lt;\/em&gt; Imaging of Zebrafish Larvae Heart Regeneration"],"prefix":"10.3791","author":[{"given":"Yuqing","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"165787","DOI":"10.1016\/j.scitotenv.2023.165787","type":"journal-article","article-title":"Potential adverse outcome pathway (aop) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (danio rerio)","volume":"900","author":"Gu","year":"2023","unstructured":"Gu, J., Guo, L., Hu, J., Ji, G., Yin, D. Potential adverse outcome pathway (aop) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (danio rerio). Sci Total Environ. 900 165787 (2023).","journal-title":"Sci Total Environ"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1039\/c0cs00118j","type":"journal-article","article-title":"Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes","volume":"40","author":"Ko","year":"2011","unstructured":"Ko, S. K., Chen, X., Yoon, J., Shin, I. Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes. Chem Soc Rev. 40 (5), 2120-2130 (2011).","journal-title":"Chem Soc Rev"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/s41592-025-02698-z","type":"journal-article","article-title":"Physics-driven self-supervised learning for fast high-resolution robust 3D reconstruction of light-field microscopy","volume":"22","author":"Lu","year":"2025","unstructured":"Lu, Z. et al. Physics-driven self-supervised learning for fast high-resolution robust 3D reconstruction of light-field microscopy. Nat Methods. 22 (7), 1545-1555 (2025).","journal-title":"Nat Methods"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/physrev.00038.2016","type":"journal-article","article-title":"Little fish, big data: Zebrafish as a model for cardiovascular and metabolic disease","volume":"97","author":"Gut","year":"2017","unstructured":"Gut, P., Reischauer, S., Stainier, D. Y. R., Arnaout, R. Little fish, big data: Zebrafish as a model for cardiovascular and metabolic disease. Physiol Rev. 97 (3), 889-938 (2017).","journal-title":"Physiol Rev"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/CIRCRESAHA.122.320396","type":"journal-article","article-title":"Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine","volume":"130","author":"Gonz\u00e1lez-Rosa","year":"2022","unstructured":"Gonz\u00e1lez-Rosa, J. M. Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine. Circ Res. 130 (12), 1803-1826 (2022).","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-pathol-011110-130330","type":"journal-article","article-title":"Zebrafish models for cancer","volume":"6","author":"Liu","year":"2011","unstructured":"Liu, S. Leach, S. D. Zebrafish models for cancer. Annu Rev Pathol. 6, 71-93 (2011).","journal-title":"Annu Rev Pathol"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/cvr\/cvab214","type":"journal-article","article-title":"Hooked on heart regeneration: The zebrafish guide to recovery","volume":"118","author":"Ross Stewart","year":"2022","unstructured":"Ross Stewart, K. M., Walker, S. L., Baker, A. H., Riley, P. R., Brittan, M. Hooked on heart regeneration: The zebrafish guide to recovery. Cardiovasc Res. 118 (7), 1667-1679 (2022).","journal-title":"Cardiovasc Res"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1242\/dev.119.1.31","type":"journal-article","article-title":"Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation","volume":"119","author":"Stainier","year":"1993","unstructured":"Stainier, D. Y., Lee, R. K., Fishman, M. C. Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development. 119 (1), 31-40 (1993).","journal-title":"Development"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1242\/dev.122.12.3809","type":"journal-article","article-title":"Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation","volume":"122","author":"Chen","year":"1996","unstructured":"Chen, J. N. Fishman, M. C. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development. 122 (12), 3809-3816 (1996).","journal-title":"Development"},{"issue":"174","key":"ref10","first-page":"e62741","type":"journal-article","article-title":"Light sheet microscopy of fast cardiac dynamics in zebrafish embryos","author":"Schlaeppi","year":"2021","unstructured":"Schlaeppi, A., Graves, A., Weber, M., Huisken, J. Light sheet microscopy of fast cardiac dynamics in zebrafish embryos. J Vis Exp. 174, e62741 (2021).","journal-title":"J Vis Exp"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1242\/dev.022426","type":"journal-article","article-title":"Selective plane illumination microscopy techniques in developmental biology","volume":"136","author":"Huisken","year":"2009","unstructured":"Huisken, J., Stainier, D. Y. Selective plane illumination microscopy techniques in developmental biology. Development. 136 (12), 1963-1975 (2009).","journal-title":"Development"},{"issue":"203","key":"ref12","first-page":"e66263","type":"journal-article","article-title":"4D light-sheet imaging of zebrafish cardiac contraction","author":"Zhang","year":"2024","unstructured":"Zhang, X. et al. 4D light-sheet imaging of zebrafish cardiac contraction. J Vis Exp. 203, e66263 (2024).","journal-title":"J Vis Exp"},{"issue":"7455","key":"ref13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature12322","type":"journal-article","article-title":"In vivo cardiac reprogramming contributes to zebrafish heart regeneration","volume":"498","author":"Zhang","year":"2013","unstructured":"Zhang, R. et al. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 498 (7455), 497-501 (2013).","journal-title":"Nature"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11886-025-02235-6","type":"journal-article","article-title":"Cardiac regeneration and repair in zebrafish and mammalian models","volume":"27","author":"Travisano","year":"2025","unstructured":"Travisano, S. I., Lien, C. L. Cardiac regeneration and repair in zebrafish and mammalian models. Curr Cardiol Rep. 27 (1), 95 (2025).","journal-title":"Curr Cardiol Rep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"115907","DOI":"10.1016\/j.ecoenv.2023.115907","type":"journal-article","article-title":"Effects of water fluoridation on early embryonic development of zebrafish","volume":"270","author":"Wei","year":"2024","unstructured":"Wei, Y. L. et al. Effects of water fluoridation on early embryonic development of zebrafish. Ecotoxicol Environ Saf. 270, 115907 (2024).","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"118203","DOI":"10.1016\/j.ecoenv.2025.118203","type":"journal-article","article-title":"Neomycin affects cardiovascular and hematopoietic system via the PI3K\/Akt pathway in zebrafish larvae","volume":"296","author":"Lin","year":"2025","unstructured":"Lin, Y. et al. Neomycin affects cardiovascular and hematopoietic system via the PI3K\/Akt pathway in zebrafish larvae. Ecotoxicol Environ Saf. 296, 118203 (2025).","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCULATIONAHA.105.588954","type":"journal-article","article-title":"In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery","volume":"113","author":"Cao","year":"2006","unstructured":"Cao, F. et al. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation. 113 (7), 1005-1014 (2006).","journal-title":"Circulation"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1364\/BOE.470058","type":"journal-article","article-title":"Heterogeneities of zebrafish vasculature development studied by a high throughput light-sheet flow imaging system","volume":"13","author":"Yang","year":"2022","unstructured":"Yang, G. et al. Heterogeneities of zebrafish vasculature development studied by a high throughput light-sheet flow imaging system. Biomed Opt Express. 13 (10), 5344-5357 (2022).","journal-title":"Biomed Opt Express"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"2350003","DOI":"10.1142\/S1793545823500037","type":"journal-article","article-title":"High-throughput sorting of two-color fluorescent-labeled zebrafish embryos","volume":"16","author":"Tang","year":"2023","unstructured":"Tang, H. et al. High-throughput sorting of two-color fluorescent-labeled zebrafish embryos. J Innovative Opt Health Sci. 16 (05), 2350003 (2023).","journal-title":"J Innovative Opt Health Sci"},{"issue":"15","key":"ref20","doi-asserted-by":"crossref","first-page":"e112900","DOI":"10.15252\/embj.2022112900","type":"journal-article","article-title":"Proteolytic activation of angiomotin by ddi2 promotes angiogenesis","volume":"42","author":"Wang","year":"2023","unstructured":"Wang, Y. et al. Proteolytic activation of angiomotin by ddi2 promotes angiogenesis. Embo J. 42 (15), e112900 (2023).","journal-title":"Embo J"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.3390\/ijms22083945","type":"journal-article","article-title":"Hemodynamic forces regulate cardiac regeneration-responsive enhancer activity during ventricle regeneration","volume":"22","author":"Geng","year":"2021","unstructured":"Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. Hemodynamic forces regulate cardiac regeneration-responsive enhancer activity during ventricle regeneration. Int J Mol Sci. 22 (8), 3945 (2021).","journal-title":"Int J Mol Sci"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nmeth.1476","type":"journal-article","article-title":"high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy","volume":"7","author":"Keller","year":"2010","unstructured":"Keller, P. J. et al. Fast, high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy. Nat Methods. 7 (8), 637-642 (2010).","journal-title":"Nat Methods"},{"issue":"13","key":"ref23","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1364\/OL.32.001938","type":"journal-article","article-title":"Lateral modulation boosts image quality in single plane illumination fluorescence microscopy","volume":"32","author":"Breuninger","year":"2007","unstructured":"Breuninger, T., Greger, K., Stelzer, E. H. Lateral modulation boosts image quality in single plane illumination fluorescence microscopy. Opt Lett. 32 (13), 1938-1940 (2007).","journal-title":"Opt Lett"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ncomms1646","type":"journal-article","article-title":"Propagation stability of self-reconstructing Bessel beams enables contrast-enhanced imaging in thick media","volume":"3","author":"Fahrbach","year":"2012","unstructured":"Fahrbach, F. O. Rohrbach, A. Propagation stability of self-reconstructing Bessel beams enables contrast-enhanced imaging in thick media. Nat Commun. 3, 632 (2012).","journal-title":"Nat Commun"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nmeth.3222","type":"journal-article","article-title":"Guide to light-sheet microscopy for adventurous biologists","volume":"12","author":"Reynaud","year":"2015","unstructured":"Reynaud, E. G., Peychl, J., Huisken, J., Tomancak, P. Guide to light-sheet microscopy for adventurous biologists. Nat Methods. 12 (1), 30-34 (2015).","journal-title":"Nat Methods"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00441-015-2247-z","type":"journal-article","article-title":"Erratum to: Light sheet-based fluorescence microscopy (LSFM) for the quantitative imaging of cells and tissues","volume":"362","author":"Pampaloni","year":"2015","unstructured":"Pampaloni, F., Chang, B. J., Stelzer, E. H. Erratum to: Light sheet-based fluorescence microscopy (LSFM) for the quantitative imaging of cells and tissues. Cell Tissue Res. 362 (1), 265 (2015).","journal-title":"Cell Tissue Res"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/app.jove.com\/t\/69620\/in-vivo-imaging-of-zebrafish-larvae-heart-regeneration","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:17:46Z","timestamp":1792588666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/69620\/in-vivo-imaging-of-zebrafish-larvae-heart-regeneration"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":26,"journal-issue":{"issue":"229","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3791\/69620","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}