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Stroke. 29 (10), 2162-2170 (1998).","journal-title":"Stroke"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1161\/01.STR.30.11.2464","type":"journal-article","article-title":"Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats","volume":"30","author":"Li","year":"1999","unstructured":"Li, F., Omae, T., Fisher, M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke. 30 (11), 2464-2470; discussion 2470-2461 (1999).","journal-title":"Stroke"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnana.2018.00010","type":"journal-article","article-title":"Cerebral artery diameter in inbred mice varies as a function of strain","volume":"12","author":"Qian","year":"2018","unstructured":"Qian, B., Rudy, R. F., Cai, T., Du, R. 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(54), e2618 (2011).","journal-title":"J Vis Exp"},{"issue":"1","key":"ref85","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nprot.2007.513","type":"journal-article","article-title":"A mouse model of intracerebral hemorrhage using autologous blood infusion","volume":"3","author":"Rynkowski","year":"2008","unstructured":"Rynkowski, M. A. et al. A mouse model of intracerebral hemorrhage using autologous blood infusion. Nat Protoc. 3 (1), 122-128 (2008).","journal-title":"Nat Protoc"},{"issue":"5","key":"ref86","doi-asserted-by":"crossref","first-page":"e97423","DOI":"10.1371\/journal.pone.0097423","type":"journal-article","article-title":"Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase","volume":"9","author":"Zhu","year":"2014","unstructured":"Zhu, W. et al. Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. 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Stroke Vasc Neurol. 5 (4), 388-395 (2020).","journal-title":"Stroke Vasc Neurol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fneur.2012.00085","type":"journal-article","article-title":"Translating basic science research to clinical application: Models and strategies for intracerebral hemorrhage","volume":"3","author":"Leonardo","year":"2012","unstructured":"Leonardo, C. C., Robbins, S., Dore, S. Translating basic science research to clinical application: Models and strategies for intracerebral hemorrhage. Front Neurol. 3, 85 (2012).","journal-title":"Front Neurol"},{"issue":"7","key":"ref90","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/STROKEAHA.107.508911","type":"journal-article","article-title":"Effects of thrombin on neurogenesis after intracerebral hemorrhage","volume":"39","author":"Yang","year":"2008","unstructured":"Yang, S. et al. Effects of thrombin on neurogenesis after intracerebral hemorrhage. Stroke. 39 (7), 2079-2084 (2008).","journal-title":"Stroke"},{"issue":"6_suppl_1","key":"ref91","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1161\/STROKEAHA.111.000662","type":"journal-article","article-title":"Hematology and inflammatory signaling of intracerebral hemorrhage","volume":"44","author":"Ziai","year":"2013","unstructured":"Ziai, W. C. Hematology and inflammatory signaling of intracerebral hemorrhage. Stroke. 44 (6_suppl_1), S74-S78 (2013).","journal-title":"Stroke"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3340\/jkns.2021.0126","type":"journal-article","article-title":"Recent stem cell research on hemorrhagic stroke: An update","volume":"65","author":"Kim","year":"2022","unstructured":"Kim, J.-T., Youn, D. H., Kim, B. J., Rhim, J. K., Jeon, J. P. Recent stem cell research on hemorrhagic stroke: An update. J Korean Neurosurg Soc. 65 (2), 161-172 (2022).","journal-title":"J Korean Neurosurg Soc"},{"issue":"1","key":"ref93","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/etm.2022.11719","type":"journal-article","article-title":"Animal models for the study of intracranial hematomas (review)","volume":"25","author":"Paiva","year":"2023","unstructured":"Paiva, W. S. et al. Animal models for the study of intracranial hematomas (review). Exp Ther Med. 25 (1), 20 (2023).","journal-title":"Exp Ther Med"},{"issue":"2","key":"ref94","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","type":"journal-article","article-title":"A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model","volume":"167","author":"Sugawara","year":"2008","unstructured":"Sugawara, T., Ayer, R., Jadhav, V., Zhang, J. H. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. 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Adv Sci. 11 (46), 2403977 (2024).","journal-title":"Adv Sci"},{"issue":"178","key":"ref98","first-page":"e63150","type":"journal-article","article-title":"Endovascular perforation model for subarachnoid hemorrhage combined with magnetic resonance imaging (mri)","author":"Liu","year":"2021","unstructured":"Liu, S. et al. Endovascular perforation model for subarachnoid hemorrhage combined with magnetic resonance imaging (mri). J Vis Exp. (178), e63150 (2021).","journal-title":"J Vis Exp"},{"issue":"5","key":"ref99","doi-asserted-by":"crossref","first-page":"e032694","DOI":"10.1161\/JAHA.123.032694","type":"journal-article","article-title":"Secondary ischemia assessment in murine and rat preclinical subarachnoid hemorrhage models: A systematic review","volume":"13","author":"F\u00fcrstenau","year":"2024","unstructured":"F\u00fcrstenau, E., Lindauer, U., Koch, H., H\u00f6llig, A. 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A surgical model of permanent and transient middle cerebral artery stroke in the sheep. PLoS One. 7 (7), e42157 (2012).","journal-title":"PLoS One"},{"issue":"6","key":"ref134","doi-asserted-by":"crossref","first-page":"e0130512","DOI":"10.1371\/journal.pone.0130512","type":"journal-article","article-title":"Elevated intracranial pressure and cerebral edema following permanent mca occlusion in an ovine model","volume":"10","author":"Wells","year":"2015","unstructured":"Wells, A. J. et al. Elevated intracranial pressure and cerebral edema following permanent mca occlusion in an ovine model. PLoS One. 10 (6), e0130512 (2015).","journal-title":"PLoS One"},{"issue":"8","key":"ref135","doi-asserted-by":"crossref","first-page":"e163398","DOI":"10.1172\/jci.insight.163398","type":"journal-article","article-title":"Establishment of a reproducible and minimally invasive ischemic stroke model in swine","volume":"8","author":"Casta\u00f1o","year":"2023","unstructured":"Casta\u00f1o, C. et al. 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The future of nonhuman primate neuroscience: Peril or possibilities? J Neurosci. 44 (37), e1458242024 (2024).","journal-title":"J Neurosci"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"1080737","DOI":"10.3389\/fimmu.2022.1080737","type":"journal-article","article-title":"Neuroinflammation and brain-peripheral interaction in ischemic stroke: A narrative review","volume":"13","author":"Cheng","year":"2022","unstructured":"Cheng, W., Zhao, Q., Li, C., Xu, Y. Neuroinflammation and brain-peripheral interaction in ischemic stroke: A narrative review. Front Immunol. 13 1080737 (2022).","journal-title":"Front Immunol"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbi.2020.02.001","type":"journal-article","article-title":"Sex differences in t cell immune responses, gut permeability and outcome after ischemic stroke in aged mice","volume":"87","author":"Ahnstedt","year":"2020","unstructured":"Ahnstedt, H. et al. 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Nurs Outlook. 72 (4), 102194 (2024).","journal-title":"Nurs Outlook"},{"issue":"7","key":"ref146","doi-asserted-by":"crossref","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","type":"journal-article","article-title":"Reporting animal research: Explanation and elaboration for the arrive guidelines 2.0","volume":"18","author":"Percie Du Sert","year":"2020","unstructured":"Percie Du Sert, N. et al. Reporting animal research: Explanation and elaboration for the arrive guidelines 2.0. PLOS Biol. 18 (7), e3000411 (2020).","journal-title":"PLOS Biol"},{"issue":"10","key":"ref147","doi-asserted-by":"crossref","first-page":"e1002273","DOI":"10.1371\/journal.pbio.1002273","type":"journal-article","article-title":"Risk of bias in reports of in vivo research: A focus for improvement","volume":"13","author":"Macleod","year":"2015","unstructured":"Macleod, M. R. et al. Risk of bias in reports of in vivo research: A focus for improvement. 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Int J Stroke. 12 (5), 462-471 (2017).","journal-title":"Int J Stroke"},{"issue":"7","key":"ref149","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1161\/01.STR.0000129653.22241.d7","type":"journal-article","article-title":"Temperature-regulated model of focal ischemia in the mouse","volume":"35","author":"Barber","year":"2004","unstructured":"Barber, P. A., Hoyte, L., Colbourne, F., Buchan, A. M. Temperature-regulated model of focal ischemia in the mouse. Stroke. 35 (7), 1720-1725 (2004).","journal-title":"Stroke"},{"issue":"4","key":"ref150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/ALN.0000000000001534","type":"journal-article","article-title":"Anesthetic neuroprotection in experimental stroke in rodents: A systematic review and meta-analysis","volume":"126","author":"Archer","year":"2017","unstructured":"Archer, D. P., Walker, A. M., Mccann, S. K., Moser, J. J., Appireddy, R. M. Anesthetic neuroprotection in experimental stroke in rodents: A systematic review and meta-analysis. Anesthesiology. 126 (4), 653-665 (2017).","journal-title":"Anesthesiology"},{"issue":"2","key":"ref151","doi-asserted-by":"crossref","first-page":"e995","DOI":"10.1002\/cpz1.995","type":"journal-article","article-title":"Mouse and rat anesthesia and analgesia","volume":"4","author":"Oh","year":"2024","unstructured":"Oh, S. S. Narver, H. L. Mouse and rat anesthesia and analgesia. Curr Protoc. 4 (2), e995 (2024).","journal-title":"Curr Protoc"},{"issue":"2","key":"ref152","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jth.15154","type":"journal-article","article-title":"Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake","volume":"19","author":"Denorme","year":"2021","unstructured":"Denorme, F., Portier, I., Kosaka, Y., Campbell, R. A. Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake. J Thrombosis Haemostasis. 19 (2), 536-546 (2021).","journal-title":"J Thrombosis Haemostasis"},{"issue":"2","key":"ref153","doi-asserted-by":"crossref","first-page":"2","DOI":"10.6030\/1939-067X-2.2.2","type":"journal-article","article-title":"Rodent stroke model guidelines for preclinical stroke trials (1st edition)","volume":"2","author":"Liu","year":"2009","unstructured":"Liu, S., Zhen, G., Meloni, B. P., Campbell, K., Winn, H. R. Rodent stroke model guidelines for preclinical stroke trials (1st edition). J Exp Stroke Transl Med. 2 (2), 2-27 (2009).","journal-title":"J Exp Stroke Transl Med"},{"issue":"3","key":"ref154","doi-asserted-by":"crossref","first-page":"e1000344","DOI":"10.1371\/journal.pbio.1000344","type":"journal-article","article-title":"Publication bias in reports of animal stroke studies leads to major overstatement of efficacy","volume":"8","author":"Sena","year":"2010","unstructured":"Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W., Macleod, M. R. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol. 8 (3), e1000344 (2010).","journal-title":"PLoS Biol"},{"issue":"6","key":"ref155","first-page":"469","type":"journal-article","article-title":"To treat or not to treat: The effects of pain on experimental parameters","volume":"67","author":"Peterson","year":"2017","unstructured":"Peterson, N. C., Nunamaker, E. A., Turner, P. V. To treat or not to treat: The effects of pain on experimental parameters. Comp Med. 67 (6), 469-482 (2017).","journal-title":"Comp Med"},{"issue":"12","key":"ref156","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1177\/0271678X19875212","type":"journal-article","article-title":"Optimizing functional outcome endpoints for stroke recovery studies","volume":"39","author":"Balkaya","year":"2019","unstructured":"Balkaya, M. Cho, S. Optimizing functional outcome endpoints for stroke recovery studies. J Cereb Blood Flow Metab. 39 (12), 2323-2342 (2019).","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref157","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3389\/fneur.2020.00875","type":"journal-article","article-title":"Consensus-based core set of outcome measures for clinical motor rehabilitation after stroke\u2014a delphi study","volume":"11","author":"Pohl","year":"2020","unstructured":"Pohl, J. et al. Consensus-based core set of outcome measures for clinical motor rehabilitation after stroke\u2014a delphi study. Front Neurol. 11, 875 (2020).","journal-title":"Front Neurol"},{"issue":"1","key":"ref158","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1161\/STROKEAHA.125.052056","type":"journal-article","article-title":"Preclinical ischemic stroke multicenter (prism) trials collective statement: Opportunities, challenges, and recommendations for a new era","volume":"57","author":"Ayata","year":"2026","unstructured":"Ayata, C. et al. Preclinical ischemic stroke multicenter (prism) trials collective statement: Opportunities, challenges, and recommendations for a new era. Stroke. 57 (1), e12-e40 (2026).","journal-title":"Stroke"},{"issue":"299","key":"ref159","doi-asserted-by":"crossref","first-page":"299ra121","DOI":"10.1126\/scitranslmed.aaa9853","type":"journal-article","article-title":"Results of a preclinical randomized controlled multicenter trial (prct): Anti-cd49d treatment for acute brain ischemia","volume":"7","author":"Llovera","year":"2015","unstructured":"Llovera, G. et al. Results of a preclinical randomized controlled multicenter trial (prct): Anti-cd49d treatment for acute brain ischemia. Sci Transl Med. 7 (299), 299ra121-299ra121 (2015).","journal-title":"Sci Transl Med"},{"issue":"5","key":"ref160","doi-asserted-by":"crossref","first-page":"112302","DOI":"10.1016\/j.isci.2025.112302","type":"journal-article","article-title":"Humanized mouse model reveals t cell anxa2 as a potential therapeutic target in ischemic stroke","volume":"28","author":"Zhang","year":"2025","unstructured":"Zhang, T. et al. Humanized mouse model reveals t cell anxa2 as a potential therapeutic target in ischemic stroke. iScience. 28 (5), 112302 (2025).","journal-title":"iScience"},{"issue":"4","key":"ref161","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040877","type":"journal-article","article-title":"Organoids modeling stroke in a petri dish","volume":"12","author":"Giorgi","year":"2024","unstructured":"Giorgi, C., Castelli, V., D'angelo, M., Cimini, A. Organoids modeling stroke in a petri dish. Biomedicines. 12 (4), (2024).","journal-title":"Biomedicines"},{"issue":"6","key":"ref162","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.tibtech.2024.11.021","type":"journal-article","article-title":"Vascularized human brain organoids: Current possibilities and prospects","volume":"43","author":"Kistemaker","year":"2025","unstructured":"Kistemaker, L., Van Bodegraven, E. J., De Vries, H. E., Hol, E. M. Vascularized human brain organoids: Current possibilities and prospects. Trends Biotechnol. 43 (6), 1275-1285 (2025).","journal-title":"Trends Biotechnol"},{"issue":"11","key":"ref163","doi-asserted-by":"crossref","DOI":"10.3390\/cells12111465","type":"journal-article","article-title":"Oxygen-glucose deprivation in organotypic hippocampal cultures leads to cytoskeleton rearrangement and immune activation: Link to the potential pathomechanism of ischaemic stroke","volume":"12","author":"Bryniarska-Kubiak","year":"2023","unstructured":"Bryniarska-Kubiak, N. et al. Oxygen-glucose deprivation in organotypic hippocampal cultures leads to cytoskeleton rearrangement and immune activation: Link to the potential pathomechanism of ischaemic stroke. Cells. 12 (11), (2023).","journal-title":"Cells"},{"issue":"1","key":"ref164","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12872-023-03227-6","type":"journal-article","article-title":"Functional genomics in stroke: Current and future applications of ipscs and gene editing to dissect the function of risk variants","volume":"23","author":"Granata","year":"2023","unstructured":"Granata, A. Functional genomics in stroke: Current and future applications of ipscs and gene editing to dissect the function of risk variants. BMC Cardiovasc Disord. 23 (1), 223 (2023).","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"ref165","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020131","type":"journal-article","article-title":"Crispr-cas9 in cardiovascular medicine: Unlocking new potential for treatment","volume":"14","author":"Bonowicz","year":"2025","unstructured":"Bonowicz, K. et al. Crispr-cas9 in cardiovascular medicine: Unlocking new potential for treatment. Cells. 14 (2), (2025).","journal-title":"Cells"},{"issue":"12","key":"ref166","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.stemcr.2023.10.014","type":"journal-article","article-title":"A novel human ipsc model of col4a1\/a2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases","volume":"18","author":"Al-Thani","year":"2023","unstructured":"Al-Thani, M. et al. A novel human ipsc model of col4a1\/a2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases. Stem Cell Rep. 18 (12), 2386-2399 (2023).","journal-title":"Stem Cell Rep"},{"issue":"4","key":"ref167","doi-asserted-by":"crossref","first-page":"37429","DOI":"10.31083\/FBL37429","type":"journal-article","article-title":"Cross-species multi-omics analysis reveals myeloid-driven endothelial oxidative stress in ischemic stroke","volume":"30","author":"Cheng","year":"2025","unstructured":"Cheng, Z., Zhu, H., Feng, S., Zhang, Y., Xiong, X. Cross-species multi-omics analysis reveals myeloid-driven endothelial oxidative stress in ischemic stroke. Front Biosci (Landmark Ed). 30 (4), 37429 (2025).","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"ref168","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5152\/eurasianjmed.2023.23347","type":"journal-article","article-title":"Artificial intelligence in stroke imaging: A comprehensive review","volume":"55","author":"Koska","year":"2023","unstructured":"Koska, \u0130. Selver, A. Artificial intelligence in stroke imaging: A comprehensive review. Eurasian J Med. 55 (1), 91-97 (2023).","journal-title":"Eurasian J Med"},{"issue":"1","key":"ref169","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12915-022-01434-9","type":"journal-article","article-title":"Deep learning-based behavioral profiling of rodent stroke recovery","volume":"20","author":"Weber","year":"2022","unstructured":"Weber, R. Z., Mulders, G., Kaiser, J., Tackenberg, C., Rust, R. Deep learning-based behavioral profiling of rodent stroke recovery. BMC Biol. 20 (1), 232 (2022).","journal-title":"BMC Biol"},{"issue":"11","key":"ref170","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1161\/STROKEAHA.123.043897","type":"journal-article","article-title":"Prediction of stroke outcome in mice based on noninvasive mri and behavioral testing","volume":"54","author":"Knab","year":"2023","unstructured":"Knab, F. et al. Prediction of stroke outcome in mice based on noninvasive mri and behavioral testing. 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