{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:39:06Z","timestamp":1792589946072,"version":"4.5.0"},"reference-count":33,"publisher":"MyJove Corporation","issue":"231","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/71111","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:00:53Z","timestamp":1779231653000},"source":"Crossref","is-referenced-by-count":0,"title":["Network Pharmacology and Rat Model Analysis of Yougui Pill in Carrageenan-Induced Prostatitis"],"prefix":"10.3791","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"1","key":"ref1","first-page":"45","type":"journal-article","article-title":"Acute and chronic prostatitis","volume":"110","author":"Lam","year":"2024","unstructured":"Lam JC, Stokes W. Acute and chronic prostatitis. Am Fam Physician. 2024;110(1):45-51.","journal-title":"Am Fam Physician"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.biopha.2017.08.016","type":"journal-article","article-title":"Comprehensive overview of prostatitis","volume":"94","author":"Khan","year":"2017","unstructured":"Khan FU, Ihsan AU, Khan HU, et al. Comprehensive overview of prostatitis. Biomed Pharmacother. 2017;94:1064-1076.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jama.282.3.236","type":"journal-article","article-title":"NIH consensus definition and classification of prostatitis","volume":"282","author":"Krieger","year":"1999","unstructured":"Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999;282(3):236-237.","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.urology.2018.07.022","type":"journal-article","article-title":"Chronic prostatitis and\/or chronic pelvic pain as a psychoneuromuscular disorder: a meta-analysis","volume":"120","author":"Anderson","year":"2018","unstructured":"Anderson RU, Wise D, Nathanson BH. Chronic prostatitis and\/or chronic pelvic pain as a psychoneuromuscular disorder: a meta-analysis. Urology. 2018;120:23-29.","journal-title":"Urology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.juro.2015.10.198","type":"journal-article","article-title":"Urine trouble: alterations in brain function associated with bladder pain","volume":"196","author":"Sadler","year":"2016","unstructured":"Sadler KE, Kolber BJ. Urine trouble: alterations in brain function associated with bladder pain. J Urol. 2016;196(1):24-32.","journal-title":"J Urol"},{"issue":"10","key":"ref6","first-page":"CD012552","type":"journal-article","article-title":"Pharmacological interventions for treating chronic prostatitis\/chronic pelvic pain syndrome","volume":"10","author":"Franco","year":"2019","unstructured":"Franco JV, et al. Pharmacological interventions for treating chronic prostatitis\/chronic pelvic pain syndrome. Cochrane Database Syst Rev. 2019;10(10):CD012552.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11934-020-00978-z","type":"journal-article","article-title":"Management of chronic bacterial prostatitis","volume":"21","author":"Su","year":"2020","unstructured":"Su ZT, Zenilman JM, Sfanos KS, Herati AS. Management of chronic bacterial prostatitis. Curr Urol Rep. 2020;21(7):29.","journal-title":"Curr Urol Rep"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cmi.2022.05.035","type":"journal-article","article-title":"How I manage bacterial prostatitis","volume":"29","author":"Lam","year":"2023","unstructured":"Lam JC, Lang R, Stokes W. How I manage bacterial prostatitis. Clin Microbiol Infect. 2023;29(1):32-37.","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12906-024-04702-z","type":"journal-article","article-title":"Gardenia jasminoides fruit extract alleviates non-steroidal anti-inflammatory drug-induced gastropathy in rats","volume":"24","author":"Worapongpaiboon","year":"2024","unstructured":"Worapongpaiboon R, et al. Gardenia jasminoides fruit extract alleviates non-steroidal anti-inflammatory drug-induced gastropathy in rats. BMC Complement Med Ther. 2024;24(1):401.","journal-title":"BMC Complement Med Ther"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/HYPERTENSIONAHA.119.13289","type":"journal-article","article-title":"Alpha-blocker use and the risk of hypotension and hypotension-related clinical events in women of advanced age","volume":"74","author":"Hiremath","year":"2019","unstructured":"Hiremath S, et al. Alpha-blocker use and the risk of hypotension and hypotension-related clinical events in women of advanced age. Hypertension. 2019;74(3):645-651.","journal-title":"Hypertension"},{"issue":"1","key":"ref11","first-page":"3","type":"journal-article","article-title":"Guidelines for integrated traditional Chinese and western medicine in the diagnosis and treatment of chronic prostatitis","volume":"37","author":"Zhang","year":"2023","unstructured":"Zhang MJ, et al. Guidelines for integrated traditional Chinese and western medicine in the diagnosis and treatment of chronic prostatitis. Chin J Androl. 2023;37(1):3-17.","journal-title":"Chin J Androl"},{"issue":"8","key":"ref12","first-page":"1255","type":"journal-article","article-title":"Analysis of Yougui Wan in the treatment of andrological diseases","volume":"29","author":"Sun","year":"2017","unstructured":"Sun ZX, et al. Analysis of Yougui Wan in the treatment of andrological diseases. J West Chin Med Clin. 2017;29(8):1255-1257.","journal-title":"J West Chin Med Clin"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1234563","DOI":"10.3389\/fendo.2023.1234563","type":"journal-article","article-title":"Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-\u03baB signaling","volume":"14","author":"Xue","year":"2023","unstructured":"Xue C, et al. Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-\u03baB signaling. Front Endocrinol (Lausanne). 2023;14:1234563.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/aps.2015.85","type":"journal-article","article-title":"Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-\u03baB and NFATc1 activation and DC-STAMP expression","volume":"37","author":"Zeng","year":"2016","unstructured":"Zeng XZ, et al. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-\u03baB and NFATc1 activation and DC-STAMP expression. Acta Pharmacol Sin. 2016;37(2):255-263.","journal-title":"Acta Pharmacol Sin"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"119735","DOI":"10.1016\/j.jep.2025.119735","type":"journal-article","article-title":"Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-\u03baB signaling","author":"Yu","year":"2025","unstructured":"Yu H, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-\u03baB signaling. J Ethnopharmacol. 2025;119735.","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e202200089","DOI":"10.1002\/cbdv.202200089","type":"journal-article","article-title":"Cinnamaldehyde ameliorates dextran sulfate sodium-induced colitis in mice by modulating TLR4\/NF-\u03baB signaling pathway and NLRP3 inflammasome activation","volume":"20","author":"Tan","year":"2023","unstructured":"Tan X, et al. Cinnamaldehyde ameliorates dextran sulfate sodium-induced colitis in mice by modulating TLR4\/NF-\u03baB signaling pathway and NLRP3 inflammasome activation. Chem Biodivers. 2023;20(2):e202200089.","journal-title":"Chem Biodivers"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"649470","DOI":"10.3389\/fphar.2021.649470","type":"journal-article","article-title":"Comparative efficacy of oral Chinese patent medicine for chronic prostatitis\/chronic pelvic pain syndrome with sexual dysfunction: a Bayesian network meta-analysis of randomized controlled trials","volume":"12","author":"Zhang","year":"2021","unstructured":"Zhang Y, et al. Comparative efficacy of oral Chinese patent medicine for chronic prostatitis\/chronic pelvic pain syndrome with sexual dysfunction: a Bayesian network meta-analysis of randomized controlled trials. Front Pharmacol. 2021;12:649470.","journal-title":"Front Pharmacol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13020-023-00853-2","type":"journal-article","article-title":"Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine","volume":"18","author":"Li","year":"2023","unstructured":"Li L, Yang L, et al. Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine. Chin Med. 2023;18(1):146.","journal-title":"Chin Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.2147\/JIR.S418345","type":"journal-article","article-title":"Total flavonoids of Rhizoma Drynariae treat osteoarthritis by inhibiting arachidonic acid metabolites through AMPK\/NF\u03baB pathway","volume":"16","author":"Chen","year":"2023","unstructured":"Chen GY, et al. Total flavonoids of Rhizoma Drynariae treat osteoarthritis by inhibiting arachidonic acid metabolites through AMPK\/NF\u03baB pathway. J Inflamm Res. 2023;16:4123-4140.","journal-title":"J Inflamm Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.2147\/DDDT.S367871","type":"journal-article","article-title":"Network and experimental pharmacology to decode the action of Wendan decoction against generalized anxiety disorder","volume":"16","author":"Jin","year":"2022","unstructured":"Jin Q, et al. Network and experimental pharmacology to decode the action of Wendan decoction against generalized anxiety disorder. Drug Des Devel Ther. 2022;16:3297-3314.","journal-title":"Drug Des Devel Ther"},{"key":"ref21","first-page":"1826299","type":"journal-article","article-title":"Network pharmacology-based strategy to investigate the mechanisms of Cibotium barometz in treating osteoarthritis","volume":"2022","author":"Chen","year":"2022","unstructured":"Chen GY, et al. Network pharmacology-based strategy to investigate the mechanisms of Cibotium barometz in treating osteoarthritis. Evid Based Complement Alternat Med. 2022;2022:1826299.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"Suppl 4","key":"ref22","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","type":"journal-article","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","unstructured":"Chin CH, et al. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.","journal-title":"BMC Syst Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.2147\/DDDT.S521740","type":"journal-article","article-title":"Mechanisms of total glucosides of paeony in alleviating methotrexate-induced liver injury","volume":"19","author":"Chen","year":"2025","unstructured":"Chen GY, et al. Mechanisms of total glucosides of paeony in alleviating methotrexate-induced liver injury. Drug Des Devel Ther. 2025;19:3407-3423.","journal-title":"Drug Des Devel Ther"},{"issue":"D1","key":"ref24","doi-asserted-by":"crossref","first-page":"D368","DOI":"10.1093\/nar\/gkad1011","type":"journal-article","article-title":"AlphaFold protein structure database in 2024: providing structure coverage for over 214 million protein sequences","volume":"52","author":"Varadi","year":"2024","unstructured":"Varadi M, et al. AlphaFold protein structure database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Res. 2024;52(D1):D368-D375.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"ref25","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","type":"journal-article","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","unstructured":"Liu Y, et al. CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Res. 2022;50(W1):W159-W164.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/ijms24043898","type":"journal-article","article-title":"Low-energy shock wave suppresses prostatic pain and inflammation by modulating mitochondrial dynamics regulators on a carrageenan-induced prostatitis model in rats","volume":"24","author":"Wu","year":"2023","unstructured":"Wu ZS, Wang HJ, Lee WC, Luo HL, Lin TK, Chuang YC. Low-energy shock wave suppresses prostatic pain and inflammation by modulating mitochondrial dynamics regulators on a carrageenan-induced prostatitis model in rats. Int J Mol Sci. 2023;24(4):3898.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12987-022-00399-9","type":"journal-article","article-title":"Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells","volume":"20","author":"Luo","year":"2023","unstructured":"Luo Y, et al. Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells. Fluids Barriers CNS. 2023;20(1):1.","journal-title":"Fluids Barriers CNS"},{"issue":"13","key":"ref28","first-page":"961","type":"journal-article","article-title":"A comparative study of two methods for establishing a rat model of chronic non-bacterial prostatitis","volume":"29","author":"Tang","year":"2023","unstructured":"Tang YW, et al. A comparative study of two methods for establishing a rat model of chronic non-bacterial prostatitis. J Hainan Med Univ. 2023;29(13):961-967.","journal-title":"J Hainan Med Univ"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.12968\/hosp.1999.60.10.1213","type":"journal-article","article-title":"Prostatitis","volume":"60","author":"Thin","year":"1999","unstructured":"Thin RN. Prostatitis. Hosp Med. 1999;60(10):710-713.","journal-title":"Hosp Med"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5534\/wjmh.190135","type":"journal-article","article-title":"Impact of benign prostatic hyperplasia and\/or prostatitis on the risk of prostate cancer in Korean patients","volume":"39","author":"Kim","year":"2021","unstructured":"Kim SH, Kwon WA, Joung JY. Impact of benign prostatic hyperplasia and\/or prostatitis on the risk of prostate cancer in Korean patients. World J Mens Health. 2021;39(2):358-365.","journal-title":"World J Mens Health"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11934-023-01150-z","type":"journal-article","article-title":"Prostatitis: a review","volume":"24","author":"Yebes","year":"2023","unstructured":"Yebes A, et al. Prostatitis: a review. Curr Urol Rep. 2023;24(5):241-251.","journal-title":"Curr Urol Rep"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jama.2025.11499","type":"journal-article","article-title":"Prostatitis: a review","volume":"334","author":"Borgert","year":"2025","unstructured":"Borgert BJ, Wallen EM, Pham MN. Prostatitis: a review. JAMA. 2025;334(11):1003-1013.","journal-title":"JAMA"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.contraception.2011.11.038","type":"journal-article","article-title":"Efficacy of quercetin in treatment of benign prostatic hyperplasia in a double-blind randomized clinical trial in Iran","volume":"85","author":"Ghorbanibirgani","year":"2011","unstructured":"Ghorbanibirgani AE. Efficacy of quercetin in treatment of benign prostatic hyperplasia in a double-blind randomized clinical trial in Iran. Contraception. 2011;85(3):321.","journal-title":"Contraception"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/71111\/network-pharmacology-rat-model-analysis-yougui-pill-carrageenan","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:51Z","timestamp":1792586751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/71111\/network-pharmacology-rat-model-analysis-yougui-pill-carrageenan"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":33,"journal-issue":{"issue":"231","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3791\/71111","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}