{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:34Z","timestamp":1792586734713,"version":"4.5.0"},"reference-count":28,"publisher":"MyJove Corporation","issue":"233","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/71234","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:00:30Z","timestamp":1783724430000},"source":"Crossref","is-referenced-by-count":0,"title":["Vitamin C-Assisted Fenton Oxidation Improves Oxidative Killing of &lt;em&gt;Helicobacter pylori In Vitro&lt;\/em&gt;"],"prefix":"10.3791","author":[{"given":"Yuhung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sein","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S2468-1253(23)00070-5","type":"journal-article","article-title":"Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis","volume":"8","author":"Li","year":"2023","unstructured":"Li Y, et al. Global prevalence of Helicobacter pylori .infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023;8(6):553-564.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref2","volume-title":"List of Classifications \u2013 IARC Monographs on the Identification of Carcinogenic Hazards to Humans","year":"2023","unstructured":"IARC. List of Classifications \u2013 IARC Monographs on the Identification of Carcinogenic Hazards to Humans [Internet]. Lyon: International Agency for Research on Cancer; 2023. Available from: https:\/\/monographs.iarc.who.int\/list-of-classifications."},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gutjnl-2022-327745","type":"journal-article","article-title":"Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report","volume":"71","author":"Malfertheiner","year":"2022","unstructured":"Malfertheiner P, et al. Management of Helicobacter pylori. infection: the Maastricht VI\/Florence consensus report. Gut. 2022;71(9):1724-1762.","journal-title":"Gut"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1136\/gutjnl-2021-324032","type":"journal-article","article-title":"Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community","volume":"70","author":"Megraud","year":"2021","unstructured":"Megraud F, et al. Helicobacter pylori. resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community. Gut. 2021;70(10):1815-1822.","journal-title":"Gut"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/hel.12299","type":"journal-article","article-title":"Helicobacter pylori and antibiotic resistance, a continuing and intractable problem","volume":"21","author":"Hu","year":"2016","unstructured":"Hu Y, Zhang M, Lu B, Dai J. Helicobacter pylori. and antibiotic resistance, a continuing and intractable problem. Helicobacter. 2016;21(5):349-363.","journal-title":"Helicobacter"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1007\/s10620-012-2203-7","type":"journal-article","article-title":"Vitamin C, gastritis, and gastric disease: a historical review and update","volume":"57","author":"Aditi","year":"2012","unstructured":"Aditi A, Graham DY. Vitamin C, gastritis, and gastric disease: a historical review and update. Dig Dis Sci. 2012;57(10):2504-2515.","journal-title":"Dig Dis Sci"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10620-006-9411-y","type":"journal-article","article-title":"Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori","volume":"52","author":"Tari","year":"2007","unstructured":"Tari A, et al. Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori. Dig Dis Sci. 2007;52(1):232-239.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"ref8","first-page":"533","type":"journal-article","article-title":"Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment","volume":"89","author":"Ruiz","year":"1994","unstructured":"Ruiz B, et al. Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori. treatment. Am J Gastroenterol. 1994;89(4):533-539.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/gut.38.2.171","type":"journal-article","article-title":"Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation","volume":"38","author":"Waring","year":"1996","unstructured":"Waring AJ, et al. Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut. 1996;38(2):171-176.","journal-title":"Gut"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1083-4389.2002.00073.x","type":"journal-article","article-title":"Helicobacter pylori-related iron deficiency anemia: a review","volume":"7","author":"Barabino","year":"2002","unstructured":"Barabino A. Helicobacter pylori.-related iron deficiency anemia: a review. Helicobacter. 2002;7(2):71-75.","journal-title":"Helicobacter"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","type":"journal-article","article-title":"Activation of apoptosis signaling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","unstructured":"Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signaling pathways by reactive oxygen species. Biochim Biophys Acta. 2016;1863(12):2977-2992.","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41419-020-03118-0","type":"journal-article","article-title":"Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes, including pyroptosis","volume":"11","author":"Wiernicki","year":"2020","unstructured":"Wiernicki B, et al. Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes, including pyroptosis. Cell Death Dis. 2020;11(10):922.","journal-title":"Cell Death Dis"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"e2108646","DOI":"10.1002\/adma.202108646","type":"journal-article","article-title":"Modulating electron transfer in vanadium-based artificial enzymes for enhanced ROS-catalysis and disinfection","volume":"34","author":"Li","year":"2022","unstructured":"Li L, et al. Modulating electron transfer in vanadium-based artificial enzymes for enhanced ROS-catalysis and disinfection. Adv Mater. 2022;34(17):e2108646.","journal-title":"Adv Mater"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/antibiotics11081079","type":"journal-article","article-title":"Antibiotic resistance in bacteria\u2014a review","volume":"11","author":"Urban-Chmiel","year":"2022","unstructured":"Urban-Chmiel R, et al. Antibiotic resistance in bacteria\u2014a review. Antibiotics (Basel). 2022;11(8):1079.","journal-title":"Antibiotics (Basel)"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jmedchem.6b01243","type":"journal-article","article-title":"Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria","volume":"60","author":"Dharmaraja","year":"2017","unstructured":"Dharmaraja AT. Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria. J Med Chem. 2017;60(8):3221-3240.","journal-title":"J Med Chem"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1365-2958.2006.05302.x","type":"journal-article","article-title":"The diverse antioxidant systems of Helicobacter pylori","volume":"61","author":"Wang","year":"2006","unstructured":"Wang G, Alamuri P, Maier RJ. The diverse antioxidant systems of Helicobacter pylori. Mol Microbiol. 2006;61(4):847-860.","journal-title":"Mol Microbiol"},{"key":"ref17","first-page":"115","type":"journal-article","article-title":"Oxidation of tartaric acid in wine in the presence of heavy metal salts (activation of oxygen by iron)","volume":"3","author":"Rodopulo","year":"1951","unstructured":"Rodopulo AK. Oxidation of tartaric acid in wine in the presence of heavy metal salts (activation of oxygen by iron). Izv Akad Nauk SSSR Biol. 1951;3:115-128. Russian.","journal-title":"Izv Akad Nauk SSSR Biol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jece.2013.10.011","type":"journal-article","article-title":"A review on Fenton and improvements to the Fenton process for wastewater treatment","volume":"2","author":"Babuponnusami","year":"2014","unstructured":"Babuponnusami A, Muthukumar K. A review on Fenton and improvements to the Fenton process for wastewater treatment. J Environ Chem Eng. 2014;2(1):557-572.","journal-title":"J Environ Chem Eng"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"116529","DOI":"10.1016\/j.watres.2020.116529","type":"journal-article","article-title":"Metal-free black-red phosphorus as an efficient heterogeneous reductant to boost Fe3\u207a\/Fe2\u207a cycle for peroxymonosulfate activation","volume":"188","author":"Zhou","year":"2021","unstructured":"Zhou H, et al. Metal-free black-red phosphorus as an efficient heterogeneous reductant to boost Fe3\u207a\/Fe2\u207a cycle for peroxymonosulfate activation. Water Res. 2021;188:116529.","journal-title":"Water Res"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"e0134116","DOI":"10.1371\/journal.pone.0134116","type":"journal-article","article-title":"The evolution of stomach acidity and its relevance to the human microbiome","volume":"10","author":"Beasley","year":"2015","unstructured":"Beasley DE, Koltz AM, Lambert JE, Fierer N, Dunn RR. The evolution of stomach acidity and its relevance to the human microbiome. PLoS One. 2015;10(7):e0134116.","journal-title":"PLoS One"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.5009\/gnl17063","type":"journal-article","article-title":"Associations among gastric juice pH, atrophic gastritis, intestinal metaplasia and Helicobacter pylori infection","volume":"12","author":"Sung","year":"2018","unstructured":"Sung J, et al. Associations among gastric juice pH, atrophic gastritis, intestinal metaplasia and Helicobacter pylori. infection. Gut Liver. 2018;12(2):158-164.","journal-title":"Gut Liver"},{"issue":"20","key":"ref22","doi-asserted-by":"crossref","first-page":"e2206957","DOI":"10.1002\/advs.202206957","type":"journal-article","article-title":"Gastric acid-responsive ROS nanogenerators for effective treatment of Helicobacter pylori infection without disrupting homeostasis of intestinal flora","volume":"10","author":"Yu","year":"2023","unstructured":"Yu J, et al. Gastric acid-responsive ROS nanogenerators for effective treatment of Helicobacter pylori .infection without disrupting homeostasis of intestinal flora. Adv Sci (Weinh). 2023;10(20):e2206957.","journal-title":"Adv Sci (Weinh)"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/nu12051501","type":"journal-article","article-title":"Two faces of vitamin C\u2014an antioxidative and a pro-oxidative agent","volume":"12","author":"Ka\u017amierczak-Bara\u0144ska","year":"2020","unstructured":"Ka\u017amierczak-Bara\u0144ska J, Boguszewska K, Adamus-Grabicka A, Karwowski BT. Two faces of vitamin C\u2014an antioxidative and a pro-oxidative agent. Nutrients. 2020;12(5):1501.","journal-title":"Nutrients"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.3390\/ijms21113967","type":"journal-article","article-title":"Redox interactions of vitamin C and iron: inhibition of the pro-oxidant activity by deferiprone","volume":"21","author":"Timoshnikov","year":"2020","unstructured":"Timoshnikov VA, Kobzeva TV, Polyakov NE, Kontoghiorghes GJ. Redox interactions of vitamin C and iron: inhibition of the pro-oxidant activity by deferiprone. Int J Mol Sci. 2020;21(11):3967.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1128\/iai.63.5.1669-1673.1995","type":"journal-article","article-title":"Helicobacter pylori requires an acidic environment to survive in the presence of urea","volume":"63","author":"Clyne","year":"1995","unstructured":"Clyne M, Labigne A, Drumm B. Helicobacter pylori. requires an acidic environment to survive in the presence of urea. Infect Immun. 1995;63(5):1669-1673.","journal-title":"Infect Immun"},{"issue":"5452","key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1126\/science.287.5452.482","type":"journal-article","article-title":"A H\u207a-gated urea channel: the link between Helicobacter pylori urease and gastric colonization","volume":"287","author":"Weeks","year":"2000","unstructured":"Weeks DL, Eskandari S, Scott DR, Sachs G. A H\u207a-gated urea channel: the link between Helicobacter pylori. urease and gastric colonization. Science. 2000;287(5452):482-485.","journal-title":"Science"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1099\/00221287-148-12-3813","type":"journal-article","article-title":"Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated \u201cKatA-associated protein\u201d, KapA (HP0874)","volume":"148","author":"Harris","year":"2002","unstructured":"Harris AG, et al. Resistance to hydrogen peroxide in Helicobacter pylori.: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated \u201cKatA-associated protein\u201d, KapA (HP0874). Microbiology. 2002;148(12):3813-3825.","journal-title":"Microbiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s11671-020-03344-7","type":"journal-article","article-title":"Reactive oxygen species-related nanoparticle toxicity in the biomedical field","volume":"15","author":"Yu","year":"2020","unstructured":"Yu Z, et al. Reactive oxygen species-related nanoparticle toxicity in the biomedical field. Nanoscale Res Lett. 2020;15:115.","journal-title":"Nanoscale Res Lett"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/71234\/vitamin-c-assisted-fenton-oxidation-improves-oxidative-killing","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:19:03Z","timestamp":1792585143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/71234\/vitamin-c-assisted-fenton-oxidation-improves-oxidative-killing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":28,"journal-issue":{"issue":"233","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3791\/71234","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}