{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:35:13Z","timestamp":1792766113843,"version":"4.5.0"},"reference-count":134,"publisher":"MyJove Corporation","issue":"233","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoVE"],"DOI":"10.3791\/71378","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:01:22Z","timestamp":1783119682000},"source":"Crossref","is-referenced-by-count":1,"title":["Regulatory Mechanisms of Interleukin-1 and its Targeted Therapeutic Strategies in Osteoarthritis: An Updated Review"],"prefix":"10.3791","author":[{"given":"Fengrui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaige","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2098","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2147\/OARRR.S176666","type":"journal-article","article-title":"Novel treatments for osteoarthritis: an update","volume":"10","author":"Wu","year":"2018","unstructured":"Wu Y, Goh EL, Wang D, Ma S. Novel treatments for osteoarthritis: an update. Open Access Rheumatol. 2018;10:135-140.","journal-title":"Open Access Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"105652","DOI":"10.1016\/j.jbspin.2023.105652","type":"journal-article","article-title":"Hand osteoarthritis: A fresh look","volume":"91","author":"Richette","year":"2024","unstructured":"Richette P, Latourte A. Hand osteoarthritis: A fresh look. Joint bone spine. 2024;91:105652.","journal-title":"Joint bone spine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/BOR.0000000000000479","type":"journal-article","article-title":"Epidemiology of osteoarthritis: literature update","volume":"30","author":"Vina","year":"2018","unstructured":"Vina ER, Kwoh CK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol. 2018;30:160-167.","journal-title":"Curr Opin Rheumatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"907750","DOI":"10.3389\/fimmu.2022.907750","type":"journal-article","article-title":"Obesity, Inflammation, and Immune System in Osteoarthritis","volume":"13","author":"Nedunchezhiyan","year":"2022","unstructured":"Nedunchezhiyan U, et al. Obesity, Inflammation, and Immune System in Osteoarthritis. Front Immunol. 2022;13:907750.","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.maturitas.2016.04.006","type":"journal-article","article-title":"Obesity and osteoarthritis","volume":"89","author":"Kulkarni","year":"2016","unstructured":"Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas. 2016;89:22-28.","journal-title":"Maturitas"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11033-026-11619-y","type":"journal-article","article-title":"Role of glutamine in promoting the proliferation and chondrogenic differentiation of ATDC5 cells: based on transcriptomic analysis","volume":"53","author":"Zhang","year":"2026","unstructured":"Zhang RH, et al. Role of glutamine in promoting the proliferation and chondrogenic differentiation of ATDC5 cells: based on transcriptomic analysis. Mol Biol Rep. 2026;53:483.","journal-title":"Mol Biol Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s43465-025-01441-2","type":"journal-article","article-title":"A Meta-Analysis and Systematic Review on the Use of Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis Management","volume":"59","author":"Yang","year":"2025","unstructured":"Yang Y, et al. A Meta-Analysis and Systematic Review on the Use of Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis Management. Indian J Orthop. 2025;59:1078-1089.","journal-title":"Indian J Orthop"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.3390\/jcm13102859","type":"journal-article","article-title":"Efficacy of Anti-Interleukin-1 Therapeutics in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials from the Years 2000 to 2023","volume":"13","author":"Knapik","year":"2024","unstructured":"Knapik M, \u017belazo DA, Osowiecka K, Krajewska-W\u0142odarczyk M. Efficacy of Anti-Interleukin-1 Therapeutics in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials from the Years 2000 to 2023. J Clin Med. 2024;13:2859.","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3390\/cells12141821","type":"journal-article","article-title":"Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation","volume":"12","author":"Veronesi","year":"2023","unstructured":"Veronesi F, et al. Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation. Cells. 2023;12:1821.","journal-title":"Cells"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1136\/annrheumdis-2013-205012","type":"journal-article","article-title":"The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study","volume":"74","author":"Visser","year":"2015","unstructured":"Visser AW, et al. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis. 2015;74:1842-1847.","journal-title":"Ann Rheum Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105953","DOI":"10.1016\/j.jbspin.2025.105953","type":"journal-article","article-title":"Piezo1 at the crossroads: Mediating inflammation and mechanical stress in joint disorders","volume":"93","author":"Chen","year":"2026","unstructured":"Chen S, Li Z, Zhang J, Liu H. Piezo1 at the crossroads: Mediating inflammation and mechanical stress in joint disorders. Joint Bone Spine. 2026;93:105953.","journal-title":"Joint Bone Spine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"106226","DOI":"10.1016\/j.intimp.2020.106226","type":"journal-article","article-title":"Theobromine mitigates IL-1\u03b2-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes","volume":"82","author":"Gu","year":"2020","unstructured":"Gu R, et al. Theobromine mitigates IL-1\u03b2-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes. Int Immunopharmacol. 2020;82:106226.","journal-title":"Int Immunopharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1007\/s13577-024-01101-x","type":"journal-article","article-title":"Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome","volume":"37","author":"Xu","year":"2024","unstructured":"Xu S, et al. Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome. Hum Cell. 2024;37:1276-1289.","journal-title":"Hum Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/joca.2001.0494","type":"journal-article","article-title":"Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees","volume":"10","author":"Saito","year":"2002","unstructured":"Saito I, et al. Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees. Osteoarthritis Cartilage. 2002;10:156-162.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/art.22369","type":"journal-article","article-title":"The role of T cells in the pathogenesis of osteoarthritis","volume":"56","author":"Sakkas","year":"2007","unstructured":"Sakkas LI, Platsoucas CD. The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum. 2007;56:409-424.","journal-title":"Arthritis Rheum"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00264-020-04838-w","type":"journal-article","article-title":"Biological strategies for osteoarthritis: from early diagnosis to treatment","volume":"45","author":"Weber","year":"2021","unstructured":"Weber AE, Bolia IK, Trasolini NA. Biological strategies for osteoarthritis: from early diagnosis to treatment. Int Orthop. 2021;45:335-344.","journal-title":"Int Orthop"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cger.2021.11.015","type":"journal-article","article-title":"Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach","volume":"38","author":"Vincent","year":"2022","unstructured":"Vincent TL, et al. Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach. Clin Geriatr Med. 2022;38:193-219.","journal-title":"Clin Geriatr Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-014-9917-9","type":"journal-article","article-title":"Osteoarthritis pathogenesis: a review of molecular mechanisms","volume":"95","author":"Xia","year":"2014","unstructured":"Xia B, et al. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int. 2014;95:495-505.","journal-title":"Calcif Tissue Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","type":"journal-article","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","unstructured":"Kapoor M, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33-42.","journal-title":"Nat Rev Rheumatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3109\/1354750X.2016.1171907","type":"journal-article","article-title":"Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis","volume":"21","author":"Mabey","year":"2016","unstructured":"Mabey T, et al. Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis. Biomarkers. 2016;21:639-644.","journal-title":"Biomarkers"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/03008207.2016.1208655","type":"journal-article","article-title":"Inflammation and epigenetic regulation in osteoarthritis","volume":"58","author":"Shen","year":"2017","unstructured":"Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A. Inflammation and epigenetic regulation in osteoarthritis. Connect Tissue Res. 2017;58:49-63.","journal-title":"Connect Tissue Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.3390\/ijms22179208","type":"journal-article","article-title":"Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis","volume":"22","author":"Molnar","year":"2021","unstructured":"Molnar V, et al. Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis. Int J Mol Sci. 2021;22:9208.","journal-title":"Int J Mol Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mmr.2022.12615","type":"journal-article","article-title":"Cartilage tissue engineering: From proinflammatory and anti\u2011inflammatory cytokines to osteoarthritis treatments (Review)","volume":"25","author":"Liu","year":"2022","unstructured":"Liu S, et al. Cartilage tissue engineering: From proinflammatory and anti\u2011inflammatory cytokines to osteoarthritis treatments (Review). Mol Med Rep. 2022;25:99.","journal-title":"Mol Med Rep"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.knee.2019.10.028","type":"journal-article","article-title":"Elevated plasma and synovial fluid interleukin-8 and interleukin-18 may be associated with the pathogenesis of knee osteoarthritis","volume":"27","author":"Koh","year":"2020","unstructured":"Koh SM, et al. Elevated plasma and synovial fluid interleukin-8 and interleukin-18 may be associated with the pathogenesis of knee osteoarthritis. Knee. 2020;27:26-35.","journal-title":"Knee"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/imm.12899","type":"journal-article","article-title":"Galectin-3 is an amplifier of the interleukin-1\u03b2-mediated inflammatory response in corneal keratinocytes","volume":"154","author":"Uchino","year":"2018","unstructured":"Uchino Y, et al. Galectin-3 is an amplifier of the interleukin-1\u03b2-mediated inflammatory response in corneal keratinocytes. Immunology. 2018;154:490-499.","journal-title":"Immunology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cellsig.2018.10.005","type":"journal-article","article-title":"Interleukin-1\u03b2 signaling in osteoarthritis - chondrocytes in focus","volume":"53","author":"Jenei-Lanzl","year":"2019","unstructured":"Jenei-Lanzl Z, Meurer A, Zaucke F. Interleukin-1\u03b2 signaling in osteoarthritis - chondrocytes in focus. Cell Signal. 2019;53:212-223.","journal-title":"Cell Signal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1637731","DOI":"10.3389\/fimmu.2025.1637731","type":"journal-article","article-title":"Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications","volume":"16","author":"Zhang","year":"2025","unstructured":"Zhang K, et al. Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications. Front Immunol. 2025;16:1637731.","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/09553002.2026.2636290","type":"journal-article","article-title":"Low-dose radiotherapy in osteoarthritis: a comprehensive review of immunological and molecular mechanisms","volume":"102","author":"Khakshour","year":"2026","unstructured":"Khakshour E, et al. Low-dose radiotherapy in osteoarthritis: a comprehensive review of immunological and molecular mechanisms. Int J Radiat Biol. 2026;102:447-454.","journal-title":"Int J Radiat Biol"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.18831.1","type":"journal-article","article-title":"IL-1 in osteoarthritis: time for a critical review of the literature","volume":"8","author":"Vincent","year":"2019","unstructured":"Vincent TL. IL-1 in osteoarthritis: time for a critical review of the literature. F1000Res. 2019;8:F1000 Faculty Rev-934.","journal-title":"F1000Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0753-3322(97)87727-X","type":"journal-article","article-title":"Upregulation of enzymatic activity by interleukin-1 in osteoarthritis","volume":"51","author":"Chevalier","year":"1997","unstructured":"Chevalier X. Upregulation of enzymatic activity by interleukin-1 in osteoarthritis. Biomed Pharmacother. 1997;51:58-62.","journal-title":"Biomed Pharmacother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"105669","DOI":"10.1016\/j.clinbiomech.2022.105669","type":"journal-article","article-title":"Vastus medialis intramuscular fat is associated with reduced quadriceps strength, but not knee osteoarthritis severity","volume":"96","author":"Teoli","year":"2022","unstructured":"Teoli A, et al. Vastus medialis intramuscular fat is associated with reduced quadriceps strength, but not knee osteoarthritis severity. Clin Biomech (Bristol). 2022;96:105669.","journal-title":"Clin Biomech (Bristol)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/art.30360","type":"journal-article","article-title":"Increased interleukin-1\u03b2 gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis","volume":"63","author":"Attur","year":"2011","unstructured":"Attur M, et al. Increased interleukin-1\u03b2 gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum. 2011;63:1908-1917.","journal-title":"Arthritis Rheum"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1759720X12467868","type":"journal-article","article-title":"Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations","volume":"5","author":"Sokolove","year":"2013","unstructured":"Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013;5:77-94.","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1362012","DOI":"10.3389\/fimmu.2024.1362012","type":"journal-article","article-title":"Exploring causal correlations between inflammatory cytokines and knee osteoarthritis: a two-sample Mendelian randomization","volume":"15","author":"Zhang","year":"2024","unstructured":"Zhang J, Li K, Qiu X. Exploring causal correlations between inflammatory cytokines and knee osteoarthritis: a two-sample Mendelian randomization. Front Immunol. 2024;15:1362012.","journal-title":"Front Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"100046","DOI":"10.1016\/j.ocarto.2020.100046","type":"journal-article","article-title":"The association of plasma IL-1Ra and related cytokines with radiographic severity of early knee osteoarthritis","volume":"2","author":"Ma","year":"2020","unstructured":"Ma CA, et al. The association of plasma IL-1Ra and related cytokines with radiographic severity of early knee osteoarthritis. Osteoarthr Cartil Open. 2020;2:100046.","journal-title":"Osteoarthr Cartil Open"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41392-025-02556-6","type":"journal-article","article-title":"Osteoarthritis: molecular pathogenesis and potential therapeutic options","volume":"11","author":"Zhang","year":"2026","unstructured":"Zhang Y, et al. Osteoarthritis: molecular pathogenesis and potential therapeutic options. Signal Transduct Target Ther. 2026;11:81.","journal-title":"Signal Transduct Target Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.2147\/JIR.S474879","type":"journal-article","article-title":"Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review","volume":"17","author":"Xu","year":"2024","unstructured":"Xu Y, et al. Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review. J Inflamm Res. 2024;17:4001-4016.","journal-title":"J Inflamm Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/imr.12606","type":"journal-article","article-title":"The family of the interleukin-1 receptors","volume":"281","author":"Boraschi","year":"2018","unstructured":"Boraschi D, Italiani P, Weil S, Martin MU. The family of the interleukin-1 receptors. Immunol Rev. 2018;281:197-232.","journal-title":"Immunol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/art.1780350507","type":"journal-article","article-title":"The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function","volume":"35","author":"Martel-Pelletier","year":"1992","unstructured":"Martel-Pelletier J, et al. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum. 1992;35:530-540.","journal-title":"Arthritis Rheum"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3389\/fimmu.2019.01412","type":"journal-article","article-title":"Structural Basis of IL-1 Family Cytokine Signaling","volume":"10","author":"Fields","year":"2019","unstructured":"Fields JK, G\u00fcnther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019;10:1412.","journal-title":"Front Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0167-5699(94)90217-8","type":"journal-article","article-title":"The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1","volume":"15","author":"Colotta","year":"1994","unstructured":"Colotta F, Dower SK, Sims JE, Mantovani A. The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1. Immunol Today. 1994;15:562-566.","journal-title":"Immunol Today"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/ar411","type":"journal-article","article-title":"Production of interleukin-1 receptor antagonist by human articular chondrocytes","volume":"4","author":"Palmer","year":"2002","unstructured":"Palmer G, et al. Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis Res. 2002;4:226-231.","journal-title":"Arthritis Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.joca.2015.08.006","type":"journal-article","article-title":"Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis","volume":"23","author":"Attur","year":"2015","unstructured":"Attur M, et al. Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2015;23:1915-1924.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000055915","type":"journal-article","article-title":"Interleukin-1beta induces different gene expression of stromelysin, aggrecan and tumor-necrosis-factor-stimulated gene 6 in human osteoarthritic chondrocytes in vitro","volume":"68","author":"St\u00f6ve","year":"2000","unstructured":"St\u00f6ve J, Huch K, G\u00fcnther KP, Scharf HP. Interleukin-1beta induces different gene expression of stromelysin, aggrecan and tumor-necrosis-factor-stimulated gene 6 in human osteoarthritic chondrocytes in vitro. Pathobiology. 2000;68:144-149.","journal-title":"Pathobiology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jcb.240540110","type":"journal-article","article-title":"Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes","volume":"54","author":"Goldring","year":"1994","unstructured":"Goldring MB, et al. Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes. J Cell Biochem. 1994;54:85-99.","journal-title":"J Cell Biochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/322547a0","type":"journal-article","article-title":"Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage","volume":"322","author":"Saklatvala","year":"1986","unstructured":"Saklatvala J. Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature. 1986;322:547-549.","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.aanat.2005.06.007","type":"journal-article","article-title":"Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study","volume":"187","author":"Shakibaei","year":"2005","unstructured":"Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat. 2005;187:487-497.","journal-title":"Ann Anat"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4","type":"journal-article","article-title":"Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3","volume":"43","author":"Mengshol","year":"2000","unstructured":"Mengshol JA, et al. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 2000;43:801-811.","journal-title":"Arthritis Rheum"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1172\/JCI118636","type":"journal-article","article-title":"The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis","volume":"97","author":"Reboul","year":"1996","unstructured":"Reboul P, et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest. 1996;97:2011-2019.","journal-title":"J Clin Invest"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1053\/joca.2001.0427","type":"journal-article","article-title":"The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation","volume":"9","author":"Tortorella","year":"2001","unstructured":"Tortorella MD, Malfait AM, Deccico C, Arner E. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis cartilage. 2001;9:539-552.","journal-title":"Osteoarthritis cartilage"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar2099","type":"journal-article","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","unstructured":"Bondeson J, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther. 2006;8:R187.","journal-title":"Arthritis Res Ther"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/jor.22334","type":"journal-article","article-title":"Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation","volume":"31","author":"McNulty","year":"2013","unstructured":"McNulty AL, Rothfusz NE, Leddy HA, Guilak F. Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. J Orthop Res. 2013;31:1039-1045.","journal-title":"J Orthop Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.11355","type":"journal-article","article-title":"Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy","volume":"48","author":"Clements","year":"2003","unstructured":"Clements KM, et al. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum. 2003;48:3452-3463.","journal-title":"Arthritis Rheum"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.joca.2021.07.005","type":"journal-article","article-title":"A single dose of anti-IL-1\u03b2 antibodies prevents Western diet-induced immune activation during early stage collagenase-induced osteoarthritis, but does not ameliorate end-stage pathology","volume":"29","author":"Kruisbergen","year":"2021","unstructured":"Kruisbergen NNL, et al. A single dose of anti-IL-1\u03b2 antibodies prevents Western diet-induced immune activation during early stage collagenase-induced osteoarthritis, but does not ameliorate end-stage pathology. Osteoarthritis Cartilage. 2021;29:1462-1473.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1186\/s13018-025-06259-0","type":"journal-article","article-title":"Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4\/Stat5b\/NF-\u03baB signaling to alleviate osteoarthritis progression","volume":"20","author":"Jiang","year":"2025","unstructured":"Jiang D, et al. Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4\/Stat5b\/NF-\u03baB signaling to alleviate osteoarthritis progression. J Orthop Surg Res. 2025;20:835.","journal-title":"J Orthop Surg Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.148.2.466","type":"journal-article","article-title":"Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes","volume":"148","author":"Lotz","year":"1992","unstructured":"Lotz M, Terkeltaub R, Villiger PM. Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes. J Immunol. 1992;148:466-473.","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1172\/JCI115885","type":"journal-article","article-title":"Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid","volume":"90","author":"Villiger","year":"1992","unstructured":"Villiger PM, Terkeltaub R, Lotz M. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. J Clin Invest. 1992;90:488-496.","journal-title":"J Clin Invest"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/1529-0131(200107)44:7<1633::AID-ART286>3.0.CO;2-Z","type":"journal-article","article-title":"Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation","volume":"44","author":"Alaaeddine","year":"2001","unstructured":"Alaaeddine N, et al. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum. 2001;44:1633-1643.","journal-title":"Arthritis Rheum"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.csm.2017.02.001","type":"journal-article","article-title":"Basic Science of Articular Cartilage","volume":"36","author":"Carballo","year":"2017","unstructured":"Carballo CB, Nakagawa Y, Sekiya I, Rodeo SA. Basic Science of Articular Cartilage. Clin Sports Med. 2017;36:413-425.","journal-title":"Clin Sports Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.144.2.499","type":"journal-article","article-title":"IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro","volume":"144","author":"Guerne","year":"1990","unstructured":"Guerne PA, Carson DA, Lotz M. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol. 1990;144:499-505.","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"116068","DOI":"10.1016\/j.bone.2021.116068","type":"journal-article","article-title":"Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association","volume":"152","author":"Jones","year":"2021","unstructured":"Jones TL, et al. Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association. Bone. 2021;152:116068.","journal-title":"Bone"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","type":"journal-article","article-title":"Reactive oxygen species and superoxide dismutases: role in joint diseases","volume":"74","author":"Afonso","year":"2007","unstructured":"Afonso V, et al. Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint bone spine. 2007;74:324-329.","journal-title":"Joint bone spine"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"104997","DOI":"10.1016\/j.pestbp.2021.104997","type":"journal-article","article-title":"P-coumaric acid ameliorates fipronil induced liver injury in mice through attenuation of structural changes, oxidative stress and inflammation","volume":"180","author":"Bal","year":"2022","unstructured":"Bal SS, Leishangthem GD, Sethi RS, Singh A. P-coumaric acid ameliorates fipronil induced liver injury in mice through attenuation of structural changes, oxidative stress and inflammation. Pestic Biochem Physiol. 2022;180:104997.","journal-title":"Pestic Biochem Physiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1111\/jcmm.15763","type":"journal-article","article-title":"TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice","volume":"24","author":"Liu","year":"2020","unstructured":"Liu X, et al. TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice. J Cell Mol Med. 2020;24:11489-11499.","journal-title":"J Cell Mol Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.joca.2018.02.901","type":"journal-article","article-title":"NLRP3 as a potentially novel biomarker for the management of osteoarthritis","volume":"26","author":"McAllister","year":"2018","unstructured":"McAllister MJ, et al. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis Cartilage. 2018;26:612-619.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10787-023-01235-8","type":"journal-article","article-title":"The NLRP3 inflammasome: role in the pathobiology of chronic pain","volume":"31","author":"Chen","year":"2023","unstructured":"Chen C, Smith MT. The NLRP3 inflammasome: role in the pathobiology of chronic pain. Inflammopharmacology. 2023;31:1589-1603.","journal-title":"Inflammopharmacology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10735-026-10804-4","type":"journal-article","article-title":"Interleukin-1 Receptor-Associated Kinase 3 Attenuates Chondrocyte Senescence and Osteoarthritis via Inhibition of the TLR7\/9-NF-\u03baB Axis","volume":"57","author":"Tao","year":"2026","unstructured":"Tao T, Yin G, Wang L, Wang Y. Interleukin-1 Receptor-Associated Kinase 3 Attenuates Chondrocyte Senescence and Osteoarthritis via Inhibition of the TLR7\/9-NF-\u03baB Axis. J Mol Histol. 2026;57:148.","journal-title":"J Mol Histol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1080\/21655979.2021.2024685","type":"journal-article","article-title":"Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-\u03baB pathways in vitro","volume":"13","author":"Liu","year":"2022","unstructured":"Liu X, et al. Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-\u03baB pathways in vitro. Bioengineered. 2022;13:3450-3461.","journal-title":"Bioengineered"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1186\/s13018-023-04238-x","type":"journal-article","article-title":"Paeoniflorin shows chondroprotective effects under IL-1\u03b2 stress by regulating circ-PREX1\/miR-140-3p\/WNT5B axis","volume":"18","author":"Wu","year":"2023","unstructured":"Wu L, et al. Paeoniflorin shows chondroprotective effects under IL-1\u03b2 stress by regulating circ-PREX1\/miR-140-3p\/WNT5B axis. J Orthop Surg Res. 2023;18:766.","journal-title":"J Orthop Surg Res"},{"key":"ref70","first-page":"583","type":"journal-article","article-title":"Effects and relationship of ERK1 and ERK2 in interleukin-1\u03b2-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes","volume":"27","author":"Wang","year":"2011","unstructured":"Wang X, et al. Effects and relationship of ERK1 and ERK2 in interleukin-1\u03b2-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes. Int J Mol Med. 2011;27:583-589.","journal-title":"Int J Mol Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11626-016-0086-1","type":"journal-article","article-title":"Proliferation of rabbit chondrocyte and inhibition of IL-1\u03b2-induced apoptosis through MEK\/ERK signaling by statins","volume":"53","author":"Zhou","year":"2017","unstructured":"Zhou B, Chen D, Xu H, Zhang X. Proliferation of rabbit chondrocyte and inhibition of IL-1\u03b2-induced apoptosis through MEK\/ERK signaling by statins. In Vitro Cell Dev Biol Anim. 2017;53:124-131.","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cyto.2004.06.003","type":"journal-article","article-title":"IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways","volume":"28","author":"Fan","year":"2004","unstructured":"Fan Z, Bau B, Yang H, Aigner T. IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine. 2004;28:17-24.","journal-title":"Cytokine"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbrc.2010.09.095","type":"journal-article","article-title":"Analysis of isoform specific ERK signaling on the effects of interleukin-1\u03b2 on COX-2 expression and PGE2 production in human chondrocytes","volume":"402","author":"Wang","year":"2010","unstructured":"Wang X, et al. Analysis of isoform specific ERK signaling on the effects of interleukin-1\u03b2 on COX-2 expression and PGE2 production in human chondrocytes. Biochem Biophys Res Commun. 2010;402:23-29.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/1529-0131(200010)43:10<2189::AID-ANR6>3.0.CO;2-S","type":"journal-article","article-title":"Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta","volume":"43","author":"Robbins","year":"2000","unstructured":"Robbins JR, et al. Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta. Arthritis Rheum. 2000;43:2189-2201.","journal-title":"Arthritis Rheum"},{"key":"ref75","first-page":"661","type":"journal-article","article-title":"p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes","volume":"17","author":"Radons","year":"2006","unstructured":"Radons J, et al. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med. 2006;17:661-668.","journal-title":"Int J Mol Med"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1186\/ar3166","type":"journal-article","article-title":"Pomegranate extract inhibits the interleukin-1\u03b2-induced activation of MKK-3, p38\u03b1-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes","volume":"12","author":"Rasheed","year":"2010","unstructured":"Rasheed Z, Akhtar N, Haqqi TM. Pomegranate extract inhibits the interleukin-1\u03b2-induced activation of MKK-3, p38\u03b1-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis Res Ther. 2010;12:R195.","journal-title":"Arthritis Res Ther"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/emm.2004.31","type":"journal-article","article-title":"Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes","volume":"36","author":"Choi","year":"2004","unstructured":"Choi YA, et al. Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes. Exp Mol Med. 2004;36:226-232.","journal-title":"Exp Mol Med"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"E980","DOI":"10.1152\/ajpendo.00243.2003","type":"journal-article","article-title":"Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses","volume":"286","author":"Shikhman","year":"2004","unstructured":"Shikhman AR, Brinson DC, Lotz MK. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab. 2004;286:E980-5.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref79","first-page":"563","type":"journal-article","article-title":"Aquaporin-4 Blockage by siRNA Protects Rat Articular Chondrocytes from IL-1\u03b2-induced Apoptosis by Inhibiting p38 MAPK Signal Pathway","volume":"47","author":"Cai","year":"2017","unstructured":"Cai L, et al. Aquaporin-4 Blockage by siRNA Protects Rat Articular Chondrocytes from IL-1\u03b2-induced Apoptosis by Inhibiting p38 MAPK Signal Pathway. Ann Clin Lab Sci. 2017;47:563-571.","journal-title":"Ann Clin Lab Sci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.tice.2017.10.004","type":"journal-article","article-title":"PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis","volume":"49","author":"Ge","year":"2017","unstructured":"Ge Q, et al. PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis. Tissue cell. 2017;49:719-725.","journal-title":"Tissue cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"29780","DOI":"10.1074\/jbc.M411793200","type":"journal-article","article-title":"c-Jun\/activator protein-1 mediates interleukin-1beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes","volume":"280","author":"Hwang","year":"2005","unstructured":"Hwang SG, Yu SS, Poo H, Chun JS. c-Jun\/activator protein-1 mediates interleukin-1beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J Biol Chem. 2005;280:29780-29787.","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1159\/000341438","type":"journal-article","article-title":"Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases","volume":"30","author":"Sylvester","year":"2012","unstructured":"Sylvester J, et al. Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases. Cell Physiol Biochem. 2012;30:563-574.","journal-title":"Cell Physiol Biochem"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1002\/art.39099","type":"journal-article","article-title":"Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes","volume":"67","author":"Ismail","year":"2015","unstructured":"Ismail HM, et al. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-1836.","journal-title":"Arthritis Rheumatol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/jor.20168","type":"journal-article","article-title":"Distinct signaling pathways are involved in hypoxia- and IL-1-induced VEGF expression in human articular chondrocytes","volume":"24","author":"Murata","year":"2006","unstructured":"Murata M, et al. Distinct signaling pathways are involved in hypoxia- and IL-1-induced VEGF expression in human articular chondrocytes. J Orthop Res. 2006;24:1544-1554.","journal-title":"J Orthop Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1039\/C5MB00776C","type":"journal-article","article-title":"DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis","volume":"12","author":"Wang","year":"2016","unstructured":"Wang Y, Xu Z, Wang J, Xu S. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Mol Biosyst. 2016;12:721-728.","journal-title":"Mol Biosyst"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1074\/jbc.275.5.3687","type":"journal-article","article-title":"Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha","volume":"275","author":"Murakami","year":"2000","unstructured":"Murakami S, Lefebvre V, de Crombrugghe B. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem. 2000;275:3687-3692.","journal-title":"J Biol Chem"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3390\/cells8070734","type":"journal-article","article-title":"NF-\u03baB Signaling Pathways in Osteoarthritic Cartilage Destruction","volume":"8","author":"Choi","year":"2019","unstructured":"Choi MC, et al. NF-\u03baB Signaling Pathways in Osteoarthritic Cartilage Destruction. Cells. 2019;8:734.","journal-title":"Cells"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","type":"journal-article","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","unstructured":"Lepetsos P, Papavassiliou KA, Papavassiliou AG. Redox and NF-\u03baB signaling in osteoarthritis. Free Radic Biol Med. 2019;132:90-100.","journal-title":"Free Radic Biol Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","type":"journal-article","article-title":"NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","unstructured":"Roman-Blas JA, Jimenez SA. NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis cartilage. 2006;14:839-848.","journal-title":"Osteoarthritis cartilage"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00296-006-0114-7","type":"journal-article","article-title":"Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes","volume":"26","author":"Fan","year":"2006","unstructured":"Fan Z, et al. Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes. Rheumatol Int. 2006;26:900-903.","journal-title":"Rheumatol Int"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"25900","DOI":"10.1074\/jbc.M707692200","type":"journal-article","article-title":"Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT\/IkappaB kinase alpha pathway targeting activator protein-1","volume":"283","author":"Cahill","year":"2008","unstructured":"Cahill CM, Rogers JT. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT\/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem. 2008;283:25900-25912.","journal-title":"J Biol Chem"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10753-016-0309-3","type":"journal-article","article-title":"Tenuigenin Prevents IL-1\u03b2-induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing PI3K\/AKT\/NF-\u03baB Signaling Pathway","volume":"39","author":"Wang","year":"2016","unstructured":"Wang C, et al. Tenuigenin Prevents IL-1\u03b2-induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing PI3K\/AKT\/NF-\u03baB Signaling Pathway. Inflammation. 2016;39:807-812.","journal-title":"Inflammation"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"41988","DOI":"10.18632\/oncotarget.16716","type":"journal-article","article-title":"Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway","volume":"8","author":"Xue","year":"2017","unstructured":"Xue EX, et al. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017;8:41988-42000.","journal-title":"Oncotarget"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.joca.2007.06.006","type":"journal-article","article-title":"Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA","volume":"16","author":"Chen","year":"2008","unstructured":"Chen LX, et al. Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA. Osteoarthritis cartilage. 2008;16:174-184.","journal-title":"Osteoarthritis cartilage"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jot.2025.03.012","type":"journal-article","article-title":"PTHrP buffers Wnt\/\u03b2-catenin activity through a PKC-\u03b6 involved negative feedback loop to maintain articular cartilage homeostasis and attenuate osteoarthritis","volume":"54","author":"Tong","year":"2025","unstructured":"Tong WX, et al. PTHrP buffers Wnt\/\u03b2-catenin activity through a PKC-\u03b6 involved negative feedback loop to maintain articular cartilage homeostasis and attenuate osteoarthritis. J Orthop Translat. 2025;54:65-76.","journal-title":"J Orthop Translat"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/labinvest.2015.142","type":"journal-article","article-title":"Wnt signaling in cartilage development and diseases: lessons from animal studies","volume":"96","author":"Usami","year":"2016","unstructured":"Usami Y, Gunawardena AT, Iwamoto M, Enomoto-Iwamoto M. Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab Invest. 2016;96:186-196.","journal-title":"Lab Invest"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/labinvest.3700747","type":"journal-article","article-title":"Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration","volume":"88","author":"Yuasa","year":"2008","unstructured":"Yuasa T, et al. Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest. 2008;88:264-274.","journal-title":"Lab Invest"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.3390\/ijms18112491","type":"journal-article","article-title":"Nitric Oxide Mediates Crosstalk between Interleukin 1\u03b2 and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression","volume":"18","author":"Zhong","year":"2017","unstructured":"Zhong L, et al. Nitric Oxide Mediates Crosstalk between Interleukin 1\u03b2 and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression. Int J Mol Sci. 2017;18:2491.","journal-title":"Int J Mol Sci"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/art.24247","type":"journal-article","article-title":"Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1","volume":"60","author":"Blom","year":"2009","unstructured":"Blom AB, et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum. 2009;60:501-512.","journal-title":"Arthritis Rheum"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/art.24779","type":"journal-article","article-title":"Role of Wnt-5A in interleukin-1beta-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes","volume":"60","author":"Ge","year":"2009","unstructured":"Ge X, et al. Role of Wnt-5A in interleukin-1beta-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes. Arthritis Rheum. 2009;60:2714-2722.","journal-title":"Arthritis Rheum"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"22039","DOI":"10.1074\/jbc.M601804200","type":"journal-article","article-title":"Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes","volume":"281","author":"Ryu","year":"2006","unstructured":"Ryu JH, Chun JS. Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes. J Biol Chem. 2006;281:22039-47.","journal-title":"J Biol Chem"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/art.22867","type":"journal-article","article-title":"Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women","volume":"56","author":"Lane","year":"2007","unstructured":"Lane NE, et al. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum. 2007;56:3319-3325.","journal-title":"Arthritis Rheum"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"172925","DOI":"10.1016\/j.ejphar.2020.172925","type":"journal-article","article-title":"Protective effects of Erdosteine on interleukin-1\u03b2-stimulated inflammation via inhibiting the activation of MAPK, NF-\u03baB, and Wnt\/\u03b2-catenin signaling pathways in rat osteoarthritis","volume":"873","author":"Xi","year":"2020","unstructured":"Xi Y, et al. Protective effects of Erdosteine on interleukin-1\u03b2-stimulated inflammation via inhibiting the activation of MAPK, NF-\u03baB, and Wnt\/\u03b2-catenin signaling pathways in rat osteoarthritis. Eur J Pharmacol. 2020;873:172925.","journal-title":"Eur J Pharmacol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.joca.2024.05.008","type":"journal-article","article-title":"Repurposing drugs for the treatment of osteoarthritis","volume":"32","author":"Kuswanto","year":"2024","unstructured":"Kuswanto W, Baker MC. Repurposing drugs for the treatment of osteoarthritis. Osteoarthritis cartilage. 2024;32:886-895.","journal-title":"Osteoarthritis cartilage"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1186\/s13063-022-06715-w","type":"journal-article","article-title":"Study protocol for a randomised controlled trial of diacerein versus placebo to treat knee osteoarthritis with effusion-synovitis (DICKENS)","volume":"23","author":"Cai","year":"2022","unstructured":"Cai G, et al. Study protocol for a randomised controlled trial of diacerein versus placebo to treat knee osteoarthritis with effusion-synovitis (DICKENS). Trials. 2022;23:768.","journal-title":"Trials"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1093\/rheumatology\/keaa072","type":"journal-article","article-title":"An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis","volume":"59","author":"Pelletier","year":"2020","unstructured":"Pelletier JP, et al. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis. Rheumatology (Oxford). 2020;59:3858-3868.","journal-title":"Rheumatology (Oxford)"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1002\/1529-0131(200010)43:10<2339::AID-ANR23>3.0.CO;2-P","type":"journal-article","article-title":"Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group","volume":"43","author":"Pelletier","year":"2000","unstructured":"Pelletier JP, et al. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Arthritis Rheum. 2000;43:2339-2348.","journal-title":"Arthritis Rheum"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s10067-009-1225-9","type":"journal-article","article-title":"Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial","volume":"28","author":"Brahmachari","year":"2009","unstructured":"Brahmachari B, Chatterjee S, Ghosh A. Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial. Clin Rheumatol. 2009;28:1193-1198.","journal-title":"Clin Rheumatol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1001\/jamainternmed.2025.8237","type":"journal-article","article-title":"Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial","volume":"186","author":"Aitken","year":"2026","unstructured":"Aitken D, et al. Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial. JAMA Intern Med. 2026;186:546-555.","journal-title":"JAMA Intern Med"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"e35317","DOI":"10.1097\/MD.0000000000035317","type":"journal-article","article-title":"Efficacy and safety of diacerein and celecoxib combination therapy for knee osteoarthritis: A double-blind, randomized, placebo-controlled prospective study","volume":"102","author":"Youn","year":"2023","unstructured":"Youn S, et al. Efficacy and safety of diacerein and celecoxib combination therapy for knee osteoarthritis: A double-blind, randomized, placebo-controlled prospective study. Medicine. 2023;102:e35317.","journal-title":"Medicine"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.joca.2007.02.021","type":"journal-article","article-title":"The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study","volume":"15","author":"Louthrenoo","year":"2007","unstructured":"Louthrenoo W, et al. The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study. Osteoarthritis cartilage. 2007;15:605-614.","journal-title":"Osteoarthritis cartilage"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1002\/art.23056","type":"journal-article","article-title":"The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period","volume":"56","author":"Pavelka","year":"2007","unstructured":"Pavelka K, et al. The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period. Arthritis Rheumatol. 2007;56:4055-4064.","journal-title":"Arthritis Rheumatol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.joca.2007.07.008","type":"journal-article","article-title":"Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial","volume":"16","author":"Auw Yang","year":"2008","unstructured":"Auw Yang KG, et al. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage. 2008;16:498-505.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.joca.2008.06.014","type":"journal-article","article-title":"Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis","volume":"17","author":"Baltzer","year":"2009","unstructured":"Baltzer AW, Moser C, Jansen SA, Krauspe R. Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage. 2009;17:152-160.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.arthro.2018.12.035","type":"journal-article","article-title":"Autologous Interleukin 1 Receptor Antagonist Blood-Derived Products for Knee Osteoarthritis: A Systematic Review","volume":"35","author":"Ajrawat","year":"2019","unstructured":"Ajrawat P, Dwyer T, Chahal J. Autologous Interleukin 1 Receptor Antagonist Blood-Derived Products for Knee Osteoarthritis: A Systematic Review. Arthroscopy. 2019;35:2211-2221.","journal-title":"Arthroscopy"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"1790140","DOI":"10.3389\/fmed.2026.1790140","type":"journal-article","article-title":"From regeneration to immunomodulation: a 20-year global bibliometric analysis of platelet-rich plasma for osteoarthritis","volume":"13","author":"Wang","year":"2026","unstructured":"Wang Y, et al. From regeneration to immunomodulation: a 20-year global bibliometric analysis of platelet-rich plasma for osteoarthritis. Front Med (Lausanne). 2026;13:1790140.","journal-title":"Front Med (Lausanne)"},{"key":"ref117","first-page":"e52693","type":"journal-article","article-title":"Autologous Conditioned Plasma (ACP) and Osteoarthritis of the Knee: A Review of Current Clinical Evidence","volume":"16","author":"Gupta","year":"2024","unstructured":"Gupta A, Jain V. Autologous Conditioned Plasma (ACP) and Osteoarthritis of the Knee: A Review of Current Clinical Evidence. Cureus. 2024;16:e52693.","journal-title":"Cureus"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/art.24096","type":"journal-article","article-title":"Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study","volume":"61","author":"Chevalier","year":"2009","unstructured":"Chevalier X, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2009;61:344-352.","journal-title":"Arthritis Rheum"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/ar3430","type":"journal-article","article-title":"A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee","volume":"13","author":"Cohen","year":"2011","unstructured":"Cohen SB, et al. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther. 2011;13:R125.","journal-title":"Arthritis Res Ther"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40840","type":"journal-article","article-title":"A Phase II Trial of Lutikizumab, an Anti-Interleukin-1\u03b1\/\u03b2 Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis","volume":"71","author":"Fleischmann","year":"2019","unstructured":"Fleischmann RM, et al. A Phase II Trial of Lutikizumab, an Anti-Interleukin-1\u03b1\/\u03b2 Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis. Arthritis Rheumatol. 2019;71:1056-1069.","journal-title":"Arthritis Rheumatol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.2147\/DDDT.S464485","type":"journal-article","article-title":"Imrecoxib: Advances in Pharmacology and Therapeutics","volume":"18","author":"Wang","year":"2024","unstructured":"Wang YH, Zhu LL, Li TL, Zhou Q. Imrecoxib: Advances in Pharmacology and Therapeutics. Drug Des Devel Ther. 2024;18:1711-1725.","journal-title":"Drug Des Devel Ther"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.joca.2017.09.007","type":"journal-article","article-title":"Safety, tolerability, and pharmacodynamics of an anti-interleukin-1\u03b1\/\u03b2 dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study","volume":"25","author":"Wang","year":"2017","unstructured":"Wang SX, et al. Safety, tolerability, and pharmacodynamics of an anti-interleukin-1\u03b1\/\u03b2 dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. Osteoarthritis Cartilage. 2017;25:1952-1961.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jcph.764","type":"journal-article","article-title":"Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1\u03b1 and IL-1\u03b2 in Healthy Subjects and Patients With Osteoarthritis of the Knee","volume":"56","author":"Kosloski","year":"2016","unstructured":"Kosloski MP, et al. Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1\u03b1 and IL-1\u03b2 in Healthy Subjects and Patients With Osteoarthritis of the Knee. J Clin Pharmacol. 2016;56:1582-1590.","journal-title":"J Clin Pharmacol"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"509","DOI":"10.7326\/M20-0527","type":"journal-article","article-title":"Effects of Interleukin-1\u03b2 Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial","volume":"173","author":"Schieker","year":"2020","unstructured":"Schieker M, et al. Effects of Interleukin-1\u03b2 Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2020;173:509-515.","journal-title":"Ann Intern Med"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"eadu9804","DOI":"10.1126\/scitranslmed.adu9804","type":"journal-article","article-title":"A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint","volume":"17","author":"De la Vega","year":"2025","unstructured":"De la Vega RE, et al. A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint. Sci Transl Med. 2025;17:eadu9804.","journal-title":"Sci Transl Med"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"186","DOI":"10.22540\/JMNI-25-186","type":"journal-article","article-title":"Study on the Predictive Value of Inflammatory Factors and Biomarkers in Synovial Fluid for Disease Progression in Knee Osteoarthritis Patients","volume":"25","author":"Zhu","year":"2025","unstructured":"Zhu C, Jiang L, Liu K, Shi N. Study on the Predictive Value of Inflammatory Factors and Biomarkers in Synovial Fluid for Disease Progression in Knee Osteoarthritis Patients. J Musculoskelet Neuronal Interact. 2025;25:186-191.","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.2174\/0929867330666230407140730","type":"journal-article","article-title":"Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an In Vitro Osteoarthritis Cellular Model","volume":"31","author":"Iuliano","year":"2024","unstructured":"Iuliano M, et al. Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an In Vitro Osteoarthritis Cellular Model. Curr Med Chem. 2024;31:1740-1753.","journal-title":"Curr Med Chem"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41434-025-00515-y","type":"journal-article","article-title":"Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models","volume":"32","author":"Zhou","year":"2025","unstructured":"Zhou K, et al. Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models. Gene Ther. 2025;32:211-222.","journal-title":"Gene Ther"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1021\/acsbiomaterials.2c00332","type":"journal-article","article-title":"High-Efficiency Treatment for Osteoarthritis via Self-Assembled Dual-Functionalized Nanobiologics","volume":"8","author":"Wang","year":"2022","unstructured":"Wang C, et al. High-Efficiency Treatment for Osteoarthritis via Self-Assembled Dual-Functionalized Nanobiologics. ACS Biomater Sci Eng. 2022;8:3320-3328.","journal-title":"ACS Biomater Sci Eng"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/jor.23504","type":"journal-article","article-title":"Immunohistochemical characterization of early and advanced knee osteoarthritis by NF-\u03baB and iNOS expression","volume":"35","author":"Ostojic","year":"2017","unstructured":"Ostojic M, Soljic V, Vukojevic K, Dapic T. Immunohistochemical characterization of early and advanced knee osteoarthritis by NF-\u03baB and iNOS expression. J Orthop Res. 2017;35:1990-1997.","journal-title":"J Orthop Res"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actbio.2019.04.051","type":"journal-article","article-title":"Injectable biomaterials for delivery of interleukin-1 receptor antagonist: Toward improving its therapeutic effect","volume":"93","author":"Clements","year":"2019","unstructured":"Clements AEB, Murphy WL. Injectable biomaterials for delivery of interleukin-1 receptor antagonist: Toward improving its therapeutic effect. Acta Biomater. 2019;93:123-134.","journal-title":"Acta Biomater"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biopha.2017.02.045","type":"journal-article","article-title":"A recombinant IgG-like bispecific antibody acting as interleukin-1\u03b2 and interleukin-17A inhibitor exhibits a promising efficacy for rheumatoid arthritis","volume":"89","author":"Wang","year":"2017","unstructured":"Wang Y, et al. A recombinant IgG-like bispecific antibody acting as interleukin-1\u03b2 and interleukin-17A inhibitor exhibits a promising efficacy for rheumatoid arthritis. Biomed Pharmacother. 2017;89:426-437.","journal-title":"Biomed Pharmacother"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3390\/pharmaceutics17101272","type":"journal-article","article-title":"The Application of Novel Drug Delivery Systems in the Treatment of Osteoarthritis","volume":"17","author":"Huang","year":"2025","unstructured":"Huang P, et al. The Application of Novel Drug Delivery Systems in the Treatment of Osteoarthritis. Pharmaceutics. 2025;17:1272.","journal-title":"Pharmaceutics"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"40012","DOI":"10.1021\/acsami.5c06055","type":"journal-article","article-title":"Intelligently Actuating Dual-Barrier Hyaluronic Acid-Functionalized Inflammation-Responsive Nanohydrogel for Targeted Rheumatoid Arthritis Therapy","volume":"17","author":"Singh","year":"2025","unstructured":"Singh R, et al. Intelligently Actuating Dual-Barrier Hyaluronic Acid-Functionalized Inflammation-Responsive Nanohydrogel for Targeted Rheumatoid Arthritis Therapy. ACS Appl Mater Interfaces. 2025;17:40012-40034.","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["Journal of Visualized Experiments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jove.com\/t\/71378\/regulatory-mechanisms-interleukin-1-its-targeted-therapeutic","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:22:23Z","timestamp":1792585343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jove.com\/t\/71378\/regulatory-mechanisms-interleukin-1-its-targeted-therapeutic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":134,"journal-issue":{"issue":"233","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3791\/71378","relation":{},"ISSN":["1940-087X"],"issn-type":[{"value":"1940-087X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]}}}