{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:43:19Z","timestamp":1792248199670,"version":"4.4.0"},"reference-count":57,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2016]]},"DOI":"10.3803\/enm.2016.31.2.213","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T04:59:35Z","timestamp":1467003575000},"page":"213","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease"],"prefix":"10.3803","volume":"31","author":[{"given":"Wilmar M.","family":"Wiersinga","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"10.3803\/EnM.2016.31.2.213_ref1","first-page":"243","volume":"1","author":"Weetman","year":"2013","journal-title":"Eur Thyroid J"},{"key":"10.3803\/EnM.2016.31.2.213_ref2","first-page":"930","volume":"86","author":"Brix","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/eje.1.02060","volume":"154","author":"Hansen","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2265.2011.04318.x","volume":"76","author":"Brix","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaut.2015.07.009","volume":"64","author":"Lee","year":"2015","journal-title":"J Autoimmun"},{"key":"10.3803\/EnM.2016.31.2.213_ref6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/105072503768499653","volume":"13","author":"Villanueva","year":"2003","journal-title":"Thyroid"},{"key":"10.3803\/EnM.2016.31.2.213_ref7","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/archinte.168.15.1657","volume":"168","author":"Strieder","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.3803\/EnM.2016.31.2.213_ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref9","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1210\/jc.2003-032089","volume":"89","author":"Flynn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2265.2011.04008.x","volume":"75","author":"Pedersen","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref11","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1210\/jc.2007-0732","volume":"92","author":"Pedersen","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref12","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/jc.2012-2960","volume":"98","author":"Aghini Lombardi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/cen.12222","volume":"79","author":"Wiersinga","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1365-2265.2003.01862.x","volume":"59","author":"Strieder","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref15","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1210\/jc.2004-0431","volume":"89","author":"Belin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref16","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1001\/archinte.167.13.1428","volume":"167","author":"Asvold","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.3803\/EnM.2016.31.2.213_ref17","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1210\/jc.2008-1548","volume":"94","author":"Effraimidis","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-2265.2012.04455.x","volume":"77","author":"Carl\u00e9","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000338920","volume":"1","author":"Effraimidis","year":"2012","journal-title":"Eur Thyroid J"},{"key":"10.3803\/EnM.2016.31.2.213_ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1530\/EJE-12-0356","volume":"167","author":"Carl\u00e9","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cen.12106","volume":"79","author":"Carl\u00e9","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-10-0785","volume":"164","author":"Effraimidis","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref23","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jcem.87.4.8421","volume":"87","author":"G\u00e4rtner","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/eje.0.1480389","volume":"148","author":"Duntas","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1677\/joe.1.06661","volume":"190","author":"Turker","year":"2006","journal-title":"J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/thy.2007.0127","volume":"18","author":"Karanikas","year":"2008","journal-title":"Thyroid"},{"key":"10.3803\/EnM.2016.31.2.213_ref27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2265.2009.03758.x","volume":"73","author":"Nacamulli","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/cen.12284","volume":"80","author":"Eskes","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000439589","volume":"4","author":"Pilli","year":"2015","journal-title":"Eur Thyroid J"},{"key":"10.3803\/EnM.2016.31.2.213_ref30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s40618-015-0285-8","volume":"38","author":"de Farias","year":"2015","journal-title":"J Endocrinol Invest"},{"key":"10.3803\/EnM.2016.31.2.213_ref31","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa1012985","volume":"364","author":"Marcocci","year":"2011","journal-title":"N Engl J Med"},{"key":"10.3803\/EnM.2016.31.2.213_ref32","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jc.2006-1821","volume":"92","author":"Negro","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00394-014-0822-9","volume":"55","author":"Mao","year":"2016","journal-title":"Eur J Nutr"},{"key":"10.3803\/EnM.2016.31.2.213_ref34","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"10.3803\/EnM.2016.31.2.213_ref35","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1210\/jc.2015-2222","volume":"100","author":"Wu","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref36","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.beem.2011.04.009","volume":"25","author":"Van Belle","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref37","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.3390\/nu7042485","volume":"7","author":"Wang","year":"2015","journal-title":"Nutrients"},{"key":"10.3803\/EnM.2016.31.2.213_ref38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/thy.2013.0460","volume":"24","author":"Choi","year":"2014","journal-title":"Thyroid"},{"key":"10.3803\/EnM.2016.31.2.213_ref39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1530\/EJE-12-0048","volume":"167","author":"Effraimidis","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12020-012-9812-y","volume":"43","author":"Feng","year":"2013","journal-title":"Endocrine"},{"key":"10.3803\/EnM.2016.31.2.213_ref41","first-page":"107","volume":"14","author":"Tomer","year":"1993","journal-title":"Endocr Rev"},{"key":"10.3803\/EnM.2016.31.2.213_ref42","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1210\/jc.2009-2184","volume":"95","author":"Wang","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2249.2011.04399.x","volume":"165","author":"Effraimidis","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"10.3803\/EnM.2016.31.2.213_ref44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2265.2008.03227.x","volume":"69","author":"Brix","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref45","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1365-2249.2003.02139.x","volume":"132","author":"Strieder","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.3803\/EnM.2016.31.2.213_ref46","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0140-6736(91)92298-G","volume":"338","author":"Winsa","year":"1991","journal-title":"Lancet"},{"key":"10.3803\/EnM.2016.31.2.213_ref47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/acta.0.1280293","volume":"128","author":"Sonino","year":"1993","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10.3803\/EnM.2016.31.2.213_ref48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2265.1995.tb01879.x","volume":"42","author":"Kung","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.3803\/EnM.2016.31.2.213_ref49","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1530\/eje.0.1340699","volume":"134","author":"Radosavljevic","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref50","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.psyneuen.2011.12.009","volume":"37","author":"Effraimidis","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.3803\/EnM.2016.31.2.213_ref51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1530\/eje.1.02070","volume":"154","author":"B\u00fclow Pedersen","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/1047-2797(94)00110-F","volume":"5","author":"Massoudi","year":"1995","journal-title":"Ann Epidemiol"},{"issue":"2","key":"10.3803\/EnM.2016.31.2.213_ref53","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1136\/bmj.2.6151.1531","volume":"2","author":"Frank","year":"1978","journal-title":"Br Med J"},{"key":"10.3803\/EnM.2016.31.2.213_ref54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/105072502753451995","volume":"12","author":"Vestergaard","year":"2002","journal-title":"Thyroid"},{"key":"10.3803\/EnM.2016.31.2.213_ref55","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/EJE-08-0236","volume":"159","author":"Rotondi","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.3803\/EnM.2016.31.2.213_ref56","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1210\/jc.2010-1980","volume":"96","author":"Stagnaro-Green","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3803\/EnM.2016.31.2.213_ref57","doi-asserted-by":"crossref","first-page":"R241","DOI":"10.1530\/EJE-14-0047","volume":"170","author":"Effraimidis","year":"2014","journal-title":"Eur J Endocrinol"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/synapse.koreamed.org\/pdf\/10.3803\/EnM.2016.31.2.213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/synapse.koreamed.org\/DOIx.php?id=10.3803\/EnM.2016.31.2.213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/synapse.koreamed.org\/DOIx.php?id=10.3803\/EnM.2016.31.2.213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T18:49:31Z","timestamp":1718650171000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2016.31.2.213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2016.31.2.213","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"https:\/\/synapse.koreamed.orgDOIx.php?id=10.3803\/EnM.2016.31.2.213","URL":"https:\/\/synapse.koreamed.orgDOIx.php?id=10.3803\/EnM.2016.31.2.213","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"http:\/\/e-enm.org\/DOIx.php?id=10.3803\/EnM.2016.31.2.213","URL":"http:\/\/e-enm.org\/DOIx.php?id=10.3803\/EnM.2016.31.2.213","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2016-04-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-27","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2016 Korean Endocrine Society","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}