{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:38:06Z","timestamp":1761514686032,"version":"3.37.3"},"reference-count":31,"publisher":"Korean Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:p>Background: The aim of this study was to evaluate clinical outcomes in coronavirus disease 2019 (COVID-19) positive patients with type 2 diabetes compared to those without diabetes in Korea.Methods: We extracted claims data for patients diagnosed with COVID-19 from the National Health Insurance Service database in Korea from January 20, 2020 to March 31, 2020. We followed up this cohort until death from COVID-19 or discharge from hospital.Results: A total of 5,473 patients diagnosed with COVID-19 were analyzed, including 495 with type 2 diabetes and 4,978 without diabetes. Patients with type 2 diabetes were more likely to be treated in the intensive care unit (ICU) (P&lt;0.0001). The incidence of inhospital mortality was higher in patients with type 2 diabetes (P&lt;0.0001). After adjustment for age, sex, insurance status, and comorbidities, odds of ICU admission (adjusted odds ratio [OR], 1.59; 95% confidence interval [CI], 1.02 to 2.49; &lt;i&gt;P&lt;\/i&gt;=0.0416) and in-hospital mortality (adjusted OR, 1.90; 95% CI, 1.13 to 3.21; &lt;i&gt;P&lt;\/i&gt;=0.0161) among patients with COVID-19 infection were significantly higher in those with type 2 diabetes. However, there was no significant difference between patients with and without type 2 diabetes in ventilator, oxygen therapy, antibiotics, antiviral drugs, antipyretics, and the incidence of pneumonia after adjustment.Conclusion: COVID-19 positive patients with type 2 diabetes had poorer clinical outcomes with higher risk of ICU admission and in-hospital mortality than those without diabetes. Therefore, medical providers need to consider this more serious clinical course when planning and delivering care to type 2 diabetes patients with COVID-19 infection.<\/jats:p>","DOI":"10.3803\/enm.2020.787","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T06:50:29Z","timestamp":1607583029000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea"],"prefix":"10.3803","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-7094","authenticated-orcid":true,"given":"Ji Hong","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-0141","authenticated-orcid":true,"given":"Sang Ah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Youn","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-3407","authenticated-orcid":true,"given":"Sun Ok","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Wan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-2044","authenticated-orcid":true,"given":"Dae Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Boyko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2119","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.24171\/j.phrp.2020.11.2.05"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0146"},{"volume-title":"","year":"2020","key":"ref4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0067"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.5.395"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.1.79"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004018"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.1.35"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1008862"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2417"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0138"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2215"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.8.686"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-015-3679-z"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131774"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.9.889"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/diab.23.1.9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.2.256"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.05.177"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00015.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3319"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00547-2020"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05180-x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0375"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01387-19"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nature12005"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.787","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-787.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T05:53:07Z","timestamp":1683006787000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2020.787","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"type":"print","value":"2093-596X"},{"type":"electronic","value":"2093-5978"}],"subject":[],"published":{"date-parts":[[2020,12,31]]},"assertion":[{"value":"2020-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}