{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:53:09Z","timestamp":1790034789482,"version":"4.0.1"},"reference-count":28,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["2520140120"],"award-info":[{"award-number":["2520140120"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"Background: We investigated the clinical characteristics of parathyroid adenomas according to radioactivity on <sup>99m<\/sup>Tc-methoxyisobutylisonitrile (<sup>99m<\/sup>Tc-MIBI) single-photon emission computed tomography\/computed tomography (SPECT\/CT) in primary hyperparathyroidism (PHPT) patients.Methods: The study included 217 patients diagnosed with PHPT from 2000 to 2019 at Seoul National University Hospital who underwent <sup>99m<\/sup>Tc-MIBI SPECT\/CT scans. On SPECT\/CT, the radioactivity of parathyroid adenomas was measured as the ratio of the mean radioactivity count of the parathyroid adenoma to that of the contralateral thyroid.Results: Tumors were localized by MIBI scans in 190 patients (MIBI [+] group) and by ultrasound or parathyroid four-dimensional CT in 27 patients (MIBI [\u2013] group). The mean age was 55 years, and mean body mass index was 23.4 kg\/m<sup>2<\/sup>. Patients in the MIBI (+) group had higher parathyroid hormone (iPTH) and lower 25-hydroxy vitamin D levels than those in the MIBI (\u2013) group (168.0 pg\/mL [interquartile range, IQR, 111.0 to 250.7] vs. 134.7 pg\/mL [IQR, 98.2 to 191.2], <i>P<\/i>=0.049; 15.4 ng\/mL [IQR, 11.1 to 20.8] vs. 21.2 ng\/mL [IQR, 13.9 to 24.8], <i>P<\/i>=0.012, respectively). Patients in the MIBI (+) group had larger tumor volumes, but lower iPTH\/volume ratios than those in the MIBI (\u2013) group (1,216.66 [IQR, 513.40 to 2,663.02], 499.82 mm<sup>3<\/sup> [IQR, 167.77 to 1,229.80], <i>P<\/i>=0.002; 0.18 [IQR, 0.08 to 0.46], 0.40 pg\/mL\/mm<sup>3<\/sup> [IQR, 0.16 to 1.29], <i>P<\/i>=0.016, respectively). Adenoma radioactivity was positively correlated with calcium, iPTH, and volume (<i>r<\/i>=0.180, <i>P<\/i>=0.020; <i>r<\/i>=0.208, <i>P<\/i>=0.006; <i>r<\/i>=0.288, <i>P<\/i><0.001, respectively), but not with iPTH\/volume.Conclusion: Parathyroid adenomas with positive MIBI scans had larger volumes and higher iPTH than adenomas with negative scans, but lower iPTH per unit volume.<\/jats:p>","DOI":"10.3803\/enm.2020.823","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T06:20:31Z","timestamp":1617690031000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Radioactive Parathyroid Adenomas on Sestamibi Scans: Low Parathyroid Hormone Secretory Potential and Large Volume"],"prefix":"10.3803","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-0909","authenticated-orcid":true,"given":"Sung Hye","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-4465","authenticated-orcid":true,"given":"Chan Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"ref1","first-page":"184","volume-title":"Primary hyperparathyroidism: pathophysiology and impact on 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Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-823.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.823","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-823.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T05:52:54Z","timestamp":1683006774000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2020.823","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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