{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:55:08Z","timestamp":1788306908341,"version":"build-2803163510"},"reference-count":31,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["-2017R1D1A1B03033587"],"award-info":[{"award-number":["-2017R1D1A1B03033587"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"Background: The guanine nucleotide-binding protein, alpha stimulating (<i>GNAS<\/i>) gene has been associated with growth hormone (GH)-secreting pituitary adenoma. We investigated the prevalence of <i>GNAS<\/i> mutations in Korean patients with acromegaly and assessed whether mutation status correlated with biochemical or clinical characteristics.Methods: We studied 126 patients with acromegaly who underwent surgery between 2005 and 2014 at Severance Hospital. We performed <i>GNAS<\/i> gene analysis and evaluated age, sex, hormone levels, postoperative biochemical remission, and immunohistochemical staining results of the tumor.Results: <i>GNAS<\/i> mutations were present in 75 patients (59.5%). Patients with and without <i>GNAS<\/i> mutations showed similar age distribution and Knosp classification. The proportion of female patients was 76.5% and 48.0% in the <i>GNAS<\/i>-negative and <i>GNAS<\/i>-mutation groups, respectively (<i>P<\/i>=0.006). In immunohistochemical staining, the <i>GNAS<\/i>-mutation group showed higher GH expression in pituitary tumor tissues than the mutation-negative group (98.7% vs. 92.2%, <i>P<\/i>=0.015). Patients with <i>GNAS<\/i> mutations had higher preoperative insulin-like growth factor-1 levels (791.3 ng\/mL vs. 697.0 ng\/mL, <i>P<\/i>=0.045) and lower immediate postoperative basal (0.9 ng\/mL vs. 1.0 ng\/mL, <i>P<\/i>=0.191) and nadir GH levels (0.3 ng\/mL vs. 0.6 ng\/mL, <i>P<\/i>=0.012) in oral glucose tolerance tests. Finally, the <i>GNAS<\/i>-mutation group showed significantly higher surgical remission rates than the mutation-negative group, both at 1 week and 6 months after surgical resection (70.7% vs. 54.9%, <i>P<\/i>=0.011; 85.3% vs. 82.4%, <i>P<\/i>=0.007, respectively).Conclusion: <i>GNAS<\/i> mutations in GH-secreting pituitary tumors are associated with higher preoperative insulin-like growth factor-1 levels and surgical remission rates and lower immediate postoperative nadir GH levels. Thus, <i>GNAS<\/i> mutation status can predict surgical responsiveness in patients with acromegaly.<\/jats:p>","DOI":"10.3803\/enm.2020.875","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:31:11Z","timestamp":1616484671000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Associations of GNAS Mutations with Surgical Outcomes in Patients with Growth Hormone-Secreting Pituitary Adenoma"],"prefix":"10.3803","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-128X","authenticated-orcid":true,"given":"Hyein","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungwon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daham","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-9630","authenticated-orcid":true,"given":"Cheol Ryong","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-8370","authenticated-orcid":true,"given":"Eun Jig","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172\/jci39375"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2700"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0789-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-16-0452"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1408028"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/340692a0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1416"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.2116665"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0662-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-007-0058-2"},{"key":"ref11","first-page":"301","volume-title":"Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues","author":"Hosoi","year":"1993"},{"key":"ref12","first-page":"891","volume-title":"Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors","author":"Shi","year":"1998"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199310000-00008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.jns141083"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0b013e318265a288"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1172\/jci11887"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/jci20401"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej16-0075"},{"key":"ref20","first-page":"1604","volume-title":"Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas","author":"Barlier","year":"1998"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199308000-00003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0035"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0426-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01844"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0b013e31823f5c16"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04163.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0383-y"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra062453"},{"key":"ref29","first-page":"2035","volume-title":"Changing patterns in diagnosis and therapy of acromegaly over two decades","author":"Nachtigall","year":"2008"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3129"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-008-0136-0"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2020-875.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T05:52:47Z","timestamp":1683006767000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2020.875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2020.875","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]},"assertion":[{"value":"2020-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}