{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:34:37Z","timestamp":1790397277607,"version":"4.1.0"},"reference-count":32,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2019IP0862"],"award-info":[{"award-number":["2019IP0862"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1010723"],"award-info":[{"award-number":["2020R1C1C1010723"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:p>Background: Guidelines by the Endocrine Society Guideline on bypassing adrenal vein sampling (AVS) in patients &lt;35 years old with marked primary aldosteronism (PA) (hypokalemia and elevated plasma aldosterone concentration [PAC]) and a unilateral lesion on computed tomography (CT) are based on limited number of studies. We aimed to determine the accuracy of CT in PA patients according to age.Methods: In this retrospective study, we investigated the concordance between CT and AVS in 466 PA patients from two tertiary centers who successfully underwent AVS.Results: CT had an overall accuracy of 64.4% (300\/466). In the group with unilateral lesion, patients with hypokalemia had higher concordance than those without hypokalemia (85.0% vs. 43.6%, &lt;i&gt;P&lt;\/i&gt;&lt;0.001). In the group with marked PA (hypokalemia and PAC &gt;15.9 ng\/dL) and unilateral lesion, accuracy of CT was 84.6% (11\/13) in patients aged &lt;35 years; 100.0% (20\/20), aged 35 to 39 years; 89.4% (59\/66), aged 40 to 49 years; and 79.8% (79\/99), aged \u226550 years. Cut-off age and PAC for concordance was &lt;50 years and &gt;29.6 ng\/dL, respectively. The significant difference in accuracy of CT in 198 patients with marked PA and a unilateral lesion between the &lt;50-year age group and \u226550-year age group (90.9% vs. 79.8%, &lt;i&gt;P&lt;\/i&gt;=0.044) disappeared in 139 of 198 patients with PAC &gt; 30.0 ng\/dL (91.9% vs. 87.7%, &lt;i&gt;P&lt;\/i&gt;=0.590).Conclusion: Patients with hypokalemia, PAC &gt;30.0 ng\/dL, and unilateral lesion were at high risk of unilateral PA regardless of age.<\/jats:p>","DOI":"10.3803\/enm.2020.901","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T23:55:48Z","timestamp":1617234948000},"page":"401-412","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Diagnostic Accuracy of Computed Tomography in Predicting Primary Aldosteronism Subtype According to Age"],"prefix":"10.3803","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-247X","authenticated-orcid":true,"given":"Seung 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