{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:25:48Z","timestamp":1785529548092,"version":"3.56.0"},"reference-count":58,"publisher":"Korean Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29 Nanji-Japan 046"],"award-info":[{"award-number":["H29 Nanji-Japan 046"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2021,2,28]]},"DOI":"10.3803\/enm.2021.101","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T05:30:22Z","timestamp":1614231022000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging"],"prefix":"10.3803","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-9738","authenticated-orcid":true,"given":"Xin","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Tezuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Omata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikiyo","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-8641","authenticated-orcid":true,"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"ref1","first-page":"685","volume-title":"Medicine: the genetics of primary aldosteronism","author":"Funder","year":"2011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001948"},{"key":"ref4","first-page":"823","volume-title":"Primary aldosteronism: practical approach to diagnosis and management","author":"Byrd","year":"2018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa484"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0482-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.118.11086"},{"key":"ref10","first-page":"1182","volume-title":"Histopathological classification of cross-sectional image-negative hyperaldosteronism","author":"Yamazaki","year":"2017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00134"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3285"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90971-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198785"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2716"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2695"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2550"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/srep19546"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1530\/eje-19-0377"},{"key":"ref20","first-page":"E155","volume-title":"Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance","author":"Cheng","year":"2015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.08.012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.114.03419"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.02.026"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1530\/erc-17-0361"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.7554\/elife.06315"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.10.002"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.113.02234"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564166"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.6.2160"},{"key":"ref30","first-page":"64","volume-title":"The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension","author":"Lifton","year":"1992"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-0934-y"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0053-8"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01004"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.119.14177"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.5551\/jat.24455"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3726"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505529112"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.118.10907"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105764"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1317-1"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1980.tb03284.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz235"},{"key":"ref43","first-page":"E819","volume-title":"Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors","author":"Azizan","year":"2012"},{"key":"ref44","first-page":"724","volume-title":"Adrenal histopathology in primary aldosteronism: is it time for a change?","author":"Gioco","year":"2015"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.110.158543"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1205"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111043"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.07.016"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.7326\/m17-0882"},{"key":"ref50","first-page":"325","volume-title":"Effect on aging on plasma renin and aldosterone in normal man","author":"Weidmann","year":"1975"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1977.03630220056014"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-2-384"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.171"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1159\/000182717"},{"key":"ref55","first-page":"710","volume-title":"Aldosterone stimulation by angiotensin II: influence of gender, plasma renin, and familial resemblance","author":"Giacche","year":"2000"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.028201"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/s1568-1637(01)00007-1"},{"key":"ref58","first-page":"557","volume-title":"Alteration of subcapsular adrenocortical zonation in humans with aging: the progenitor zone predominates over the previously well-developed zona glomerulosa after 40 years of age","author":"Aiba","year":"2011"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2021-101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2021.101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2021-101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T07:48:33Z","timestamp":1614844113000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2021.101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,28]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2021.101","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,28]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-28","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}